dbPTM

ACBP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ACBP_HUMAN
UniProt AC	P07108
Protein Name	Acyl-CoA-binding protein
Gene Name	DBI
Organism	Homo sapiens (Human).
Sequence Length	87
Subcellular Localization	Endoplasmic reticulum . Golgi apparatus . Golgi localization is dependent on ligand binding (PubMed:17953517).
Protein Description	Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor..
Protein Sequence	MSQAEFEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTERPGMLDFTGKAKWDAWNELKGTSKEDAMKAYINKVEELKKKYGI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSQAEFEKA ------CCHHHHHHH	37.79	29255136
2	Acetylation	------MSQAEFEKA ------CCHHHHHHH	37.79	19413330
8	Succinylation	MSQAEFEKAAEEVRH CCHHHHHHHHHHHHH	59.21	-
8	Succinylation	MSQAEFEKAAEEVRH CCHHHHHHHHHHHHH	59.21	23954790
8	Acetylation	MSQAEFEKAAEEVRH CCHHHHHHHHHHHHH	59.21	19608861
17	Succinylation	AEEVRHLKTKPSDEE HHHHHHCCCCCCCHH	48.67	-
17	Acetylation	AEEVRHLKTKPSDEE HHHHHHCCCCCCCHH	48.67	23954790
17	Succinylation	AEEVRHLKTKPSDEE HHHHHHCCCCCCCHH	48.67	-
17	Malonylation	AEEVRHLKTKPSDEE HHHHHHCCCCCCCHH	48.67	26320211
18	Acetylation	EEVRHLKTKPSDEEM HHHHHCCCCCCCHHH	55.32	19608861
18	Phosphorylation	EEVRHLKTKPSDEEM HHHHHCCCCCCCHHH	55.32	23403867
19	Malonylation	EVRHLKTKPSDEEML HHHHCCCCCCCHHHH	40.72	26320211
19	Acetylation	EVRHLKTKPSDEEML HHHHCCCCCCCHHHH	40.72	19608861
20	Acetylation	VRHLKTKPSDEEMLF HHHCCCCCCCHHHHH	52.85	19608861
21	Phosphorylation	RHLKTKPSDEEMLFI HHCCCCCCCHHHHHE	60.24	23403867
25	Sulfoxidation	TKPSDEEMLFIYGHY CCCCCHHHHHEEEEC	3.31	30846556
28 (in isoform 4)	Phosphorylation	-	3.38	-
29	Phosphorylation	DEEMLFIYGHYKQAT CHHHHHEEEECEEEE	7.19	27155012
32	Phosphorylation	MLFIYGHYKQATVGD HHHEEEECEEEEECC	10.63	27155012
33 (in isoform 4)	Phosphorylation	-	27.99	-
36	Phosphorylation	YGHYKQATVGDINTE EEECEEEEECCCCCC	23.64	20068231
37 (in isoform 4)	Phosphorylation	-	7.90	-
42	Phosphorylation	ATVGDINTERPGMLD EEECCCCCCCCCCCC	33.43	28555341
47 (in isoform 5)	Phosphorylation	-	3.44	-
47	Sulfoxidation	INTERPGMLDFTGKA CCCCCCCCCCCCCCC	3.44	28465586
51	Phosphorylation	RPGMLDFTGKAKWDA CCCCCCCCCCCCHHH	37.12	20068231
52 (in isoform 5)	Phosphorylation	-	28.11	-
53	Acetylation	GMLDFTGKAKWDAWN CCCCCCCCCCHHHHH	43.67	23236377
53	Malonylation	GMLDFTGKAKWDAWN CCCCCCCCCCHHHHH	43.67	26320211
53	Ubiquitination	GMLDFTGKAKWDAWN CCCCCCCCCCHHHHH	43.67	-
53 (in isoform 1)	Ubiquitination	-	43.67	21890473
53	Ubiquitination	GMLDFTGKAKWDAWN CCCCCCCCCCHHHHH	43.67	22053931
55	Ubiquitination	LDFTGKAKWDAWNEL CCCCCCCCHHHHHHC	49.44	19608861
55	Acetylation	LDFTGKAKWDAWNEL CCCCCCCCHHHHHHC	49.44	19608861
55	N6-malonyllysine	LDFTGKAKWDAWNEL CCCCCCCCHHHHHHC	49.44	-
55	Malonylation	LDFTGKAKWDAWNEL CCCCCCCCHHHHHHC	49.44	21908771
55 (in isoform 1)	Ubiquitination	-	49.44	21890473
55	Succinylation	LDFTGKAKWDAWNEL CCCCCCCCHHHHHHC	49.44	-
56	Acetylation	DFTGKAKWDAWNELK CCCCCCCHHHHHHCC	12.86	19608861
56 (in isoform 5)	Phosphorylation	-	12.86	-
56	Ubiquitination	DFTGKAKWDAWNELK CCCCCCCHHHHHHCC	12.86	19608861
59	Acetylation	GKAKWDAWNELKGTS CCCCHHHHHHCCCCC	9.07	19608861
61	Acetylation	AKWDAWNELKGTSKE CCHHHHHHCCCCCHH	40.95	19608861
63	Succinylation	WDAWNELKGTSKEDA HHHHHHCCCCCHHHH	54.70	23954790
63	Ubiquitination	WDAWNELKGTSKEDA HHHHHHCCCCCHHHH	54.70	-
63 (in isoform 1)	Ubiquitination	-	54.70	21890473
63	Ubiquitination	WDAWNELKGTSKEDA HHHHHHCCCCCHHHH	54.70	21890473
65	Phosphorylation	AWNELKGTSKEDAMK HHHHCCCCCHHHHHH	34.73	-
65	Ubiquitination	AWNELKGTSKEDAMK HHHHCCCCCHHHHHH	34.73	21890473
66	Phosphorylation	WNELKGTSKEDAMKA HHHCCCCCHHHHHHH	42.59	30576142
67	Succinylation	NELKGTSKEDAMKAY HHCCCCCHHHHHHHH	60.49	23954790
70 (in isoform 2)	Ubiquitination	-	11.49	21890473
70	Ubiquitination	KGTSKEDAMKAYINK CCCCHHHHHHHHHHH	11.49	21890473
72 (in isoform 2)	Ubiquitination	-	39.49	21890473
72	Ubiquitination	TSKEDAMKAYINKVE CCHHHHHHHHHHHHH	39.49	21890473
72	Acetylation	TSKEDAMKAYINKVE CCHHHHHHHHHHHHH	39.49	21339330
73	Ubiquitination	SKEDAMKAYINKVEE CHHHHHHHHHHHHHH	9.43	21890473
74	Phosphorylation	KEDAMKAYINKVEEL HHHHHHHHHHHHHHH	10.25	28152594
77	Succinylation	AMKAYINKVEELKKK HHHHHHHHHHHHHHH	41.27	-
77	Ubiquitination	AMKAYINKVEELKKK HHHHHHHHHHHHHHH	41.27	22053931
77 (in isoform 1)	Ubiquitination	-	41.27	21890473
77	Acetylation	AMKAYINKVEELKKK HHHHHHHHHHHHHHH	41.27	19608861
77	Succinylation	AMKAYINKVEELKKK HHHHHHHHHHHHHHH	41.27	23954790
77	Ubiquitination	AMKAYINKVEELKKK HHHHHHHHHHHHHHH	41.27	19608861
78	Ubiquitination	MKAYINKVEELKKKY HHHHHHHHHHHHHHH	6.29	19608861
78	Acetylation	MKAYINKVEELKKKY HHHHHHHHHHHHHHH	6.29	19608861
80	Ubiquitination	AYINKVEELKKKYGI HHHHHHHHHHHHHCC	69.72	21890473
80	Acetylation	AYINKVEELKKKYGI HHHHHHHHHHHHHCC	69.72	19608861
80 (in isoform 2)	Ubiquitination	-	69.72	21890473
82	Acetylation	INKVEELKKKYGI-- HHHHHHHHHHHCC--	50.96	25953088
82	Ubiquitination	INKVEELKKKYGI-- HHHHHHHHHHHCC--	50.96	-
87	Ubiquitination	ELKKKYGI------- HHHHHHCC-------	4.65	21890473
90 (in isoform 5)	Phosphorylation	-		27642862
94	Ubiquitination	I-------------- C--------------		21890473
94 (in isoform 2)	Ubiquitination	-		21890473
97	Acetylation	----------------- -----------------		19608861
97	Ubiquitination	----------------- -----------------		19608861
112 (in isoform 5)	Phosphorylation	-		27251275
114	Ubiquitination	---------------------------------- ----------------------------------		21890473
114	Ubiquitination	---------------------------------- ----------------------------------		21890473
114 (in isoform 5)	Ubiquitination	-		-
116	Acetylation	------------------------------------ ------------------------------------		19608861
116	Ubiquitination	------------------------------------ ------------------------------------		19608861
116 (in isoform 5)	Ubiquitination	-		-
116	Ubiquitination	------------------------------------ ------------------------------------		21890473
116	Ubiquitination	------------------------------------ ------------------------------------		21890473
119	Ubiquitination	--------------------------------------- ---------------------------------------		19608861
119	Acetylation	--------------------------------------- ---------------------------------------		19608861
124	Ubiquitination	-------------------------------------------- --------------------------------------------		21890473
124 (in isoform 5)	Ubiquitination	-		-
124	Ubiquitination	-------------------------------------------- --------------------------------------------		21890473
138	Ubiquitination	---------------------------------------------------------- ----------------------------------------------------------		19608861
138	Ubiquitination	---------------------------------------------------------- ----------------------------------------------------------		21890473
138 (in isoform 5)	Ubiquitination	-		-
138	Acetylation	---------------------------------------------------------- ----------------------------------------------------------		19608861
138	Ubiquitination	---------------------------------------------------------- ----------------------------------------------------------		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ACBP_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ACBP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ACBP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CH10_HUMAN	HSPE1	physical	26344197
LEG3_HUMAN	LGALS3	physical	26344197
MFTC_HUMAN	SLC25A32	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ACBP_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Complete amino acid sequences of bovine and human endozepines.Homology with rat diazepam binding inhibitor."; Marquardt H., Todaro G.J., Shoyab M.; J. Biol. Chem. 261:9727-9731(1986). Cited for: PROTEIN SEQUENCE OF 2-87 (ISOFORM 1), AND ACETYLATION AT SER-2.	3525533 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-8; LYS-19; LYS-55 ANDLYS-77, AND MASS SPECTROMETRY.	19608861 [Abstract]
Malonylation
Reference	PubMed
"The first identification of lysine malonylation substrates and itsregulatory enzyme."; Peng C., Lu Z., Xie Z., Cheng Z., Chen Y., Tan M., Luo H., Zhang Y.,He W., Yang K., Zwaans B.M., Tishkoff D., Ho L., Lombard D., He T.C.,Dai J., Verdin E., Ye Y., Zhao Y.; Mol. Cell. Proteomics 10:M111.012658.01-M111.012658.12(2011). Cited for: MALONYLATION AT LYS-55.	21908771 [Abstract]
N6-malonyllysine
Reference	PubMed
"The first identification of lysine malonylation substrates and itsregulatory enzyme."; Peng C., Lu Z., Xie Z., Cheng Z., Chen Y., Tan M., Luo H., Zhang Y.,He W., Yang K., Zwaans B.M., Tishkoff D., Ho L., Lombard D., He T.C.,Dai J., Verdin E., Ye Y., Zhao Y.; Mol. Cell. Proteomics 10:M111.012658.01-M111.012658.12(2011). Cited for: MALONYLATION AT LYS-55.	21908771 [Abstract]
Phosphorylation
Reference	PubMed
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-29, AND MASSSPECTROMETRY.	18083107 [Abstract]