dbPTM

PKP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PKP1_HUMAN
UniProt AC	Q13835
Protein Name	Plakophilin-1
Gene Name	PKP1
Organism	Homo sapiens (Human).
Sequence Length	747
Subcellular Localization	Isoform 1: Nucleus. Cell junction, desmosome. Nucleus.
Protein Description	Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis..
Protein Sequence	MNHSPLKTALAYECFQDQDNSTLALPSDQKMKTGTSGRQRVQEQVMMTVKRQKSKSSQSSTLSHSNRGSMYDGLADNYNYGTTSRSSYYSKFQAGNGSWGYPIYNGTLKREPDNRRFSSYSQMENWSRHYPRGSCNTTGAGSDICFMQKIKASRSEPDLYCDPRGTLRKGTLGSKGQKTTQNRYSFYSTCSGQKAIKKCPVRPPSCASKQDPVYIPPISCNKDLSFGHSRASSKICSEDIECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKELQGVLRQQGFDRNMLGTLAGANSLRNFTSRF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MNHSPLKTALA ----CCCCHHHHHHH	27.24	25849741
7	Methylation	-MNHSPLKTALAYEC -CCCCHHHHHHHHHH	34.83	115975065
12	Phosphorylation	PLKTALAYECFQDQD HHHHHHHHHHHCCCC	17.68	25106551
21	Phosphorylation	CFQDQDNSTLALPSD HHCCCCCCEEECCCC	32.84	28348404
22	Phosphorylation	FQDQDNSTLALPSDQ HCCCCCCEEECCCCC	23.46	28348404
33	Phosphorylation	PSDQKMKTGTSGRQR CCCCCCCCCCCHHHH	42.04	-
35	Phosphorylation	DQKMKTGTSGRQRVQ CCCCCCCCCHHHHHH	32.99	-
36	Phosphorylation	QKMKTGTSGRQRVQE CCCCCCCCHHHHHHH	33.07	-
54	Phosphorylation	MTVKRQKSKSSQSST HHHHHHHCCCCCCCC	29.45	27794612
56	Phosphorylation	VKRQKSKSSQSSTLS HHHHHCCCCCCCCCC	40.47	27794612
57	Phosphorylation	KRQKSKSSQSSTLSH HHHHCCCCCCCCCCC	37.51	27794612
59	Phosphorylation	QKSKSSQSSTLSHSN HHCCCCCCCCCCCCC	27.52	27251275
60	Phosphorylation	KSKSSQSSTLSHSNR HCCCCCCCCCCCCCC	26.23	27251275
61	Phosphorylation	SKSSQSSTLSHSNRG CCCCCCCCCCCCCCC	37.21	27251275
63	Phosphorylation	SSQSSTLSHSNRGSM CCCCCCCCCCCCCCC	25.59	27794612
65	Phosphorylation	QSSTLSHSNRGSMYD CCCCCCCCCCCCCCC	25.50	19060867
69	Phosphorylation	LSHSNRGSMYDGLAD CCCCCCCCCCCCCCC	15.78	26356563
71	Phosphorylation	HSNRGSMYDGLADNY CCCCCCCCCCCCCCC	14.46	26356563
78	Phosphorylation	YDGLADNYNYGTTSR CCCCCCCCCCCCCCC	15.43	25106551
80	Phosphorylation	GLADNYNYGTTSRSS CCCCCCCCCCCCCHH	12.89	25106551
82	Phosphorylation	ADNYNYGTTSRSSYY CCCCCCCCCCCHHHC	15.96	26356563
83	Phosphorylation	DNYNYGTTSRSSYYS CCCCCCCCCCHHHCC	20.13	26356563
84	Phosphorylation	NYNYGTTSRSSYYSK CCCCCCCCCHHHCCE	29.97	26356563
86	Phosphorylation	NYGTTSRSSYYSKFQ CCCCCCCHHHCCEEC	23.59	24719451
87	Phosphorylation	YGTTSRSSYYSKFQA CCCCCCHHHCCEECC	27.29	24719451
88	Phosphorylation	GTTSRSSYYSKFQAG CCCCCHHHCCEECCC	17.01	24275569
89	Phosphorylation	TTSRSSYYSKFQAGN CCCCHHHCCEECCCC	13.82	24275569
90	Phosphorylation	TSRSSYYSKFQAGNG CCCHHHCCEECCCCC	20.82	24275569
98	Phosphorylation	KFQAGNGSWGYPIYN EECCCCCCCCCCCCC	22.71	26356563
101	Phosphorylation	AGNGSWGYPIYNGTL CCCCCCCCCCCCCCC	4.72	26356563
104	Phosphorylation	GSWGYPIYNGTLKRE CCCCCCCCCCCCCCC	11.75	25394399
107	Phosphorylation	GYPIYNGTLKREPDN CCCCCCCCCCCCCCC	26.01	25106551
118	Phosphorylation	EPDNRRFSSYSQMEN CCCCCCCCCHHHHHH	26.93	25106551
119	Phosphorylation	PDNRRFSSYSQMENW CCCCCCCCHHHHHHC	26.54	26356563
120	Phosphorylation	DNRRFSSYSQMENWS CCCCCCCHHHHHHCH	11.17	19845377
121	Phosphorylation	NRRFSSYSQMENWSR CCCCCCHHHHHHCHH	25.62	26356563
127	Phosphorylation	YSQMENWSRHYPRGS HHHHHHCHHHCCCCC	22.29	26356563
134	Phosphorylation	SRHYPRGSCNTTGAG HHHCCCCCCCCCCCC	12.89	23090842
137	Phosphorylation	YPRGSCNTTGAGSDI CCCCCCCCCCCCCCC	30.82	23090842
138	Phosphorylation	PRGSCNTTGAGSDIC CCCCCCCCCCCCCCE	15.84	25056879
142	Phosphorylation	CNTTGAGSDICFMQK CCCCCCCCCCEEEEH	24.22	25056879
153	Phosphorylation	FMQKIKASRSEPDLY EEEHHHHCCCCCCCE	31.19	25849741
155	Phosphorylation	QKIKASRSEPDLYCD EHHHHCCCCCCCEEC	51.49	27461979
160	Phosphorylation	SRSEPDLYCDPRGTL CCCCCCCEECCCCCC	11.37	25394399
166	Phosphorylation	LYCDPRGTLRKGTLG CEECCCCCCCCCCCC	25.35	25056879
171	Phosphorylation	RGTLRKGTLGSKGQK CCCCCCCCCCCCCCC	30.86	24719451
174	Phosphorylation	LRKGTLGSKGQKTTQ CCCCCCCCCCCCCCC	36.40	-
179	Phosphorylation	LGSKGQKTTQNRYSF CCCCCCCCCCCCCCE	26.23	23090842
180	Phosphorylation	GSKGQKTTQNRYSFY CCCCCCCCCCCCCEE	30.77	23090842
184	Phosphorylation	QKTTQNRYSFYSTCS CCCCCCCCCEEECCC	15.64	26356563
185	Phosphorylation	KTTQNRYSFYSTCSG CCCCCCCCEEECCCC	17.93	25394399
187	Phosphorylation	TQNRYSFYSTCSGQK CCCCCCEEECCCCCH	9.34	25394399
188	Phosphorylation	QNRYSFYSTCSGQKA CCCCCEEECCCCCHH	22.41	26356563
189	Phosphorylation	NRYSFYSTCSGQKAI CCCCEEECCCCCHHH	10.18	26356563
191	Phosphorylation	YSFYSTCSGQKAIKK CCEEECCCCCHHHHC	44.33	25394399
205	Phosphorylation	KCPVRPPSCASKQDP CCCCCCCCCCCCCCC	25.62	26356563
208	Phosphorylation	VRPPSCASKQDPVYI CCCCCCCCCCCCEEC	34.87	26356563
214	Phosphorylation	ASKQDPVYIPPISCN CCCCCCEECCCCCCC	17.07	25106551
219	Phosphorylation	PVYIPPISCNKDLSF CEECCCCCCCCCCCC	19.88	-
225	Phosphorylation	ISCNKDLSFGHSRAS CCCCCCCCCCCCCCC	39.04	27966365
229	Phosphorylation	KDLSFGHSRASSKIC CCCCCCCCCCCCCCC	29.89	27966365
232	Phosphorylation	SFGHSRASSKICSED CCCCCCCCCCCCCCC	30.93	24719451
233	Phosphorylation	FGHSRASSKICSEDI CCCCCCCCCCCCCCC	25.67	24211406
237	Phosphorylation	RASSKICSEDIECSG CCCCCCCCCCCCCCC	41.60	22777824
336	Phosphorylation	NGIREAVSLLRRTGN CCHHHHHHHHHHHCC	28.83	-
341	Phosphorylation	AVSLLRRTGNAEIQK HHHHHHHHCCHHHHH	28.49	-
351	Phosphorylation	AEIQKQLTGLLWNLS HHHHHHHHHHHHHCC	24.24	22210691
358	Phosphorylation	TGLLWNLSSTDELKE HHHHHHCCCCHHHHH	28.16	22210691
359	Phosphorylation	GLLWNLSSTDELKEE HHHHHCCCCHHHHHH	42.94	22210691
360	Phosphorylation	LLWNLSSTDELKEEL HHHHCCCCHHHHHHH	30.07	22210691
391	Phosphorylation	SGWCDGNSNMSREVV CCCCCCCCCCCCHHC	39.16	28348404
492	Phosphorylation	RLDAEVPTRYRQLEY CCCCCCCHHHHHHHH	45.57	20068231
499	Phosphorylation	TRYRQLEYNARNAYT HHHHHHHHHHHHCCC	23.78	26356563
505	Phosphorylation	EYNARNAYTEKSSTG HHHHHHCCCCCCCCC	20.98	28509920
506	Phosphorylation	YNARNAYTEKSSTGC HHHHHCCCCCCCCCC	34.23	28509920
509	Phosphorylation	RNAYTEKSSTGCFSN HHCCCCCCCCCCCCC	27.22	28348404
510	Phosphorylation	NAYTEKSSTGCFSNK HCCCCCCCCCCCCCC	39.63	27251275
511	Phosphorylation	AYTEKSSTGCFSNKS CCCCCCCCCCCCCCH	45.09	27794612
515	Phosphorylation	KSSTGCFSNKSDKMM CCCCCCCCCCHHHCC	47.64	27794612
518	Phosphorylation	TGCFSNKSDKMMNNN CCCCCCCHHHCCCCC	46.87	19060867
526	Phosphorylation	DKMMNNNYDCPLPEE HHCCCCCCCCCCCHH	22.50	25106551
535	Phosphorylation	CPLPEEETNPKGSGW CCCCHHHCCCCCCCC	61.16	-
544	Phosphorylation	PKGSGWLYHSDAIRT CCCCCCCCCHHHHHH	7.86	-
654	Phosphorylation	HTGNTSNSEDILSSA CCCCCCCHHHHHHHH	36.09	24719451
663	Phosphorylation	DILSSACYTVRNLMA HHHHHHHHHHHHHHH	14.16	-
671	Phosphorylation	TVRNLMASQPQLAKQ HHHHHHHCCHHHHHH	28.55	27499020
682	Phosphorylation	LAKQYFSSSMLNNII HHHHHCCHHHHHHHH	15.18	28348404
683	Phosphorylation	AKQYFSSSMLNNIIN HHHHCCHHHHHHHHH	26.54	24719451
709	Phosphorylation	EAARLLLSDMWSSKE HHHHHHHHHHCCHHH	25.95	25159151
713	Phosphorylation	LLLSDMWSSKELQGV HHHHHHCCHHHHHHH	25.54	25627689
714	Phosphorylation	LLSDMWSSKELQGVL HHHHHCCHHHHHHHH	18.03	20068231
739	Phosphorylation	GTLAGANSLRNFTSR HHHHCHHHHHHHHHC	28.33	25106551

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
54	S	Phosphorylation	Kinase	AKT2	P31751	PSP
56	S	Phosphorylation	Kinase	AKT2	P31751	PSP
57	S	Phosphorylation	Kinase	AKT2	P31751	PSP
59	S	Phosphorylation	Kinase	AKT2	P31751	PSP
60	S	Phosphorylation	Kinase	AKT2	P31751	PSP
61	T	Phosphorylation	Kinase	AKT2	P31751	PSP
63	S	Phosphorylation	Kinase	AKT2	P31751	PSP
65	S	Phosphorylation	Kinase	AKT2	P31751	PSP
69	S	Phosphorylation	Kinase	AKT2	P31751	PSP
82	T	Phosphorylation	Kinase	AKT2	P31751	PSP
84	S	Phosphorylation	Kinase	AKT2	P31751	PSP
118	S	Phosphorylation	Kinase	AKT2	P31751	PSP
119	S	Phosphorylation	Kinase	AKT2	P31751	PSP
121	S	Phosphorylation	Kinase	AKT2	P31751	PSP
127	S	Phosphorylation	Kinase	AKT2	P31751	PSP
166	T	Phosphorylation	Kinase	AKT2	P31751	PSP
171	T	Phosphorylation	Kinase	AKT2	P31751	PSP
174	S	Phosphorylation	Kinase	AKT2	P31751	PSP
179	T	Phosphorylation	Kinase	AKT2	P31751	PSP
180	T	Phosphorylation	Kinase	AKT2	P31751	PSP
185	S	Phosphorylation	Kinase	AKT2	P31751	PSP
188	S	Phosphorylation	Kinase	AKT2	P31751	PSP
189	T	Phosphorylation	Kinase	AKT2	P31751	PSP
191	S	Phosphorylation	Kinase	AKT2	P31751	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PKP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PKP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VIME_HUMAN	VIM	physical	10852826
K1C14_HUMAN	KRT14	physical	10852826
K2C8_HUMAN	KRT8	physical	10852826
DESP_HUMAN	DSP	physical	10852826
DSC1_HUMAN	DSC1	physical	14673151
TNS2_HUMAN	TENC1	physical	25416956
GT2D1_HUMAN	GTF2IRD1	physical	26275350

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
604536	Ectodermal dysplasia-skin fragility syndrome (EDSFS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PKP1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-214 AND TYR-499, ANDMASS SPECTROMETRY.	18083107 [Abstract]