KCTD3_HUMAN - dbPTM
KCTD3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KCTD3_HUMAN
UniProt AC Q9Y597
Protein Name BTB/POZ domain-containing protein KCTD3
Gene Name KCTD3
Organism Homo sapiens (Human).
Sequence Length 815
Subcellular Localization Cell membrane .
Protein Description Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics..
Protein Sequence MAGGHCGSFPAAAAGSGEIVQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISTLRDETGAIFIDRDPAAFAPILNFLRTKELDLRGVSINVLRHEAEFYGITPLVRRLLLCEELERSSCGSVLFHGYLPPPGIPSRKINNTVRSADSRNGLNSTEGEARGNGTQPVLSGTGEETVRLGFPVDPRKVLIVAGHHNWIVAAYAHFAVCYRIKESSGWQQVFTSPYLDWTIERVALNAKVVGGPHGDKDKMVAVASESSIILWSVQDGGSGSEIGVFSLGVPVDALFFIGNQLVATSHTGKVGVWNAVTQHWQVQDVVPITSYDTAGSFLLLGCNNGSIYYIDMQKFPLRMKDNDLLVTELYHDPSNDAITALSVYLTPKTSVSGNWIEIAYGTSSGAVRVIVQHPETVGSGPQLFQTFTVHRSPVTKIMLSEKHLVSVCADNNHVRTWTVTRFRGMISTQPGSTPLASFKILSLEETESHGSYSSGNDIGPFGERDDQQVFIQKVVPITNKLFVRLSSTGKRICEIQAVDCTTISSFTVRECEGSSRMGSRPRRYLFTGHTNGSIQMWDLTTAMDMVNKSEDKDVGGPTEEELLKLLDQCDLSTSRCATPNISPATSVVQHSHLRESNSSLQLQHHDTTHEAATYGSMRPYRESPLLARARRTESFHSYRDFQTINLNRNVERAVPENGNLGPIQAEVKGATGECNISERKSPGVEIKSLRELDSGLEVHKIAEGFSESKKRSSEDENENKIEFRKKGGFEGGGFLGRKKVPYLASSPSTSDGGTDSPGTASPSPTKTTPSPRHKKSDSSGQEYSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
31PhosphorylationVGGTRFSTSRQTLMW
ECCCEEECCCCEEEE		25.8029116813
35PhosphorylationRFSTSRQTLMWIPDS
EEECCCCEEEECCHH		19.9224719451
36UbiquitinationFSTSRQTLMWIPDSF
EECCCCEEEECCHHH		1.7129967540
46PhosphorylationIPDSFFSSLLSGRIS
CCHHHHHHHHHCCCC		28.3328355574
54PhosphorylationLLSGRISTLRDETGA
HHHCCCCCCCCCCCC		24.3624719451
81UbiquitinationILNFLRTKELDLRGV
HHHHHHCCCCCCCCC		50.2533845483
86MethylationRTKELDLRGVSINVL
HCCCCCCCCCEEEEE		43.04115480873
135UbiquitinationYLPPPGIPSRKINNT
CCCCCCCCHHHCCCC		33.7133845483
138UbiquitinationPPGIPSRKINNTVRS
CCCCCHHHCCCCCCC		54.8729967540
142PhosphorylationPSRKINNTVRSADSR
CHHHCCCCCCCCCCC		16.89-
148PhosphorylationNTVRSADSRNGLNST
CCCCCCCCCCCCCCC		27.6228857561
237UbiquitinationERVALNAKVVGGPHG
EEEEECCEEECCCCC		36.0633845483
248UbiquitinationGPHGDKDKMVAVASE
CCCCCHHCEEEEEEC		40.8033845483
324UbiquitinationPITSYDTAGSFLLLG
EECCEECCCCEEEEE		14.5623000965
330UbiquitinationTAGSFLLLGCNNGSI
CCCCEEEEEECCCEE		8.8223000965
350UbiquitinationQKFPLRMKDNDLLVT
CCCCCCCCCCCEEEE		47.1233845483
401UbiquitinationSGAVRVIVQHPETVG
CCCEEEEEECCCCCC		3.8027667366
408UbiquitinationVQHPETVGSGPQLFQ
EECCCCCCCCCCEEE		34.0127667366
426 (in isoform 2)Ubiquitination-26.7621890473
426UbiquitinationVHRSPVTKIMLSEKH
EECCCCCEEEECCCE		26.7623000965
426 (in isoform 1)Ubiquitination-26.7621890473
432UbiquitinationTKIMLSEKHLVSVCA
CEEEECCCEEEEEEC		38.5723000965
458PhosphorylationRFRGMISTQPGSTPL
EEECCCCCCCCCCCC		28.0527282143
462PhosphorylationMISTQPGSTPLASFK
CCCCCCCCCCCEEEE		33.2723186163
463PhosphorylationISTQPGSTPLASFKI
CCCCCCCCCCEEEEE		28.3927282143
467PhosphorylationPGSTPLASFKILSLE
CCCCCCEEEEEEEEE		34.4527282143
503 (in isoform 1)Ubiquitination-40.1421890473
503UbiquitinationDQQVFIQKVVPITNK
CCEEEEEEEEECCCC		40.1427667366
503 (in isoform 2)Ubiquitination-40.1421890473
510 (in isoform 2)Ubiquitination-34.3521890473
510 (in isoform 1)Ubiquitination-34.3521890473
510UbiquitinationKVVPITNKLFVRLSS
EEEECCCCEEEEECC		34.3527667366
537PhosphorylationCTTISSFTVRECEGS
CCEECEEEEEECCCC		22.1724719451
582UbiquitinationMVNKSEDKDVGGPTE
HCCCCCCCCCCCCCH		50.7029967540
588PhosphorylationDKDVGGPTEEELLKL
CCCCCCCCHHHHHHH		60.3420068231
594UbiquitinationPTEEELLKLLDQCDL
CCHHHHHHHHHHCCC		60.6829967540
602PhosphorylationLLDQCDLSTSRCATP
HHHHCCCCCCCCCCC		15.8728450419
603PhosphorylationLDQCDLSTSRCATPN
HHHCCCCCCCCCCCC		27.7323401153
604PhosphorylationDQCDLSTSRCATPNI
HHCCCCCCCCCCCCC		23.2222617229
607PhosphorylationDLSTSRCATPNISPA
CCCCCCCCCCCCCCC		25.6132645325
608PhosphorylationLSTSRCATPNISPAT
CCCCCCCCCCCCCCC		22.0920873877
612PhosphorylationRCATPNISPATSVVQ
CCCCCCCCCCCCHHC		18.3428985074
615PhosphorylationTPNISPATSVVQHSH
CCCCCCCCCHHCCHH		25.9929978859
616PhosphorylationPNISPATSVVQHSHL
CCCCCCCCHHCCHHH		23.5429978859
621PhosphorylationATSVVQHSHLRESNS
CCCHHCCHHHCCCCC		13.7129978859
626PhosphorylationQHSHLRESNSSLQLQ
CCHHHCCCCCCCEEE		35.2623312004
628PhosphorylationSHLRESNSSLQLQHH
HHHCCCCCCCEEEEC		41.5323917254
629PhosphorylationHLRESNSSLQLQHHD
HHCCCCCCCEEEECC		25.1223186163
637PhosphorylationLQLQHHDTTHEAATY
CEEEECCCCCHHCCC		26.2023312004
638PhosphorylationQLQHHDTTHEAATYG
EEEECCCCCHHCCCC		24.6323312004
643PhosphorylationDTTHEAATYGSMRPY
CCCCHHCCCCCCCCC		35.1523312004
644PhosphorylationTTHEAATYGSMRPYR
CCCHHCCCCCCCCCC		11.5023312004
646UbiquitinationHEAATYGSMRPYRES
CHHCCCCCCCCCCCC		10.9529967540
646PhosphorylationHEAATYGSMRPYRES
CHHCCCCCCCCCCCC		10.9523312004
650PhosphorylationTYGSMRPYRESPLLA
CCCCCCCCCCCCHHH		19.3523312004
653PhosphorylationSMRPYRESPLLARAR
CCCCCCCCCHHHHHH		16.3227732954
662PhosphorylationLLARARRTESFHSYR
HHHHHHCCCCCCCCC		30.3528450419
664PhosphorylationARARRTESFHSYRDF
HHHHCCCCCCCCCCC		27.8723401153
667PhosphorylationRRTESFHSYRDFQTI
HCCCCCCCCCCCCEE		21.6128450419
668PhosphorylationRTESFHSYRDFQTIN
CCCCCCCCCCCCEEE		12.9623927012
673PhosphorylationHSYRDFQTINLNRNV
CCCCCCCEEECCCCC		16.3023186163
701PhosphorylationQAEVKGATGECNISE
EEEECCCCCCCCCCC		42.0323403867
707PhosphorylationATGECNISERKSPGV
CCCCCCCCCCCCCCC		19.8423403867
709PhosphorylationGECNISERKSPGVEI
CCCCCCCCCCCCCEE		37.6532645325
711PhosphorylationCNISERKSPGVEIKS
CCCCCCCCCCCEECC		32.8629255136
718PhosphorylationSPGVEIKSLRELDSG
CCCCEECCHHCCCCC		38.0225278378
724PhosphorylationKSLRELDSGLEVHKI
CCHHCCCCCCCHHHH		58.8828188228
736PhosphorylationHKIAEGFSESKKRSS
HHHHHCCCCCCCCCC		52.3921815630
738PhosphorylationIAEGFSESKKRSSED
HHHCCCCCCCCCCCC		42.1327251275
739AcetylationAEGFSESKKRSSEDE
HHCCCCCCCCCCCCC		48.4230589645
742PhosphorylationFSESKKRSSEDENEN
CCCCCCCCCCCCCCC		47.1323663014
743PhosphorylationSESKKRSSEDENENK
CCCCCCCCCCCCCCC		53.7723663014
748UbiquitinationRSSEDENENKIEFRK
CCCCCCCCCCCCHHH		58.8329967540
750MethylationSEDENENKIEFRKKG
CCCCCCCCCCHHHCC		37.12-
750UbiquitinationSEDENENKIEFRKKG
CCCCCCCCCCHHHCC		37.1229967540
772PhosphorylationLGRKKVPYLASSPST
CCCCCCCEEECCCCC		20.2123312004
775PhosphorylationKKVPYLASSPSTSDG
CCCCEEECCCCCCCC		39.9423312004
776PhosphorylationKVPYLASSPSTSDGG
CCCEEECCCCCCCCC		19.7730576142
778PhosphorylationPYLASSPSTSDGGTD
CEEECCCCCCCCCCC		42.3530576142
779PhosphorylationYLASSPSTSDGGTDS
EEECCCCCCCCCCCC		33.9323312004
780PhosphorylationLASSPSTSDGGTDSP
EECCCCCCCCCCCCC		38.3023312004
784PhosphorylationPSTSDGGTDSPGTAS
CCCCCCCCCCCCCCC		38.5428450419
786PhosphorylationTSDGGTDSPGTASPS
CCCCCCCCCCCCCCC		25.6828450419
789PhosphorylationGGTDSPGTASPSPTK
CCCCCCCCCCCCCCC		27.6121082442
791PhosphorylationTDSPGTASPSPTKTT
CCCCCCCCCCCCCCC		26.2525159151
793PhosphorylationSPGTASPSPTKTTPS
CCCCCCCCCCCCCCC		42.5830278072
795PhosphorylationGTASPSPTKTTPSPR
CCCCCCCCCCCCCCC		45.4130278072
796PhosphoglycerylationTASPSPTKTTPSPRH
CCCCCCCCCCCCCCC		54.51-
797PhosphorylationASPSPTKTTPSPRHK
CCCCCCCCCCCCCCC		46.5523312004
798PhosphorylationSPSPTKTTPSPRHKK
CCCCCCCCCCCCCCC		24.2723312004
800PhosphorylationSPTKTTPSPRHKKSD
CCCCCCCCCCCCCCC		32.2623312004
806PhosphorylationPSPRHKKSDSSGQEY
CCCCCCCCCCCCCCC		47.7525159151
808PhosphorylationPRHKKSDSSGQEYSL
CCCCCCCCCCCCCCC		43.3825159151
809PhosphorylationRHKKSDSSGQEYSL-
CCCCCCCCCCCCCC-		49.8725159151
813PhosphorylationSDSSGQEYSL-----
CCCCCCCCCC-----		13.8523403867
814PhosphorylationDSSGQEYSL------
CCCCCCCCC------		27.1823403867
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KCTD3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KCTD3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KCTD3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LRC40_HUMANLRRC40physical
22939629
MTNA_HUMANMRI1physical
22939629
STXB1_HUMANSTXBP1physical
22939629
SHKB1_HUMANSHKBP1physical
28514442
KCD15_HUMANKCTD15physical
28514442
FHL3_HUMANFHL3physical
28514442
KCTD1_HUMANKCTD1physical
28514442
ASPC1_HUMANASPSCR1physical
28514442
RD23B_HUMANRAD23Bphysical
28514442
CUL3_HUMANCUL3physical
28514442
TPC6B_HUMANTRAPPC6Bphysical
28514442
TPPC9_HUMANTRAPPC9physical
28514442
CG043_HUMANC7orf43physical
28514442
PIMT_HUMANPCMT1physical
28514442
KI13B_HUMANKIF13Bphysical
27173435
ZBT21_HUMANZBTB21physical
27173435
CING_HUMANCGNphysical
27173435
GGYF1_HUMANGIGYF1physical
27173435
LRFN1_HUMANLRFN1physical
27173435
SRGP2_HUMANSRGAP2physical
27173435
SI1L1_HUMANSIPA1L1physical
27173435
LIMA1_HUMANLIMA1physical
27173435
MAGI1_HUMANMAGI1physical
27173435
NF1_HUMANNF1physical
27173435
TESK2_HUMANTESK2physical
27173435
RGPS2_HUMANRALGPS2physical
27173435
DCLK1_HUMANDCLK1physical
27173435
CBY1_HUMANCBY1physical
27173435
HDAC4_HUMANHDAC4physical
27173435
GGYF2_HUMANGIGYF2physical
27173435
NADK_HUMANNADKphysical
27173435
SRS12_HUMANSRSF12physical
27173435
SYDE1_HUMANSYDE1physical
27173435
NGAP_HUMANRASAL2physical
27173435
AGAP1_HUMANAGAP1physical
27173435
RPTOR_HUMANRPTORphysical
27173435
PKHA7_HUMANPLEKHA7physical
27173435
KIF1C_HUMANKIF1Cphysical
27173435
NAV1_HUMANNAV1physical
27173435
F110B_HUMANFAM110Bphysical
27173435
UBP21_HUMANUSP21physical
27173435
MELK_HUMANMELKphysical
27173435
MFR1L_HUMANMTFR1Lphysical
27173435
STA13_HUMANSTARD13physical
27173435
HDAC5_HUMANHDAC5physical
27173435
MILK1_HUMANMICALL1physical
27173435
HDAC7_HUMANHDAC7physical
27173435
FGD6_HUMANFGD6physical
27173435
F110A_HUMANFAM110Aphysical
27173435
LARP1_HUMANLARP1physical
27173435
TBCD1_HUMANTBC1D1physical
27173435
DEP1B_HUMANDEPDC1Bphysical
27173435
DCP1B_HUMANDCP1Bphysical
27173435
CRTC3_HUMANCRTC3physical
27173435
DCP1A_HUMANDCP1Aphysical
27173435
KIF1B_HUMANKIF1Bphysical
27173435
PKHA5_HUMANPLEKHA5physical
27173435
PANK2_HUMANPANK2physical
27173435
REEP3_HUMANREEP3physical
27173435
CRTC2_HUMANCRTC2physical
27173435
AFAD_HUMANMLLT4physical
27173435
CRTC1_HUMANCRTC1physical
27173435
KLC3_HUMANKLC3physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KCTD3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-711, AND MASSSPECTROMETRY.

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