NPS3A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NPS3A_HUMAN
• UniProt AC: Q9UFN0
• Protein Name: Protein NipSnap homolog 3A
• Gene Name: NIPSNAP3A
• Organism: Homo sapiens (Human).
• Sequence Length: 247
• Subcellular Localization: Cytoplasm, cytosol . May be part of some vesicular structure distinct from lysosomal vesicles.
• Protein Sequence: MLVLRSALTRALASRTLAPQMCSSFATGPRQYDGIFYEFRSYYLKPSKMNEFLENFEKNAHLRTAHSELVGYWSVEFGGRMNTVFHIWKYDNFAHRTEVRKALAKDKEWQEQFLIPNLALIDKQESEITYLVPWCKLEKPPKEGVYELATFQMKPGGPALWGDAFKRAVHAHVNLGYTKLVGVFHTEYGALNRVHVLWWNESADSRAAGRHKSHEDPRVVAAVRESVNYLVSQQNMLLIPTSFSPLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	FATGPRQYDGIFYEF HCCCCCCCCCEEEEE	19.88	22210691
37	Phosphorylation	RQYDGIFYEFRSYYL CCCCCEEEEEHHHCC	16.55	22210691
41	Phosphorylation	GIFYEFRSYYLKPSK CEEEEEHHHCCCHHH	24.37	22210691
42	Phosphorylation	IFYEFRSYYLKPSKM EEEEEHHHCCCHHHH	14.46	22210691
45	Acetylation	EFRSYYLKPSKMNEF EEHHHCCCHHHHHHH	30.99	25825284
45	Succinylation	EFRSYYLKPSKMNEF EEHHHCCCHHHHHHH	30.99	23954790
45	Malonylation	EFRSYYLKPSKMNEF EEHHHCCCHHHHHHH	30.99	26320211
48	Malonylation	SYYLKPSKMNEFLEN HHCCCHHHHHHHHHH	55.03	26320211
48	Acetylation	SYYLKPSKMNEFLEN HHCCCHHHHHHHHHH	55.03	19608861
49	Sulfoxidation	YYLKPSKMNEFLENF HCCCHHHHHHHHHHH	7.34	21406390
89	Acetylation	NTVFHIWKYDNFAHR EEEEEEEEECCCCCH	41.97	25038526
107	Ubiquitination	RKALAKDKEWQEQFL HHHHHCCHHHHHHHC	61.21	29967540
154	Acetylation	ELATFQMKPGGPALW EEEEEEECCCCCCCH	29.72	25038526
166	Ubiquitination	ALWGDAFKRAVHAHV CCHHHHHHHHHHHHC	40.96	19608861
166	Acetylation	ALWGDAFKRAVHAHV CCHHHHHHHHHHHHC	40.96	19608861
166	2-Hydroxyisobutyrylation	ALWGDAFKRAVHAHV CCHHHHHHHHHHHHC	40.96	-
166	Malonylation	ALWGDAFKRAVHAHV CCHHHHHHHHHHHHC	40.96	26320211
166	Methylation	ALWGDAFKRAVHAHV CCHHHHHHHHHHHHC	40.96	19608861
226	Phosphorylation	VVAAVRESVNYLVSQ HHHHHHHHHHHHHHC	12.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NPS3A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NPS3A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NPS3A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HAP1_HUMAN	HAP1	physical	16169070
ELP1_HUMAN	IKBKAP	physical	16169070
MIC60_HUMAN	IMMT	physical	16169070
SETB1_HUMAN	SETDB1	physical	16169070
KIFA3_HUMAN	KIFAP3	physical	21900206
F219A_HUMAN	FAM219A	physical	21900206
CC90B_HUMAN	CCDC90B	physical	21900206
P63_HUMAN	TP63	physical	21988832
CEP70_HUMAN	CEP70	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-45; LYS-48 AND LYS-166, ANDMASS SPECTROMETRY.
PubMed: 19608861