AN34A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AN34A_HUMAN
• UniProt AC: Q69YU3
• Protein Name: Ankyrin repeat domain-containing protein 34A
• Gene Name: ANKRD34A
• Organism: Homo sapiens (Human).
• Sequence Length: 496
• Protein Sequence: MLHTEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRAQEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPTEGRPGIERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEAQESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLTLPPAGSAPSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPIPDIRPQPGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSMQTEQIRLLGGFQSLGGPGEPGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Methylation	ALLRAVGQGKLRLAR HHHHHHHCHHHHHHH	38.97	26797129
30	Phosphorylation	LLLEGGAYVNEGDAQ HHHHCCCEECCCCCC	13.69	24043423
40	Phosphorylation	EGDAQGETALMAACR CCCCCCHHHHHHHHH	31.73	24043423
95	Phosphorylation	GGGAAVASLLLAHGA CHHHHHHHHHHHCCC	16.98	22210691
105	Phosphorylation	LAHGADPSVRDHAGA HHCCCCHHHHCHHHH	30.27	22210691
145	Phosphorylation	GTEVIIITTDTSPSG CCEEEEEECCCCCCC	14.28	29978859
146	Phosphorylation	TEVIIITTDTSPSGT CEEEEEECCCCCCCC	27.20	29978859
148	Phosphorylation	VIIITTDTSPSGTKK EEEEECCCCCCCCHH	40.21	29978859
149	Phosphorylation	IIITTDTSPSGTKKT EEEECCCCCCCCHHH	21.63	29978859
151	Phosphorylation	ITTDTSPSGTKKTRQ EECCCCCCCCHHHHH	59.88	29978859
153	Phosphorylation	TDTSPSGTKKTRQYL CCCCCCCCHHHHHHH	33.43	29978859
201	Phosphorylation	GGGRGMLSPRAQEEE CCCCCCCCHHHHHHH	11.93	22199227
247	Phosphorylation	KPLKRLNSEPWGLVA CCCCCCCCCCCCCCC	50.02	25850435
291	Phosphorylation	PRLSRRHSTEGPEDP CCCCCCCCCCCCCCC	26.75	27273156
292	Phosphorylation	RLSRRHSTEGPEDPP CCCCCCCCCCCCCCC	38.54	23927012
316	Phosphorylation	GPLSRRNTAPEAQES CCCCCCCCCHHHHHH	41.60	27732954
323	Phosphorylation	TAPEAQESGPPSGLR CCHHHHHHCCCCHHH	44.51	46164235
327	Phosphorylation	AQESGPPSGLRQKLS HHHHCCCCHHHHHHH	54.30	21712546
351	Phosphorylation	PGHLCPDSPESSRLS CCCCCCCCCCHHHHH	18.73	27732954
354	Phosphorylation	LCPDSPESSRLSLER CCCCCCCHHHHHHHC	24.92	27732954
355	Phosphorylation	CPDSPESSRLSLERR CCCCCCHHHHHHHCH	35.26	27732954
376	Phosphorylation	LTLPPAGSAPSPRQS CCCCCCCCCCCCCCC	38.83	27732954
379	Phosphorylation	PPAGSAPSPRQSQES CCCCCCCCCCCCCCC	32.22	27732954
383	Phosphorylation	SAPSPRQSQESLPGA CCCCCCCCCCCCCCC	36.88	27251275
386	Phosphorylation	SPRQSQESLPGAVSP CCCCCCCCCCCCCCC	32.02	27251275
392	Phosphorylation	ESLPGAVSPLSGRRR CCCCCCCCCCCCCCC	21.42	29255136
395	Phosphorylation	PGAVSPLSGRRRSPG CCCCCCCCCCCCCCC	33.37	29255136
400	Phosphorylation	PLSGRRRSPGLLERR CCCCCCCCCCHHHCC	22.85	27273156
409	Phosphorylation	GLLERRGSGTLLLDH CHHHCCCCCEEEECH	27.13	27732954
411	Phosphorylation	LERRGSGTLLLDHIS HHCCCCCEEEECHHH	18.87	27732954
418	Phosphorylation	TLLLDHISQTRPGFL EEEECHHHCCCCCCC	23.29	28348404
420	Phosphorylation	LLDHISQTRPGFLPP EECHHHCCCCCCCCC	31.85	28348404
449	Phosphorylation	QPGGRAPSLPAPPYA CCCCCCCCCCCCCCC	46.10	28555341
455	Phosphorylation	PSLPAPPYAGAPGSP CCCCCCCCCCCCCCH	19.33	26657352
461	Phosphorylation	PYAGAPGSPRTKRKL CCCCCCCCHHHHHHH	15.34	30278072
473	Phosphorylation	RKLVRRHSMQTEQIR HHHHHHHCCCHHHHH	15.69	18388127
487	Phosphorylation	RLLGGFQSLGGPGEP HHHHCHHHCCCCCCC	27.07	9382609

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AN34A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
15	Q	Methylation	Methylated at Gln-15 by N6AMT1.	26797129

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AN34A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRFN1_HUMAN	LRFN1	physical	27173435
SRS12_HUMAN	SRSF12	physical	27173435
UBP21_HUMAN	USP21	physical	27173435
F110A_HUMAN	FAM110A	physical	27173435
F110B_HUMAN	FAM110B	physical	27173435
MAGI1_HUMAN	MAGI1	physical	27173435
TESK2_HUMAN	TESK2	physical	27173435
LIMA1_HUMAN	LIMA1	physical	27173435
ZBT21_HUMAN	ZBTB21	physical	27173435
DCLK1_HUMAN	DCLK1	physical	27173435
TBC25_HUMAN	TBC1D25	physical	27173435
GGYF1_HUMAN	GIGYF1	physical	27173435
SRGP2_HUMAN	SRGAP2	physical	27173435
SYDE1_HUMAN	SYDE1	physical	27173435
AGAP1_HUMAN	AGAP1	physical	27173435
KCTD3_HUMAN	KCTD3	physical	27173435
SI1L1_HUMAN	SIPA1L1	physical	27173435
KI13B_HUMAN	KIF13B	physical	27173435
HDAC4_HUMAN	HDAC4	physical	27173435
NADK_HUMAN	NADK	physical	27173435
AFAD_HUMAN	MLLT4	physical	27173435
SH3B4_HUMAN	SH3BP4	physical	27173435
MELK_HUMAN	MELK	physical	27173435
DEP1B_HUMAN	DEPDC1B	physical	27173435
NGAP_HUMAN	RASAL2	physical	27173435
PKHA7_HUMAN	PLEKHA7	physical	27173435
NF1_HUMAN	NF1	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435
KIF1C_HUMAN	KIF1C	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.