dbPTM

P63_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	P63_HUMAN
UniProt AC	Q9H3D4
Protein Name	Tumor protein 63
Gene Name	TP63
Organism	Homo sapiens (Human).
Sequence Length	680
Subcellular Localization	Nucleus .
Protein Description	Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter..
Protein Sequence	MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10 (in isoform 10)	Phosphorylation	-	20.30	24043423
13	Phosphorylation	SRCATLQYCPDPYIQ CCCEECCCCCCHHHH	14.73	22817900
13 (in isoform 10)	Phosphorylation	-	14.73	24043423
15 (in isoform 10)	Phosphorylation	-	40.45	24043423
16 (in isoform 10)	Phosphorylation	-	45.10	24043423
17 (in isoform 10)	Phosphorylation	-	17.17	24043423
18	Phosphorylation	LQYCPDPYIQRFVET CCCCCCHHHHHHHCC	19.64	22817900
30	Phosphorylation	VETPAHFSWKESYYR HCCCCCCCHHHHHHH	27.63	27067055
36	Phosphorylation	FSWKESYYRSTMSQS CCHHHHHHHHCCCCC	13.84	22817900
43	Phosphorylation	YRSTMSQSTQTNEFL HHHCCCCCCCCCCCC	18.38	-
46	Phosphorylation	TMSQSTQTNEFLSPE CCCCCCCCCCCCCHH	36.48	-
51	Phosphorylation	TQTNEFLSPEVFQHI CCCCCCCCHHHHHHH	25.08	-
66 (in isoform 2)	Phosphorylation	-	2.46	-
68 (in isoform 2)	Phosphorylation	-	25.22	-
149	Phosphorylation	SVTAPSPYAQPSSTF CCCCCCCCCCCCCCC	23.39	22817900
160	Phosphorylation	SSTFDALSPSPAIPS CCCCCCCCCCCCCCC	25.67	-
162	Phosphorylation	TFDALSPSPAIPSNT CCCCCCCCCCCCCCC	24.48	-
171	Phosphorylation	AIPSNTDYPGPHSFD CCCCCCCCCCCCCEE	14.19	22817900
202	Phosphorylation	STELKKLYCQIAKTC EHHHHHHHHHHHCCC	7.38	29496907
231	Phosphorylation	VIRAMPVYKKAEHVT EEEEEECCCCCHHHH	10.82	-
232	Acetylation	IRAMPVYKKAEHVTE EEEEECCCCCHHHHH	45.82	82517801
242	Methylation	EHVTEVVKRCPNHEL HHHHHHHHHCCCCHH	54.16	-
281	Phosphorylation	QYVEDPITGRQSVLV EEEECCCCCCEEEEE	31.53	-
290	Phosphorylation	RQSVLVPYEPPQVGT CEEEEEECCCCCCCC	33.32	22817900
326	Phosphorylation	RPILIIVTLETRDGQ CCEEEEEEEECCCCC	14.41	19413330
329	Phosphorylation	LIIVTLETRDGQVLG EEEEEEECCCCCEEC	36.85	19413330
358	Phosphorylation	DRKADEDSIRKQQVS CCCCCHHHHHHHHCC	23.42	-
365	Phosphorylation	SIRKQQVSDSTKNGD HHHHHHCCCCCCCCC	22.85	24043423
367	Phosphorylation	RKQQVSDSTKNGDGT HHHHCCCCCCCCCCC	33.50	24043423
368	Phosphorylation	KQQVSDSTKNGDGTK HHHCCCCCCCCCCCC	33.25	24043423
374	Phosphorylation	STKNGDGTKRPFRQN CCCCCCCCCCCCCCC	28.72	30631047
388	Phosphorylation	NTHGIQMTSIKKRRS CCCCCCCCCEEECCC	15.78	27080861
389	Phosphorylation	THGIQMTSIKKRRSP CCCCCCCCEEECCCC	27.37	27080861
395	Phosphorylation	TSIKKRRSPDDELLY CCEEECCCCCCCCEE	36.39	25106551
397 (in isoform 8)	Phosphorylation	-	64.36	27067055
402	Phosphorylation	SPDDELLYLPVRGRE CCCCCCEEEECCCHH	22.91	27642862
431	Phosphorylation	MQYLPQHTIETYRQQ HHHCCHHHHHHHHHH	18.43	28450419
434	Phosphorylation	LPQHTIETYRQQQQQ CCHHHHHHHHHHHHH	21.83	28450419
435	Phosphorylation	PQHTIETYRQQQQQQ CHHHHHHHHHHHHHH	8.14	28450419
451	Phosphorylation	QHLLQKQTSIQSPSS HHHHHHHHHCCCCCC	34.53	25106551
452	Phosphorylation	HLLQKQTSIQSPSSY HHHHHHHHCCCCCCC	19.01	25106551
455	Phosphorylation	QKQTSIQSPSSYGNS HHHHHCCCCCCCCCC	25.69	23927012
457	Phosphorylation	QTSIQSPSSYGNSSP HHHCCCCCCCCCCCC	41.25	23927012
458	Phosphorylation	TSIQSPSSYGNSSPP HHCCCCCCCCCCCCC	40.21	25106551
459	Phosphorylation	SIQSPSSYGNSSPPL HCCCCCCCCCCCCCH	25.35	25106551
462	Phosphorylation	SPSSYGNSSPPLNKM CCCCCCCCCCCHHHC	39.60	23927012
463	Phosphorylation	PSSYGNSSPPLNKMN CCCCCCCCCCHHHCC	34.24	28731282
477	Phosphorylation	NSMNKLPSVSQLINP CCCCCCCCHHHHCCH	44.85	19282665
479	Phosphorylation	MNKLPSVSQLINPQQ CCCCCCHHHHCCHHH	24.49	22817900
491	Phosphorylation	PQQRNALTPTTIPDG HHHCCCCCCCCCCCC	19.04	19282665
491 (in isoform 7)	Phosphorylation	-	19.04	27067055
551	Phosphorylation	PTDCSIVSFLARLGC CCCCHHHHHHHHCCC	16.93	24719451
560	Phosphorylation	LARLGCSSCLDYFTT HHHCCCCHHHHHHHC	23.83	22817900
588	Sumoylation	MDDLASLKIPEQFRH HHHHHHCCCCHHHHH	54.44	-
588	Sumoylation	MDDLASLKIPEQFRH HHHHHHCCCCHHHHH	54.44	-
599	Ubiquitination	QFRHAIWKGILDHRQ HHHHHHHHHHCCHHH	29.93	-
611	Phosphorylation	HRQLHEFSSPSHLLR HHHHHCCCCHHHHCC	38.05	23927012
612	Phosphorylation	RQLHEFSSPSHLLRT HHHHCCCCHHHHCCC	35.42	25394399
614	Phosphorylation	LHEFSSPSHLLRTPS HHCCCCHHHHCCCCC	28.81	27080861
619	Phosphorylation	SPSHLLRTPSSASTV CHHHHCCCCCCCCEE	27.73	27794612
621	Phosphorylation	SHLLRTPSSASTVSV HHHCCCCCCCCEEEC	37.61	25394399
622	Phosphorylation	HLLRTPSSASTVSVG HHCCCCCCCCEEECC	27.69	25394399
624	Phosphorylation	LRTPSSASTVSVGSS CCCCCCCCEEECCCC	31.15	27794612
625	Phosphorylation	RTPSSASTVSVGSSE CCCCCCCEEECCCCC	19.27	27794612
627	Phosphorylation	PSSASTVSVGSSETR CCCCCEEECCCCCCC	22.35	27067055
645	Phosphorylation	VIDAVRFTLRQTISF HHHHHHEEEEECCCC	15.51	24719451
651	Phosphorylation	FTLRQTISFPPRDEW EEEEECCCCCCCCCC	34.78	24719451
676	Sumoylation	RNKQQRIKEEGE--- HHHHHHHHHCCC---	52.48	-
676	Sumoylation	RNKQQRIKEEGE--- HHHHHHHHHCCC---	52.48	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
43	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
46	T	Phosphorylation	Kinase	GAK	O14976	PSP
51	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
66	S	Phosphorylation	Kinase	TGFBR1	P36897	PSP
66	S	Phosphorylation	Kinase	P38A	Q16539	PSP
68	S	Phosphorylation	Kinase	TGFBR1	P36897	PSP
68	S	Phosphorylation	Kinase	P38A	Q16539	PSP
149	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
171	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
281	T	Phosphorylation	Kinase	GAK	O14976	PSP
290	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
301	S	Phosphorylation	Kinase	P38A	Q16539	PSP
361	S	Phosphorylation	Kinase	P38A	Q16539	PSP
385	S	Phosphorylation	Kinase	ATM	Q13315	GPS
397	T	Phosphorylation	Kinase	CDK2	P24941	GPS
466	S	Phosphorylation	Kinase	P70-SUBFAMILY	-	GPS
479	S	Phosphorylation	Kinase	ATM	Q13315	PSP
491	T	Phosphorylation	Kinase	HIPK2	Q9H2X6	PSP
491	T	Phosphorylation	Kinase	CDK2	P24941	PSP
560	S	Phosphorylation	Kinase	RPS6KB1	P23443	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	RCHY1	Q96PM5	PMID:23235527
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW7	Q969H0	PMID:24658274
-	K	Ubiquitination	E3 ubiquitin ligase	WWP1	Q9H0M0	PMID:18806757
-	K	Ubiquitination	E3 ubiquitin ligase	ITCH	Q96J02	PMID:16861923
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4L	Q96PU5	PMID:16908849
-	K	Ubiquitination	E3 ubiquitin ligase	CRBN	Q96SW2	PMID:31591562

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of P63_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of P63_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RACK1_HUMAN	GNB2L1	physical	12692135
ROAA_HUMAN	HNRNPAB	physical	12692135
SFR15_HUMAN	SCAF4	physical	12692135
YAP1_HUMAN	YAP1	physical	11278685
HIPK2_HUMAN	HIPK2	physical	11925430
FBW1A_HUMAN	BTRC	physical	17965458
ADHX_HUMAN	ADH5	physical	20308539
CBPC2_HUMAN	AGBL2	physical	20308539
ASPM_HUMAN	ASPM	physical	20308539
BRD8_HUMAN	BRD8	physical	20308539
NPRL3_HUMAN	NPRL3	physical	20308539
TPC11_HUMAN	TRAPPC11	physical	20308539
CDT1_HUMAN	CDT1	physical	20308539
DAB2P_HUMAN	DAB2IP	physical	20308539
DDX23_HUMAN	DDX23	physical	20308539
DNJB6_HUMAN	DNAJB6	physical	20308539
DPH1_HUMAN	DPH1	physical	20308539
AGO1_HUMAN	AGO1	physical	20308539
AGO2_HUMAN	AGO2	physical	20308539
GAS8_HUMAN	GAS8	physical	20308539
IF2B1_HUMAN	IGF2BP1	physical	20308539
JPH1_HUMAN	JPH1	physical	20308539
MTHSD_HUMAN	MTHFSD	physical	20308539
MYL9_HUMAN	MYL9	physical	20308539
N4BP2_HUMAN	N4BP2	physical	20308539
PIWL1_HUMAN	PIWIL1	physical	20308539
RNF38_HUMAN	RNF38	physical	20308539
SMRD2_HUMAN	SMARCD2	physical	20308539
TRM11_HUMAN	TRMT11	physical	20308539
MDM2_HUMAN	MDM2	physical	21088494
MDM4_HUMAN	MDM4	physical	21088494
TF65_HUMAN	RELA	physical	22020940
IKKA_HUMAN	CHUK	physical	20145131
IKKB_HUMAN	IKBKB	physical	20145131
FBXW7_HUMAN	FBXW7	physical	20571051
RACK1_HUMAN	GNB2L1	physical	15467455
1433S_HUMAN	SFN	physical	15467455
MDM2_HUMAN	MDM2	physical	11714701
UBC9_HUMAN	UBE2I	physical	15539951
UBE4B_HUMAN	UBE4B	physical	18418053
DAXX_HUMAN	DAXX	physical	12954772
DAXX_HUMAN	DAXX	physical	15339933
ZN363_HUMAN	RCHY1	physical	23235527
WWOX_HUMAN	WWOX	physical	23370280
ITCH_HUMAN	ITCH	physical	23370280
TNR6_HUMAN	FAS	physical	20085233
PYR1_HUMAN	CAD	physical	20085233
FLNC_HUMAN	FLNC	physical	20085233
DHX9_HUMAN	DHX9	physical	20085233
SC24C_HUMAN	SEC24C	physical	20085233
TERA_HUMAN	VCP	physical	20085233
SACS_HUMAN	SACS	physical	20085233
PSMD2_HUMAN	PSMD2	physical	20085233
HNRPR_HUMAN	HNRNPR	physical	20085233
GOGA4_HUMAN	GOLGA4	physical	20085233
GRP78_HUMAN	HSPA5	physical	20085233
FUS_HUMAN	FUS	physical	20085233
A2MG_HUMAN	A2M	physical	20085233
HNRPQ_HUMAN	SYNCRIP	physical	20085233
ZN676_HUMAN	ZNF676	physical	20085233
P63_HUMAN	TP63	physical	20085233
CPSF6_HUMAN	CPSF6	physical	20085233
PLST_HUMAN	PLS3	physical	20085233
K2C5_HUMAN	KRT5	physical	20085233
CARM1_HUMAN	CARM1	physical	20085233
HNRPL_HUMAN	HNRNPL	physical	20085233
TCPQ_HUMAN	CCT8	physical	20085233
NONO_HUMAN	NONO	physical	20085233
HNRPK_HUMAN	HNRNPK	physical	20085233
K2C6C_HUMAN	KRT6C	physical	20085233
TBA1C_HUMAN	TUBA1C	physical	20085233
ATPA_HUMAN	ATP5A1	physical	20085233
RL3_HUMAN	RPL3	physical	20085233
EF1A1_HUMAN	EEF1A1	physical	20085233
RSSA_HUMAN	RPSA	physical	20085233
ZBTB4_HUMAN	ZBTB4	physical	20085233
HNRC1_HUMAN	HNRNPCL1	physical	20085233
ROA3_HUMAN	HNRNPA3	physical	20085233
ROAA_HUMAN	HNRNPAB	physical	20085233
MAP1A_HUMAN	MAP1A	physical	20085233
RLA0_HUMAN	RPLP0	physical	20085233
H13_HUMAN	HIST1H1D	physical	20085233
UACA_HUMAN	UACA	physical	20085233
SNRPA_HUMAN	SNRPA	physical	20085233
RENT2_HUMAN	UPF2	physical	20085233
CENPE_HUMAN	CENPE	physical	20085233
SAFB1_HUMAN	SAFB	physical	20085233
S1PR5_HUMAN	S1PR5	physical	20085233
RL24_HUMAN	RPL24	physical	20085233
RL13A_HUMAN	RPL13A	physical	20085233
RL12_HUMAN	RPL12	physical	20085233
MLRS_HUMAN	MYLPF	physical	20085233
HS90B_HUMAN	HSP90AB1	physical	20085233
ETV4_HUMAN	ETV4	physical	21150337
CEBPB_HUMAN	CEBPB	physical	21150337
NFYA_HUMAN	NFYA	physical	21150337
NFKB1_HUMAN	NFKB1	physical	21150337
STK11_HUMAN	STK11	physical	21150337
P53_HUMAN	TP53	physical	23687300
EP300_HUMAN	EP300	physical	23589370
EP300_HUMAN	EP300	physical	15965232
BRCA1_HUMAN	BRCA1	physical	24556685
P53_HUMAN	TP53	physical	22575646
ITCH_HUMAN	ITCH	physical	25485500
CHK2_HUMAN	CHEK2	physical	28514442
P73_HUMAN	TP73	physical	28514442
SH3K1_HUMAN	SH3KBP1	physical	28514442
RP3A_HUMAN	RPH3A	physical	28514442
FOXK1_HUMAN	FOXK1	physical	28514442
FOXK2_HUMAN	FOXK2	physical	28514442
PEX14_HUMAN	PEX14	physical	28514442
ATF3_HUMAN	ATF3	physical	24554706
P53_HUMAN	TP53	physical	24554706

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
103285	Acro-dermato-ungual-lacrimal-tooth syndrome (ADULT syndrome)
106260	Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC)
604292	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)
605289	Split-hand/foot malformation 4 (SHFM4)
603543	Limb-mammary syndrome (LMS)
	Note=Defects in TP63 are a cause of cervical, colon, head and neck, lung and ovarian cancers.
129400
129400	Non-syndromic orofacial cleft 8 (OFC8)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of P63_HUMAN

Related Literatures of Post-Translational Modification