UBX2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBX2A_HUMAN
• UniProt AC: P68543
• Protein Name: UBX domain-containing protein 2A
• Gene Name: UBXN2A
• Organism: Homo sapiens (Human).
• Sequence Length: 259
• Protein Sequence: MKDVDNLKSIKEEWVCETGSDNQPLGNNQQSNCEYFVDSLFEEAQKVSSKCVSPAEQKKQVDVNIKLWKNGFTVNDDFRSYSDGASQQFLNSIKKGELPSELQGIFDKEEVDVKVEDKKNEICLSTKPVFQPFSGQGHRLGSATPKIVSKAKNIEVENKNNLSAVPLNNLEPITNIQIWLANGKRIVQKFNITHRVSHIKDFIEKYQGSQRSPPFSLATALPVLRLLDETLTLEEADLQNAVIIQRLQKTASFRELSEH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MKDVDNLKS ------CCCHHHHHH	67.47	-
2	Ubiquitination	------MKDVDNLKS ------CCCHHHHHH	67.47	-
7	Ubiquitination	-MKDVDNLKSIKEEW -CCCHHHHHHHHHHH	3.89	23000965
8	Ubiquitination	MKDVDNLKSIKEEWV CCCHHHHHHHHHHHE	57.29	33845483
10	Ubiquitination	DVDNLKSIKEEWVCE CHHHHHHHHHHHEEC	6.60	21890473
35	Ubiquitination	NQQSNCEYFVDSLFE CCCCCHHHHHHHHHH	15.88	21890473
36	Ubiquitination	QQSNCEYFVDSLFEE CCCCHHHHHHHHHHH	1.99	23000965
50	Ubiquitination	EAQKVSSKCVSPAEQ HHHHHHHHCCCHHHH	31.02	-
50	Ubiquitination	EAQKVSSKCVSPAEQ HHHHHHHHCCCHHHH	31.02	33845483
53	Phosphorylation	KVSSKCVSPAEQKKQ HHHHHCCCHHHHHHC	28.06	26091039
59	Ubiquitination	VSPAEQKKQVDVNIK CCHHHHHHCCCCEEE	56.07	29967540
66	Ubiquitination	KQVDVNIKLWKNGFT HCCCCEEEEECCCEE	42.99	23000965
69	Ubiquitination	DVNIKLWKNGFTVND CCEEEEECCCEECCC	58.59	21890473
69	Ubiquitination	DVNIKLWKNGFTVND CCEEEEECCCEECCC	58.59	23000965
94	Ubiquitination	QQFLNSIKKGELPSE HHHHHHHHCCCCCHH	55.32	21890473
94	Ubiquitination	QQFLNSIKKGELPSE HHHHHHHHCCCCCHH	55.32	21890473
95	Ubiquitination	QFLNSIKKGELPSEL HHHHHHHCCCCCHHH	56.82	23000965
95	Ubiquitination	QFLNSIKKGELPSEL HHHHHHHCCCCCHHH	56.82	-
108	Ubiquitination	ELQGIFDKEEVDVKV HHCCCCCHHHCCEEE	45.05	29967540
114	Ubiquitination	DKEEVDVKVEDKKNE CHHHCCEEECCCCCC	35.13	33845483
125	Ubiquitination	KKNEICLSTKPVFQP CCCCEEEECCCCCCC	29.94	23000965
130	Ubiquitination	CLSTKPVFQPFSGQG EEECCCCCCCCCCCC	11.79	23000965
141	Ubiquitination	SGQGHRLGSATPKIV CCCCCCCCCCCHHHH	18.39	23000965
146	Ubiquitination	RLGSATPKIVSKAKN CCCCCCHHHHHHHCC	51.92	21890473
152	Ubiquitination	PKIVSKAKNIEVENK HHHHHHHCCCEECCC	63.29	21890473
184	Ubiquitination	QIWLANGKRIVQKFN EEEEECCCCHHHHCC	38.47	23000965
189	Ubiquitination	NGKRIVQKFNITHRV CCCCHHHHCCCHHCH	29.50	23000965
196	Ubiquitination	KFNITHRVSHIKDFI HCCCHHCHHHHHHHH	3.66	-
200	Ubiquitination	THRVSHIKDFIEKYQ HHCHHHHHHHHHHHC	40.96	23000965
205	Ubiquitination	HIKDFIEKYQGSQRS HHHHHHHHHCCCCCC	37.75	23000965
212	Phosphorylation	KYQGSQRSPPFSLAT HHCCCCCCCCCCHHH	29.32	-
249	Ubiquitination	VIIQRLQKTASFREL HHHHHHHHHCCHHHH	51.13	-
252	Phosphorylation	QRLQKTASFRELSEH HHHHHHCCHHHHHCC	30.02	23186163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBX2A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBX2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBX2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHAX_HUMAN	PHAX	physical	21900206
ACBP_HUMAN	DBI	physical	21900206
TERA_HUMAN	VCP	physical	21900206
GRP75_HUMAN	HSPA9	physical	26634371
TERA_HUMAN	VCP	physical	26389662
ASPC1_HUMAN	ASPSCR1	physical	26389662
PP1R7_HUMAN	PPP1R7	physical	26389662
PP1RB_HUMAN	PPP1R11	physical	26389662
LACTB_HUMAN	LACTB	physical	26389662
PP1B_HUMAN	PPP1CB	physical	26389662
MLRS_HUMAN	MYLPF	physical	26389662
NSF1C_HUMAN	NSFL1C	physical	26389662
PP1A_HUMAN	PPP1CA	physical	26389662
UBX10_HUMAN	UBXN10	physical	26389662
VCIP1_HUMAN	VCPIP1	physical	26389662
TERA_HUMAN	VCP	physical	28514442
PP1RB_HUMAN	PPP1R11	physical	28514442
ASPC1_HUMAN	ASPSCR1	physical	28514442
PP1R7_HUMAN	PPP1R7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.