TBX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBX2_HUMAN
• UniProt AC: Q13207
• Protein Name: T-box transcription factor TBX2
• Gene Name: TBX2
• Organism: Homo sapiens (Human).
• Sequence Length: 712
• Subcellular Localization: Nucleus .
• Protein Description: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation..
• Protein Sequence: MREPALAASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALPPGALAKPLPDPGLAGAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPSLRLYEEHCKPERDGAESDASSCDPPPAREPPTSPGAAPSPLRLHRARAEEKSCAADSDPEPERLSEERAGAPLGRSPAPDSASPTRLTEPERARERRSPERGKEPAESGGDGPFGLRSLEKERAEARRKDEGRKEAAEGKEQGLAPLVVQTDSASPLGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQFTMGPGAFSAMGMGHLLASVAGGGNGGGGGPGTAAGLDAGGLGPAASAASTAAPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPATSAAAAAAAAAGSLSRSPFLGSARPRLRFSPYQIPVTIPPSTSLLTTGLASEGSKAAGGNSREPSPLPELALRKVGAPSRGALSPSGSAKEAANELQSIQRLVSGLESQRALSPGRESPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
91	Phosphorylation	PPAAHLRSLKSLEPE CCHHHHHHHCCCCCC	46.65	23312004
94	Phosphorylation	AHLRSLKSLEPEDEV HHHHHHCCCCCCCCC	43.17	29507054
123	O-linked_Glycosylation	DQFHKLGTEMVITKS HHHHHHCCEEEEECC	31.20	30379171
128	O-linked_Glycosylation	LGTEMVITKSGRRMF HCCEEEEECCCCCCC	14.03	30379171
165	Phosphorylation	VAADDCRYKFHNSRW EECCCCEEEECCCCE	25.08	-
187	Phosphorylation	PEMPKRMYIHPDSPA CCCCCCEEECCCCCC	10.50	-
210	Ubiquitination	PVAFHKLKLTNNISD CCEEEEEEECCCCCH	59.05	-
247	Phosphorylation	NDILKLPYSTFRTYV HHCEECCCCCCCEEE	30.68	-
252	Phosphorylation	LPYSTFRTYVFPETD CCCCCCCEEECCCCC	21.61	-
253	Phosphorylation	PYSTFRTYVFPETDF CCCCCCEEECCCCCE	8.88	-
258	Phosphorylation	RTYVFPETDFIAVTA CEEECCCCCEEEEEE	36.13	-
275	Ubiquitination	NDKITQLKIDNNPFA CCCCEEEEECCCCCC	37.89	-
283	Ubiquitination	IDNNPFAKGFRDTGN ECCCCCCCCCCCCCC	59.99	-
295	Ubiquitination	TGNGRREKRKQLTLP CCCCHHHHHHHCCHH	64.18	-
300	Phosphorylation	REKRKQLTLPSLRLY HHHHHHCCHHHHHHH	33.84	24425749
303	Phosphorylation	RKQLTLPSLRLYEEH HHHCCHHHHHHHHHH	29.27	24719451
320	Phosphorylation	PERDGAESDASSCDP CCCCCCCCCHHHCCC	37.63	25849741
323	Phosphorylation	DGAESDASSCDPPPA CCCCCCHHHCCCCCC	36.17	25849741
324	Phosphorylation	GAESDASSCDPPPAR CCCCCHHHCCCCCCC	25.02	29255136
335	Phosphorylation	PPAREPPTSPGAAPS CCCCCCCCCCCCCCC	59.26	25849741
336	Phosphorylation	PAREPPTSPGAAPSP CCCCCCCCCCCCCCH	27.40	20363803
342	Phosphorylation	TSPGAAPSPLRLHRA CCCCCCCCHHHHHHH	31.66	29255136
355	Phosphorylation	RARAEEKSCAADSDP HHHHHHHCCCCCCCC	16.56	24702127
360	Phosphorylation	EKSCAADSDPEPERL HHCCCCCCCCCHHHH	50.79	29255136
368	Phosphorylation	DPEPERLSEERAGAP CCCHHHHCHHHCCCC	43.57	22617229
379	Phosphorylation	AGAPLGRSPAPDSAS CCCCCCCCCCCCCCC	24.50	29255136
384	Phosphorylation	GRSPAPDSASPTRLT CCCCCCCCCCCCCCC	29.59	29255136
386	Phosphorylation	SPAPDSASPTRLTEP CCCCCCCCCCCCCCH	30.65	29255136
388	Phosphorylation	APDSASPTRLTEPER CCCCCCCCCCCCHHH	35.50	29255136
391	Phosphorylation	SASPTRLTEPERARE CCCCCCCCCHHHHHH	46.32	23312004
401	Phosphorylation	ERARERRSPERGKEP HHHHHHCCCCCCCCC	37.02	24719451
411	Phosphorylation	RGKEPAESGGDGPFG CCCCCHHHCCCCCCC	50.62	27251275
594	Phosphorylation	ASALPATSAAAAAAA HHCCCHHHHHHHHHH	20.30	25137130
635	Phosphorylation	VTIPPSTSLLTTGLA EECCCCCCHHHCCCC	26.22	-
638	Phosphorylation	PPSTSLLTTGLASEG CCCCCHHHCCCCCCC	24.90	-
643	Phosphorylation	LLTTGLASEGSKAAG HHHCCCCCCCCCCCC	47.75	-
646	Phosphorylation	TGLASEGSKAAGGNS CCCCCCCCCCCCCCC	18.31	-
653	Phosphorylation	SKAAGGNSREPSPLP CCCCCCCCCCCCCCC	41.10	29255136
657	Phosphorylation	GGNSREPSPLPELAL CCCCCCCCCCCHHHH	34.02	29255136
671	Phosphorylation	LRKVGAPSRGALSPS HHHCCCCCCCCCCCC	42.69	29514088
676	Phosphorylation	APSRGALSPSGSAKE CCCCCCCCCCCCHHH	19.24	29255136
678	Phosphorylation	SRGALSPSGSAKEAA CCCCCCCCCCHHHHH	41.84	29255136
680	Phosphorylation	GALSPSGSAKEAANE CCCCCCCCHHHHHHH	40.27	30242111
700	Phosphorylation	RLVSGLESQRALSPG HHHHHHHHHHCCCCC	29.97	30108239
705	Phosphorylation	LESQRALSPGRESPK HHHHHCCCCCCCCCC	25.07	29255136
710	Phosphorylation	ALSPGRESPK----- CCCCCCCCCC-----	36.31	29255136

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBX2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LZTR1_HUMAN	LZTR1	physical	20211142
EGR1_HUMAN	EGR1	physical	20348948
SOX2_HUMAN	SOX2	physical	23674600
PML_HUMAN	PML	physical	22002537

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.