ATF3_HUMAN - dbPTM
ATF3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATF3_HUMAN
UniProt AC P18847
Protein Name Cyclic AMP-dependent transcription factor ATF-3
Gene Name ATF3
Organism Homo sapiens (Human).
Sequence Length 181
Subcellular Localization Nucleus .
Protein Description This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters..
Protein Sequence MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEKLESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
20PhosphorylationEVSASAIVPCLSPPG
HCCHHHEEECCCCCC
2.4724719451
21UbiquitinationVSASAIVPCLSPPGS
CCHHHEEECCCCCCC
13.7632015554
23UbiquitinationASAIVPCLSPPGSLV
HHHEEECCCCCCCEE
7.6332015554
42SumoylationANLTPFVKEELRFAI
CCCCHHHHHHHHHHH
45.94-
42SumoylationANLTPFVKEELRFAI
CCCCHHHHHHHHHHH
45.94-
46MethylationPFVKEELRFAIQNKH
HHHHHHHHHHHHCHH
23.41-
49UbiquitinationKEELRFAIQNKHLCH
HHHHHHHHHCHHHHH
4.2232015554
52UbiquitinationLRFAIQNKHLCHRMS
HHHHHHCHHHHHHHH
22.9032015554
59PhosphorylationKHLCHRMSSALESVT
HHHHHHHHHHHHHCC
16.6525627689
60PhosphorylationHLCHRMSSALESVTV
HHHHHHHHHHHHCCC
27.7728555341
63UbiquitinationHRMSSALESVTVSDR
HHHHHHHHHCCCCCC
42.7732015554
64PhosphorylationRMSSALESVTVSDRP
HHHHHHHHCCCCCCC
24.7628842319
72UbiquitinationVTVSDRPLGVSITKA
CCCCCCCCCEEEEEC
12.6229967540
78UbiquitinationPLGVSITKAEVAPEE
CCCEEEEECCCCCHH
40.6632015554
78SumoylationPLGVSITKAEVAPEE
CCCEEEEECCCCCHH
40.6628112733
79UbiquitinationLGVSITKAEVAPEED
CCEEEEECCCCCHHH
14.0832015554
118UbiquitinationTECLQKESEKLESVN
HHHHHHHHHHHHHHC
47.2522817900
120UbiquitinationCLQKESEKLESVNAE
HHHHHHHHHHHHCHH
67.8232015554
129UbiquitinationESVNAELKAQIEELK
HHHCHHHHHHHHHHH
29.7429967540
136UbiquitinationKAQIEELKNEKQHLI
HHHHHHHHHHHHHHH
67.3632015554
162PhosphorylationVRAQNGRTPEDERNL
EECCCCCCCHHHHHH
32.2127794612
175UbiquitinationNLFIQQIKEGTLQS-
HHHHHHHHHCCCCC-
45.8322817900
175SumoylationNLFIQQIKEGTLQS-
HHHHHHHHHCCCCC-
45.8328112733
175 (in isoform 1)Ubiquitination-45.8321906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseMDM2Q00987
PMID:20592017

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATF3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATF3_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
JUN_HUMANJUNphysical
14667575
SMAD3_HUMANSMAD3physical
12718878
IGS21_HUMANIGSF21physical
16169070
LRIF1_HUMANLRIF1physical
16169070
P53_HUMANTP53physical
16169070
JUND_HUMANJUNDphysical
8152431
JUN_HUMANJUNphysical
8622660
JUN_HUMANJUNphysical
1827203
P53_HUMANTP53physical
15933712
RPC4_HUMANPOLR3Dphysical
20211142
ATF2_HUMANATF2physical
20211142
CREST_HUMANSS18L1physical
20211142
SMCA4_HUMANSMARCA4physical
14673171
TF65_HUMANRELAphysical
16291753
CEBPE_HUMANCEBPEphysical
17042743
HDAC1_HUMANHDAC1physical
20360311
JUN_HUMANJUNphysical
20304822
SMAD2_HUMANSMAD2physical
20930144
SMAD3_HUMANSMAD3physical
20930144
CBP_HUMANCREBBPphysical
19932681
STAT1_HUMANSTAT1physical
19647793
MDM2_HUMANMDM2physical
20592017
PDX1_HUMANPDX1physical
21986529
SMCA4_HUMANSMARCA4physical
21300803
ACTB_HUMANACTBphysical
21300803
HDAC6_HUMANHDAC6physical
22989952
ATF3_HUMANATF3physical
18255255
FHL2_HUMANFHL2physical
18255255
ID3_HUMANID3physical
18255255
SRA1_HUMANSRA1physical
20398657
MAFF_HUMANMAFFphysical
23661758
BATF3_HUMANBATF3physical
23661758
BATF_HUMANBATFphysical
23661758
ATF3_HUMANATF3physical
23661758
ATF4_HUMANATF4physical
23661758
FOSL1_HUMANFOSL1physical
23661758
FOS_HUMANFOSphysical
23661758
JUNB_HUMANJUNBphysical
23661758
JUN_HUMANJUNphysical
23661758
ATF2_HUMANATF2physical
23661758
CEBPE_HUMANCEBPEphysical
23661758
CEBPA_HUMANCEBPAphysical
23661758
CEBPG_HUMANCEBPGphysical
23661758
DDIT3_HUMANDDIT3physical
23661758
SUV91_HUMANSUV39H1physical
23455924
KAT5_HUMANKAT5physical
25865756
P63_HUMANTP63physical
24554706

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00852Pseudoephedrine
Regulatory Network of ATF3_HUMAN

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Related Literatures of Post-Translational Modification

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