ATF3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATF3_HUMAN
• UniProt AC: P18847
• Protein Name: Cyclic AMP-dependent transcription factor ATF-3
• Gene Name: ATF3
• Organism: Homo sapiens (Human).
• Sequence Length: 181
• Subcellular Localization: Nucleus .
• Protein Description: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters..
• Protein Sequence: MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEKLESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	EVSASAIVPCLSPPG HCCHHHEEECCCCCC	2.47	24719451
21	Ubiquitination	VSASAIVPCLSPPGS CCHHHEEECCCCCCC	13.76	32015554
23	Ubiquitination	ASAIVPCLSPPGSLV HHHEEECCCCCCCEE	7.63	32015554
42	Sumoylation	ANLTPFVKEELRFAI CCCCHHHHHHHHHHH	45.94	-
42	Sumoylation	ANLTPFVKEELRFAI CCCCHHHHHHHHHHH	45.94	-
46	Methylation	PFVKEELRFAIQNKH HHHHHHHHHHHHCHH	23.41	-
49	Ubiquitination	KEELRFAIQNKHLCH HHHHHHHHHCHHHHH	4.22	32015554
52	Ubiquitination	LRFAIQNKHLCHRMS HHHHHHCHHHHHHHH	22.90	32015554
59	Phosphorylation	KHLCHRMSSALESVT HHHHHHHHHHHHHCC	16.65	25627689
60	Phosphorylation	HLCHRMSSALESVTV HHHHHHHHHHHHCCC	27.77	28555341
63	Ubiquitination	HRMSSALESVTVSDR HHHHHHHHHCCCCCC	42.77	32015554
64	Phosphorylation	RMSSALESVTVSDRP HHHHHHHHCCCCCCC	24.76	28842319
72	Ubiquitination	VTVSDRPLGVSITKA CCCCCCCCCEEEEEC	12.62	29967540
78	Ubiquitination	PLGVSITKAEVAPEE CCCEEEEECCCCCHH	40.66	32015554
78	Sumoylation	PLGVSITKAEVAPEE CCCEEEEECCCCCHH	40.66	28112733
79	Ubiquitination	LGVSITKAEVAPEED CCEEEEECCCCCHHH	14.08	32015554
118	Ubiquitination	TECLQKESEKLESVN HHHHHHHHHHHHHHC	47.25	22817900
120	Ubiquitination	CLQKESEKLESVNAE HHHHHHHHHHHHCHH	67.82	32015554
129	Ubiquitination	ESVNAELKAQIEELK HHHCHHHHHHHHHHH	29.74	29967540
136	Ubiquitination	KAQIEELKNEKQHLI HHHHHHHHHHHHHHH	67.36	32015554
162	Phosphorylation	VRAQNGRTPEDERNL EECCCCCCCHHHHHH	32.21	27794612
175	Ubiquitination	NLFIQQIKEGTLQS- HHHHHHHHHCCCCC-	45.83	22817900
175	Sumoylation	NLFIQQIKEGTLQS- HHHHHHHHHCCCCC-	45.83	28112733
175 (in isoform 1)	Ubiquitination	-	45.83	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	MDM2	Q00987	PMID:20592017

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATF3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATF3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JUN_HUMAN	JUN	physical	14667575
SMAD3_HUMAN	SMAD3	physical	12718878
IGS21_HUMAN	IGSF21	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
P53_HUMAN	TP53	physical	16169070
JUND_HUMAN	JUND	physical	8152431
JUN_HUMAN	JUN	physical	8622660
JUN_HUMAN	JUN	physical	1827203
P53_HUMAN	TP53	physical	15933712
RPC4_HUMAN	POLR3D	physical	20211142
ATF2_HUMAN	ATF2	physical	20211142
CREST_HUMAN	SS18L1	physical	20211142
SMCA4_HUMAN	SMARCA4	physical	14673171
TF65_HUMAN	RELA	physical	16291753
CEBPE_HUMAN	CEBPE	physical	17042743
HDAC1_HUMAN	HDAC1	physical	20360311
JUN_HUMAN	JUN	physical	20304822
SMAD2_HUMAN	SMAD2	physical	20930144
SMAD3_HUMAN	SMAD3	physical	20930144
CBP_HUMAN	CREBBP	physical	19932681
STAT1_HUMAN	STAT1	physical	19647793
MDM2_HUMAN	MDM2	physical	20592017
PDX1_HUMAN	PDX1	physical	21986529
SMCA4_HUMAN	SMARCA4	physical	21300803
ACTB_HUMAN	ACTB	physical	21300803
HDAC6_HUMAN	HDAC6	physical	22989952
ATF3_HUMAN	ATF3	physical	18255255
FHL2_HUMAN	FHL2	physical	18255255
ID3_HUMAN	ID3	physical	18255255
SRA1_HUMAN	SRA1	physical	20398657
MAFF_HUMAN	MAFF	physical	23661758
BATF3_HUMAN	BATF3	physical	23661758
BATF_HUMAN	BATF	physical	23661758
ATF3_HUMAN	ATF3	physical	23661758
ATF4_HUMAN	ATF4	physical	23661758
FOSL1_HUMAN	FOSL1	physical	23661758
FOS_HUMAN	FOS	physical	23661758
JUNB_HUMAN	JUNB	physical	23661758
JUN_HUMAN	JUN	physical	23661758
ATF2_HUMAN	ATF2	physical	23661758
CEBPE_HUMAN	CEBPE	physical	23661758
CEBPA_HUMAN	CEBPA	physical	23661758
CEBPG_HUMAN	CEBPG	physical	23661758
DDIT3_HUMAN	DDIT3	physical	23661758
SUV91_HUMAN	SUV39H1	physical	23455924
KAT5_HUMAN	KAT5	physical	25865756
P63_HUMAN	TP63	physical	24554706

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00852: Pseudoephedrine