dbPTM

LIMA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LIMA1_HUMAN
UniProt AC	Q9UHB6
Protein Name	LIM domain and actin-binding protein 1
Gene Name	LIMA1
Organism	Homo sapiens (Human).
Sequence Length	759
Subcellular Localization	Cytoplasm. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. This cytoskeletal protein co-localizes with actin stress fibers and focal adhesion plaques.
Protein Description	Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments..
Protein Sequence	MESSPFNRRQWTSLSLRVTAKELSLVNKNKSSAIVEIFSKYQKAAEETNMEKKRSNTENLSQHFRKGTLTVLKKKWENPGLGAESHTDSLRNSSTEIRHRADHPPAEVTSHAASGAKADQEEQIHPRSRLRSPPEALVQGRYPHIKDGEDLKDHSTESKKMENCLGESRHEVEKSEISENTDASGKIEKYNVPLNRLKMMFEKGEPTQTKILRAQSRSASGRKISENSYSLDDLEIGPGQLSSSTFDSEKNESRRNLELPRLSETSIKDRMAKYQAAVSKQSSSTNYTNELKASGGEIKIHKMEQKENVPPGPEVCITHQEGEKISANENSLAVRSTPAEDDSRDSQVKSEVQQPVHPKPLSPDSRASSLSESSPPKAMKKFQAPARETCVECQKTVYPMERLLANQQVFHISCFRCSYCNNKLSLGTYASLHGRIYCKPHFNQLFKSKGNYDEGFGHRPHKDLWASKNENEEILERPAQLANARETPHSPGVEDAPIAKVGVLAASMEAKASSQQEKEDKPAETKKLRIAWPPPTELGSSGSALEEGIKMSKPKWPPEDEISKPEVPEDVDLDLKKLRRSSSLKERSRPFTVAASFQSTSVKSPKTVSPPIRKGWSMSEQSEESVGGRVAERKQVENAKASKKNGNVGKTTWQNKESKGETGKRSKEGHSLEMENENLVENGADSDEDDNSFLKQQSPQEPKSLNWSSFVDNTFAEEFTTQNQKSQDVELWEGEVVKELSVEEQIKRNRYYDEDEDEE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MESSPFNR -------CCCCCCCH	11.56	20068231
1 (in isoform 2)	Acetylation	-	11.56	22814378
1 (in isoform 5)	Acetylation	-	11.56	22814378
3	Phosphorylation	-----MESSPFNRRQ -----CCCCCCCHHH	41.85	19691289
4	Phosphorylation	----MESSPFNRRQW ----CCCCCCCHHHC	21.87	25159151
8 (in isoform 5)	Phosphorylation	-	32.33	27251275
12	Phosphorylation	PFNRRQWTSLSLRVT CCCHHHCHHEEEEEE	16.08	23927012
13	Phosphorylation	FNRRQWTSLSLRVTA CCHHHCHHEEEEEEH	17.01	23927012
15	Phosphorylation	RRQWTSLSLRVTAKE HHHCHHEEEEEEHHH	17.56	25159151
21	Ubiquitination	LSLRVTAKELSLVNK EEEEEEHHHHHHHCC	50.23	21890473
21	Ubiquitination	LSLRVTAKELSLVNK EEEEEEHHHHHHHCC	50.23	21890473
21	Ubiquitination	LSLRVTAKELSLVNK EEEEEEHHHHHHHCC	50.23	23000965
21 (in isoform 1)	Ubiquitination	-	50.23	21890473
21 (in isoform 4)	Ubiquitination	-	50.23	-
24	Phosphorylation	RVTAKELSLVNKNKS EEEHHHHHHHCCCCC	31.22	24719451
26 (in isoform 2)	Ubiquitination	-	9.59	21890473
29	Ubiquitination	ELSLVNKNKSSAIVE HHHHHCCCCCHHHHH	44.21	29967540
32	Phosphorylation	LVNKNKSSAIVEIFS HHCCCCCHHHHHHHH	24.51	-
39	Phosphorylation	SAIVEIFSKYQKAAE HHHHHHHHHHHHHHH	35.79	24719451
40	Ubiquitination	AIVEIFSKYQKAAEE HHHHHHHHHHHHHHH	40.74	21890473
40	Ubiquitination	AIVEIFSKYQKAAEE HHHHHHHHHHHHHHH	40.74	21890473
40	Ubiquitination	AIVEIFSKYQKAAEE HHHHHHHHHHHHHHH	40.74	21890473
40 (in isoform 1)	Ubiquitination	-	40.74	21890473
40 (in isoform 4)	Ubiquitination	-	40.74	-
41	Phosphorylation	IVEIFSKYQKAAEET HHHHHHHHHHHHHHH	17.66	-
43	Ubiquitination	EIFSKYQKAAEETNM HHHHHHHHHHHHHCH	46.61	-
50	Sulfoxidation	KAAEETNMEKKRSNT HHHHHHCHHHHHHCC	11.88	30846556
50	Ubiquitination	KAAEETNMEKKRSNT HHHHHHCHHHHHHCC	11.88	23000965
55	Phosphorylation	TNMEKKRSNTENLSQ HCHHHHHHCCCCHHH	57.91	26055452
57	Phosphorylation	MEKKRSNTENLSQHF HHHHHHCCCCHHHHH	27.74	25159151
57	Ubiquitination	MEKKRSNTENLSQHF HHHHHHCCCCHHHHH	27.74	29967540
61	Phosphorylation	RSNTENLSQHFRKGT HHCCCCHHHHHHHCC	32.94	28857561
65	Phosphorylation	ENLSQHFRKGTLTVL CCHHHHHHHCCEEEE	34.08	32142685
68	Phosphorylation	SQHFRKGTLTVLKKK HHHHHHCCEEEEHHH	23.45	28857561
69	Phosphorylation	QHFRKGTLTVLKKKW HHHHHCCEEEEHHHC	4.20	32142685
70	Phosphorylation	HFRKGTLTVLKKKWE HHHHCCEEEEHHHCC	24.51	20068231
72	Phosphorylation	RKGTLTVLKKKWENP HHCCEEEEHHHCCCC	5.92	32142685
73	Ubiquitination	KGTLTVLKKKWENPG HCCEEEEHHHCCCCC	48.23	22817900
74	Ubiquitination	GTLTVLKKKWENPGL CCEEEEHHHCCCCCC	59.98	22817900
75	Ubiquitination	TLTVLKKKWENPGLG CEEEEHHHCCCCCCC	59.14	21890473
75	Ubiquitination	TLTVLKKKWENPGLG CEEEEHHHCCCCCCC	59.14	21890473
75	Ubiquitination	TLTVLKKKWENPGLG CEEEEHHHCCCCCCC	59.14	22817900
75 (in isoform 1)	Ubiquitination	-	59.14	21890473
75 (in isoform 4)	Ubiquitination	-	59.14	-
76	Ubiquitination	LTVLKKKWENPGLGA EEEEHHHCCCCCCCC	21.34	24816145
85	Phosphorylation	NPGLGAESHTDSLRN CCCCCCCCCHHHHHC	31.02	28348404
87	Phosphorylation	GLGAESHTDSLRNSS CCCCCCCHHHHHCCC	36.24	27696853
89	Phosphorylation	GAESHTDSLRNSSTE CCCCCHHHHHCCCHH	30.31	27050516
93	Phosphorylation	HTDSLRNSSTEIRHR CHHHHHCCCHHHHHH	32.00	27696853
94	Phosphorylation	TDSLRNSSTEIRHRA HHHHHCCCHHHHHHC	33.34	27696853
95	Phosphorylation	DSLRNSSTEIRHRAD HHHHCCCHHHHHHCC	34.94	30576142
108	Ubiquitination	ADHPPAEVTSHAASG CCCCCHHHHCHHHCC	7.85	24816145
109	Phosphorylation	DHPPAEVTSHAASGA CCCCHHHHCHHHCCC	13.29	16674116
110	Phosphorylation	HPPAEVTSHAASGAK CCCHHHHCHHHCCCC	19.12	16674116
113	Ubiquitination	AEVTSHAASGAKADQ HHHHCHHHCCCCCCH	11.76	29967540
114	Phosphorylation	EVTSHAASGAKADQE HHHCHHHCCCCCCHH	39.81	25159151
120	Ubiquitination	ASGAKADQEEQIHPR HCCCCCCHHHCCCCC	62.07	21963094
120 (in isoform 2)	Ubiquitination	-	62.07	21890473
128	Phosphorylation	EEQIHPRSRLRSPPE HHCCCCCHHCCCCCH	39.87	24732914
132	Phosphorylation	HPRSRLRSPPEALVQ CCCHHCCCCCHHHHC	49.77	29255136
132	Ubiquitination	HPRSRLRSPPEALVQ CCCHHCCCCCHHHHC	49.77	23000965
132 (in isoform 2)	Ubiquitination	-	49.77	21890473
139	Ubiquitination	SPPEALVQGRYPHIK CCCHHHHCCCCCCCC	31.34	27667366
142	Phosphorylation	EALVQGRYPHIKDGE HHHHCCCCCCCCCCH	13.14	29396449
146	Acetylation	QGRYPHIKDGEDLKD CCCCCCCCCCHHHCC	57.56	26051181
155	Phosphorylation	GEDLKDHSTESKKME CHHHCCCCHHHHHHH	43.96	24719451
159	Acetylation	KDHSTESKKMENCLG CCCCHHHHHHHHHHC	50.32	12430253
160	Acetylation	DHSTESKKMENCLGE CCCHHHHHHHHHHCC	61.80	24469713
160	Ubiquitination	DHSTESKKMENCLGE CCCHHHHHHHHHHCC	61.80	21890473
160 (in isoform 3)	Ubiquitination	-	61.80	21890473
161	Ubiquitination	HSTESKKMENCLGES CCHHHHHHHHHHCCC	5.27	21890473
166	Ubiquitination	KKMENCLGESRHEVE HHHHHHHCCCHHHHH	32.79	29967540
168	Phosphorylation	MENCLGESRHEVEKS HHHHHCCCHHHHHHH	36.82	21815630
171 (in isoform 5)	Phosphorylation	-	51.79	25159151
174	Acetylation	ESRHEVEKSEISENT CCHHHHHHHHHCCCC	59.57	26051181
175	Phosphorylation	SRHEVEKSEISENTD CHHHHHHHHHCCCCC	27.02	23312004
176 (in isoform 5)	Phosphorylation	-	62.70	21406692
177 (in isoform 5)	Phosphorylation	-	8.92	21406692
178	Phosphorylation	EVEKSEISENTDASG HHHHHHHCCCCCCCC	22.27	25159151
183 (in isoform 5)	Phosphorylation	-	20.39	25159151
184	Phosphorylation	ISENTDASGKIEKYN HCCCCCCCCCEEECC	43.35	21815630
186	Acetylation	ENTDASGKIEKYNVP CCCCCCCCEEECCCC	45.24	26051181
186	Ubiquitination	ENTDASGKIEKYNVP CCCCCCCCEEECCCC	45.24	21906983
186 (in isoform 1)	Ubiquitination	-	45.24	21890473
187 (in isoform 5)	Phosphorylation	-	6.69	29514088
188	Phosphorylation	TDASGKIEKYNVPLN CCCCCCEEECCCCHH	53.63	32142685
189	Acetylation	DASGKIEKYNVPLNR CCCCCEEECCCCHHH	45.67	26051181
189	Ubiquitination	DASGKIEKYNVPLNR CCCCCEEECCCCHHH	45.67	29967540
190	Phosphorylation	ASGKIEKYNVPLNRL CCCCEEECCCCHHHH	14.49	29978859
191 (in isoform 5)	Phosphorylation	-	39.74	22210691
198	Methylation	NVPLNRLKMMFEKGE CCCHHHHHHHHHCCC	25.69	-
203	Acetylation	RLKMMFEKGEPTQTK HHHHHHHCCCCCHHH	58.26	26051181
203 (in isoform 5)	Phosphorylation	-	58.26	30183078
206 (in isoform 5)	Phosphorylation	-	38.17	22210691
207	Phosphorylation	MFEKGEPTQTKILRA HHHCCCCCHHHHHHH	44.56	26074081
209	Phosphorylation	EKGEPTQTKILRAQS HCCCCCHHHHHHHHH	23.64	26074081
210	Acetylation	KGEPTQTKILRAQSR CCCCCHHHHHHHHHC	29.90	26051181
210	Ubiquitination	KGEPTQTKILRAQSR CCCCCHHHHHHHHHC	29.90	23000965
215	Phosphorylation	QTKILRAQSRSASGR HHHHHHHHHCCCCCC	32.70	32142685
216	Phosphorylation	TKILRAQSRSASGRK HHHHHHHHCCCCCCC	27.50	26074081
218	Phosphorylation	ILRAQSRSASGRKIS HHHHHHCCCCCCCCC	31.84	28258704
218	Ubiquitination	ILRAQSRSASGRKIS HHHHHHCCCCCCCCC	31.84	24816145
220	Phosphorylation	RAQSRSASGRKISEN HHHHCCCCCCCCCCC	40.14	28258704
225	Phosphorylation	SASGRKISENSYSLD CCCCCCCCCCCCCCC	33.49	25159151
228	Phosphorylation	GRKISENSYSLDDLE CCCCCCCCCCCCCCE	16.43	25159151
229	Phosphorylation	RKISENSYSLDDLEI CCCCCCCCCCCCCEE	25.49	30278072
230	Phosphorylation	KISENSYSLDDLEIG CCCCCCCCCCCCEEC	25.74	23927012
242	Phosphorylation	EIGPGQLSSSTFDSE EECCCCCCCCCCCCC	17.85	24732914
243	Phosphorylation	IGPGQLSSSTFDSEK ECCCCCCCCCCCCCC	41.83	24732914
244	Phosphorylation	GPGQLSSSTFDSEKN CCCCCCCCCCCCCCC	29.71	24732914
245	Phosphorylation	PGQLSSSTFDSEKNE CCCCCCCCCCCCCCC	33.15	24732914
248	Phosphorylation	LSSSTFDSEKNESRR CCCCCCCCCCCCCCC	46.40	24732914
253	Phosphorylation	FDSEKNESRRNLELP CCCCCCCCCCCCCCC	46.03	24732914
253	Ubiquitination	FDSEKNESRRNLELP CCCCCCCCCCCCCCC	46.03	29967540
263	Phosphorylation	NLELPRLSETSIKDR CCCCCCCCHHCHHHH	39.86	28355574
265	Phosphorylation	ELPRLSETSIKDRMA CCCCCCHHCHHHHHH	32.17	19691289
266	Phosphorylation	LPRLSETSIKDRMAK CCCCCHHCHHHHHHH	24.48	23401153
268	Acetylation	RLSETSIKDRMAKYQ CCCHHCHHHHHHHHH	38.76	26051181
268	Succinylation	RLSETSIKDRMAKYQ CCCHHCHHHHHHHHH	38.76	23954790
268	Ubiquitination	RLSETSIKDRMAKYQ CCCHHCHHHHHHHHH	38.76	24816145
273	Acetylation	SIKDRMAKYQAAVSK CHHHHHHHHHHHHHC	28.66	26051181
273	Ubiquitination	SIKDRMAKYQAAVSK CHHHHHHHHHHHHHC	28.66	29967540
274	Phosphorylation	IKDRMAKYQAAVSKQ HHHHHHHHHHHHHCC	8.21	28796482
279	Phosphorylation	AKYQAAVSKQSSSTN HHHHHHHHCCCCCCC	21.91	20068231
280	Methylation	KYQAAVSKQSSSTNY HHHHHHHCCCCCCCC	47.83	-
280	Ubiquitination	KYQAAVSKQSSSTNY HHHHHHHCCCCCCCC	47.83	21906983
280 (in isoform 1)	Ubiquitination	-	47.83	21890473
282	Phosphorylation	QAAVSKQSSSTNYTN HHHHHCCCCCCCCCC	29.96	28152594
283	Phosphorylation	AAVSKQSSSTNYTNE HHHHCCCCCCCCCCC	38.39	28152594
284	Phosphorylation	AVSKQSSSTNYTNEL HHHCCCCCCCCCCCC	26.39	28152594
285	Phosphorylation	VSKQSSSTNYTNELK HHCCCCCCCCCCCCH	33.90	28152594
287	Phosphorylation	KQSSSTNYTNELKAS CCCCCCCCCCCCHHC	15.84	25884760
288	Phosphorylation	QSSSTNYTNELKASG CCCCCCCCCCCHHCC	25.04	28152594
292	Acetylation	TNYTNELKASGGEIK CCCCCCCHHCCCEEE	34.04	26051181
292	Methylation	TNYTNELKASGGEIK CCCCCCCHHCCCEEE	34.04	-
292	Ubiquitination	TNYTNELKASGGEIK CCCCCCCHHCCCEEE	34.04	23000965
292 (in isoform 1)	Ubiquitination	-	34.04	21890473
294	Phosphorylation	YTNELKASGGEIKIH CCCCCHHCCCEEEEE	45.82	26055452
299	Ubiquitination	KASGGEIKIHKMEQK HHCCCEEEEEECCCC	34.16	27667366
303	Ubiquitination	GEIKIHKMEQKENVP CEEEEEECCCCCCCC	4.00	21890473
306	Acetylation	KIHKMEQKENVPPGP EEEECCCCCCCCCCC	37.64	26051181
307	Phosphorylation	IHKMEQKENVPPGPE EEECCCCCCCCCCCC	64.25	32645325
309	Ubiquitination	KMEQKENVPPGPEVC ECCCCCCCCCCCCEE	6.75	29967540
324	Acetylation	ITHQEGEKISANENS EEECCCCEECCCCCC	53.47	26051181
326	Phosphorylation	HQEGEKISANENSLA ECCCCEECCCCCCEE	35.79	24732914
331	Phosphorylation	KISANENSLAVRSTP EECCCCCCEEEECCC	16.13	19691289
331 (in isoform 4)	Phosphorylation	-	16.13	25159151
336	Phosphorylation	ENSLAVRSTPAEDDS CCCEEEECCCCCCCC	31.95	24732914
336 (in isoform 4)	Phosphorylation	-	31.95	21406692
337	Phosphorylation	NSLAVRSTPAEDDSR CCEEEECCCCCCCCC	18.89	24732914
337 (in isoform 4)	Phosphorylation	-	18.89	21406692
343	Phosphorylation	STPAEDDSRDSQVKS CCCCCCCCCHHHHHH	50.76	25159151
343 (in isoform 4)	Phosphorylation	-	50.76	25159151
346	Phosphorylation	AEDDSRDSQVKSEVQ CCCCCCHHHHHHHCC	35.44	24732914
347 (in isoform 4)	Phosphorylation	-	51.45	29514088
348	Ubiquitination	DDSRDSQVKSEVQQP CCCCHHHHHHHCCCC	9.49	29967540
349	Acetylation	DSRDSQVKSEVQQPV CCCHHHHHHHCCCCC	33.01	26051181
350	Phosphorylation	SRDSQVKSEVQQPVH CCHHHHHHHCCCCCC	44.11	23927012
351 (in isoform 4)	Phosphorylation	-	38.33	22210691
354	Ubiquitination	QVKSEVQQPVHPKPL HHHHHCCCCCCCCCC	47.35	29967540
359	Acetylation	VQQPVHPKPLSPDSR CCCCCCCCCCCCCCC	43.65	26051181
359	Malonylation	VQQPVHPKPLSPDSR CCCCCCCCCCCCCCC	43.65	26320211
359	Ubiquitination	VQQPVHPKPLSPDSR CCCCCCCCCCCCCCC	43.65	29967540
362	Phosphorylation	PVHPKPLSPDSRASS CCCCCCCCCCCCHHH	34.88	29255136
363 (in isoform 4)	Phosphorylation	-	51.81	30183078
365	Phosphorylation	PKPLSPDSRASSLSE CCCCCCCCCHHHCCC	32.88	29255136
366 (in isoform 4)	Phosphorylation	-	45.96	22210691
368	Phosphorylation	LSPDSRASSLSESSP CCCCCCHHHCCCCCC	30.60	26846344
369	Phosphorylation	SPDSRASSLSESSPP CCCCCHHHCCCCCCC	34.62	29255136
371	Phosphorylation	DSRASSLSESSPPKA CCCHHHCCCCCCCHH	37.06	26846344
373	Phosphorylation	RASSLSESSPPKAMK CHHHCCCCCCCHHHH	44.78	29255136
374	Phosphorylation	ASSLSESSPPKAMKK HHHCCCCCCCHHHHH	40.96	29255136
375	Phosphorylation	SSLSESSPPKAMKKF HHCCCCCCCHHHHHC	43.63	32142685
377	Acetylation	LSESSPPKAMKKFQA CCCCCCCHHHHHCCC	65.58	26051181
377	Ubiquitination	LSESSPPKAMKKFQA CCCCCCCHHHHHCCC	65.58	24816145
378	Ubiquitination	SESSPPKAMKKFQAP CCCCCCHHHHHCCCC	22.32	24816145
381	Acetylation	SPPKAMKKFQAPARE CCCHHHHHCCCCHHH	29.62	26051181
384	Phosphorylation	KAMKKFQAPARETCV HHHHHCCCCHHHHHH	11.67	32142685
395	Acetylation	ETCVECQKTVYPMER HHHHHHHHHHHCHHH	52.17	26051181
396	Phosphorylation	TCVECQKTVYPMERL HHHHHHHHHHCHHHH	10.21	28857561
396	Ubiquitination	TCVECQKTVYPMERL HHHHHHHHHHCHHHH	10.21	29967540
398	Phosphorylation	VECQKTVYPMERLLA HHHHHHHHCHHHHHC	11.33	28102081
413	Phosphorylation	NQQVFHISCFRCSYC CCCEEEEEEEECCCC	9.91	28857561
423	Acetylation	RCSYCNNKLSLGTYA ECCCCCCEEEECCCH	26.01	26051181
425	Phosphorylation	SYCNNKLSLGTYASL CCCCCEEEECCCHHH	26.77	27080861
428	Phosphorylation	NNKLSLGTYASLHGR CCEEEECCCHHHCCE	22.62	28152594
429	Phosphorylation	NKLSLGTYASLHGRI CEEEECCCHHHCCEE	7.75	28152594
431	Phosphorylation	LSLGTYASLHGRIYC EEECCCHHHCCEEEE	15.53	28152594
437	Phosphorylation	ASLHGRIYCKPHFNQ HHHCCEEEECHHHHH	7.96	-
439	Acetylation	LHGRIYCKPHFNQLF HCCEEEECHHHHHHH	25.26	26051181
439	Succinylation	LHGRIYCKPHFNQLF HCCEEEECHHHHHHH	25.26	-
439	Succinylation	LHGRIYCKPHFNQLF HCCEEEECHHHHHHH	25.26	-
445	Ubiquitination	CKPHFNQLFKSKGNY ECHHHHHHHHCCCCC	6.48	32015554
447	Acetylation	PHFNQLFKSKGNYDE HHHHHHHHCCCCCCC	60.91	26051181
447	Methylation	PHFNQLFKSKGNYDE HHHHHHHHCCCCCCC	60.91	-
449	Methylation	FNQLFKSKGNYDEGF HHHHHHCCCCCCCCC	52.33	-
450	Phosphorylation	NQLFKSKGNYDEGFG HHHHHCCCCCCCCCC	45.05	32645325
452	Phosphorylation	LFKSKGNYDEGFGHR HHHCCCCCCCCCCCC	24.84	25394399
462	Ubiquitination	GFGHRPHKDLWASKN CCCCCCHHHHHCCCC	58.14	21890473
462	Ubiquitination	GFGHRPHKDLWASKN CCCCCCHHHHHCCCC	58.14	22817900
462 (in isoform 1)	Ubiquitination	-	58.14	21890473
463	Ubiquitination	FGHRPHKDLWASKNE CCCCCHHHHHCCCCC	44.39	21890473
463	Ubiquitination	FGHRPHKDLWASKNE CCCCCHHHHHCCCCC	44.39	21890473
463 (in isoform 4)	Ubiquitination	-	44.39	-
467	Phosphorylation	PHKDLWASKNENEEI CHHHHHCCCCCCHHH	25.16	30576142
468	Acetylation	HKDLWASKNENEEIL HHHHHCCCCCCHHHH	61.61	26051181
468	Ubiquitination	HKDLWASKNENEEIL HHHHHCCCCCCHHHH	61.61	29967540
469	Ubiquitination	KDLWASKNENEEILE HHHHCCCCCCHHHHH	55.63	29967540
487	Phosphorylation	QLANARETPHSPGVE HHHHHCCCCCCCCCC	22.28	29255136
490	Phosphorylation	NARETPHSPGVEDAP HHCCCCCCCCCCCCC	25.26	25159151
491	Phosphorylation	ARETPHSPGVEDAPI HCCCCCCCCCCCCCH	48.06	32142685
491	Ubiquitination	ARETPHSPGVEDAPI HCCCCCCCCCCCCCH	48.06	29967540
497	Ubiquitination	SPGVEDAPIAKVGVL CCCCCCCCHHHHHHH	39.12	29967540
507	Phosphorylation	KVGVLAASMEAKASS HHHHHHHHHHHHHCC	16.14	25159151
508	Sulfoxidation	VGVLAASMEAKASSQ HHHHHHHHHHHHCCH	5.07	21406390
527	Phosphorylation	DKPAETKKLRIAWPP CCCCCCCCEEEECCC	50.87	32142685
536	Phosphorylation	RIAWPPPTELGSSGS EEECCCCCCCCCCCH	50.01	26657352
539	Phosphorylation	WPPPTELGSSGSALE CCCCCCCCCCCHHHH	17.34	33259812
540	Phosphorylation	PPPTELGSSGSALEE CCCCCCCCCCHHHHH	44.12	20068231
541	Phosphorylation	PPTELGSSGSALEEG CCCCCCCCCHHHHHH	34.66	26657352
543	Phosphorylation	TELGSSGSALEEGIK CCCCCCCHHHHHHHC	31.46	20068231
555	Ubiquitination	GIKMSKPKWPPEDEI HHCCCCCCCCCCCCC	75.87	29967540
556	Ubiquitination	IKMSKPKWPPEDEIS HCCCCCCCCCCCCCC	23.39	29967540
564	Acetylation	PPEDEISKPEVPEDV CCCCCCCCCCCCCCC	51.35	26051181
576	Acetylation	EDVDLDLKKLRRSSS CCCCCCHHHHHCCCC	49.80	26051181
581	Phosphorylation	DLKKLRRSSSLKERS CHHHHHCCCCHHHCC	20.18	30576142
582	Phosphorylation	LKKLRRSSSLKERSR HHHHHCCCCHHHCCC	37.57	26657352
583	Phosphorylation	KKLRRSSSLKERSRP HHHHCCCCHHHCCCC	44.71	30576142
588	Phosphorylation	SSSLKERSRPFTVAA CCCHHHCCCCCEEEE	45.45	23927012
588	Ubiquitination	SSSLKERSRPFTVAA CCCHHHCCCCCEEEE	45.45	32015554
592	Phosphorylation	KERSRPFTVAASFQS HHCCCCCEEEEEEEC	16.36	23927012
596	Phosphorylation	RPFTVAASFQSTSVK CCCEEEEEEECCCCC	17.68	23927012
599	Phosphorylation	TVAASFQSTSVKSPK EEEEEEECCCCCCCC	22.19	30266825
600	Phosphorylation	VAASFQSTSVKSPKT EEEEEECCCCCCCCC	27.10	30266825
601	Phosphorylation	AASFQSTSVKSPKTV EEEEECCCCCCCCCC	32.56	30266825
604	Phosphorylation	FQSTSVKSPKTVSPP EECCCCCCCCCCCCC	29.49	23927012
607	Phosphorylation	TSVKSPKTVSPPIRK CCCCCCCCCCCCCCC	29.60	30266825
609	Phosphorylation	VKSPKTVSPPIRKGW CCCCCCCCCCCCCCC	30.14	23927012
610	Phosphorylation	KSPKTVSPPIRKGWS CCCCCCCCCCCCCCC	24.81	32645325
617	Phosphorylation	PPIRKGWSMSEQSEE CCCCCCCCCCCCCCC	22.54	30266825
618	Sulfoxidation	PIRKGWSMSEQSEES CCCCCCCCCCCCCCC	4.05	30846556
619	Phosphorylation	IRKGWSMSEQSEESV CCCCCCCCCCCCCCC	27.28	30266825
622	Phosphorylation	GWSMSEQSEESVGGR CCCCCCCCCCCCCCH	39.00	23927012
625	Phosphorylation	MSEQSEESVGGRVAE CCCCCCCCCCCHHHH	23.24	23403867
642	Phosphorylation	QVENAKASKKNGNVG HHHHHHHHHHCCCCC	43.38	-
650	Ubiquitination	KKNGNVGKTTWQNKE HHCCCCCCCCCCCCC	38.20	29967540
651	Ubiquitination	KNGNVGKTTWQNKES HCCCCCCCCCCCCCC	27.60	29967540
656	Acetylation	GKTTWQNKESKGETG CCCCCCCCCCCCCCC	48.54	26051181
656	Ubiquitination	GKTTWQNKESKGETG CCCCCCCCCCCCCCC	48.54	29967540
657	Ubiquitination	KTTWQNKESKGETGK CCCCCCCCCCCCCCC	66.29	29967540
666	Phosphorylation	KGETGKRSKEGHSLE CCCCCCCCCCCCCCC	38.25	23927012
671	Phosphorylation	KRSKEGHSLEMENEN CCCCCCCCCCCCCCC	36.56	23927012
686	Phosphorylation	LVENGADSDEDDNSF CHHCCCCCCCCCCCH	42.22	29255136
687	Phosphorylation	VENGADSDEDDNSFL HHCCCCCCCCCCCHH	64.98	32142685
692	Phosphorylation	DSDEDDNSFLKQQSP CCCCCCCCHHHHCCC	38.66	23927012
698	Phosphorylation	NSFLKQQSPQEPKSL CCHHHHCCCCCCCCC	26.51	29255136
699	Phosphorylation	SFLKQQSPQEPKSLN CHHHHCCCCCCCCCC	37.91	33259812
704	Phosphorylation	QSPQEPKSLNWSSFV CCCCCCCCCCHHHHC	37.34	28176443
708	Phosphorylation	EPKSLNWSSFVDNTF CCCCCCHHHHCCHHH	16.90	25159151
709	Phosphorylation	PKSLNWSSFVDNTFA CCCCCHHHHCCHHHH	22.39	25159151
714	Phosphorylation	WSSFVDNTFAEEFTT HHHHCCHHHHHHHHC	21.54	25159151
720	Phosphorylation	NTFAEEFTTQNQKSQ HHHHHHHHCCCCCCC	30.65	23663014
721	Phosphorylation	TFAEEFTTQNQKSQD HHHHHHHCCCCCCCC	30.73	23663014
726	Phosphorylation	FTTQNQKSQDVELWE HHCCCCCCCCEEEEC	23.11	30266825
741	Phosphorylation	GEVVKELSVEEQIKR CEEEEECCHHHHHHH	28.68	30266825
747	Acetylation	LSVEEQIKRNRYYDE CCHHHHHHHCCCCCC	43.23	26051181
747	Ubiquitination	LSVEEQIKRNRYYDE CCHHHHHHHCCCCCC	43.23	32015554
748	Ubiquitination	SVEEQIKRNRYYDED CHHHHHHHCCCCCCC	34.19	32015554
751	Phosphorylation	EQIKRNRYYDEDEDE HHHHHCCCCCCCCCC	20.86	25106551
752	Phosphorylation	QIKRNRYYDEDEDEE HHHHCCCCCCCCCCC	15.04	25106551

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
362	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
374	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
604	S	Phosphorylation	Kinase	MAPK3	P27361	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LIMA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LIMA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
VATB1_HUMAN	ATP6V1B1	physical	22939629
ACTS_HUMAN	ACTA1	physical	26496610
ACTB_HUMAN	ACTB	physical	26496610
ACTG_HUMAN	ACTG1	physical	26496610
ACTN4_HUMAN	ACTN4	physical	26496610
AP2A1_HUMAN	AP2A1	physical	26496610
AP2A2_HUMAN	AP2A2	physical	26496610
AP2B1_HUMAN	AP2B1	physical	26496610
ANXA2_HUMAN	ANXA2	physical	26496610
RHOA_HUMAN	RHOA	physical	26496610
DYST_HUMAN	DST	physical	26496610
CALD1_HUMAN	CALD1	physical	26496610
CAZA1_HUMAN	CAPZA1	physical	26496610
CAPZB_HUMAN	CAPZB	physical	26496610
CAV1_HUMAN	CAV1	physical	26496610
CD44_HUMAN	CD44	physical	26496610
CDC42_HUMAN	CDC42	physical	26496610
COF1_HUMAN	CFL1	physical	26496610
COF2_HUMAN	CFL2	physical	26496610
AP2M1_HUMAN	AP2M1	physical	26496610
CLCA_HUMAN	CLTA	physical	26496610
CLCB_HUMAN	CLTB	physical	26496610
CLH1_HUMAN	CLTC	physical	26496610
CBPM_HUMAN	CPM	physical	26496610
KC1G3_HUMAN	CSNK1G3	physical	26496610
DAB2_HUMAN	DAB2	physical	26496610
DAPK3_HUMAN	DAPK3	physical	26496610
DREB_HUMAN	DBN1	physical	26496610
DSG2_HUMAN	DSG2	physical	26496610
EF1D_HUMAN	EEF1D	physical	26496610
STOM_HUMAN	STOM	physical	26496610
EPS15_HUMAN	EPS15	physical	26496610
FER_HUMAN	FER	physical	26496610
FLNA_HUMAN	FLNA	physical	26496610
FLNB_HUMAN	FLNB	physical	26496610
FLOT2_HUMAN	FLOT2	physical	26496610
GELS_HUMAN	GSN	physical	26496610
ITPR3_HUMAN	ITPR3	physical	26496610
PLAK_HUMAN	JUP	physical	26496610
RASK_HUMAN	KRAS	physical	26496610
RSSA_HUMAN	RPSA	physical	26496610
LEG1_HUMAN	LGALS1	physical	26496610
ABLM1_HUMAN	ABLIM1	physical	26496610
LYN_HUMAN	LYN	physical	26496610
MYO1B_HUMAN	MYO1B	physical	26496610
MYO1C_HUMAN	MYO1C	physical	26496610
MYO1E_HUMAN	MYO1E	physical	26496610
MYO5A_HUMAN	MYO5A	physical	26496610
MYO5B_HUMAN	MYO5B	physical	26496610
P3C2A_HUMAN	PIK3C2A	physical	26496610
PLEC_HUMAN	PLEC	physical	26496610
PP1A_HUMAN	PPP1CA	physical	26496610
PP1G_HUMAN	PPP1CC	physical	26496610
TWF1_HUMAN	TWF1	physical	26496610
RAB1A_HUMAN	RAB1A	physical	26496610
RAB5C_HUMAN	RAB5C	physical	26496610
RAC1_HUMAN	RAC1	physical	26496610
RALA_HUMAN	RALA	physical	26496610
RAP1A_HUMAN	RAP1A	physical	26496610
RAP1B_HUMAN	RAP1B	physical	26496610
SIPA1_HUMAN	SIPA1	physical	26496610
SPTN1_HUMAN	SPTAN1	physical	26496610
SPTB2_HUMAN	SPTBN1	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
TMOD1_HUMAN	TMOD1	physical	26496610
BACD2_HUMAN	TNFAIP1	physical	26496610
TBG1_HUMAN	TUBG1	physical	26496610
COR2A_HUMAN	CORO2A	physical	26496610
YES_HUMAN	YES1	physical	26496610
LUZP1_HUMAN	LUZP1	physical	26496610
CLH2_HUMAN	CLTCL1	physical	26496610
PICAL_HUMAN	PICALM	physical	26496610
SRBS2_HUMAN	SORBS2	physical	26496610
EIF3H_HUMAN	EIF3H	physical	26496610
IQGA1_HUMAN	IQGAP1	physical	26496610
HIP1R_HUMAN	HIP1R	physical	26496610
RAI3_HUMAN	GPRC5A	physical	26496610
PDLI1_HUMAN	PDLIM1	physical	26496610
NUMBL_HUMAN	NUMBL	physical	26496610
3BP5_HUMAN	SH3BP5	physical	26496610
EPN4_HUMAN	CLINT1	physical	26496610
TOM20_HUMAN	TOMM20	physical	26496610
SC16A_HUMAN	SEC16A	physical	26496610
WDR1_HUMAN	WDR1	physical	26496610
ARPC3_HUMAN	ARPC3	physical	26496610
ARC1B_HUMAN	ARPC1B	physical	26496610
FLOT1_HUMAN	FLOT1	physical	26496610
BASP1_HUMAN	BASP1	physical	26496610
IPO7_HUMAN	IPO7	physical	26496610
AKAP2_HUMAN	AKAP2	physical	26496610
TWF2_HUMAN	TWF2	physical	26496610
SYNPO_HUMAN	SYNPO	physical	26496610
RRAS2_HUMAN	RRAS2	physical	26496610
MPRIP_HUMAN	MPRIP	physical	26496610
CYFP1_HUMAN	CYFIP1	physical	26496610
COBL_HUMAN	COBL	physical	26496610
COR1C_HUMAN	CORO1C	physical	26496610
ZDHC5_HUMAN	ZDHHC5	physical	26496610
PKHG3_HUMAN	PLEKHG3	physical	26496610
DECR2_HUMAN	DECR2	physical	26496610
RAI14_HUMAN	RAI14	physical	26496610
TES_HUMAN	TES	physical	26496610
ZBT20_HUMAN	ZBTB20	physical	26496610
PACN3_HUMAN	PACSIN3	physical	26496610
TMOD3_HUMAN	TMOD3	physical	26496610
BMP2K_HUMAN	BMP2K	physical	26496610
NEB1_HUMAN	PPP1R9A	physical	26496610
MYO5C_HUMAN	MYO5C	physical	26496610
DBLOH_HUMAN	DIABLO	physical	26496610
COR1B_HUMAN	CORO1B	physical	26496610
RHG21_HUMAN	ARHGAP21	physical	26496610
DEN1A_HUMAN	DENND1A	physical	26496610
RAP2C_HUMAN	RAP2C	physical	26496610
AFAP1_HUMAN	AFAP1	physical	26496610
INF2_HUMAN	INF2	physical	26496610
AHNK_HUMAN	AHNAK	physical	26496610
EFHD2_HUMAN	EFHD2	physical	26496610
CYBR1_HUMAN	CYBRD1	physical	26496610
MYO19_HUMAN	MYO19	physical	26496610
ARP5L_HUMAN	ARPC5L	physical	26496610
BACD3_HUMAN	KCTD10	physical	26496610
NEB2_HUMAN	PPP1R9B	physical	26496610
STON2_HUMAN	STON2	physical	26496610
SSH2_HUMAN	SSH2	physical	26496610
NEXN_HUMAN	NEXN	physical	26496610
CYTSB_HUMAN	SPECC1	physical	26496610
FCHO2_HUMAN	FCHO2	physical	26496610
MISP_HUMAN	MISP	physical	26496610
CCD50_HUMAN	CCDC50	physical	26496610
UBX2A_HUMAN	UBXN2A	physical	26496610
PPR18_HUMAN	PPP1R18	physical	26496610
TPRN_HUMAN	TPRN	physical	26496610
PCX3_HUMAN	PCNXL3	physical	26496610
KI13B_HUMAN	KIF13B	physical	27173435
ZBT21_HUMAN	ZBTB21	physical	27173435
GGYF1_HUMAN	GIGYF1	physical	27173435
LRFN1_HUMAN	LRFN1	physical	27173435
SI1L1_HUMAN	SIPA1L1	physical	27173435
MAGI1_HUMAN	MAGI1	physical	27173435
TESK2_HUMAN	TESK2	physical	27173435
DCLK1_HUMAN	DCLK1	physical	27173435
SRS12_HUMAN	SRSF12	physical	27173435
SYDE1_HUMAN	SYDE1	physical	27173435
F110B_HUMAN	FAM110B	physical	27173435
CING_HUMAN	CGN	physical	27173435
F110A_HUMAN	FAM110A	physical	27173435
HDAC4_HUMAN	HDAC4	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435
NADK_HUMAN	NADK	physical	27173435
NGAP_HUMAN	RASAL2	physical	27173435
MELK_HUMAN	MELK	physical	27173435
KIF1C_HUMAN	KIF1C	physical	27173435
GGYF2_HUMAN	GIGYF2	physical	27173435
NAV1_HUMAN	NAV1	physical	27173435
AFAD_HUMAN	MLLT4	physical	27173435
RPTOR_HUMAN	RPTOR	physical	27173435
HDAC7_HUMAN	HDAC7	physical	27173435
SH3B4_HUMAN	SH3BP4	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LIMA1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362; SER-374; SER-604;SER-617 AND SER-686, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-490, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-368; SER-373; SER-374AND SER-609, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-132; SER-225;TYR-229; SER-230; SER-362; SER-374; SER-490; SER-604; SER-609;SER-617; SER-619; SER-622; SER-686; SER-692 AND SER-698, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-374; SER-490;SER-686 AND SER-692, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-490, AND MASSSPECTROMETRY.	18088087 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-263; SER-374;SER-490 AND SER-609, AND MASS SPECTROMETRY.	19007248 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362 AND SER-490, ANDMASS SPECTROMETRY.	17287340 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-362; SER-365;SER-374; THR-487 AND SER-490, AND MASS SPECTROMETRY.	17924679 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; SER-490 ANDSER-604, AND MASS SPECTROMETRY.	16565220 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362; SER-490; SER-686;SER-692 AND SER-698, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Global phosphoproteome of HT-29 human colon adenocarcinoma cells."; Kim J.-E., Tannenbaum S.R., White F.M.; J. Proteome Res. 4:1339-1346(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-487 AND SER-490, ANDMASS SPECTROMETRY.	16083285 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374, AND MASSSPECTROMETRY.	15302935 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-752, AND MASSSPECTROMETRY.	15592455 [Abstract]