MFTC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MFTC_HUMAN
• UniProt AC: Q9H2D1
• Protein Name: Mitochondrial folate transporter/carrier
• Gene Name: SLC25A32
• Organism: Homo sapiens (Human).
• Sequence Length: 315
• Subcellular Localization: Mitochondrion inner membrane; Multi-pass membrane protein.
• Protein Description: Transports folate across the inner membranes of mitochondria..
• Protein Sequence: MTGQGQSASGSSAWSTVFRHVRYENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFLLDLREKRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTGQGQSAS ------CCCCCCCCC	37.91	24043423
7	Phosphorylation	-MTGQGQSASGSSAW -CCCCCCCCCCCCHH	31.09	24043423
9	Phosphorylation	TGQGQSASGSSAWST CCCCCCCCCCCHHHH	44.44	24043423
11	Phosphorylation	QGQSASGSSAWSTVF CCCCCCCCCHHHHHH	17.87	24043423
12	Phosphorylation	GQSASGSSAWSTVFR CCCCCCCCHHHHHHH	36.96	24043423
15	Phosphorylation	ASGSSAWSTVFRHVR CCCCCHHHHHHHHHC	17.89	24043423
16	Phosphorylation	SGSSAWSTVFRHVRY CCCCHHHHHHHHHCH	16.98	24719451
31	Phosphorylation	ENLIAGVSGGVLSNL HHHHHCCCCCHHHHH	28.98	23879269
134	Phosphorylation	AAEAGAMTLCITNPL HHHHCCCEEEECCCC	20.24	25850435
138	Phosphorylation	GAMTLCITNPLWVTK CCCEEEECCCCEECC	29.77	25850435
144	Phosphorylation	ITNPLWVTKTRLMLQ ECCCCEECCHHHHHH	18.34	25850435
146	Phosphorylation	NPLWVTKTRLMLQYD CCCEECCHHHHHHHH	21.48	24719451
148	Ubiquitination	LWVTKTRLMLQYDAV CEECCHHHHHHHHHH	4.93	22817900
152	Phosphorylation	KTRLMLQYDAVVNSP CHHHHHHHHHHHCCC	11.25	-
158	Phosphorylation	QYDAVVNSPHRQYKG HHHHHHCCCCHHHCC	15.52	24719451
163	Phosphorylation	VNSPHRQYKGMFDTL HCCCCHHHCCHHHHH	14.96	22817900
175	Ubiquitination	DTLVKIYKYEGVRGL HHHHHHHCCCCCCHH	40.06	29967540
176	Phosphorylation	TLVKIYKYEGVRGLY HHHHHHCCCCCCHHH	10.84	-
203	Phosphorylation	GALQFMAYELLKLKY HHHHHHHHHHHHHHH	8.70	-
209	Ubiquitination	AYELLKLKYNQHINR HHHHHHHHHHHHHHC	40.34	29967540
209	Acetylation	AYELLKLKYNQHINR HHHHHHHHHHHHHHC	40.34	27452117
272	Ubiquitination	VITKTWRKEGVGGFY HHHHHHHHCCCCCCC	50.83	29967540
280	Ubiquitination	EGVGGFYKGIAPNLI CCCCCCCCCCCCCCC	41.39	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MFTC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MFTC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MFTC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLSI_HUMAN	PLS1	physical	26186194
PMVK_HUMAN	PMVK	physical	26186194
LASP1_HUMAN	LASP1	physical	26186194
CCD25_HUMAN	CCDC25	physical	26186194
UBE2T_HUMAN	UBE2T	physical	26186194
PICAL_HUMAN	PICALM	physical	26186194
NPS3A_HUMAN	NIPSNAP3A	physical	26186194
CGL_HUMAN	CTH	physical	26186194
TCEA1_HUMAN	TCEA1	physical	26186194
DENR_HUMAN	DENR	physical	26186194
PLPHP_HUMAN	PROSC	physical	26186194
PEBB_HUMAN	CBFB	physical	26186194
CCD25_HUMAN	CCDC25	physical	28514442
PLPHP_HUMAN	PROSC	physical	28514442
CGL_HUMAN	CTH	physical	28514442
PLSI_HUMAN	PLS1	physical	28514442
TCEA1_HUMAN	TCEA1	physical	28514442
SPAG7_HUMAN	SPAG7	physical	28514442
PNPO_HUMAN	PNPO	physical	28514442
PMVK_HUMAN	PMVK	physical	28514442
PEBB_HUMAN	CBFB	physical	28514442
IRGQ_HUMAN	IRGQ	physical	28514442
LASP1_HUMAN	LASP1	physical	28514442
DENR_HUMAN	DENR	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00158: Folic Acid