GOSR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GOSR1_HUMAN
• UniProt AC: O95249
• Protein Name: Golgi SNAP receptor complex member 1
• Gene Name: GOSR1
• Organism: Homo sapiens (Human).
• Sequence Length: 250
• Subcellular Localization: Golgi apparatus membrane ; Single-pass type IV membrane protein . Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network (By similarity). Enriched on vesicular components at the terminal rims of the Golgi. Found in Go
• Protein Description: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi..
• Protein Sequence: MAAGTSSYWEDLRKQARQLENELDLKLVSFSKLCTSYSHSSTRDGRRDRYSSDTTPLLNGSSQDRMFETMAIEIEQLLARLTGVNDKMAEYTNSAGVPSLNAALMHTLQRHRDILQDYTHEFHKTKANFMAIRERENLMGSVRKDIESYKSGSGVNNRRTELFLKEHDHLRNSDRLIEETISIAMATKENMTSQRGMLKSIHSKMNTLANRFPAVNSLIQRINLRKRRDSLILGGVIGICTILLLLYAFH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAGTSSYW ------CCCCCHHHH	18.01	22223895
5	Phosphorylation	---MAAGTSSYWEDL ---CCCCCHHHHHHH	15.13	27486199
6	Phosphorylation	--MAAGTSSYWEDLR --CCCCCHHHHHHHH	22.10	25159151
7	Phosphorylation	-MAAGTSSYWEDLRK -CCCCCHHHHHHHHH	33.82	27486199
8	Phosphorylation	MAAGTSSYWEDLRKQ CCCCCHHHHHHHHHH	16.75	27486199
26	Ubiquitination	LENELDLKLVSFSKL HHHHHHHHHHHHHHH	46.65	-
26	Malonylation	LENELDLKLVSFSKL HHHHHHHHHHHHHHH	46.65	26320211
29	Phosphorylation	ELDLKLVSFSKLCTS HHHHHHHHHHHHHHH	33.95	24719451
32	Ubiquitination	LKLVSFSKLCTSYSH HHHHHHHHHHHHCCC	45.64	-
36	Phosphorylation	SFSKLCTSYSHSSTR HHHHHHHHCCCCCCC	24.52	-
37	Phosphorylation	FSKLCTSYSHSSTRD HHHHHHHCCCCCCCC	7.70	-
38	Phosphorylation	SKLCTSYSHSSTRDG HHHHHHCCCCCCCCC	19.36	-
40	Phosphorylation	LCTSYSHSSTRDGRR HHHHCCCCCCCCCCC	27.71	28857561
49	Phosphorylation	TRDGRRDRYSSDTTP CCCCCCCCCCCCCCC	31.27	20736484
50	Phosphorylation	RDGRRDRYSSDTTPL CCCCCCCCCCCCCCC	19.47	28450419
51	Phosphorylation	DGRRDRYSSDTTPLL CCCCCCCCCCCCCCC	23.72	28450419
52	Phosphorylation	GRRDRYSSDTTPLLN CCCCCCCCCCCCCCC	30.00	21815630
53	Phosphorylation	RRDRYSSDTTPLLNG CCCCCCCCCCCCCCC	48.97	-
54	Phosphorylation	RDRYSSDTTPLLNGS CCCCCCCCCCCCCCC	32.06	28450419
55	Phosphorylation	DRYSSDTTPLLNGSS CCCCCCCCCCCCCCC	19.55	28450419
59	Acetylation	SDTTPLLNGSSQDRM CCCCCCCCCCCCCHH	56.85	19608861
122	Acetylation	LQDYTHEFHKTKANF HHHHHHHHHHHHHCH	5.78	-
124	Acetylation	DYTHEFHKTKANFMA HHHHHHHHHHHCHHH	57.97	19608861
124	Ubiquitination	DYTHEFHKTKANFMA HHHHHHHHHHHCHHH	57.97	-
130	Sulfoxidation	HKTKANFMAIREREN HHHHHCHHHHHHHHH	2.80	21406390
139	Phosphorylation	IRERENLMGSVRKDI HHHHHHHHHHHHHHH	5.92	24719451
141	Phosphorylation	ERENLMGSVRKDIES HHHHHHHHHHHHHHH	12.56	23401153
144	Ubiquitination	NLMGSVRKDIESYKS HHHHHHHHHHHHHHC	61.98	-
148	Phosphorylation	SVRKDIESYKSGSGV HHHHHHHHHHCCCCC	37.89	-
149	Phosphorylation	VRKDIESYKSGSGVN HHHHHHHHHCCCCCC	9.07	-
150	Ubiquitination	RKDIESYKSGSGVNN HHHHHHHHCCCCCCC	58.58	21890473
150	Methylation	RKDIESYKSGSGVNN HHHHHHHHCCCCCCC	58.58	-
151	Phosphorylation	KDIESYKSGSGVNNR HHHHHHHCCCCCCCH	29.92	20068231
160	Phosphorylation	SGVNNRRTELFLKEH CCCCCHHHHHHHHHC	33.53	28555341
165	Ubiquitination	RRTELFLKEHDHLRN HHHHHHHHHCHHHCC	45.74	21890473
180	Phosphorylation	SDRLIEETISIAMAT HHHHHHHHHHHHHHC	13.77	24905233
182	Phosphorylation	RLIEETISIAMATKE HHHHHHHHHHHHCCC	16.24	24905233
187	Phosphorylation	TISIAMATKENMTSQ HHHHHHHCCCCCCCC	26.30	24905233
188	Ubiquitination	ISIAMATKENMTSQR HHHHHHCCCCCCCCH	37.24	21906983
192	Phosphorylation	MATKENMTSQRGMLK HHCCCCCCCCHHHHH	33.03	24905233
193	Phosphorylation	ATKENMTSQRGMLKS HCCCCCCCCHHHHHH	13.70	24905233
199	Ubiquitination	TSQRGMLKSIHSKMN CCCHHHHHHHHHHHH	38.17	-
200	Phosphorylation	SQRGMLKSIHSKMNT CCHHHHHHHHHHHHH	22.90	28857561
204	Ubiquitination	MLKSIHSKMNTLANR HHHHHHHHHHHHHHH	23.23	21890473
217	Phosphorylation	NRFPAVNSLIQRINL HHCHHHHHHHHHHCC	21.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GOSR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GOSR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GOSR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STX5_HUMAN	STX5	physical	9647643
STX5_HUMAN	STX5	physical	11927603
YKT6_HUMAN	YKT6	physical	11927603
BET1_HUMAN	BET1	physical	11927603
BET1L_HUMAN	BET1L	physical	11927603
STX5_HUMAN	STX5	physical	9325254
SCFD1_HUMAN	SCFD1	physical	20562859
NSF_HUMAN	NSF	physical	20562859
SC22B_HUMAN	SEC22B	physical	20562859
PKP1_HUMAN	PKP1	physical	20562859
DSC1_HUMAN	DSC1	physical	20562859
A4_HUMAN	APP	physical	21832049
STX12_HUMAN	STX12	physical	22939629
RHOA_HUMAN	RHOA	genetic	26472760
PTAR1_HUMAN	PTAR1	genetic	26472760
TPC13_HUMAN	TRAPPC13	genetic	26472760

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.