S1PR5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S1PR5_HUMAN
• UniProt AC: Q9H228
• Protein Name: Sphingosine 1-phosphate receptor 5
• Gene Name: S1PR5
• Organism: Homo sapiens (Human).
• Sequence Length: 398
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells..
• Protein Sequence: MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	N-linked_Glycosylation	EVIVLHYNYTGKLRG EEEEEEECCCCCCCC	19.69	UniProtKB CARBOHYD
125	Phosphorylation	ALTASVLSLLAIALE HHCHHHHHHHHHHHH	21.12	22210691
134	Phosphorylation	LAIALERSLTMARRG HHHHHHHHHHHHHHC	20.86	22210691
136	Phosphorylation	IALERSLTMARRGPA HHHHHHHHHHHHCCC	15.27	22210691
146	Phosphorylation	RRGPAPVSSRGRTLA HHCCCCCCHHHHHHH	17.17	-
147	Phosphorylation	RGPAPVSSRGRTLAM HCCCCCCHHHHHHHH	38.70	28450419
216	Phosphorylation	CALYARIYCQVRANA HHHHHHHHHHHHHCC	3.26	-
235	Phosphorylation	ARPGTAGTTSTRARR CCCCCCCCCCHHHHC	18.34	22210691
236	Phosphorylation	RPGTAGTTSTRARRK CCCCCCCCCHHHHCC	27.47	22210691
299	Phosphorylation	LGLAMANSLLNPIIY HHHHHHHHHHHHHHH	25.37	-
309	Phosphorylation	NPIIYTLTNRDLRHA HHHHHHCCCHHHHHH	22.02	-
323	S-palmitoylation	ALLRLVCCGRHSCGR HHHHHHHCCCCCCCC	4.12	-
327	Phosphorylation	LVCCGRHSCGRDPSG HHHCCCCCCCCCCCC	19.53	22468782
338	Phosphorylation	DPSGSQQSASAAEAS CCCCCHHHHHHHHHC	19.29	26471730
340	Phosphorylation	SGSQQSASAAEASGG CCCHHHHHHHHHCCC	33.00	26471730
359	Phosphorylation	LPPGLDGSFSGSERS CCCCCCCCCCCCCCC	18.86	29083192
361	Phosphorylation	PGLDGSFSGSERSSP CCCCCCCCCCCCCCC	43.01	29083192
363	Phosphorylation	LDGSFSGSERSSPQR CCCCCCCCCCCCCCC	28.74	29083192
375	Phosphorylation	PQRDGLDTSGSTGSP CCCCCCCCCCCCCCC	39.78	30266825
376	Phosphorylation	QRDGLDTSGSTGSPG CCCCCCCCCCCCCCC	30.34	30266825
378	Phosphorylation	DGLDTSGSTGSPGAP CCCCCCCCCCCCCCC	29.39	30266825
379	Phosphorylation	GLDTSGSTGSPGAPT CCCCCCCCCCCCCCC	45.24	30266825
381	Phosphorylation	DTSGSTGSPGAPTAA CCCCCCCCCCCCCCH	21.90	30266825
393	Phosphorylation	TAARTLVSEPAAD-- CCHHHHHCCCCCC--	40.76	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S1PR5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S1PR5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S1PR5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of S1PR5_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.