K2C3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K2C3_HUMAN
• UniProt AC: P12035
• Protein Name: Keratin, type II cytoskeletal 3
• Gene Name: KRT3
• Organism: Homo sapiens (Human).
• Sequence Length: 628
• Protein Sequence: MSRQASKTSGGGSQGFSGRSAVVSGSSRMSCVAHSGGAGGGAYGFRSGAGGFGSRSLYNLGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGGFGGGRGMGGGFGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQEVTINQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQGTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINKRTAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVVLSMDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKSEIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAGGYGGGYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIGGGFGGGSSGFSGGSGFGSISGARYGVSGGGFSSASNRGGSIKFSQSSQSSQRYSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	SKTSGGGSQGFSGRS CCCCCCCCCCCCCCE	30.33	-
17	Phosphorylation	GGGSQGFSGRSAVVS CCCCCCCCCCEEEEE	39.87	-
20	Phosphorylation	SQGFSGRSAVVSGSS CCCCCCCEEEEECCC	29.01	30206219
24	Phosphorylation	SGRSAVVSGSSRMSC CCCEEEEECCCCEEE	26.76	30206219
26	Phosphorylation	RSAVVSGSSRMSCVA CEEEEECCCCEEEEE	13.78	30206219
27	Phosphorylation	SAVVSGSSRMSCVAH EEEEECCCCEEEEEE	35.21	30206219
30	Phosphorylation	VSGSSRMSCVAHSGG EECCCCEEEEEECCC	12.34	30206219
43	Phosphorylation	GGAGGGAYGFRSGAG CCCCCCCCCCCCCCC	21.77	25954137
47	Phosphorylation	GGAYGFRSGAGGFGS CCCCCCCCCCCCCCC	30.63	25954137
54	Phosphorylation	SGAGGFGSRSLYNLG CCCCCCCCCCEEECC	19.21	25954137
56	Phosphorylation	AGGFGSRSLYNLGGN CCCCCCCCEEECCCC	36.58	24719451
65	Phosphorylation	YNLGGNKSISISVAA EECCCCCEEEEEEEE	26.10	27251275
69	Phosphorylation	GNKSISISVAAGGSR CCCEEEEEEEECCCC	10.02	20860994
75	Phosphorylation	ISVAAGGSRAGGFGG EEEEECCCCCCCCCC	20.31	20860994
203	Ubiquitination	AQEREQIKTLNNKFA HHHHHHHHHHHHHHH	46.80	22817900
204	Phosphorylation	QEREQIKTLNNKFAS HHHHHHHHHHHHHHH	36.03	24719451
208	Sumoylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	-
208	Ubiquitination	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	21963094
208	Acetylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	132989
208	Sumoylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	-
208	Methylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	132989
208	Neddylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	32015554
211	Phosphorylation	TLNNKFASFIDKVRF HHHHHHHHHHHHHHH	26.35	28355574
215	Ubiquitination	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	21963094
215	Acetylation	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	7705677
224	Ubiquitination	RFLEQQNKVLETKWN HHHHHHHHHHHHHHH	43.81	16196087
274	Phosphorylation	GERGRLDSELKNMED CCCCCCHHHHCCHHH	49.79	23090842
289	Neddylation	LVEDFKKKYEDEINK HHHHHHHHHHHHHHH	55.23	32015554
289	Ubiquitination	LVEDFKKKYEDEINK HHHHHHHHHHHHHHH	55.23	21906983
296	Methylation	KYEDEINKRTAAENE HHHHHHHHHHCHHCC	57.71	-
298	Phosphorylation	EDEINKRTAAENEFV HHHHHHHHCHHCCCE	31.65	29083192
364	Phosphorylation	LSMDNNRSLDLDSII EECCCCCCCCHHHHH	28.49	20166139
393	Phosphorylation	KAEAEALYQTKLGEL HHHHHHHHHHHHHHH	22.60	22817900
395	Phosphorylation	EAEALYQTKLGELQT HHHHHHHHHHHHHHC	18.06	-
402	Phosphorylation	TKLGELQTTAGRHGD HHHHHHHCCCCCCCC	31.10	-
444	Phosphorylation	KQNANLQTAIAEAEQ HHCCCHHHHHHHHHH	24.17	-
485	Phosphorylation	LARLLRDYQELMNVK HHHHHHHHHHHHCHH	9.46	20068231
504	Ubiquitination	VEIATYRKLLEGEEY HHHHHHHHHHCCCCC	47.19	22817900
511	Phosphorylation	KLLEGEEYRMSGECP HHHCCCCCCCCCCCC	13.81	-
587	Phosphorylation	SSGFSGGSGFGSISG CCCCCCCCCCCCCCC	34.18	22210691
591	Phosphorylation	SGGSGFGSISGARYG CCCCCCCCCCCCEEC	16.01	22210691
597	Phosphorylation	GSISGARYGVSGGGF CCCCCCEECCCCCCC	22.73	-
605	Phosphorylation	GVSGGGFSSASNRGG CCCCCCCCCCCCCCC	28.41	-
606	Phosphorylation	VSGGGFSSASNRGGS CCCCCCCCCCCCCCC	33.19	-
608	Phosphorylation	GGGFSSASNRGGSIK CCCCCCCCCCCCCEE	29.07	-
613	Phosphorylation	SASNRGGSIKFSQSS CCCCCCCCEEECCCC	25.98	-
627	Phosphorylation	SQSSQRYSR------ CCCCCCCCC------	33.43	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K2C3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K2C3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K2C3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K2C5_HUMAN	KRT5	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 122100: Corneal dystrophy, Meesmann (MECD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.