dbPTM

IRGQ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IRGQ_HUMAN
UniProt AC	Q8WZA9
Protein Name	Immunity-related GTPase family Q protein
Gene Name	IRGQ
Organism	Homo sapiens (Human).
Sequence Length	623
Subcellular Localization
Protein Description
Protein Sequence	MPPPQGDVTALFLGPPGLGKSALIAALCDKDVETLEAPEGRPDSGVPSLRAAGPGLFLGELSCPPAAPGPWAAEANVLVLVLPGPEGNGEPLAPALGEAALAALARGTPLLAVRNLRPGDSQTAAQARDQTAALLNSAGLGAADLFVLPANCGSSDGCEELERLRAALQSQAEALRRLLPPAQDGFEVLGAAELEAVREAFETGGLEAALSWVRSGLERLGSARLDLAVAGKADVGLVVDMLLGLDPGDPGAAPASVPTAPTPFPAPERPNVVLWTVPLGHTGTATTAAAASHPTHYDALILVTPGAPTEKDWAQVQALLLPDAPLVCVRTDGEGEDPECLGEGKMENPKGESLKNAGGGGLENALSKGREKCSAGSQKAGSGEGPGKAGSEGLQQVVGMKKSGGGDSERAAALSPEDETWEVLEEAPPPVFPLRPGGLPGLCEWLRRALPPAQAGALLLALPPASPSAARTKAAALRAGAWRPALLASLAAAAAPLPGLGWACDVALLRGQLAEWRRGLGLEPTALARRERALGLASGELAARAHFPGPVTRAEVEARLGAWAGEGTAGGAALGALSFLWPAGGAAATGGLGYRAAHGVLLQALDEMRADAEAVLAPPEPAQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	LCDKDVETLEAPEGR HCCCCCCCCCCCCCC	29.73	27251275
44	Phosphorylation	APEGRPDSGVPSLRA CCCCCCCCCCCCHHC	44.35	22617229
48	Phosphorylation	RPDSGVPSLRAAGPG CCCCCCCCHHCCCCC	28.25	23663014
121	Phosphorylation	RNLRPGDSQTAAQAR ECCCCCCHHHHHHHH	35.03	24275569
170	Phosphorylation	RLRAALQSQAEALRR HHHHHHHHHHHHHHH	32.01	21406692
203	Phosphorylation	AVREAFETGGLEAAL HHHHHHHHCCHHHHH	30.05	18669648
368	Acetylation	GLENALSKGREKCSA HHHHHHHHCHHHCCC	63.94	7664539
382	Phosphorylation	AGSQKAGSGEGPGKA CCCCCCCCCCCCCCC	38.23	28985074
391	Phosphorylation	EGPGKAGSEGLQQVV CCCCCCCCCHHHHHH	33.09	28348404
400	Sulfoxidation	GLQQVVGMKKSGGGD HHHHHHCCCCCCCCC	3.14	21406390
401	Acetylation	LQQVVGMKKSGGGDS HHHHHCCCCCCCCCH	37.55	25953088
415	Phosphorylation	SERAAALSPEDETWE HHHHHCCCCCCHHHH	22.86	27732954
420	Phosphorylation	ALSPEDETWEVLEEA CCCCCCHHHHHHHHC	38.97	27732954
466	Phosphorylation	LLALPPASPSAARTK HHHCCCCCHHHHHHH	25.76	27050516
468	Phosphorylation	ALPPASPSAARTKAA HCCCCCHHHHHHHHH	31.87	26074081
525	Phosphorylation	RGLGLEPTALARRER HHCCCCHHHHHHHHH	25.57	-
578	Phosphorylation	GAALGALSFLWPAGG HHHHHHHHHHCCCCC	20.12	28258704
589	Phosphorylation	PAGGAAATGGLGYRA CCCCHHHCCCHHHHH	27.36	28258704

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IRGQ_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IRGQ_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IRGQ_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of IRGQ_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IRGQ_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-203, AND MASSSPECTROMETRY.	18669648 [Abstract]