dbPTM

K1C15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	K1C15_HUMAN
UniProt AC	P19012
Protein Name	Keratin, type I cytoskeletal 15
Gene Name	KRT15
Organism	Homo sapiens (Human).
Sequence Length	456
Subcellular Localization
Protein Description
Protein Sequence	MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGGGGSRSISASSARFVSSGSGGGYGGGMRVCGFGGGAGSVFGGGFGGGVGGGFGGGFGGGDGGLLSGNEKITMQNLNDRLASYLDKVRALEEANADLEVKIHDWYQKQTPTSPECDYSQYFKTIEELRDKIMATTIDNSRVILEIDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAGIAIREASSGGGGSSSNFHINVEESVDGQVVSSHKREI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 2)	Phosphorylation	-	34.25	29978859
2	Phosphorylation	------MTTTFLQTS ------CCEEEEECC	34.25	-
4 (in isoform 2)	Phosphorylation	-	17.12	29978859
4	Phosphorylation	----MTTTFLQTSSS ----CCEEEEECCCC	17.12	25307156
6 (in isoform 2)	Phosphorylation	-	5.22	29978859
8	Phosphorylation	MTTTFLQTSSSTFGG CCEEEEECCCCCCCC	32.49	28348404
9	Phosphorylation	TTTFLQTSSSTFGGG CEEEEECCCCCCCCC	14.88	28348404
10	Phosphorylation	TTFLQTSSSTFGGGS EEEEECCCCCCCCCC	36.46	28348404
11	Phosphorylation	TFLQTSSSTFGGGST EEEECCCCCCCCCCC	27.76	27251275
12	Phosphorylation	FLQTSSSTFGGGSTR EEECCCCCCCCCCCC	28.39	27251275
15 (in isoform 2)	Phosphorylation	-	23.76	29978859
16 (in isoform 2)	Phosphorylation	-	26.65	29978859
17	Phosphorylation	SSTFGGGSTRGGSLL CCCCCCCCCCCCCCC	20.43	28355574
19 (in isoform 2)	Phosphorylation	-	49.53	29978859
20 (in isoform 2)	Phosphorylation	-	30.08	29978859
22	Phosphorylation	GGSTRGGSLLAGGGG CCCCCCCCCCCCCCC	24.04	28355574
34	Phosphorylation	GGGFGGGSLSGGGGS CCCCCCCCCCCCCCC	23.72	28355574
36	Phosphorylation	GFGGGSLSGGGGSRS CCCCCCCCCCCCCCC	36.77	25106551
41	Phosphorylation	SLSGGGGSRSISASS CCCCCCCCCCCCCCC	26.57	23927012
43	Phosphorylation	SGGGGSRSISASSAR CCCCCCCCCCCCCCE	23.69	28348404
45	Phosphorylation	GGGSRSISASSARFV CCCCCCCCCCCCEEE	24.28	25106551
48	Phosphorylation	SRSISASSARFVSSG CCCCCCCCCEEEECC	24.15	-
53	Phosphorylation	ASSARFVSSGSGGGY CCCCEEEECCCCCCC	26.69	25394399
54	Phosphorylation	SSARFVSSGSGGGYG CCCEEEECCCCCCCC	31.51	23927012
56	Phosphorylation	ARFVSSGSGGGYGGG CEEEECCCCCCCCCC	35.89	25394399
60	Phosphorylation	SSGSGGGYGGGMRVC ECCCCCCCCCCEECC	18.84	23927012
75	Phosphorylation	GFGGGAGSVFGGGFG CCCCCCCCCCCCCCC	17.46	27251275
102	Phosphorylation	GGDGGLLSGNEKITM CCCCCCCCCCCEEEE	44.61	22210691
118	Phosphorylation	NLNDRLASYLDKVRA CHHHHHHHHHHHHHH	30.71	27273156
119	Phosphorylation	LNDRLASYLDKVRAL HHHHHHHHHHHHHHH	17.20	21082442
122	Ubiquitination	RLASYLDKVRALEEA HHHHHHHHHHHHHHH	30.90	21906983
122	Acetylation	RLASYLDKVRALEEA HHHHHHHHHHHHHHH	30.90	24786923
141	Phosphorylation	EVKIHDWYQKQTPTS EEEEEHHHHCCCCCC	16.34	-
145	Phosphorylation	HDWYQKQTPTSPECD EHHHHCCCCCCCCCC	35.25	28355574
147	Phosphorylation	WYQKQTPTSPECDYS HHHCCCCCCCCCCHH	61.37	28348404
148	Phosphorylation	YQKQTPTSPECDYSQ HHCCCCCCCCCCHHH	21.65	28355574
195	Phosphorylation	ADDFRLKYENELALR CHHHHHHHHCHHHHH	28.69	18083107
220	Phosphorylation	RRVLDELTLARTDLE HHHHHHHHHHCCCHH	19.14	24719451
224	Phosphorylation	DELTLARTDLEMQIE HHHHHHCCCHHHHHC	39.05	20068231
239	Phosphorylation	GLNEELAYLKKNHEE CHHHHHHHHHHCCHH	31.51	-
241	Sumoylation	NEELAYLKKNHEEEM HHHHHHHHHCCHHHH	38.56	-
241	Ubiquitination	NEELAYLKKNHEEEM HHHHHHHHHCCHHHH	38.56	-
241	Sumoylation	NEELAYLKKNHEEEM HHHHHHHHHCCHHHH	38.56	-
300	Methylation	VEAWFFSKTEELNKE HHHHHHCCHHHHHHH	55.59	115971621
301	Phosphorylation	EAWFFSKTEELNKEV HHHHHCCHHHHHHHH	33.23	-
310	Phosphorylation	ELNKEVASNTEMIQT HHHHHHHHCCHHHHC	49.84	21406692
312	Phosphorylation	NKEVASNTEMIQTSK HHHHHHCCHHHHCCH	25.16	21406692
317	Phosphorylation	SNTEMIQTSKTEITD HCCHHHHCCHHHHHH	22.67	21406692
318	Phosphorylation	NTEMIQTSKTEITDL CCHHHHCCHHHHHHH	22.62	21406692
323	Phosphorylation	QTSKTEITDLRRTMQ HCCHHHHHHHHHHHH	23.81	-
328	Phosphorylation	EITDLRRTMQELEIE HHHHHHHHHHHHHHH	19.44	-
341	Phosphorylation	IELQSQLSMKAGLEN HHHHHHHHHHHCCCH	15.59	-
349	Phosphorylation	MKAGLENSLAETECR HHHCCCHHHHHHHHH	21.41	27251275
389	Phosphorylation	MEAQNQEYKMLLDIK HHHHHHHHHHHHHHH	7.61	-
405	Phosphorylation	RLEQEIATYRSLLEG HHHHHHHHHHHHHCC	25.73	-
406	Phosphorylation	LEQEIATYRSLLEGQ HHHHHHHHHHHHCCC	6.81	-
426	Phosphorylation	GIAIREASSGGGGSS CEEEEECCCCCCCCC	25.43	27251275
427	Phosphorylation	IAIREASSGGGGSSS EEEEECCCCCCCCCC	48.80	28348404
432	Phosphorylation	ASSGGGGSSSNFHIN CCCCCCCCCCCEEEE	33.59	28348404
433	Phosphorylation	SSGGGGSSSNFHINV CCCCCCCCCCEEEEE	32.35	28348404
434	Phosphorylation	SGGGGSSSNFHINVE CCCCCCCCCEEEEEE	45.25	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of K1C15_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of K1C15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of K1C15_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MCM10_HUMAN	MCM10	physical	16189514
SMRD1_HUMAN	SMARCD1	physical	16189514
PCM1_HUMAN	PCM1	physical	16189514
DEPP_HUMAN	C10orf10	physical	16189514
EXOC8_HUMAN	EXOC8	physical	16189514
TCHP_HUMAN	TCHP	physical	16189514
SGF29_HUMAN	CCDC101	physical	16189514
ZC21C_HUMAN	ZC2HC1C	physical	16189514
LDOC1_HUMAN	LDOC1	physical	16189514
USBP1_HUMAN	USHBP1	physical	16189514
K1C18_HUMAN	KRT18	physical	16189514
KANL1_HUMAN	KANSL1	physical	16189514
GCP4_HUMAN	TUBGCP4	physical	16189514
CC185_HUMAN	CCDC185	physical	16189514
RCOR3_HUMAN	RCOR3	physical	16189514
K1C20_HUMAN	KRT20	physical	16189514
TS101_HUMAN	TSG101	physical	16189514
K1C19_HUMAN	KRT19	physical	16189514
UBP2_HUMAN	USP2	physical	16189514
CA216_HUMAN	C1orf216	physical	16189514
ABI3_HUMAN	ABI3	physical	16189514
NOC4L_HUMAN	NOC4L	physical	16189514
WAC_HUMAN	WAC	physical	16189514
DGC6L_HUMAN	DGCR6L	physical	16189514
TXD11_HUMAN	TXNDC11	physical	16189514
CACO1_HUMAN	CALCOCO1	physical	16189514
CC120_HUMAN	CCDC120	physical	16189514
RIBC2_HUMAN	RIBC2	physical	16189514
RHPN1_HUMAN	RHPN1	physical	16189514
F107A_HUMAN	FAM107A	physical	16189514
ARC_HUMAN	ARC	physical	16189514
LNX1_HUMAN	LNX1	physical	16189514
NUD18_HUMAN	NUDT18	physical	16189514
ZN638_HUMAN	ZNF638	physical	16189514
AMOL2_HUMAN	AMOTL2	physical	16189514
KRT81_HUMAN	KRT81	physical	16189514
TEKT4_HUMAN	TEKT4	physical	16189514
NIF3L_HUMAN	NIF3L1	physical	16189514
SKT_HUMAN	KIAA1217	physical	16189514
PSA1_HUMAN	PSMA1	physical	16189514
ABI2_HUMAN	ABI2	physical	16189514
ABLM1_HUMAN	ABLIM1	physical	16189514
K0408_HUMAN	KIAA0408	physical	16189514
PRS8_HUMAN	PSMC5	physical	16189514
PERI_HUMAN	PRPH	physical	16189514
MD2BP_HUMAN	MAD2L1BP	physical	16189514
KRT86_HUMAN	KRT86	physical	25416956
RBTN2_HUMAN	LMO2	physical	25416956
MOS_HUMAN	MOS	physical	25416956
NFL_HUMAN	NEFL	physical	25416956
P85B_HUMAN	PIK3R2	physical	25416956
PKN1_HUMAN	PKN1	physical	25416956
PSA1_HUMAN	PSMA1	physical	25416956
PSB1_HUMAN	PSMB1	physical	25416956
RA51D_HUMAN	RAD51D	physical	25416956
SMCE1_HUMAN	SMARCE1	physical	25416956
TYB4_HUMAN	TMSB4X	physical	25416956
LMO4_HUMAN	LMO4	physical	25416956
UBP2_HUMAN	USP2	physical	25416956
HGS_HUMAN	HGS	physical	25416956
CREB5_HUMAN	CREB5	physical	25416956
CEP57_HUMAN	CEP57	physical	25416956
ABI2_HUMAN	ABI2	physical	25416956
HM20B_HUMAN	HMG20B	physical	25416956
MS18B_HUMAN	OIP5	physical	25416956
ZFY26_HUMAN	ZFYVE26	physical	25416956
ARFP2_HUMAN	ARFIP2	physical	25416956
PRP31_HUMAN	PRPF31	physical	25416956
CYH4_HUMAN	CYTH4	physical	25416956
WAC_HUMAN	WAC	physical	25416956
SPG21_HUMAN	SPG21	physical	25416956
AMOL2_HUMAN	AMOTL2	physical	25416956
NUP54_HUMAN	NUP54	physical	25416956
MBD3_HUMAN	MBD3	physical	25416956
K1C20_HUMAN	KRT20	physical	25416956
CCHCR_HUMAN	CCHCR1	physical	25416956
CCD87_HUMAN	CCDC87	physical	25416956
RCOR3_HUMAN	RCOR3	physical	25416956
SKT_HUMAN	KIAA1217	physical	25416956
CIP1_HUMAN	CCNB1IP1	physical	25416956
NOC4L_HUMAN	NOC4L	physical	25416956
ZN576_HUMAN	ZNF576	physical	25416956
ZC21C_HUMAN	ZC2HC1C	physical	25416956
EPC1_HUMAN	EPC1	physical	25416956
F110A_HUMAN	FAM110A	physical	25416956
TCHP_HUMAN	TCHP	physical	25416956
ZGPAT_HUMAN	ZGPAT	physical	25416956
BEX2_HUMAN	BEX2	physical	25416956
KLC4_HUMAN	KLC4	physical	25416956
K2C71_HUMAN	KRT71	physical	25416956
SGF29_HUMAN	CCDC101	physical	25416956
HAUS1_HUMAN	HAUS1	physical	25416956
ADIP_HUMAN	SSX2IP	physical	25416956
IKIP_HUMAN	IKBIP	physical	25416956
CA216_HUMAN	C1orf216	physical	25416956
GLCTK_HUMAN	GLYCTK	physical	25416956
SHPS1_HUMAN	SIRPA	physical	25416956
K2C80_HUMAN	KRT80	physical	25416956
ZN417_HUMAN	ZNF417	physical	25416956
KLC3_HUMAN	KLC3	physical	25416956
C2CD6_HUMAN	ALS2CR11	physical	25416956
AMOT_HUMAN	AMOT	physical	25416956
RIBC1_HUMAN	RIBC1	physical	25416956
DEUP1_HUMAN	CCDC67	physical	25416956
TXLNB_HUMAN	TXLNB	physical	25416956
PPR18_HUMAN	PPP1R18	physical	25416956
TXLNA_HUMAN	TXLNA	physical	25416956
MORN3_HUMAN	MORN3	physical	25416956
KANL1_HUMAN	KANSL1	physical	25416956
K2C6C_HUMAN	KRT6C	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
K2C73_HUMAN	KRT73	physical	25416956
K2C79_HUMAN	KRT79	physical	25416956
K2C1B_HUMAN	KRT77	physical	25416956
TELO2_HUMAN	TELO2	physical	21516116

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of K1C15_HUMAN

Related Literatures of Post-Translational Modification