EGR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EGR1_HUMAN
• UniProt AC: P18146
• Protein Name: Early growth response protein 1 {ECO:0000303|PubMed:2377485}
• Gene Name: EGR1
• Organism: Homo sapiens (Human).
• Sequence Length: 543
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Transcriptional regulator. [PubMed: 20121949 Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity Binds double-stranded target DNA, irrespective of the cytosine methylation status]
• Protein Sequence: MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGAPEGSGSNSSSSSSGGGGGGGGGSNSSSSSSTFNPQADTGEQPYEHLTAESFPDISLNNEKVLVETSYPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPASSSSAPSPAASSASASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPAAKGGFQVPMIPDYLFPQQQGDLGLGTPDQKPFQGLESRTQQPSLTPLSTIKAFATQSGSQDLKALNTSYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASSATSSLSSYPSPVATSYPSPVTTSYPSPATTSYPSPVPTSFSSPGSSTYPSPVHSGFPSPSVATTYSSVPPAFPAQVSSFPSSAVTNSFSASTGLSDMTATFSPRTIEIC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	KAEMQLMSPLQISDP HHHHHHCCCCCCCCC	30.93	23090842
17	Phosphorylation	LMSPLQISDPFGSFP HCCCCCCCCCCCCCC	26.69	28857561
22	Phosphorylation	QISDPFGSFPHSPTM CCCCCCCCCCCCCCC	35.66	28450419
26	Phosphorylation	PFGSFPHSPTMDNYP CCCCCCCCCCCCCCC	23.46	28450419
28	Phosphorylation	GSFPHSPTMDNYPKL CCCCCCCCCCCCCCH	39.92	28450419
32	Phosphorylation	HSPTMDNYPKLEEMM CCCCCCCCCCHHHHH	9.47	28450419
104	Phosphorylation	YEHLTAESFPDISLN CCHHCHHHCCCCCCC	39.35	22817900
119	Phosphorylation	NEKVLVETSYPSQTT CCEEEEEECCCCCCC	26.53	24043423
119	O-linked_Glycosylation	NEKVLVETSYPSQTT CCEEEEEECCCCCCC	26.53	28657654
120	O-linked_Glycosylation	EKVLVETSYPSQTTR CEEEEEECCCCCCCC	22.88	28657654
120	Phosphorylation	EKVLVETSYPSQTTR CEEEEEECCCCCCCC	22.88	24043423
121	Phosphorylation	KVLVETSYPSQTTRL EEEEEECCCCCCCCC	17.83	24043423
123	Phosphorylation	LVETSYPSQTTRLPP EEEECCCCCCCCCCC	31.74	24043423
123	O-linked_Glycosylation	LVETSYPSQTTRLPP EEEECCCCCCCCCCC	31.74	28657654
125	O-linked_Glycosylation	ETSYPSQTTRLPPIT EECCCCCCCCCCCCE	20.44	28657654
125	Phosphorylation	ETSYPSQTTRLPPIT EECCCCCCCCCCCCE	20.44	24043423
126	O-linked_Glycosylation	TSYPSQTTRLPPITY ECCCCCCCCCCCCEE	23.67	28657654
126	Phosphorylation	TSYPSQTTRLPPITY ECCCCCCCCCCCCEE	23.67	24043423
148	Phosphorylation	PAPNSGNTLWPEPLF ECCCCCCCCCCHHHH	33.45	22817900
196	Phosphorylation	PLSCAVPSNDSSPIY CCCCCCCCCCCCCCC	46.82	22817900
301	Phosphorylation	AFATQSGSQDLKALN HHHCCCCCHHHHHHC	26.26	22817900
305	Sumoylation	QSGSQDLKALNTSYQ CCCCHHHHHHCHHHH	60.15	28112733
317	Acetylation	SYQSQLIKPSRMRKY HHHHHCCCHHHHHCC	45.60	22424773
378	Phosphorylation	RICMRNFSRSDHLTT EEEECCCCCCCCEEE	34.13	22817900
389	Phosphorylation	HLTTHIRTHTGEKPF CEEEEEEECCCCCCE	24.16	-
391	Phosphorylation	TTHIRTHTGEKPFAC EEEEEECCCCCCEEE	46.56	8662759
422	Acetylation	TKIHLRQKDKKADKS HHHHHCHHCCCCCHH	66.15	15225550
424	Acetylation	IHLRQKDKKADKSVV HHHCHHCCCCCHHHC	57.82	15225550
425	Acetylation	HLRQKDKKADKSVVA HHCHHCCCCCHHHCC	72.46	15225550
526	Phosphorylation	TNSFSASTGLSDMTA CCCCCCCCCCCCCCE	41.69	8662759
536	Phosphorylation	SDMTATFSPRTIEIC CCCCEEECCCEEEEC	14.76	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
104	S	Phosphorylation	Kinase	CSNK2A1	P19139	GPS
148	T	Phosphorylation	Kinase	CSNK2A1	P19139	GPS
196	S	Phosphorylation	Kinase	CSNK2A1	P19139	GPS
301	S	Phosphorylation	Kinase	CSNK2A1	P19139	GPS
378	S	Phosphorylation	Kinase	CSNK2A1	P19139	GPS
378	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
378	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EGR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EGR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CEBPB_HUMAN	CEBPB	physical	12947119
NAB2_HUMAN	NAB2	physical	8668170
PITX1_HUMAN	PITX1	physical	10082522
SNAI1_HUMAN	SNAI1	physical	20121949
SP1_HUMAN	SP1	physical	20121949
PTEN_HUMAN	PTEN	physical	21354147
SRA1_HUMAN	SRA1	physical	20398657
EP300_HUMAN	EP300	physical	15225550
MDM2_HUMAN	MDM2	physical	15225550
P53_HUMAN	TP53	physical	15225550
CDN2A_HUMAN	CDKN2A	physical	19057511
ARF_HUMAN	CDKN2A	physical	19057511
EP300_HUMAN	EP300	physical	9806899
CEBPB_HUMAN	CEBPB	physical	22260630
EP300_HUMAN	EP300	physical	20018936
FOSL2_HUMAN	FOSL2	physical	26496610
JUNB_HUMAN	JUNB	physical	26496610
JUND_HUMAN	JUND	physical	26496610
MAGB2_HUMAN	MAGEB2	physical	26496610
PSMD2_HUMAN	PSMD2	physical	26496610
MED6_HUMAN	MED6	physical	26496610
POP1_HUMAN	POP1	physical	26496610
DNJC8_HUMAN	DNAJC8	physical	26496610
PHIP_HUMAN	PHIP	physical	26496610
ARID2_HUMAN	ARID2	physical	26496610
CTNB1_HUMAN	CTNNB1	physical	21743491
MIDN_HUMAN	MIDN	physical	28514442
NAB1_HUMAN	NAB1	physical	28514442
NEST_HUMAN	NES	physical	28514442
WDFY1_HUMAN	WDFY1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.