TPC6B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPC6B_HUMAN
• UniProt AC: Q86SZ2
• Protein Name: Trafficking protein particle complex subunit 6B
• Gene Name: TRAPPC6B
• Organism: Homo sapiens (Human).
• Sequence Length: 158
• Subcellular Localization: Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.
• Protein Description: May play a role in vesicular transport from endoplasmic reticulum to Golgi..
• Protein Sequence: MADEALFLLLHNEMVSGVYKSAEQGEVENGRCITKLENMGFRVGQGLIERFTKDTARFKDELDIMKFICKDFWTTVFKKQIDNLRTNHQGIYVLQDNKFRLLTQMSAGKQYLEHASKYLAFTCGLIRGGLSNLGIKSIVTAEVSSMPACKFQVMIQKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	MVSGVYKSAEQGEVE HHHCCHHCCCCCCCC	21.25	24114839
35	Acetylation	ENGRCITKLENMGFR CCCEEEEEHHHHCCE	33.61	25953088
35	Ubiquitination	ENGRCITKLENMGFR CCCEEEEEHHHHCCE	33.61	29967540
53	Acetylation	GLIERFTKDTARFKD HHHHHHHCCCHHHHH	50.82	7966137
53	Ubiquitination	GLIERFTKDTARFKD HHHHHHHCCCHHHHH	50.82	29967540
70	Acetylation	DIMKFICKDFWTTVF HHHHHHHHHHHHHHH	51.66	20167786
71	Ubiquitination	IMKFICKDFWTTVFK HHHHHHHHHHHHHHH	39.65	21890473
78	2-Hydroxyisobutyrylation	DFWTTVFKKQIDNLR HHHHHHHHHHHHHHC	39.16	-
86 (in isoform 2)	Phosphorylation	-	39.97	24043423
90 (in isoform 2)	Phosphorylation	-	12.97	24043423
94 (in isoform 2)	Phosphorylation	-	2.73	24043423
98	Acetylation	IYVLQDNKFRLLTQM EEEEECCEEEEEHHH	39.90	19608861
109	Ubiquitination	LTQMSAGKQYLEHAS EHHHHHHHHHHHHHH	35.17	23000965
109 (in isoform 1)	Ubiquitination	-	35.17	21890473
144	Phosphorylation	SIVTAEVSSMPACKF EEEEEECCCCCCHHH	16.66	24719451
145	Phosphorylation	IVTAEVSSMPACKFQ EEEEECCCCCCHHHH	33.68	28348404
157	Ubiquitination	KFQVMIQKL------ HHHHEEECC------	45.28	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPC6B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPC6B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPC6B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPC10_HUMAN	TRAPPC10	physical	21525244
TPC6A_HUMAN	TRAPPC6A	physical	21525244
TPC2L_HUMAN	TRAPPC2L	physical	21525244
TPC2A_HUMAN	TRAPPC2	physical	21525244
TPC2B_HUMAN	TRAPPC2	physical	21525244
TPPC3_HUMAN	TRAPPC3	physical	21525244
TPC3L_HUMAN	TRAPPC3L	physical	21525244
TPPC3_HUMAN	TRAPPC3	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-98, AND MASS SPECTROMETRY.
PubMed: 19608861