dbPTM

SACS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SACS_HUMAN
UniProt AC	Q9NZJ4
Protein Name	Sacsin
Gene Name	SACS
Organism	Homo sapiens (Human).
Sequence Length	4579
Subcellular Localization	Cytoplasm . Predominantly cytoplasmic, a small portion is present in the nucleus and also shows a partial mitochondrial overlap with the mitochondrial marker Hsp60.
Protein Description	Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins..
Protein Sequence	METKENRWVPVTVLPGCVGCRTVAALASWTVRDVKERIFAETGFPVSEQRLWRGGRELSDWIKIGDLTSKNCHLFVNLQSKGLKGGGRFGQTTPPLVDFLKDILRRYPEGGQILKELIQNAEDAGATEVKFLYDETQYGTETLWSKDMAPYQGPALYVYNNAVFTPEDWHGIQEIARSRKKDDPLKVGRFGIGFNSVYHITDVPCIFSGDQIGMLDPHQTLFGPHESGQCWNLKDDSKEISELSDQFAPFVGIFGSTKETFINGNFPGTFFRFPLRLQPSQLSSNLYNKQKVLELFESFRADADTVLLFLKSVQDVSLYVREADGTEKLVFRVTSSESKALKHERPNSIKILGTAISNYCKKTPSNNITCVTYHVNIVLEEESTKDAQKTSWLVCNSVGGRGISSKLDSLADELKFVPIIGIAMPLSSRDDEAKGATSDFSGKAFCFLPLPPGEESSTGLPVHISGFFGLTDNRRSIKWRELDQWRDPAALWNEFLVMNVVPKAYATLILDSIKRLEMEKSSDFPLSVDVIYKLWPEASKVKVHWQPVLEPLFSELLQNAVIYSISCDWVRLEQVYFSELDENLEYTKTVLNYLQSSGKQIAKVPGNVDAAVQLTAASGTTPVRKVTPAWVRQVLRKCAHLGCAEEKLHLLEFVLSDQAYSELLGLELLPLQNGNFVPFSSSVSDQDVIYITSAEYPRSLFPSLEGRFILDNLKPHLVAALKEAAQTRGRPCTQLQLLNPERFARLIKEVMNTFWPGRELIVQWYPFDENRNHPSVSWLKMVWKNLYIHFSEDLTLFDEMPLIPRTILEEGQTCVELIRLRIPSLVILDDESEAQLPEFLADIVQKLGGFVLKKLDASIQHPLIKKYIHSPLPSAVLQIMEKMPLQKLCNQITSLLPTHKDALRKFLASLTDSSEKEKRIIQELAIFKRINHSSDQGISSYTKLKGCKVLHHTAKLPADLRLSISVIDSSDEATIRLANMLKIEQLKTTSCLKLVLKDIENAFYSHEEVTQLMLWVLENLSSLKNENPNVLEWLTPLKFIQISQEQMVSAGELFDPDIEVLKDLFCNEEGTYFPPSVFTSPDILHSLRQIGLKNEASLKEKDVVQVAKKIEALQVGACPDQDVLLKKAKTLLLVLNKNHTLLQSSEGKMTLKKIKWVPACKERPPNYPGSLVWKGDLCNLCAPPDMCDVGHAILIGSSLPLVESIHVNLEKALGIFTKPSLSAVLKHFKIVVDWYSSKTFSDEDYYQFQHILLEIYGFMHDHLNEGKDSFRALKFPWVWTGKKFCPLAQAVIKPIHDLDLQPYLHNVPKTMAKFHQLFKVCGSIEELTSDHISMVIQKIYLKSDQDLSEQESKQNLHLMLNIIRWLYSNQIPASPNTPVPIHHSKNPSKLIMKPIHECCYCDIKVDDLNDLLEDSVEPIILVHEDIPMKTAEWLKVPCLSTRLINPENMGFEQSGQREPLTVRIKNILEEYPSVSDIFKELLQNADDANATECSFLIDMRRNMDIRENLLDPGMAACHGPALWSFNNSQFSDSDFVNITRLGESLKRGEVDKVGKFGLGFNSVYHITDIPIIMSREFMIMFDPNINHISKHIKDKSNPGIKINWSKQQKRLRKFPNQFKPFIDVFGCQLPLTVEAPYSYNGTLFRLSFRTQQEAKVSEVSSTCYNTADIYSLVDEFSLCGHRLIIFTQSVKSMYLKYLKIEETNPSLAQDTVIIKKKSCSSKALNTPVLSVLKEAAKLMKTCSSSNKKLPSDEPKSSCILQITVEEFHHVFRRIADLQSPLFRGPDDDPAALFEMAKSGQSKKPSDELSQKTVECTTWLLCTCMDTGEALKFSLSESGRRLGLVPCGAVGVQLSEIQDQKWTVKPHIGEVFCYLPLRIKTGLPVHINGCFAVTSNRKEIWKTDTKGRWNTTFMRHVIVKAYLQVLSVLRDLATSGELMDYTYYAVWPDPDLVHDDFSVICQGFYEDIAHGKGKELTKVFSDGSTWVSMKNVRFLDDSILKRRDVGSAAFKIFLKYLKKTGSKNLCAVELPSSVKLGFEEAGCKQILLENTFSEKQFFSEVFFPNIQEIEAELRDPLMIFVLNEKVDEFSGVLRVTPCIPCSLEGHPLVLPSRLIHPEGRVAKLFDIKDGRFPYGSTQDYLNPIILIKLVQLGMAKDDILWDDMLERAVSVAEINKSDHVAACLRSSILLSLIDEKLKIRDPRAKDFAAKYQTIRFLPFLTKPAGFSLDWKGNSFKPETMFAATDLYTAEHQDIVCLLQPILNENSHSFRGCGSVSLAVKEFLGLLKKPTVDLVINQLKEVAKSVDDGITLYQENITNACYKYLHEALMQNEITKMSIIDKLKPFSFILVENAYVDSEKVSFHLNFEAAPYLYQLPNKYKNNFRELFETVGVRQSCTVEDFALVLESIDQERGTKQITEENFQLCRRIISEGIWSLIREKKQEFCEKNYGKILLPDTNLMLLPAKSLCYNDCPWIKVKDTTVKYCHADIPREVAVKLGAVPKRHKALERYASNVCFTTLGTEFGQKEKLTSRIKSILNAYPSEKEMLKELLQNADDAKATEICFVFDPRQHPVDRIFDDKWAPLQGPALCVYNNQPFTEDDVRGIQNLGKGTKEGNPYKTGQYGIGFNSVYHITDCPSFISGNDILCIFDPHARYAPGATSISPGRMFRDLDADFRTQFSDVLDLYLGTHFKLDNCTMFRFPLRNAEMAKVSEISSVPASDRMVQNLLDKLRSDGAELLMFLNHMEKISICEIDKSTGALNVLYSVKGKITDGDRLKRKQFHASVIDSVTKKRQLKDIPVQQITYTMDTEDSEGNLTTWLICNRSGFSSMEKVSKSVISAHKNQDITLFPRGGVAACITHNYKKPHRAFCFLPLSLETGLPFHVNGHFALDSARRNLWRDDNGVGVRSDWNNSLMTALIAPAYVELLIQLKKRYFPGSDPTLSVLQNTPIHVVKDTLKKFLSFFPVNRLDLQPDLYCLVKALYNCIHEDMKRLLPVVRAPNIDGSDLHSAVIITWINMSTSNKTRPFFDNLLQDELQHLKNADYNITTRKTVAENVYRLKHLLLEIGFNLVYNCDETANLYHCLIDADIPVSYVTPADIRSFLMTFSSPDTNCHIGKLPCRLQQTNLKLFHSLKLLVDYCFKDAEENEIEVEGLPLLITLDSVLQTFDAKRPKFLTTYHELIPSRKDLFMNTLYLKYSNILLNCKVAKVFDISSFADLLSSVLPREYKTKSCTKWKDNFASESWLKNAWHFISESVSVKEDQEETKPTFDIVVDTLKDWALLPGTKFTVSANQLVVPEGDVLLPLSLMHIAVFPNAQSDKVFHALMKAGCIQLALNKICSKDSAFVPLLSCHTANIESPTSILKALHYMVQTSTFRAEKLVENDFEALLMYFNCNLNHLMSQDDIKILKSLPCYKSISGRYVSIGKFGTCYVLTKSIPSAEVEKWTQSSSSAFLEEKIHLKELYEVIGCVPVDDLEVYLKHLLPKIENLSYDAKLEHLIYLKNRLSSAEELSEIKEQLFEKLESLLIIHDANSRLKQAKHFYDRTVRVFEVMLPEKLFIPNDFFKKLEQLIKPKNHVTFMTSWVEFLRNIGLKYILSQQQLLQFAKEISVRANTENWSKETLQNTVDILLHHIFQERMDLLSGNFLKELSLIPFLCPERAPAEFIRFHPQYQEVNGTLPLIKFNGAQVNPKFKQCDVLQLLWTSCPILPEKATPLSIKEQEGSDLGPQEQLEQVLNMLNVNLDPPLDKVINNCRNICNITTLDEEMVKTRAKVLRSIYEFLSAEKREFRFQLRGVAFVMVEDGWKLLKPEEVVINLEYESDFKPYLYKLPLELGTFHQLFKHLGTEDIISTKQYVEVLSRIFKNSEGKQLDPNEMRTVKRVVSGLFRSLQNDSVKVRSDLENVRDLALYLPSQDGRLVKSSILVFDDAPHYKSRIQGNIGVQMLVDLSQCYLGKDHGFHTKLIMLFPQKLRPRLLSSILEEQLDEETPKVCQFGALCSLQGRLQLLLSSEQFITGLIRIMKHENDNAFLANEEKAIRLCKALREGLKVSCFEKLQTTLRVKGFNPIPHSRSETFAFLKRFGNAVILLYIQHSDSKDINFLLALAMTLKSATDNLISDTSYLIAMLGCNDIYRIGEKLDSLGVKYDSSEPSKLELPMPGTPIPAEIHYTLLMDPMNVFYPGEYVGYLVDAEGGDIYGSYQPTYTYAIIVQEVEREDADNSSFLGKIYQIDIGYSEYKIVSSLDLYKFSRPEESSQSRDSAPSTPTSPTEFLTPGLRSIPPLFSGRESHKTSSKHQSPKKLKVNSLPEILKEVTSVVEQAWKLPESERKKIIRRLYLKWHPDKNPENHDIANEVFKHLQNEINRLEKQAFLDQNADRASRRTFSTSASRFQSDKYSFQRFYTSWNQEATSHKSERQQQNKEKCPPSAGQTYSQRFFVPPTFKSVGNPVEARRWLRQARANFSAARNDLHKNANEWVCFKCYLSTKLALIAADYAVRGKSDKDVKPTALAQKIEEYSQQLEGLTNDVHTLEAYGVDSLKTRYPDLLPFPQIPNDRFTSEVAMRVMECTACIIIKLENFMQQKV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Ubiquitination	RDVKERIFAETGFPV HHHHHHHHHHCCCCH	6.69	24816145
47	Phosphorylation	AETGFPVSEQRLWRG HHCCCCHHHHHHHCC	28.40	27762562
70	Acetylation	KIGDLTSKNCHLFVN EECCCCCCCCEEEEE	59.36	22361641
91	Ubiquitination	KGGGRFGQTTPPLVD CCCCCCCCCCCCHHH	39.22	29967540
115	Ubiquitination	PEGGQILKELIQNAE CCCHHHHHHHHHCCH	52.70	29967540
183	Ubiquitination	ARSRKKDDPLKVGRF HHHCCCCCCCCCCEE	60.35	24816145
186	Acetylation	RKKDDPLKVGRFGIG CCCCCCCCCCEEECC	48.29	30592099
186	Ubiquitination	RKKDDPLKVGRFGIG CCCCCCCCCCEEECC	48.29	24816145
214	Ubiquitination	FSGDQIGMLDPHQTL CCCCCCCCCCCCCCC	4.02	29967540
238	Ubiquitination	WNLKDDSKEISELSD CCCCCCHHHHHHHHH	67.09	29967540
242	Ubiquitination	DDSKEISELSDQFAP CCHHHHHHHHHHCHH	58.93	29967540
259	Ubiquitination	GIFGSTKETFINGNF EEECCCEEEECCCCC	49.38	20972266
259 (in isoform 2)	Ubiquitination	-	49.38	21906983
280	Phosphorylation	FPLRLQPSQLSSNLY CCEECCHHHHCCCCC	30.69	28509920
283	Phosphorylation	RLQPSQLSSNLYNKQ ECCHHHHCCCCCCHH	15.00	28509920
284	Phosphorylation	LQPSQLSSNLYNKQK CCHHHHCCCCCCHHH	39.17	28509920
287	Phosphorylation	SQLSSNLYNKQKVLE HHHCCCCCCHHHHHH	25.27	29978859
289	Ubiquitination	LSSNLYNKQKVLELF HCCCCCCHHHHHHHH	37.63	-
291	Ubiquitination	SNLYNKQKVLELFES CCCCCHHHHHHHHHH	50.85	-
317	Phosphorylation	LKSVQDVSLYVREAD EEHHCEEEEEEEECC	23.44	24719451
338	Phosphorylation	FRVTSSESKALKHER EEEECCCCCCCCCCC	25.77	19413330
361	Ubiquitination	TAISNYCKKTPSNNI HHHHHHCCCCCCCCE	49.69	29967540
386 (in isoform 2)	Ubiquitination	-	55.08	21906983
389	Ubiquitination	ESTKDAQKTSWLVCN CCCCCHHHCEEEEEE	46.37	29967540
403	Ubiquitination	NSVGGRGISSKLDSL ECCCCCCHHHHHHHH	3.96	20972266
406	Ubiquitination	GGRGISSKLDSLADE CCCCHHHHHHHHHHH	49.91	20972266
406 (in isoform 1)	Ubiquitination	-	49.91	21906983
409	Phosphorylation	GISSKLDSLADELKF CHHHHHHHHHHHCCC	35.57	23403867
427	Phosphorylation	IGIAMPLSSRDDEAK EEEEEECCCCCCHHC	19.91	20873877
428	Phosphorylation	GIAMPLSSRDDEAKG EEEEECCCCCCHHCC	47.62	20873877
434	Ubiquitination	SSRDDEAKGATSDFS CCCCCHHCCCCCCCC	47.21	-
437	Phosphorylation	DDEAKGATSDFSGKA CCHHCCCCCCCCCCE	37.18	20873877
438	Phosphorylation	DEAKGATSDFSGKAF CHHCCCCCCCCCCEE	35.80	20873877
441	Phosphorylation	KGATSDFSGKAFCFL CCCCCCCCCCEEEEE	44.36	20873877
514	Ubiquitination	TLILDSIKRLEMEKS HHHHHHHHHHHCCCC	55.68	-
533	Ubiquitination	LSVDVIYKLWPEASK CCHHHHHHHCCCHHC	32.71	21906983
533 (in isoform 1)	Ubiquitination	-	32.71	21906983
593	Phosphorylation	YTKTVLNYLQSSGKQ HHHHHHHHHHHCCCC	11.27	22817900
596	Phosphorylation	TVLNYLQSSGKQIAK HHHHHHHHCCCCEEC	38.16	25599653
597	Phosphorylation	VLNYLQSSGKQIAKV HHHHHHHCCCCEECC	36.73	25599653
599	Malonylation	NYLQSSGKQIAKVPG HHHHHCCCCEECCCC	40.24	26320211
621	Phosphorylation	LTAASGTTPVRKVTP HHCCCCCCCCCCCCH	24.26	25627689
625	Ubiquitination	SGTTPVRKVTPAWVR CCCCCCCCCCHHHHH	51.17	-
706	Ubiquitination	SLFPSLEGRFILDNL HHCCCCCCCCHHHCC	34.78	27667366
714	Ubiquitination	RFILDNLKPHLVAAL CCHHHCCCHHHHHHH	36.32	-
718	Ubiquitination	DNLKPHLVAALKEAA HCCCHHHHHHHHHHH	2.38	29967540
722	Ubiquitination	PHLVAALKEAAQTRG HHHHHHHHHHHHHCC	40.35	-
850	Ubiquitination	IVQKLGGFVLKKLDA HHHHHCCHHHHHCCH	5.73	27667366
853	Ubiquitination	KLGGFVLKKLDASIQ HHCCHHHHHCCHHCC	46.09	27667366
854	Ubiquitination	LGGFVLKKLDASIQH HCCHHHHHCCHHCCC	47.65	-
859	Ubiquitination	LKKLDASIQHPLIKK HHHCCHHCCCHHHHH	4.71	27667366
862	Ubiquitination	LDASIQHPLIKKYIH CCHHCCCHHHHHHCC	21.29	27667366
865	Ubiquitination	SIQHPLIKKYIHSPL HCCCHHHHHHCCCCC	47.40	29967540
867	Phosphorylation	QHPLIKKYIHSPLPS CCHHHHHHCCCCCCH	10.00	29083192
870	Phosphorylation	LIKKYIHSPLPSAVL HHHHHCCCCCCHHHH	20.69	29083192
874	Phosphorylation	YIHSPLPSAVLQIME HCCCCCCHHHHHHHH	38.40	29083192
898	Phosphorylation	QITSLLPTHKDALRK HHHHHCCHHHHHHHH	41.34	-
905	Ubiquitination	THKDALRKFLASLTD HHHHHHHHHHHHCCC	45.65	-
909	Phosphorylation	ALRKFLASLTDSSEK HHHHHHHHCCCCHHH	33.67	-
914	Phosphorylation	LASLTDSSEKEKRII HHHCCCCHHHHHHHH	56.34	28509920
928	Ubiquitination	IQELAIFKRINHSSD HHHHHHHHHCCCCCC	46.37	-
943	Acetylation	QGISSYTKLKGCKVL CCCCCCHHHCCCEEE	39.71	19608861
943	Malonylation	QGISSYTKLKGCKVL CCCCCCHHHCCCEEE	39.71	26320211
943	Ubiquitination	QGISSYTKLKGCKVL CCCCCCHHHCCCEEE	39.71	-
946	Ubiquitination	SSYTKLKGCKVLHHT CCCHHHCCCEEEEEC	27.24	29967540
955	Ubiquitination	KVLHHTAKLPADLRL EEEEECCCCCCCEEE	57.04	-
962	Ubiquitination	KLPADLRLSISVIDS CCCCCEEEEEEEECC	7.48	29967540
982	Ubiquitination	IRLANMLKIEQLKTT HHHHHHCCHHHCCCC	33.17	-
987	Ubiquitination	MLKIEQLKTTSCLKL HCCHHHCCCCCHHHH	49.83	-
989	Phosphorylation	KIEQLKTTSCLKLVL CHHHCCCCCHHHHHH	18.82	-
1021	Phosphorylation	LWVLENLSSLKNENP HHHHHHHHHCCCCCC	45.25	24719451
1093	Ubiquitination	SLRQIGLKNEASLKE HHHHCCCCCCCCCCH	47.75	29967540
1109	Ubiquitination	DVVQVAKKIEALQVG HHHHHHHHHHHHCCC	35.72	29967540
1195 (in isoform 2)	Ubiquitination	-	4.04	21906983
1220	Phosphorylation	LGIFTKPSLSAVLKH HCCCCCCCHHHHHHH	36.19	21406692
1222	Phosphorylation	IFTKPSLSAVLKHFK CCCCCCHHHHHHHCC	22.22	21406692
1274	Ubiquitination	KDSFRALKFPWVWTG CCHHHHCCCCEEECC	48.69	-
1342	Ubiquitination	VIQKIYLKSDQDLSE HHHHHHCCCCCCCCH	34.71	21906983
1342 (in isoform 1)	Ubiquitination	-	34.71	21906983
1435	Methylation	MKTAEWLKVPCLSTR CCCCHHHCCCCCCCC	45.24	82989411
1435	Ubiquitination	MKTAEWLKVPCLSTR CCCCHHHCCCCCCCC	45.24	-
1465	Ubiquitination	EPLTVRIKNILEEYP CCCCHHHHHHHHHCC	27.63	-
1568	Ubiquitination	NSVYHITDIPIIMSR CCEEECCCCCEEECC	44.02	29967540
1568 (in isoform 2)	Ubiquitination	-	44.02	21906983
1632	Phosphorylation	FGCQLPLTVEAPYSY CCCCCEEEEECCCCC	17.85	32142685
1650 (in isoform 2)	Ubiquitination	-	32.37	21906983
1687	Phosphorylation	GHRLIIFTQSVKSMY CCEEEEEEHHHHHHH	14.99	29083192
1689	Phosphorylation	RLIIFTQSVKSMYLK EEEEEEHHHHHHHHH	28.58	29083192
1692	Phosphorylation	IFTQSVKSMYLKYLK EEEHHHHHHHHHHCC	15.54	29083192
1694	Phosphorylation	TQSVKSMYLKYLKIE EHHHHHHHHHHCCCC	13.72	29083192
1706	Phosphorylation	KIEETNPSLAQDTVI CCCCCCCCCCCCEEE	38.11	-
1711	Phosphorylation	NPSLAQDTVIIKKKS CCCCCCCEEEEECCC	11.09	-
1715	Ubiquitination	AQDTVIIKKKSCSSK CCCEEEEECCCCCCH	42.92	21906983
1715 (in isoform 1)	Ubiquitination	-	42.92	21906983
1733	Ubiquitination	TPVLSVLKEAAKLMK CHHHHHHHHHHHHHH	43.05	-
1737	Acetylation	SVLKEAAKLMKTCSS HHHHHHHHHHHHHCC	57.04	7711471
1779	Phosphorylation	RRIADLQSPLFRGPD HHHHHCCCCCCCCCC	30.76	19664994
1797	Ubiquitination	AALFEMAKSGQSKKP HHHHHHHHHCCCCCC	54.53	2190698
1797 (in isoform 1)	Ubiquitination	-	54.53	21906983
1802	Ubiquitination	MAKSGQSKKPSDELS HHHHCCCCCCCHHHH	61.90	-
1805	Phosphorylation	SGQSKKPSDELSQKT HCCCCCCCHHHHHHH	53.23	22167270
1809	Phosphorylation	KKPSDELSQKTVECT CCCCHHHHHHHHHHH	27.81	24719451
1910	Phosphorylation	DTKGRWNTTFMRHVI CCCCCCCCHHHHHHH	17.91	-
1911	Phosphorylation	TKGRWNTTFMRHVIV CCCCCCCHHHHHHHH	16.54	-
1926	Phosphorylation	KAYLQVLSVLRDLAT HHHHHHHHHHHHHHH	21.90	24719451
1975	Ubiquitination	AHGKGKELTKVFSDG CCCCCCEEEEEECCC	6.82	24816145
1989	Ubiquitination	GSTWVSMKNVRFLDD CCCEEEEECEEECCH	44.80	-
1997	Phosphorylation	NVRFLDDSILKRRDV CEEECCHHHHHCCCH	29.50	21406692
2000	Ubiquitination	FLDDSILKRRDVGSA ECCHHHHHCCCHHHH	43.66	-
2043	Ubiquitination	GFEEAGCKQILLENT CCCCCCCCEEEEECC	39.18	-
2119	Ubiquitination	RLIHPEGRVAKLFDI CEECCCCCEEEEEEC	24.45	24816145
2122	Ubiquitination	HPEGRVAKLFDIKDG CCCCCEEEEEECCCC	46.99	24816145
2128	Ubiquitination	AKLFDIKDGRFPYGS EEEEECCCCCCCCCC	54.56	24816145
2131	Ubiquitination	FDIKDGRFPYGSTQD EECCCCCCCCCCCHH	7.17	24816145
2139	Phosphorylation	PYGSTQDYLNPIILI CCCCCHHCCCHHHHH	9.88	-
2195	Ubiquitination	LLSLIDEKLKIRDPR HHHHHCHHCCCCCCC	51.86	-
2197	Ubiquitination	SLIDEKLKIRDPRAK HHHCHHCCCCCCCHH	46.92	-
2267	Ubiquitination	ILNENSHSFRGCGSV HCCCCCCCCCCCCHH	19.23	23000965
2303	Phosphorylation	QLKEVAKSVDDGITL HHHHHHHHCCCCCCH	22.50	24043423
2309	Phosphorylation	KSVDDGITLYQENIT HHCCCCCCHHHHHHH	25.58	24043423
2311	Phosphorylation	VDDGITLYQENITNA CCCCCCHHHHHHHHH	12.72	24043423
2316	Phosphorylation	TLYQENITNACYKYL CHHHHHHHHHHHHHH	28.48	24043423
2320	Phosphorylation	ENITNACYKYLHEAL HHHHHHHHHHHHHHH	10.56	22817900
2322	Phosphorylation	ITNACYKYLHEALMQ HHHHHHHHHHHHHHC	6.19	22817900
2334	Acetylation	LMQNEITKMSIIDKL HHCCCCCCCHHHHHC	35.99	20167786
2348	Ubiquitination	LKPFSFILVENAYVD CCCCEEEEEEEEECC	3.58	29967540
2358	Acetylation	NAYVDSEKVSFHLNF EEECCCCCEEEEEEC	47.32	20167786
2364	Phosphorylation	EKVSFHLNFEAAPYL CCEEEEEECCCHHHH	24.92	32645325
2372	Phosphorylation	FEAAPYLYQLPNKYK CCCHHHHHHCCHHHC	11.36	24706070
2411	Ubiquitination	LESIDQERGTKQITE HHHHHCCCCCCHHCH	53.07	23000965
2414	Ubiquitination	IDQERGTKQITEENF HHCCCCCCHHCHHHH	42.39	23000965
2420	Ubiquitination	TKQITEENFQLCRRI CCHHCHHHHHHHHHH	24.59	23000965
2423	Ubiquitination	ITEENFQLCRRIISE HCHHHHHHHHHHHHH	1.83	23000965
2495	Acetylation	IPREVAVKLGAVPKR CCHHHHHHCCCCCHH	31.31	25953088
2495	Ubiquitination	IPREVAVKLGAVPKR CCHHHHHHCCCCCHH	31.31	29967540
2501	Acetylation	VKLGAVPKRHKALER HHCCCCCHHHHHHHH	61.61	130639
2509	Phosphorylation	RHKALERYASNVCFT HHHHHHHHHHCCEEE	12.66	21712546
2511	Phosphorylation	KALERYASNVCFTTL HHHHHHHHCCEEEEC	22.36	25159151
2516	Phosphorylation	YASNVCFTTLGTEFG HHHCCEEEECCCCCC	18.91	23403867
2517	Phosphorylation	ASNVCFTTLGTEFGQ HHCCEEEECCCCCCC	11.70	22210691
2520	Phosphorylation	VCFTTLGTEFGQKEK CEEEECCCCCCCHHH	31.11	23312004
2654	Phosphorylation	IFDPHARYAPGATSI EECCCCCCCCCCCCC	20.24	27794612
2659	Phosphorylation	ARYAPGATSISPGRM CCCCCCCCCCCCCCC	32.29	27794612
2660	Phosphorylation	RYAPGATSISPGRMF CCCCCCCCCCCCCCC	22.12	27794612
2662	Phosphorylation	APGATSISPGRMFRD CCCCCCCCCCCCCCC	22.52	27794612
2696	Phosphorylation	HFKLDNCTMFRFPLR CEECCCCEEEEEECC	26.12	28258704
2709	Ubiquitination	LRNAEMAKVSEISSV CCCHHHHCHHHHCCC	45.01	-
2833	Phosphorylation	FSSMEKVSKSVISAH CCCHHHHHHHHHHHH	30.22	22468782
2902	Ubiquitination	NLWRDDNGVGVRSDW HCCCCCCCCCCCCCC	25.26	29967540
3049	Ubiquitination	DYNITTRKTVAENVY CCCCCCCCHHHHHHH	45.30	29967540
3124	Phosphorylation	LPCRLQQTNLKLFHS CCCCCHHHCHHHHHH	29.56	19413330
3138	Phosphorylation	SLKLLVDYCFKDAEE HHHHHHHHHCCCCHH	7.72	27794612
3177	Phosphorylation	RPKFLTTYHELIPSR CCCCHHCHHHHCCCC	6.51	19835603
3197	O-linked_Glycosylation	NTLYLKYSNILLNCK CCHHHHHHCHHHCCE	18.79	30379171
3354	Ubiquitination	LLSCHTANIESPTSI HHHCCCCCCCCHHHH	39.45	29967540
3360	Phosphorylation	ANIESPTSILKALHY CCCCCHHHHHHHHHH	29.34	24719451
3367	Phosphorylation	SILKALHYMVQTSTF HHHHHHHHHHHCCCC	10.38	-
3367	Ubiquitination	SILKALHYMVQTSTF HHHHHHHHHHHCCCC	10.38	29967540
3435	Phosphorylation	TCYVLTKSIPSAEVE EEEEEECCCCHHHHH	34.20	21406692
3438	Phosphorylation	VLTKSIPSAEVEKWT EEECCCCHHHHHHHH	35.08	21406692
3463	Phosphorylation	KIHLKELYEVIGCVP HHCHHHHHHHHCCEE	14.83	22817900
3477	Phosphorylation	PVDDLEVYLKHLLPK EHHHHHHHHHHHHHH	10.72	22817900
3501	Ubiquitination	LEHLIYLKNRLSSAE HHHHHHHHHCCCCHH	24.05	29967540
3514	Ubiquitination	AEELSEIKEQLFEKL HHHHHHHHHHHHHHH	35.04	29967540
3541	Phosphorylation	LKQAKHFYDRTVRVF HHHHHHHHHHHEEEE	12.30	23917254
3670	Phosphorylation	FIRFHPQYQEVNGTL HHCCCCCHHCCCCCC	15.87	29083192
3676	Phosphorylation	QYQEVNGTLPLIKFN CHHCCCCCCCEEEEC	21.72	29083192
3720	Ubiquitination	PLSIKEQEGSDLGPQ CCCHHCCCCCCCCHH	62.85	24816145
3759	Phosphorylation	CRNICNITTLDEEMV HCHHCCCCCCCHHHH	13.81	28258704
3768	Phosphorylation	LDEEMVKTRAKVLRS CCHHHHHHHHHHHHH	25.17	28258704
3775	Phosphorylation	TRAKVLRSIYEFLSA HHHHHHHHHHHHHHH	25.92	25627689
3781	Phosphorylation	RSIYEFLSAEKREFR HHHHHHHHHHCCCHH	39.44	26091039
3864	Ubiquitination	LSRIFKNSEGKQLDP HHHHHHCCCCCCCCH	48.60	24816145
3867	Ubiquitination	IFKNSEGKQLDPNEM HHHCCCCCCCCHHHH	43.57	24816145
3873	Ubiquitination	GKQLDPNEMRTVKRV CCCCCHHHHHHHHHH	35.12	24816145
3876	Phosphorylation	LDPNEMRTVKRVVSG CCHHHHHHHHHHHHH	29.12	22210691
3876	Ubiquitination	LDPNEMRTVKRVVSG CCHHHHHHHHHHHHH	29.12	24816145
3882	Phosphorylation	RTVKRVVSGLFRSLQ HHHHHHHHHHHHHHC	27.24	22210691
3886	Ubiquitination	RVVSGLFRSLQNDSV HHHHHHHHHHCCCCC	41.31	29967540
3894	Ubiquitination	SLQNDSVKVRSDLEN HHCCCCCEEHHHCCC	35.56	-
3918	Ubiquitination	SQDGRLVKSSILVFD CCCCCEEEEEEEEEC	42.98	-
4033	Ubiquitination	AFLANEEKAIRLCKA CCCCCHHHHHHHHHH	42.82	29967540
4052	Acetylation	LKVSCFEKLQTTLRV CCCHHHHHHHHHEEC	26.16	25953088
4052	Malonylation	LKVSCFEKLQTTLRV CCCHHHHHHHHHEEC	26.16	26320211
4055	Phosphorylation	SCFEKLQTTLRVKGF HHHHHHHHHEECCCC	37.93	28555341
4056	Phosphorylation	CFEKLQTTLRVKGFN HHHHHHHHEECCCCC	10.29	21210654
4105	Phosphorylation	FLLALAMTLKSATDN HHHHHHHHHHHHCCC	25.98	25599653
4117	Phosphorylation	TDNLISDTSYLIAML CCCHHCCHHHHHHHH	16.69	32142685
4135	Acetylation	DIYRIGEKLDSLGVK CHHHHHHHHHHCCCC	53.00	23236377
4135	Malonylation	DIYRIGEKLDSLGVK CHHHHHHHHHHCCCC	53.00	26320211
4177	Phosphorylation	MDPMNVFYPGEYVGY ECCCCCCCCCCEEEE	13.17	-
4181	Phosphorylation	NVFYPGEYVGYLVDA CCCCCCCEEEEEEEC	12.70	-
4217	Ubiquitination	VEREDADNSSFLGKI EECCCCCCCCCCCEE	41.07	29967540
4246	Phosphorylation	SLDLYKFSRPEESSQ EEEEEECCCCCCCCC	42.65	24719451
4251	Phosphorylation	KFSRPEESSQSRDSA ECCCCCCCCCCCCCC	31.83	22817900
4252	Phosphorylation	FSRPEESSQSRDSAP CCCCCCCCCCCCCCC	35.14	29523821
4254	Phosphorylation	RPEESSQSRDSAPST CCCCCCCCCCCCCCC	39.75	29523821
4257	Phosphorylation	ESSQSRDSAPSTPTS CCCCCCCCCCCCCCC	40.75	25022875
4260	Phosphorylation	QSRDSAPSTPTSPTE CCCCCCCCCCCCCHH	46.89	22617229
4261	Phosphorylation	SRDSAPSTPTSPTEF CCCCCCCCCCCCHHH	29.53	25159151
4263	Phosphorylation	DSAPSTPTSPTEFLT CCCCCCCCCCHHHCC	47.64	29255136
4264	Phosphorylation	SAPSTPTSPTEFLTP CCCCCCCCCHHHCCC	30.91	29255136
4266	Phosphorylation	PSTPTSPTEFLTPGL CCCCCCCHHHCCCCC	38.85	29255136
4270	Phosphorylation	TSPTEFLTPGLRSIP CCCHHHCCCCCCCCC	22.19	25022875
4275	Phosphorylation	FLTPGLRSIPPLFSG HCCCCCCCCCCCCCC	44.48	28555341
4281	Phosphorylation	RSIPPLFSGRESHKT CCCCCCCCCCCCCCC	44.62	24719451
4288	Phosphorylation	SGRESHKTSSKHQSP CCCCCCCCCCCCCCC	32.58	23403867
4289	Phosphorylation	GRESHKTSSKHQSPK CCCCCCCCCCCCCCC	42.04	23403867
4290	Phosphorylation	RESHKTSSKHQSPKK CCCCCCCCCCCCCCC	39.11	23403867
4292	Ubiquitination	SHKTSSKHQSPKKLK CCCCCCCCCCCCCCC	34.99	27667366
4294	Phosphorylation	KTSSKHQSPKKLKVN CCCCCCCCCCCCCCC	38.10	26329039
4302	Phosphorylation	PKKLKVNSLPEILKE CCCCCCCCHHHHHHH	48.57	20068231
4333	Phosphorylation	KKIIRRLYLKWHPDK HHHHHHHHHHCCCCC	12.39	22817900
4364	Ubiquitination	NEINRLEKQAFLDQN HHHHHHHHHHHHCCC	52.06	29967540
4374	Methylation	FLDQNADRASRRTFS HHCCCCHHHHHHHCC	31.86	115493105
4379	Phosphorylation	ADRASRRTFSTSASR CHHHHHHHCCCCHHH	22.34	26437602
4381	Phosphorylation	RASRRTFSTSASRFQ HHHHHHCCCCHHHHH	22.34	26437602
4382	Phosphorylation	ASRRTFSTSASRFQS HHHHHCCCCHHHHHC	24.91	26437602
4419	Ubiquitination	RQQQNKEKCPPSAGQ HHHHHHCCCCCCCCC	54.36	-
4428	Phosphorylation	PPSAGQTYSQRFFVP CCCCCCCCCCCEECC	8.56	22817900
4436	Ubiquitination	SQRFFVPPTFKSVGN CCCEECCCCCCCCCC	45.20	27667366
4439	Methylation	FFVPPTFKSVGNPVE EECCCCCCCCCCHHH	46.86	115977467
4439	Ubiquitination	FFVPPTFKSVGNPVE EECCCCCCCCCCHHH	46.86	27667366
4445	Ubiquitination	FKSVGNPVEARRWLR CCCCCCHHHHHHHHH	11.87	27667366
4448	Ubiquitination	VGNPVEARRWLRQAR CCCHHHHHHHHHHHH	19.46	27667366
4482	Acetylation	FKCYLSTKLALIAAD HHHHHHHHHHHHHHH	28.52	26051181
4498	Acetylation	AVRGKSDKDVKPTAL HHCCCCCCCCCHHHH	72.08	25953088
4578	Ubiquitination	LENFMQQKV------ HHHHHHCCC------	32.78	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SACS_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SACS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SACS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSA3_HUMAN	PSMA3	physical	19208651
T22D4_HUMAN	TSC22D4	physical	16713569
RPA12_HUMAN	ZNRD1	physical	16713569
ACTN4_HUMAN	ACTN4	physical	16713569
PICK1_HUMAN	PICK1	physical	16713569
UBE3A_HUMAN	UBE3A	physical	23671107

Drug and Disease Associations

Kegg Disease
OMIM Disease
270550	Spastic ataxia Charlevoix-Saguenay type (SACS)
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SACS_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-943, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4264, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-4333, AND MASSSPECTROMETRY.	18083107 [Abstract]