dbPTM

ZN638_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZN638_HUMAN
UniProt AC	Q14966
Protein Name	Zinc finger protein 638
Gene Name	ZNF638
Organism	Homo sapiens (Human).
Sequence Length	1978
Subcellular Localization	Nucleus speckle .
Protein Description	Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). Binds to cytidine clusters in double-stranded DNA. [PubMed: 8647861 May also regulate alternative splicing of target genes during adipogenesis (By similarity]
Protein Sequence	MSRPRFNPRGDFPLQRPRAPNPSGMRPPGPFMRPGSMGLPRFYPAGRARGIPHRFAGHESYQNMGPQRMNVQVTQHRTDPRLTKEKLDFHEAQQKKGKPHGSRWDDEPHISASVAVKQSSVTQVTEQSPKVQSRYTKESASSILASFGLSNEDLEELSRYPDEQLTPENMPLILRDIRMRKMGRRLPNLPSQSRNKETLGSEAVSSNVIDYGHASKYGYTEDPLEVRIYDPEIPTDEVENEFQSQQNISASVPNPNVICNSMFPVEDVFRQMDFPGESSNNRSFFSVESGTKMSGLHISGGQSVLEPIKSVNQSINQTVSQTMSQSLIPPSMNQQPFSSELISSVSQQERIPHEPVINSSNVHVGSRGSKKNYQSQADIPIRSPFGIVKASWLPKFSHADAQKMKRLPTPSMMNDYYAASPRIFPHLCSLCNVECSHLKDWIQHQNTSTHIESCRQLRQQYPDWNPEILPSRRNEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRSRSRSPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGGHSIRCKSKNLEDDTLSECKQVSDKAVSLQRKLRKEQSLHYGSVLLITELPEDGCTEEDVRKLFQPFGKVNDVLIVPYRKEAYLEMEFKEAITAIMKYIETTPLTIKGKSVKICVPGKKKAQNKEVKKKTLESKKVSASTLKRDADASKAVEIVTSTSAAKTGQAKASVAKVNKSTGKSASSVKSVVTVAVKGNKASIKTAKSGGKKSLEAKKTGNVKNKDSNKPVTIPENSEIKTSIEVKATENCAKEAISDAALEATENEPLNKETEEMCVMLVSNLPNKGYSVEEVYDLAKPFGGLKDILILSSHKKAYIEINRKAAESMVKFYTCFPVLMDGNQLSISMAPENMNIKDEEAIFITLVKENDPEANIDTIYDRFVHLDNLPEDGLQCVLCVGLQFGKVDHHVFISNRNKAILQLDSPESAQSMYSFLKQNPQNIGDHMLTCSLSPKIDLPEVQIEHDPELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETLVQQEEPCEEEAEKATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECALNQQMFNSDLEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVEAVAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKETRMDLQIGTEKAEKNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSILAVSDVSSSKPSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLLKPTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETEARPSIMKRDDSNNKTLAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPSQAKQNPLKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGELSFVTLDEIGEEEDAAAHLAQALVTVDEVIDEEELNMEEMVKNSNSLFTLDELIDQDDCISHSEPKDVTVLSVAEEQDLLKQERLVTVDEIGEVEELPLNESADITFATLNTKGNEGDTVRDSIGFISSQVPEDPSTLVTVDEIQDDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKVELAQSKNDHPTDKKGNRKKRAVDTKKTKLESLSQVGPVNENVMEEDLKTMIERHLTAKTPTKRVRIGKTLPSEKAVVTEPAKGEEAFQMSEVDEESGLKDSEPERKRKKTEDSSSGKSVASDVPEELDFLVPKAGFFCPICSLFYSGEKAMTNHCKSTRHKQNTEKFMAKQRKEKEQNEAEERSSR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Dimethylation	RPPGPFMRPGSMGLP CCCCCCCCCCCCCCC	32.57	-
33	Methylation	RPPGPFMRPGSMGLP CCCCCCCCCCCCCCC	32.57	54561969
36	Phosphorylation	GPFMRPGSMGLPRFY CCCCCCCCCCCCCCC	16.62	24719451
41	Dimethylation	PGSMGLPRFYPAGRA CCCCCCCCCCCCCCC	49.09	-
41	Methylation	PGSMGLPRFYPAGRA CCCCCCCCCCCCCCC	49.09	54561985
47	Asymmetric dimethylarginine	PRFYPAGRARGIPHR CCCCCCCCCCCCCCC	24.18	-
47	Methylation	PRFYPAGRARGIPHR CCCCCCCCCCCCCCC	24.18	24129315
49	Asymmetric dimethylarginine	FYPAGRARGIPHRFA CCCCCCCCCCCCCCC	42.06	-
49	Methylation	FYPAGRARGIPHRFA CCCCCCCCCCCCCCC	42.06	24129315
54	Asymmetric dimethylarginine	RARGIPHRFAGHESY CCCCCCCCCCCCHHH	20.11	-
54	Methylation	RARGIPHRFAGHESY CCCCCCCCCCCCHHH	20.11	24129315
61	Phosphorylation	RFAGHESYQNMGPQR CCCCCHHHHCCCCCC	10.83	17360941
68	Dimethylation	YQNMGPQRMNVQVTQ HHCCCCCCCCEEEEE	23.06	-
68	Methylation	YQNMGPQRMNVQVTQ HHCCCCCCCCEEEEE	23.06	30763587
86	Ubiquitination	DPRLTKEKLDFHEAQ CCCCCHHHCCHHHHH	55.71	-
96	Ubiquitination	FHEAQQKKGKPHGSR HHHHHHHCCCCCCCC	68.76	-
119	Phosphorylation	ASVAVKQSSVTQVTE CEEEEECCCCEEECC	22.51	23403867
120	Phosphorylation	SVAVKQSSVTQVTEQ EEEEECCCCEEECCC	27.04	24732914
122	Phosphorylation	AVKQSSVTQVTEQSP EEECCCCEEECCCCC	21.19	28348404
125	Phosphorylation	QSSVTQVTEQSPKVQ CCCCEEECCCCCCHH	20.63	25159151
128	Phosphorylation	VTQVTEQSPKVQSRY CEEECCCCCCHHCCC	22.06	19664994
130	Ubiquitination	QVTEQSPKVQSRYTK EECCCCCCHHCCCCH	59.14	-
133	Phosphorylation	EQSPKVQSRYTKESA CCCCCHHCCCCHHHH	30.18	24732914
191	Phosphorylation	RRLPNLPSQSRNKET HCCCCCCCCCCCCHH	43.91	23186163
193	Phosphorylation	LPNLPSQSRNKETLG CCCCCCCCCCCHHHC	42.00	23186163
196	Acetylation	LPSQSRNKETLGSEA CCCCCCCCHHHCCHH	51.47	26051181
196	Ubiquitination	LPSQSRNKETLGSEA CCCCCCCCHHHCCHH	51.47	-
216	Ubiquitination	IDYGHASKYGYTEDP CCCCCHHHCCCCCCC	43.40	-
219	Phosphorylation	GHASKYGYTEDPLEV CCHHHCCCCCCCCEE	12.13	27642862
279	Phosphorylation	MDFPGESSNNRSFFS CCCCCCCCCCCCEEE	33.55	29214152
283	Phosphorylation	GESSNNRSFFSVESG CCCCCCCCEEEECCC	32.54	25159151
286	Phosphorylation	SNNRSFFSVESGTKM CCCCCEEEECCCCCC	23.98	23312004
289	Phosphorylation	RSFFSVESGTKMSGL CCEEEECCCCCCEEE	50.00	23917254
291	Phosphorylation	FFSVESGTKMSGLHI EEEECCCCCCEEEEE	32.62	25627689
292	Sumoylation	FSVESGTKMSGLHIS EEECCCCCCEEEEEC	34.30	28112733
294	Phosphorylation	VESGTKMSGLHISGG ECCCCCCEEEEECCC	39.50	23312004
299	Phosphorylation	KMSGLHISGGQSVLE CCEEEEECCCCCCHH	26.56	25159151
303	Phosphorylation	LHISGGQSVLEPIKS EEECCCCCCHHHHHH	31.76	28450419
359	Phosphorylation	PHEPVINSSNVHVGS CCCCCCCCCCCEECC	16.50	21406692
360	Phosphorylation	HEPVINSSNVHVGSR CCCCCCCCCCEECCC	38.08	20068231
366	Phosphorylation	SSNVHVGSRGSKKNY CCCCEECCCCCCCCC	32.17	20068231
367	Methylation	SNVHVGSRGSKKNYQ CCCEECCCCCCCCCC	47.69	115920557
369	Phosphorylation	VHVGSRGSKKNYQSQ CEECCCCCCCCCCCC	39.07	25159151
371	Ubiquitination	VGSRGSKKNYQSQAD ECCCCCCCCCCCCCC	63.69	-
373	Phosphorylation	SRGSKKNYQSQADIP CCCCCCCCCCCCCCC	20.58	24732914
375	Phosphorylation	GSKKNYQSQADIPIR CCCCCCCCCCCCCCC	19.58	23898821
382	Methylation	SQADIPIRSPFGIVK CCCCCCCCCCCCEEE	32.68	115920561
383	Phosphorylation	QADIPIRSPFGIVKA CCCCCCCCCCCEEEH	25.87	25159151
409	Phosphorylation	QKMKRLPTPSMMNDY HHHHCCCCHHHHCCH	32.37	21712546
411	Phosphorylation	MKRLPTPSMMNDYYA HHCCCCHHHHCCHHH	32.89	23312004
416	Phosphorylation	TPSMMNDYYAASPRI CHHHHCCHHHCCCCH	7.04	26462736
417	Phosphorylation	PSMMNDYYAASPRIF HHHHCCHHHCCCCHH	9.88	28450419
420	Phosphorylation	MNDYYAASPRIFPHL HCCHHHCCCCHHHHH	13.41	25159151
488	Phosphorylation	NETPRRRSHSPSPRR CCCCCCCCCCCCCCC	26.89	27362937
490	Phosphorylation	TPRRRSHSPSPRRSR CCCCCCCCCCCCCCC	28.46	20363803
492	Phosphorylation	RRRSHSPSPRRSRRS CCCCCCCCCCCCCCC	33.77	27362937
496	Phosphorylation	HSPSPRRSRRSSSSH CCCCCCCCCCCCCCC	33.07	17081983
499	Phosphorylation	SPRRSRRSSSSHRFR CCCCCCCCCCCCCHH	33.20	23663014
500	Phosphorylation	PRRSRRSSSSHRFRR CCCCCCCCCCCCHHH	33.77	23663014
501	Phosphorylation	RRSRRSSSSHRFRRS CCCCCCCCCCCHHHC	31.26	23663014
502	Phosphorylation	RSRRSSSSHRFRRSR CCCCCCCCCCHHHCC	22.19	23663014
508	Phosphorylation	SSHRFRRSRSPMHYM CCCCHHHCCCCCCHH	32.62	23401153
510	Phosphorylation	HRFRRSRSPMHYMYR CCHHHCCCCCCHHCC	28.02	23401153
514	Phosphorylation	RSRSPMHYMYRPRSR HCCCCCCHHCCCCCC	6.92	30631047
516	Phosphorylation	RSPMHYMYRPRSRSP CCCCCHHCCCCCCCH	15.42	23403867
520	Phosphorylation	HYMYRPRSRSPRICH CHHCCCCCCCHHHHH	39.53	20068231
522	Phosphorylation	MYRPRSRSPRICHRF HCCCCCCCHHHHHHH	21.56	20068231
527 (in isoform 5)	Ubiquitination	-	25.89	21906983
537	Phosphorylation	ISRYRSRSRSRSPYR HHHHHHCCCCCCCCC	35.54	24144214
539	Phosphorylation	RYRSRSRSRSPYRIR HHHHCCCCCCCCCCC	38.05	20068231
541	Phosphorylation	RSRSRSRSPYRIRNP HHCCCCCCCCCCCCC	27.77	20068231
543	Phosphorylation	RSRSRSPYRIRNPFR CCCCCCCCCCCCCCC	21.66	24719451
552	Phosphorylation	IRNPFRGSPKCFRSV CCCCCCCCCCCCCCC	19.55	22167270
557	Methylation	RGSPKCFRSVSPERM CCCCCCCCCCCHHHH	45.69	115386535
558	Phosphorylation	GSPKCFRSVSPERMS CCCCCCCCCCHHHHH	13.49	23401153
560	Phosphorylation	PKCFRSVSPERMSRR CCCCCCCCHHHHHHH	23.45	23401153
565	Phosphorylation	SVSPERMSRRSVRSS CCCHHHHHHHCCCHH	30.66	23090842
568	Phosphorylation	PERMSRRSVRSSDRK HHHHHHHCCCHHHHH	22.29	-
571	Phosphorylation	MSRRSVRSSDRKKAL HHHHCCCHHHHHHHH	34.14	28102081
572	Phosphorylation	SRRSVRSSDRKKALE HHHCCCHHHHHHHHH	30.76	28102081
576	Ubiquitination	VRSSDRKKALEDVVQ CCHHHHHHHHHHHHH	60.13	-
585	Phosphorylation	LEDVVQRSGHGTEFN HHHHHHHCCCCHHHC	20.32	25159151
589	Phosphorylation	VQRSGHGTEFNKQKH HHHCCCCHHHCHHHH	31.56	20068231
593	Ubiquitination	GHGTEFNKQKHLEAA CCCHHHCHHHHHHHH	67.07	-
602	Acetylation	KHLEAADKGHSPAQK HHHHHHHCCCCCCCC	54.52	25953088
602	Ubiquitination	KHLEAADKGHSPAQK HHHHHHHCCCCCCCC	54.52	-
605	Phosphorylation	EAADKGHSPAQKPKT HHHHCCCCCCCCCCC	30.51	23927012
612	Phosphorylation	SPAQKPKTSSGTKPS CCCCCCCCCCCCCCC	36.33	29496963
613	Phosphorylation	PAQKPKTSSGTKPSV CCCCCCCCCCCCCCC	32.66	22199227
614	Phosphorylation	AQKPKTSSGTKPSVK CCCCCCCCCCCCCCC	56.57	25159151
616	Phosphorylation	KPKTSSGTKPSVKPT CCCCCCCCCCCCCCC	41.55	22199227
619	Phosphorylation	TSSGTKPSVKPTSAT CCCCCCCCCCCCCCC	44.31	27174698
623	Phosphorylation	TKPSVKPTSATKSDS CCCCCCCCCCCCCCC	25.85	22199227
624	Phosphorylation	KPSVKPTSATKSDSN CCCCCCCCCCCCCCC	42.33	25159151
626	Phosphorylation	SVKPTSATKSDSNLG CCCCCCCCCCCCCCC	30.74	25159151
628	Phosphorylation	KPTSATKSDSNLGGH CCCCCCCCCCCCCCC	41.75	25159151
630	Phosphorylation	TSATKSDSNLGGHSI CCCCCCCCCCCCCCE	40.83	25159151
636	Phosphorylation	DSNLGGHSIRCKSKN CCCCCCCCEEEECCC	18.27	23401153
641	Phosphorylation	GHSIRCKSKNLEDDT CCCEEEECCCCCCCC	30.33	23401153
642	Acetylation	HSIRCKSKNLEDDTL CCEEEECCCCCCCCH	51.55	26051181
648	Phosphorylation	SKNLEDDTLSECKQV CCCCCCCCHHHHHHH	44.50	26552605
650	Phosphorylation	NLEDDTLSECKQVSD CCCCCCHHHHHHHHH	42.94	23401153
653	Ubiquitination	DDTLSECKQVSDKAV CCCHHHHHHHHHHHH	50.08	-
656	Phosphorylation	LSECKQVSDKAVSLQ HHHHHHHHHHHHHHH	30.79	29116813
658	Acetylation	ECKQVSDKAVSLQRK HHHHHHHHHHHHHHH	43.09	25953088
658	Ubiquitination	ECKQVSDKAVSLQRK HHHHHHHHHHHHHHH	43.09	-
661	Phosphorylation	QVSDKAVSLQRKLRK HHHHHHHHHHHHHHH	24.52	28188228
671	Phosphorylation	RKLRKEQSLHYGSVL HHHHHHHCCCCCCEE	20.43	28348404
674	Phosphorylation	RKEQSLHYGSVLLIT HHHHCCCCCCEEEEE	19.18	28348404
676	Phosphorylation	EQSLHYGSVLLITEL HHCCCCCCEEEEEEC	11.48	28348404
716	Phosphorylation	VPYRKEAYLEMEFKE EECCHHHHHHHHHHH	12.32	-
731	Phosphorylation	AITAIMKYIETTPLT HHHHHHHHHHCCCEE	6.14	-
738	Phosphorylation	YIETTPLTIKGKSVK HHHCCCEEECCEEEE	23.11	-
743	Phosphorylation	PLTIKGKSVKICVPG CEEECCEEEEEECCC	36.99	25367160
770	Phosphorylation	TLESKKVSASTLKRD HHHCCCCCHHHHCCC	25.94	23312004
772	Phosphorylation	ESKKVSASTLKRDAD HCCCCCHHHHCCCCC	27.11	23312004
773	Phosphorylation	SKKVSASTLKRDADA CCCCCHHHHCCCCCH	35.69	23312004
775	Sumoylation	KVSASTLKRDADASK CCCHHHHCCCCCHHH	48.60	28112733
788	Phosphorylation	SKAVEIVTSTSAAKT HHCEEEEECCCHHHH	31.76	21406692
789	Phosphorylation	KAVEIVTSTSAAKTG HCEEEEECCCHHHHC	14.96	25159151
790	Phosphorylation	AVEIVTSTSAAKTGQ CEEEEECCCHHHHCC	17.02	21406692
791	Phosphorylation	VEIVTSTSAAKTGQA EEEEECCCHHHHCCC	26.46	22199227
795	Phosphorylation	TSTSAAKTGQAKASV ECCCHHHHCCCEEEE	29.78	22817900
801	Phosphorylation	KTGQAKASVAKVNKS HHCCCEEEEEEECCC	23.15	22817900
808	Phosphorylation	SVAKVNKSTGKSASS EEEEECCCCCCCHHH	36.87	22817900
809	Phosphorylation	VAKVNKSTGKSASSV EEEECCCCCCCHHHC	50.68	22817900
815	Phosphorylation	STGKSASSVKSVVTV CCCCCHHHCEEEEEE	33.03	24719451
818	Phosphorylation	KSASSVKSVVTVAVK CCHHHCEEEEEEEEE	21.47	25954137
821	Phosphorylation	SSVKSVVTVAVKGNK HHCEEEEEEEEECCC	10.69	24719451
825	Acetylation	SVVTVAVKGNKASIK EEEEEEEECCCHHEE	47.21	25953088
853	Acetylation	KTGNVKNKDSNKPVT HHCCCCCCCCCCCEE	57.74	7684907
855	Phosphorylation	GNVKNKDSNKPVTIP CCCCCCCCCCCEECC	48.65	29396449
857	Acetylation	VKNKDSNKPVTIPEN CCCCCCCCCEECCCC	44.83	26051181
860	Phosphorylation	KDSNKPVTIPENSEI CCCCCCEECCCCCCC	39.06	29396449
865	Phosphorylation	PVTIPENSEIKTSIE CEECCCCCCCCEEEE	38.75	20068231
868	Acetylation	IPENSEIKTSIEVKA CCCCCCCCEEEEEEE	31.97	7684917
885	Phosphorylation	NCAKEAISDAALEAT HHHHHHHHHHHHHHH	28.39	25849741
892	Phosphorylation	SDAALEATENEPLNK HHHHHHHHCCCCCCC	29.93	29255136
927	Ubiquitination	EEVYDLAKPFGGLKD HHHHHHHCCCCCHHH	48.45	-
943	2-Hydroxyisobutyrylation	LILSSHKKAYIEINR EEEECCCCEEEHHCH	40.78	-
943	Ubiquitination	LILSSHKKAYIEINR EEEECCCCEEEHHCH	40.78	-
945	Phosphorylation	LSSHKKAYIEINRKA EECCCCEEEHHCHHH	14.15	28102081
951	Acetylation	AYIEINRKAAESMVK EEEHHCHHHHHHHHH	47.67	7976059
951	Ubiquitination	AYIEINRKAAESMVK EEEHHCHHHHHHHHH	47.67	-
1052	Phosphorylation	KAILQLDSPESAQSM EEEEECCCHHHHHHH	38.88	24719451
1055	Phosphorylation	LQLDSPESAQSMYSF EECCCHHHHHHHHHH	34.68	28348404
1060	Phosphorylation	PESAQSMYSFLKQNP HHHHHHHHHHHHHCC	11.08	-
1061	Phosphorylation	ESAQSMYSFLKQNPQ HHHHHHHHHHHHCCC	18.56	24719451
1076	Phosphorylation	NIGDHMLTCSLSPKI CCCCCEEEEECCCCC	7.77	20873877
1078	Phosphorylation	GDHMLTCSLSPKIDL CCCEEEEECCCCCCC	27.01	24719451
1080	Phosphorylation	HMLTCSLSPKIDLPE CEEEEECCCCCCCCC	14.09	24719451
1098	Acetylation	EHDPELEKESPGLKN CCCHHHHHCCCCCCC	75.91	26051181
1098	Ubiquitination	EHDPELEKESPGLKN CCCHHHHHCCCCCCC	75.91	-
1100	Phosphorylation	DPELEKESPGLKNSP CHHHHHCCCCCCCCC	35.02	29255136
1106	Phosphorylation	ESPGLKNSPIDESEV CCCCCCCCCCCHHHC	22.96	25159151
1115	Phosphorylation	IDESEVQTATDSPSV CCHHHCCCCCCCCCC	36.38	30576142
1117	Phosphorylation	ESEVQTATDSPSVKP HHHCCCCCCCCCCCC	40.16	30576142
1119	Phosphorylation	EVQTATDSPSVKPNE HCCCCCCCCCCCCCC	18.08	25849741
1121	Phosphorylation	QTATDSPSVKPNELE CCCCCCCCCCCCCCC	46.88	30576142
1131	Phosphorylation	PNELEEESTPSIQTE CCCCCCCCCCCHHHH	49.23	30576142
1132	Phosphorylation	NELEEESTPSIQTET CCCCCCCCCCHHHHH	25.08	30576142
1134	Phosphorylation	LEEESTPSIQTETLV CCCCCCCCHHHHHHC	27.67	28348404
1137	Phosphorylation	ESTPSIQTETLVQQE CCCCCHHHHHHCCCC	29.30	28348404
1139	Phosphorylation	TPSIQTETLVQQEEP CCCHHHHHHCCCCCC	35.30	28348404
1155	Phosphorylation	EEEAEKATCDSDFAV HHHHHHCCCCCCCHH	28.10	25159151
1158	Phosphorylation	AEKATCDSDFAVETL HHHCCCCCCCHHEEE	36.45	25159151
1226	Phosphorylation	PKTALLPSDSVFAEE CCCCCCCCCHHHCHH	42.35	28348404
1228	Phosphorylation	TALLPSDSVFAEERN CCCCCCCHHHCHHHC	24.38	28348404
1243	Phosphorylation	LKGILEESPSEAEDF CCHHHHCCHHHHHHH	25.09	20068231
1245	Phosphorylation	GILEESPSEAEDFIS HHHHCCHHHHHHHHH	59.73	25849741
1252	Phosphorylation	SEAEDFISGITQTMV HHHHHHHHHHHHHHH	24.92	28464451
1255	Phosphorylation	EDFISGITQTMVEAV HHHHHHHHHHHHHHH	22.85	20068231
1257	Phosphorylation	FISGITQTMVEAVAE HHHHHHHHHHHHHHH	17.97	30301811
1328	Phosphorylation	RMDLQIGTEKAEKNE HHHHHHCHHHHHHCC	35.62	20860994
1330	Acetylation	DLQIGTEKAEKNEGR HHHHCHHHHHHCCCC	62.78	20167786
1352	Acetylation	KMAAMKEKPAENTLF HHHHHCCCCCCCCCC	43.97	25953088
1372	Acetylation	KGVGQANKPDETSKT CCCCCCCCCCCCCCC	57.78	26051181
1376	Phosphorylation	QANKPDETSKTSILA CCCCCCCCCCCEEEE	42.79	-
1377	Phosphorylation	ANKPDETSKTSILAV CCCCCCCCCCEEEEE	31.71	-
1379	Phosphorylation	KPDETSKTSILAVSD CCCCCCCCEEEEEEC	22.29	28450419
1380	Phosphorylation	PDETSKTSILAVSDV CCCCCCCEEEEEECC	21.24	28450419
1385	Phosphorylation	KTSILAVSDVSSSKP CCEEEEEECCCCCCC	27.04	28450419
1388	Phosphorylation	ILAVSDVSSSKPSIK EEEEECCCCCCCCEE	33.61	28450419
1389	Phosphorylation	LAVSDVSSSKPSIKA EEEECCCCCCCCEEE	42.08	28450419
1390	Phosphorylation	AVSDVSSSKPSIKAV EEECCCCCCCCEEEE	40.87	28450419
1391	Acetylation	VSDVSSSKPSIKAVI EECCCCCCCCEEEEE	44.74	26822725
1391	Ubiquitination	VSDVSSSKPSIKAVI EECCCCCCCCEEEEE	44.74	-
1393	Phosphorylation	DVSSSKPSIKAVIVS CCCCCCCCEEEEEEC	40.22	20068231
1400	Phosphorylation	SIKAVIVSSPKAKAT CEEEEEECCCCCCCE	29.78	29255136
1401	Phosphorylation	IKAVIVSSPKAKATV EEEEEECCCCCCCEE	21.37	29255136
1407	Phosphorylation	SSPKAKATVSKTENQ CCCCCCCEECCCCCC	25.30	23186163
1409	Phosphorylation	PKAKATVSKTENQKS CCCCCEECCCCCCCC	29.52	23917254
1430	Acetylation	RDQINAEKKLSAKEF HHHCCHHHHCCHHHH	57.51	25953088
1430	Ubiquitination	RDQINAEKKLSAKEF HHHCCHHHHCCHHHH	57.51	2190698
1430 (in isoform 1)	Ubiquitination	-	57.51	21906983
1430 (in isoform 3)	Ubiquitination	-	57.51	21906983
1433	Phosphorylation	INAEKKLSAKEFGLL CCHHHHCCHHHHCCC	46.29	23898821
1441	Acetylation	AKEFGLLKPTSARSG HHHHCCCCCCCCCCC	51.82	23954790
1443	O-linked_Glycosylation	EFGLLKPTSARSGLA HHCCCCCCCCCCCCC	33.17	OGP
1443	Phosphorylation	EFGLLKPTSARSGLA HHCCCCCCCCCCCCC	33.17	28555341
1444	Phosphorylation	FGLLKPTSARSGLAE HCCCCCCCCCCCCCC	30.16	28555341
1455	Acetylation	GLAESSSKFKPTQSS CCCCCCCCCCCCCCC	60.39	25953088
1459	Phosphorylation	SSSKFKPTQSSLTRG CCCCCCCCCCCCCCC	41.49	26074081
1461	Phosphorylation	SKFKPTQSSLTRGGS CCCCCCCCCCCCCCC	29.78	20860994
1462	Phosphorylation	KFKPTQSSLTRGGSG CCCCCCCCCCCCCCH	24.76	26074081
1464	Phosphorylation	KPTQSSLTRGGSGRI CCCCCCCCCCCCHHH	29.26	23401153
1465	Methylation	PTQSSLTRGGSGRIS CCCCCCCCCCCHHHH	53.41	80701595
1468	Phosphorylation	SSLTRGGSGRISALQ CCCCCCCCHHHHHHH	27.94	26074081
1472	Phosphorylation	RGGSGRISALQGKLS CCCCHHHHHHHHHHH	22.90	26074081
1477	Acetylation	RISALQGKLSKLDYR HHHHHHHHHHCCCHH	36.30	25953088
1477	Ubiquitination	RISALQGKLSKLDYR HHHHHHHHHHCCCHH	36.30	-
1479	Phosphorylation	SALQGKLSKLDYRDI HHHHHHHHCCCHHHH	34.36	22817900
1480	Acetylation	ALQGKLSKLDYRDIT HHHHHHHCCCHHHHH	56.67	25953088
1480	Ubiquitination	ALQGKLSKLDYRDIT HHHHHHHCCCHHHHH	56.67	-
1487	Phosphorylation	KLDYRDITKQSQETE CCCHHHHHHHCCCCC	27.59	23312004
1490	Phosphorylation	YRDITKQSQETEARP HHHHHHHCCCCCCCC	31.38	29214152
1493	Phosphorylation	ITKQSQETEARPSIM HHHHCCCCCCCCCCC	27.58	23312004
1498	Phosphorylation	QETEARPSIMKRDDS CCCCCCCCCCCCCCC	29.75	23312004
1575	Phosphorylation	TLKNVPFSELNLKKK HHHCCCHHHHCCCCC	34.79	27251275
1580	2-Hydroxyisobutyrylation	PFSELNLKKKKGKTS CHHHHCCCCCCCCCC	62.57	-
1639	Phosphorylation	MEEMVKNSNSLFTLD HHHHHHHCCCCCCHH	23.29	23663014
1641	Phosphorylation	EMVKNSNSLFTLDEL HHHHHCCCCCCHHHH	25.36	23663014
1656	Phosphorylation	IDQDDCISHSEPKDV CCCCCCCCCCCCCCC	27.56	23663014
1658	Phosphorylation	QDDCISHSEPKDVTV CCCCCCCCCCCCCEE	49.13	23663014
1664	Phosphorylation	HSEPKDVTVLSVAEE CCCCCCCEEEEHHHH	26.34	30266825
1667	Phosphorylation	PKDVTVLSVAEEQDL CCCCEEEEHHHHHHH	18.23	19664994
1676	Sumoylation	AEEQDLLKQERLVTV HHHHHHHHHCCCEEE	58.36	28112733
1676	Ubiquitination	AEEQDLLKQERLVTV HHHHHHHHHCCCEEE	58.36	-
1697	Phosphorylation	EELPLNESADITFAT EECCCCCCCCEEEEE	30.12	29496963
1701	Phosphorylation	LNESADITFATLNTK CCCCCCEEEEEECCC	14.04	28122231
1704	Phosphorylation	SADITFATLNTKGNE CCCEEEEEECCCCCC	19.15	28122231
1707	Phosphorylation	ITFATLNTKGNEGDT EEEEEECCCCCCCCC	43.36	28122231
1744	Phosphorylation	DEIQDDSSDLHLVTL EECCCCCCCEEEEEH	51.70	22468782
1761	Phosphorylation	VTEEDEDSLADFNNL CCCCCCCCHHHHHCH	24.33	22468782
1797	Phosphorylation	LKVELAQSKNDHPTD HHHEHHHHCCCCCCC	28.02	25599653
1803	Phosphorylation	QSKNDHPTDKKGNRK HHCCCCCCCCCCCCC	57.96	25599653
1819	Phosphorylation	RAVDTKKTKLESLSQ CCCCCCCHHHHHHHH	42.28	28348404
1820	Sumoylation	AVDTKKTKLESLSQV CCCCCCHHHHHHHHC	60.17	28112733
1823	Phosphorylation	TKKTKLESLSQVGPV CCCHHHHHHHHCCCC	43.70	28348404
1825	Phosphorylation	KTKLESLSQVGPVNE CHHHHHHHHCCCCCC	31.90	17525332
1848	Phosphorylation	TMIERHLTAKTPTKR HHHHHHHCCCCCCCC	21.71	23403867
1851	Phosphorylation	ERHLTAKTPTKRVRI HHHHCCCCCCCCEEC	33.45	23927012
1853	Phosphorylation	HLTAKTPTKRVRIGK HHCCCCCCCCEECCC	36.39	28152594
1860	Acetylation	TKRVRIGKTLPSEKA CCCEECCCCCCCCCE	44.51	25953088
1866	Acetylation	GKTLPSEKAVVTEPA CCCCCCCCEEECCCC	51.31	23236377
1870	Phosphorylation	PSEKAVVTEPAKGEE CCCCEEECCCCCCCC	29.65	30108239
1874	Acetylation	AVVTEPAKGEEAFQM EEECCCCCCCCCCCC	77.04	26051181
1882	Phosphorylation	GEEAFQMSEVDEESG CCCCCCCCCCCHHCC	24.56	30266825
1888	Phosphorylation	MSEVDEESGLKDSEP CCCCCHHCCCCCCCH	47.59	23403867
1891	Acetylation	VDEESGLKDSEPERK CCHHCCCCCCCHHHH	63.83	19818679
1893	Phosphorylation	EESGLKDSEPERKRK HHCCCCCCCHHHHHC	54.16	30108239
1910	Phosphorylation	EDSSSGKSVASDVPE CCCCCCCCHHCCCCH	26.83	28450419
1913	Phosphorylation	SSGKSVASDVPEELD CCCCCHHCCCCHHHC	36.66	28450419
1938	Phosphorylation	PICSLFYSGEKAMTN CHHHHHHCCHHHHCC	32.89	21712546
1958	Acetylation	RHKQNTEKFMAKQRK HHHHHHHHHHHHHHH	38.10	25953088
1976	Phosphorylation	QNEAEERSSR----- HHHHHHHHCC-----	100.00	28102081
1977	Phosphorylation	NEAEERSSR------ HHHHHHHCC------	100.00	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
375	S	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZN638_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZN638_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR412_HUMAN	KRTAP4-12	physical	16189514
FBLN4_HUMAN	EFEMP2	physical	16189514
HOOK2_HUMAN	HOOK2	physical	16189514
FHL2_HUMAN	FHL2	physical	11813260
SF3A3_HUMAN	SF3A3	physical	26344197
KCTD3_HUMAN	KCTD3	physical	27173435
KI13B_HUMAN	KIF13B	physical	27173435
ZBT21_HUMAN	ZBTB21	physical	27173435
GGYF1_HUMAN	GIGYF1	physical	27173435
LRFN1_HUMAN	LRFN1	physical	27173435
SRGP2_HUMAN	SRGAP2	physical	27173435
SI1L1_HUMAN	SIPA1L1	physical	27173435
LIMA1_HUMAN	LIMA1	physical	27173435
MAGI1_HUMAN	MAGI1	physical	27173435
TESK2_HUMAN	TESK2	physical	27173435
DCLK1_HUMAN	DCLK1	physical	27173435
SRS12_HUMAN	SRSF12	physical	27173435
SYDE1_HUMAN	SYDE1	physical	27173435
AGAP1_HUMAN	AGAP1	physical	27173435
CDK16_HUMAN	CDK16	physical	27173435
MAST3_HUMAN	MAST3	physical	27173435
F110B_HUMAN	FAM110B	physical	27173435
UBP21_HUMAN	USP21	physical	27173435
AN34A_HUMAN	ANKRD34A	physical	27173435
FA53C_HUMAN	FAM53C	physical	27173435
F110A_HUMAN	FAM110A	physical	27173435
HDAC4_HUMAN	HDAC4	physical	27173435
CING_HUMAN	CGN	physical	27173435
TBC25_HUMAN	TBC1D25	physical	27173435
NF1_HUMAN	NF1	physical	27173435
NADK_HUMAN	NADK	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435
TIAM1_HUMAN	TIAM1	physical	27173435
M3K21_HUMAN	KIAA1804	physical	27173435
NGAP_HUMAN	RASAL2	physical	27173435
MELK_HUMAN	MELK	physical	27173435
PKHA7_HUMAN	PLEKHA7	physical	27173435
KIF1C_HUMAN	KIF1C	physical	27173435
LPIN3_HUMAN	LPIN3	physical	27173435
DEP1B_HUMAN	DEPDC1B	physical	27173435
GGYF2_HUMAN	GIGYF2	physical	27173435
NAV1_HUMAN	NAV1	physical	27173435
AFAD_HUMAN	MLLT4	physical	27173435
STA13_HUMAN	STARD13	physical	27173435
SH3B4_HUMAN	SH3BP4	physical	27173435
PKHA5_HUMAN	PLEKHA5	physical	27173435
RPTOR_HUMAN	RPTOR	physical	27173435
HDAC7_HUMAN	HDAC7	physical	27173435
LARP1_HUMAN	LARP1	physical	27173435
RAB3I_HUMAN	RAB3IP	physical	27173435
INP5E_HUMAN	INPP5E	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZN638_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128; SER-1100 ANDSER-1401, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-795; SER-801; SER-808AND THR-809, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128; SER-558 ANDSER-560, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128; SER-383; SER-420;SER-552; SER-558; SER-560; SER-1100; SER-1401 AND SER-1882, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-125; SER-128 ANDSER-770, AND MASS SPECTROMETRY.	19007248 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1825, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383, AND MASSSPECTROMETRY.	17924679 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128; SER-605 ANDSER-1100, AND MASS SPECTROMETRY.	16565220 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-508; SER-510; SER-520;SER-522; SER-552; SER-558; SER-560 AND SER-605, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, AND MASSSPECTROMETRY.	15302935 [Abstract]