K1C14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K1C14_HUMAN
• UniProt AC: P02533
• Protein Name: Keratin, type I cytoskeletal 14
• Gene Name: KRT14
• Organism: Homo sapiens (Human).
• Sequence Length: 472
• Subcellular Localization: Cytoplasm. Nucleus. Expressed in both as a filamentous pattern.
• Protein Description: The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro..
• Protein Sequence: MTTCSRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGSCRAPSTYGGGLSVSSSRFSSGGACGLGGGYGGGFSSSSSSFGSGFGGGYGGGLGAGLGGGFGGGFAGGDGLLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPAEIKDYSPYFKTIEDLRNKILTATVDNANVLLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELTLARADLEMQIESLKEELAYLKKNHEEEMNALRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFTKTEELNREVATNSELVQSGKSEISELRRTMQNLEIELQSQLSMKASLENSLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSSQFSSGSQSSRDVTSSSRQIRTKVMDVHDGKVVSTHEQVLRTKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	TTCSRQFTSSSSMKG CCCCCCCCCCCCCCC	21.25	25106551
10	Phosphorylation	TCSRQFTSSSSMKGS CCCCCCCCCCCCCCC	29.52	25394399
11	Phosphorylation	CSRQFTSSSSMKGSC CCCCCCCCCCCCCCC	24.31	23927012
12	Phosphorylation	SRQFTSSSSMKGSCG CCCCCCCCCCCCCCC	33.93	25394399
13	Phosphorylation	RQFTSSSSMKGSCGI CCCCCCCCCCCCCCC	26.85	25394399
15	Methylation	FTSSSSMKGSCGIGG CCCCCCCCCCCCCCC	50.01	-
17	Phosphorylation	SSSSMKGSCGIGGGI CCCCCCCCCCCCCCC	12.03	23927012
28	Phosphorylation	GGGIGGGSSRISSVL CCCCCCCCCCCCHHH	21.51	25394399
29	Phosphorylation	GGIGGGSSRISSVLA CCCCCCCCCCCHHHC	36.59	27251275
32	Phosphorylation	GGGSSRISSVLAGGS CCCCCCCCHHHCCCC	17.18	25394399
33	Phosphorylation	GGSSRISSVLAGGSC CCCCCCCHHHCCCCC	20.83	25394399
39	Phosphorylation	SSVLAGGSCRAPSTY CHHHCCCCCCCCCCC	10.26	25394399
44	Phosphorylation	GGSCRAPSTYGGGLS CCCCCCCCCCCCCCE	33.02	28731282
45	Phosphorylation	GSCRAPSTYGGGLSV CCCCCCCCCCCCCEE	25.73	25106551
46	Phosphorylation	SCRAPSTYGGGLSVS CCCCCCCCCCCCEEC	20.36	26356563
51	Phosphorylation	STYGGGLSVSSSRFS CCCCCCCEECCCCCC	24.19	26356563
53	Phosphorylation	YGGGLSVSSSRFSSG CCCCCEECCCCCCCC	21.15	26356563
54	Phosphorylation	GGGLSVSSSRFSSGG CCCCEECCCCCCCCC	24.31	26356563
55	Phosphorylation	GGLSVSSSRFSSGGA CCCEECCCCCCCCCC	29.82	26356563
128	Phosphorylation	NLNDRLASYLDKVRA CHHHHHHHHHHHHHH	30.71	25106551
129	Phosphorylation	LNDRLASYLDKVRAL HHHHHHHHHHHHHHH	17.20	21082442
132	Ubiquitination	RLASYLDKVRALEEA HHHHHHHHHHHHHHH	30.90	21987572
132	Acetylation	RLASYLDKVRALEEA HHHHHHHHHHHHHHH	30.90	19608861
151	Phosphorylation	EVKIRDWYQRQRPAE EEHHHHHHHHHCCHH	9.71	-
163	Phosphorylation	PAEIKDYSPYFKTIE CHHHCCCCCCCCCHH	24.21	-
165	Phosphorylation	EIKDYSPYFKTIEDL HHCCCCCCCCCHHHH	16.27	-
167	Ubiquitination	KDYSPYFKTIEDLRN CCCCCCCCCHHHHHH	42.63	23503661
204	Phosphorylation	ADDFRTKYETELNLR CHHHHHHHHHHHHHC	27.72	-
213	Phosphorylation	TELNLRMSVEADING HHHHHCEEEEECHHH	15.46	22468782
229	Phosphorylation	RRVLDELTLARADLE HHHHHHHHHHHHHHH	19.14	24719451
241	Phosphorylation	DLEMQIESLKEELAY HHHHHHHHHHHHHHH	46.50	22210691
243	Methylation	EMQIESLKEELAYLK HHHHHHHHHHHHHHH	59.42	23644510
243	"N6,N6-dimethyllysine"	EMQIESLKEELAYLK HHHHHHHHHHHHHHH	59.42	-
248	Phosphorylation	SLKEELAYLKKNHEE HHHHHHHHHHHCCHH	31.51	-
250	Sumoylation	KEELAYLKKNHEEEM HHHHHHHHHCCHHHH	38.56	-
250	Sumoylation	KEELAYLKKNHEEEM HHHHHHHHHCCHHHH	38.56	-
250	Ubiquitination	KEELAYLKKNHEEEM HHHHHHHHHCCHHHH	38.56	22817900
251	Ubiquitination	EELAYLKKNHEEEMN HHHHHHHHCCHHHHH	62.02	22817900
281	Phosphorylation	AAPGVDLSRILNEMR CCCCCCHHHHHHHHH	16.89	22468782
291	Phosphorylation	LNEMRDQYEKMAEKN HHHHHHHHHHHHHHH	23.08	21253578
293	Ubiquitination	EMRDQYEKMAEKNRK HHHHHHHHHHHHHHH	38.18	23503661
297	Ubiquitination	QYEKMAEKNRKDAEE HHHHHHHHHHHHHHH	53.14	23503661
319	Phosphorylation	ELNREVATNSELVQS HHCHHHHCCHHHHHC	44.44	21712546
321	Phosphorylation	NREVATNSELVQSGK CHHHHCCHHHHHCCH	28.14	21815630
326	Phosphorylation	TNSELVQSGKSEISE CCHHHHHCCHHHHHH	40.48	21815630
328	Ubiquitination	SELVQSGKSEISELR HHHHHCCHHHHHHHH	50.60	21987572
329	Phosphorylation	ELVQSGKSEISELRR HHHHCCHHHHHHHHH	43.62	21815630
332	Phosphorylation	QSGKSEISELRRTMQ HCCHHHHHHHHHHHH	26.90	21815630
354	Phosphorylation	SQLSMKASLENSLEE HHHHHHHHHHHHHHH	30.60	22985185
358	Phosphorylation	MKASLENSLEETKGR HHHHHHHHHHHHHHH	27.99	24719451
363	Ubiquitination	ENSLEETKGRYCMQL HHHHHHHHHHHHHHH	44.67	-
379	Phosphorylation	QIQEMIGSVEEQLAQ HHHHHHCCHHHHHHH	18.54	24043423
398	Phosphorylation	MEQQNQEYKILLDVK HHHHCHHEEEEHHHH	8.12	29978859
399	Ubiquitination	EQQNQEYKILLDVKT HHHCHHEEEEHHHHH	26.56	23503661
405	Ubiquitination	YKILLDVKTRLEQEI EEEEHHHHHHHHHHH	27.82	23503661
414	Phosphorylation	RLEQEIATYRRLLEG HHHHHHHHHHHHHCC	24.19	-
415	Phosphorylation	LEQEIATYRRLLEGE HHHHHHHHHHHHCCC	5.68	21253578
427	Phosphorylation	EGEDAHLSSSQFSSG CCCCCCCCCCCCCCC	20.34	26356563
428	Phosphorylation	GEDAHLSSSQFSSGS CCCCCCCCCCCCCCC	34.22	26356563
429	Phosphorylation	EDAHLSSSQFSSGSQ CCCCCCCCCCCCCCC	31.69	25394399
432	Phosphorylation	HLSSSQFSSGSQSSR CCCCCCCCCCCCCCC	26.59	25394399
433	Phosphorylation	LSSSQFSSGSQSSRD CCCCCCCCCCCCCCC	43.69	23927012
435	Phosphorylation	SSQFSSGSQSSRDVT CCCCCCCCCCCCCCC	28.92	28731282
437	Phosphorylation	QFSSGSQSSRDVTSS CCCCCCCCCCCCCCC	29.10	25106551
438	Phosphorylation	FSSGSQSSRDVTSSS CCCCCCCCCCCCCCC	25.51	20166139
442	Phosphorylation	SQSSRDVTSSSRQIR CCCCCCCCCCCHHHE	27.47	23927012
443	Phosphorylation	QSSRDVTSSSRQIRT CCCCCCCCCCHHHEE	26.60	23927012
444	Phosphorylation	SSRDVTSSSRQIRTK CCCCCCCCCHHHEEE	21.85	23927012
445	Phosphorylation	SRDVTSSSRQIRTKV CCCCCCCCHHHEEEE	28.15	23927012
462	Phosphorylation	VHDGKVVSTHEQVLR CCCCEEEECHHHHHC	27.34	28348404
463	Phosphorylation	HDGKVVSTHEQVLRT CCCEEEECHHHHHCC	20.16	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K1C14_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K1C14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K1C14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K2C5_HUMAN	KRT5	physical	22939629
K2C3_HUMAN	KRT3	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 131760: Epidermolysis bullosa simplex, Dowling-Meara type (DM-EBS)
• 131800: Epidermolysis bullosa simplex, Weber-Cockayne type (WC-EBS)
• 131900: Epidermolysis bullosa simplex, Koebner type (K-EBS)
• 601001: Epidermolysis bullosa simplex, autosomal recessive 1 (EBSB1)
• 161000: Naegeli-Franceschetti-Jadassohn syndrome (NFJS)
• 125595: Dermatopathia pigmentosa reticularis (DPR)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.