dbPTM

K2C5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	K2C5_HUMAN
UniProt AC	P13647
Protein Name	Keratin, type II cytoskeletal 5
Gene Name	KRT5
Organism	Homo sapiens (Human).
Sequence Length	590
Subcellular Localization
Protein Description
Protein Sequence	MSRQSSVSFRSGGSRSFSTASAITPSVSRTSFTSVSRSGGGGGGGFGRVSLAGACGVGGYGSRSLYNLGGSKRISISTSGGSFRNRFGAGAGGGYGFGGGAGSGFGFGGGAGGGFGLGGGAGFGGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPSIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLVEDFKNKYEDEINKRTTAENEFVMLKKDVDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRAEIDNVKKQCANLQNAIADAEQRGELALKDARNKLAELEEALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTSSVSSGYGSGSGYGGGLGGGLGGGLGGGLAGGSSGSYYSSSSGGVGLGGGLSVGGSGFSASSGRGLGVGFGSGGGSSSSVKFVSTTSSSRKSFKS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSRQSSVSF ------CCCCCCEEE	38.74	28355574
5	Phosphorylation	---MSRQSSVSFRSG ---CCCCCCEEECCC	31.43	28355574
6	Phosphorylation	--MSRQSSVSFRSGG --CCCCCCEEECCCC	17.28	28355574
8	Phosphorylation	MSRQSSVSFRSGGSR CCCCCCEEECCCCCC	19.52	25394399
11	Phosphorylation	QSSVSFRSGGSRSFS CCCEEECCCCCCCCE	45.56	25394399
14	Phosphorylation	VSFRSGGSRSFSTAS EEECCCCCCCCEECC	28.42	23927012
16	Phosphorylation	FRSGGSRSFSTASAI ECCCCCCCCEECCEE	25.83	28355574
18	Phosphorylation	SGGSRSFSTASAITP CCCCCCCEECCEECC	25.06	28355574
19	Phosphorylation	GGSRSFSTASAITPS CCCCCCEECCEECCC	23.71	28355574
21	Phosphorylation	SRSFSTASAITPSVS CCCCEECCEECCCCC	21.94	28355574
24	Phosphorylation	FSTASAITPSVSRTS CEECCEECCCCCCCE	14.82	28355574
26	Phosphorylation	TASAITPSVSRTSFT ECCEECCCCCCCEEE	24.87	23927012
28	Phosphorylation	SAITPSVSRTSFTSV CEECCCCCCCEEEEE	33.89	25394399
30	Phosphorylation	ITPSVSRTSFTSVSR ECCCCCCCEEEEECC	22.23	23927012
31	Phosphorylation	TPSVSRTSFTSVSRS CCCCCCCEEEEECCC	25.97	25394399
33	Phosphorylation	SVSRTSFTSVSRSGG CCCCCEEEEECCCCC	28.17	23927012
34	Phosphorylation	VSRTSFTSVSRSGGG CCCCEEEEECCCCCC	18.98	28355574
36	Phosphorylation	RTSFTSVSRSGGGGG CCEEEEECCCCCCCC	22.09	28355574
38	Phosphorylation	SFTSVSRSGGGGGGG EEEEECCCCCCCCCC	33.99	25106551
50	Phosphorylation	GGGFGRVSLAGACGV CCCCCCCCCCCCCCC	15.90	23927012
60	Phosphorylation	GACGVGGYGSRSLYN CCCCCCCCCCCEEEE	13.14	23927012
62	Phosphorylation	CGVGGYGSRSLYNLG CCCCCCCCCEEEECC	15.37	23927012
64	Phosphorylation	VGGYGSRSLYNLGGS CCCCCCCEEEECCCC	36.58	28355574
66	Phosphorylation	GYGSRSLYNLGGSKR CCCCCEEEECCCCCC	15.02	23927012
71	Phosphorylation	SLYNLGGSKRISIST EEEECCCCCCEEEEE	19.57	28355574
72	Methylation	LYNLGGSKRISISTS EEECCCCCCEEEEEC	57.96	7379933
72	Acetylation	LYNLGGSKRISISTS EEECCCCCCEEEEEC	57.96	7379933
75	Phosphorylation	LGGSKRISISTSGGS CCCCCCEEEEECCCC	17.96	28355574
77	Phosphorylation	GSKRISISTSGGSFR CCCCEEEEECCCCCC	15.10	28355574
78	Phosphorylation	SKRISISTSGGSFRN CCCEEEEECCCCCCC	29.71	23927012
79	Phosphorylation	KRISISTSGGSFRNR CCEEEEECCCCCCCC	34.07	25394399
82	Phosphorylation	SISTSGGSFRNRFGA EEEECCCCCCCCCCC	25.26	28355574
151	Phosphorylation	TVNQSLLTPLNLQID EECHHHHCCCCCCCC	30.90	-
173	Ubiquitination	TEEREQIKTLNNKFA HHHHHHHHHHHHHHH	46.80	22817900
174	Phosphorylation	EEREQIKTLNNKFAS HHHHHHHHHHHHHHH	36.03	24719451
178	Methylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	132991
178	Sumoylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	-
178	Sumoylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	-
178	Ubiquitination	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	21963094
178	Neddylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	32015554
178	Acetylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	132991
181	Phosphorylation	TLNNKFASFIDKVRF HHHHHHHHHHHHHHH	26.35	28355574
185	Acetylation	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	7705685
185	Ubiquitination	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	21963094
194	Ubiquitination	RFLEQQNKVLDTKWT HHHHHHHCHHHHHHH	39.58	16196087
199	Methylation	QNKVLDTKWTLLQEQ HHCHHHHHHHHHHHH	37.54	72616219
201	Phosphorylation	KVLDTKWTLLQEQGT CHHHHHHHHHHHHCC	21.10	24719451
210	Phosphorylation	LQEQGTKTVRQNLEP HHHHCCHHHHHHHHH	22.28	24719451
222	Phosphorylation	LEPLFEQYINNLRRQ HHHHHHHHHHHHHHH	9.83	-
232	Phosphorylation	NLRRQLDSIVGERGR HHHHHHHHHHCHHHH	27.97	28355574
242	Phosphorylation	GERGRLDSELRNMQD CHHHHHHHHHHHHHH	43.02	28355574
255	Neddylation	QDLVEDFKNKYEDEI HHHHHHHHHHHHHHH	65.92	32015554
255	Ubiquitination	QDLVEDFKNKYEDEI HHHHHHHHHHHHHHH	65.92	22817900
257	Neddylation	LVEDFKNKYEDEINK HHHHHHHHHHHHHHH	51.08	32015554
257	Ubiquitination	LVEDFKNKYEDEINK HHHHHHHHHHHHHHH	51.08	21906983
257	Methylation	LVEDFKNKYEDEINK HHHHHHHHHHHHHHH	51.08	55169325
258	Phosphorylation	VEDFKNKYEDEINKR HHHHHHHHHHHHHHC	37.70	20736484
264	Methylation	KYEDEINKRTTAENE HHHHHHHHCCCCCCE	57.70	-
264	Ubiquitination	KYEDEINKRTTAENE HHHHHHHHCCCCCCE	57.70	29901268
283	Phosphorylation	KKDVDAAYMNKVELE ECCCCHHHHCCHHHH	11.71	18083107
316	Phosphorylation	AELSQMQTHVSDTSV HHHHHCCCCCCCCEE	20.92	20068231
319	Phosphorylation	SQMQTHVSDTSVVLS HHCCCCCCCCEEEEE	27.80	20068231
321	Phosphorylation	MQTHVSDTSVVLSMD CCCCCCCCEEEEECC	18.86	20068231
322	Phosphorylation	QTHVSDTSVVLSMDN CCCCCCCEEEEECCC	18.41	20068231
326	Phosphorylation	SDTSVVLSMDNNRNL CCCEEEEECCCCCCC	16.69	20068231
337	Phosphorylation	NRNLDLDSIIAEVKA CCCCCHHHHHHHHHH	24.16	26657352
346	Phosphorylation	IAEVKAQYEEIANRS HHHHHHHHHHHHHCC	22.01	26356563
353	Phosphorylation	YEEIANRSRTEAESW HHHHHHCCHHHHHHH	43.28	24719451
355	Phosphorylation	EIANRSRTEAESWYQ HHHHCCHHHHHHHHH	40.57	-
359	Phosphorylation	RSRTEAESWYQTKYE CCHHHHHHHHHHHHH	37.82	18452278
361	Phosphorylation	RTEAESWYQTKYEEL HHHHHHHHHHHHHHH	18.65	19060867
363	Phosphorylation	EAESWYQTKYEELQQ HHHHHHHHHHHHHHH	21.64	19060867
365	Phosphorylation	ESWYQTKYEELQQTA HHHHHHHHHHHHHHH	20.30	22817900
426	Ubiquitination	QRGELALKDARNKLA HHHHHHHHHHHHHHH	43.67	33845483
443	Sumoylation	EEALQKAKQDMARLL HHHHHHHHHHHHHHH	54.59	-
443	Sumoylation	EEALQKAKQDMARLL HHHHHHHHHHHHHHH	54.59	-
453	Phosphorylation	MARLLREYQELMNTK HHHHHHHHHHHHCCC	10.80	-
472	Ubiquitination	VEIATYRKLLEGEEC HHHHHHHHHHCCCCC	47.19	22817900
480	Methylation	LLEGEECRLSGEGVG HHCCCCCCCCCCCCC	34.86	-
567	Phosphorylation	GLGVGFGSGGGSSSS CCCCCCCCCCCCCCC	31.81	28731282
571	Phosphorylation	GFGSGGGSSSSVKFV CCCCCCCCCCCEEEE	30.26	23927012
572	Phosphorylation	FGSGGGSSSSVKFVS CCCCCCCCCCEEEEE	29.88	23927012
573	Phosphorylation	GSGGGSSSSVKFVST CCCCCCCCCEEEEEC	40.63	25394399
574	Phosphorylation	SGGGSSSSVKFVSTT CCCCCCCCEEEEECC	31.13	25394399
579	Phosphorylation	SSSVKFVSTTSSSRK CCCEEEEECCCCCCC	29.15	23927012
580	Phosphorylation	SSVKFVSTTSSSRKS CCEEEEECCCCCCCC	25.95	23927012
581	Phosphorylation	SVKFVSTTSSSRKSF CEEEEECCCCCCCCC	21.07	23927012
582	Phosphorylation	VKFVSTTSSSRKSFK EEEEECCCCCCCCCC	26.80	23927012
583	Phosphorylation	KFVSTTSSSRKSFKS EEEECCCCCCCCCCC	31.88	28731282
584	Phosphorylation	FVSTTSSSRKSFKS- EEECCCCCCCCCCC-	43.42	25247763
587	Phosphorylation	TTSSSRKSFKS---- CCCCCCCCCCC----	36.48	25106551
590	Phosphorylation	SSRKSFKS------- CCCCCCCC-------	43.36	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of K2C5_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of K2C5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of K2C5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K1C18_HUMAN	KRT18	physical	9786957
K1C15_HUMAN	KRT15	physical	25416956
K1H1_HUMAN	KRT31	physical	25416956
KRT38_HUMAN	KRT38	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
K1C10_HUMAN	KRT10	physical	26344197
K1C16_HUMAN	KRT16	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
131760	Epidermolysis bullosa simplex, Dowling-Meara type (DM-EBS)
609352	Epidermolysis bullosa simplex, with migratory circinate erythema (EBSMCE)
131800	Epidermolysis bullosa simplex, Weber-Cockayne type (WC-EBS)
131900	Epidermolysis bullosa simplex, Koebner type (K-EBS)
131960	Epidermolysis bullosa simplex, with mottled pigmentation (MP-EBS)
179850	Dowling-Degos disease 1 (DDD1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of K2C5_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-60 AND TYR-66, AND MASSSPECTROMETRY.	19534553 [Abstract]
"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks."; Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.; Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-60, AND MASSSPECTROMETRY.	17389395 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-60 AND TYR-66, AND MASSSPECTROMETRY.	18083107 [Abstract]