CEBPE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CEBPE_HUMAN
• UniProt AC: Q15744
• Protein Name: CCAAT/enhancer-binding protein epsilon
• Gene Name: CEBPE
• Organism: Homo sapiens (Human).
• Sequence Length: 281
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional activator. [PubMed: 26019275 C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation]
• Protein Sequence: MSHGTYYECEPRGGQQPLEFSGGRAGPGELGDMCEHEASIDLSAYIESGEEQLLSDLFAVKPAPEARGLKGPGTPAFPHYLPPDPRPFAYPPHTFGPDRKALGPGIYSSPGSYDPRAVAVKEEPRGPEGSRAASRGSYNPLQYQVAHCGQTAMHLPPTLAAPGQPLRVLKAPLATAAPPCSPLLKAPSPAGPLHKGKKAVNKDSLEYRLRRERNNIAVRKSRDKAKRRILETQQKVLEYMAENERLRSRVEQLTQELDTLRNLFRQIPEAANLIKGVGGCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSHGTYYEC ------CCCCCEEEC	30.53	28450419
6	Phosphorylation	--MSHGTYYECEPRG --CCCCCEEECCCCC	11.23	27642862
7	Phosphorylation	-MSHGTYYECEPRGG -CCCCCEEECCCCCC	17.59	27642862
21	Phosphorylation	GQQPLEFSGGRAGPG CCCCCEECCCCCCCC	30.84	28450419
74	Phosphorylation	RGLKGPGTPAFPHYL CCCCCCCCCCCCCCC	17.99	15677566
80	Phosphorylation	GTPAFPHYLPPDPRP CCCCCCCCCCCCCCC	22.57	-
107	Phosphorylation	KALGPGIYSSPGSYD CCCCCCCCCCCCCCC	14.71	28796482
108	Phosphorylation	ALGPGIYSSPGSYDP CCCCCCCCCCCCCCC	28.30	28796482
109	Phosphorylation	LGPGIYSSPGSYDPR CCCCCCCCCCCCCCC	19.13	28796482
112	Phosphorylation	GIYSSPGSYDPRAVA CCCCCCCCCCCCEEE	29.73	28796482
113	Phosphorylation	IYSSPGSYDPRAVAV CCCCCCCCCCCEEEE	35.56	28796482
121	Sumoylation	DPRAVAVKEEPRGPE CCCEEEEEECCCCCC	46.77	28112733
121	Sumoylation	DPRAVAVKEEPRGPE CCCEEEEEECCCCCC	46.77	-
121	Acetylation	DPRAVAVKEEPRGPE CCCEEEEEECCCCCC	46.77	77115209
175	Phosphorylation	VLKAPLATAAPPCSP EEECCCCCCCCCCCC	30.91	26074081
181	Phosphorylation	ATAAPPCSPLLKAPS CCCCCCCCCCCCCCC	25.10	23401153
188	Phosphorylation	SPLLKAPSPAGPLHK CCCCCCCCCCCCCCC	32.04	23401153
198	Acetylation	GPLHKGKKAVNKDSL CCCCCCCCCCCHHHH	67.26	77115213
207	Phosphorylation	VNKDSLEYRLRRERN CCHHHHHHHHHHHHH	21.90	-
254	Phosphorylation	RSRVEQLTQELDTLR HHHHHHHHHHHHHHH	21.49	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
74	T	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
74	T	Phosphorylation	Kinase	MAPK_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CEBPE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CEBPE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PO2F1_HUMAN	POU2F1	physical	20211142
TBX2_HUMAN	TBX2	physical	20211142
ELOB_HUMAN	TCEB2	physical	20211142
MED16_HUMAN	MED16	physical	20211142
MYCPP_HUMAN	DENND4A	physical	20211142
TF2AY_HUMAN	GTF2A1L	physical	20211142
NELFB_HUMAN	NELFB	physical	20211142
TAF5L_HUMAN	TAF5L	physical	20211142
ALX4_HUMAN	ALX4	physical	20211142
ZFP2_HUMAN	ZFP2	physical	20211142
KDM2B_HUMAN	KDM2B	physical	20211142
ZN384_HUMAN	ZNF384	physical	20211142
CEBPG_HUMAN	CEBPG	physical	15588942
DDIT3_HUMAN	DDIT3	physical	15588942
SI1L1_HUMAN	SIPA1L1	physical	15588942
AF17_HUMAN	MLLT6	physical	15588942
LDOC1_HUMAN	LDOC1	physical	15588942
PIAS1_HUMAN	PIAS1	physical	15588942
UBC9_HUMAN	UBE2I	physical	15588942
ZMYM2_HUMAN	ZMYM2	physical	15588942
CSN3_HUMAN	COPS3	physical	15588942
STAT6_HUMAN	STAT6	physical	15588942
RB_HUMAN	RB1	physical	12947005
E2F1_HUMAN	E2F1	physical	12947005
BATF3_HUMAN	BATF3	physical	23661758
BATF2_HUMAN	BATF2	physical	23661758
BATF_HUMAN	BATF	physical	23661758
ATF3_HUMAN	ATF3	physical	23661758
ATF5_HUMAN	ATF5	physical	23661758
ATF4_HUMAN	ATF4	physical	23661758
FOSL1_HUMAN	FOSL1	physical	23661758
FOS_HUMAN	FOS	physical	23661758
JUN_HUMAN	JUN	physical	23661758
CEBPE_HUMAN	CEBPE	physical	23661758
CEBPA_HUMAN	CEBPA	physical	23661758
TNR27_HUMAN	EDA2R	physical	21988832
GPR22_HUMAN	GPR22	physical	21988832
IL7_HUMAN	IL7	physical	21988832
SERC_HUMAN	PSAT1	physical	21988832
KC1AL_HUMAN	CSNK1A1L	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.