dbPTM

PHIP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PHIP_HUMAN
UniProt AC	Q8WWQ0
Protein Name	PH-interacting protein
Gene Name	PHIP
Organism	Homo sapiens (Human).
Sequence Length	1821
Subcellular Localization	Nucleus.
Protein Description	Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization..
Protein Sequence	MSCERKGLSELRSELYFLIARFLEDGPCQQAAQVLIREVAEKELLPRRTDWTGKEHPRTYQNLVKYYRHLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNKSCKHVVWKGSALAALHCGRPPESPVNYGSPPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIFGFGSSSKYDKIADQMFFHSDYRPLIRDANNFVLDEQTQQAPHLMPPPFLVDVDGNPHPSRYQRLVPGRENCREEQLIPQMGVTSSGLNQVLSQQANQEISPLDSMIQRLQQEQDLRRSGEAVISNTSRLSRGSISSTSEVHSPPNVGLRRSGQIEGVRQMHSNAPRSEIATERDLVAWSRRVVVPELSAGVASRQEEWRTAKGEEEIKTYRSEEKRKHLTVPKENKIPTVSKNHAHEHFLDLGESKKQQTNQHNYRTRSALEETPRPSEEIENGSSSSDEGEVVAVSGGTSEEEERAWHSDGSSSDYSSDYSDWTADAGINLQPPKKVPKNKTKKAESSSDEEEESEKQKQKQIKKEKKKVNEEKDGPISPKKKKPKERKQKRLAVGELTENGLTLEEWLPSTWITDTIPRRCPFVPQMGDEVYYFRQGHEAYVEMARKNKIYSINPKKQPWHKMELREQELMKIVGIKYEVGLPTLCCLKLAFLDPDTGKLTGGSFTMKYHDMPDVIDFLVLRQQFDDAKYRRWNIGDRFRSVIDDAWWFGTIESQEPLQLEYPDSLFQCYNVCWDNGDTEKMSPWDMELIPNNAVFPEELGTSVPLTDGECRSLIYKPLDGEWGTNPRDEECERIVAGINQLMTLDIASAFVAPVDLQAYPMYCTVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEPGSPIVKSAKFVTDLLLHFIKDQTCYNIIPLYNSMKKKVLSDSEDEEKDADVPGTSTRKRKDHQPRRRLRNRAQSYDIQAWKKQCEELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMDFATVRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFFEEHISSVLSDYKSALRFHKRNTITKRRKKRNRSSSVSSSAASSPERKKRILKPQLKSESSTSAFSTPTRSIPPRHNAAQINGKTESSSVVRTRSNRVVVDPVVTEQPSTSSAAKTFITKANASAIPGKTILENSVKHSKALNTLSSPGQSSFSHGTRNNSAKENMEKEKPVKRKMKSSVLPKASTLSKSSAVIEQGDCKNNALVPGTIQVNGHGGQPSKLVKRGPGRKPKVEVNTNSGEIIHKKRGRKPKKLQYAKPEDLEQNNVHPIRDEVLPSSTCNFLSETNNVKEDLLQKKNRGGRKPKRKMKTQKLDADLLVPASVKVLRRSNRKKIDDPIDEEEEFEELKGSEPHMRTRNQGRRTAFYNEDDSEEEQRQLLFEDTSLTFGTSSRGRVRKLTEKAKANLIGW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MSCERKGLSELRS --CCCCCCCHHHHHH	41.74	21890473
6	Ubiquitination	--MSCERKGLSELRS --CCCCCCCHHHHHH	41.74	23000965
16	Phosphorylation	SELRSELYFLIARFL HHHHHHHHHHHHHHH	7.71	-
42	Ubiquitination	LIREVAEKELLPRRT HHHHHHHHHCCCCCC	43.88	-
54	Ubiquitination	RRTDWTGKEHPRTYQ CCCCCCCCCCCCHHH	45.54	29967540
65	Ubiquitination	RTYQNLVKYYRHLAP CHHHHHHHHHHHHCH	39.47	21890473
65	Acetylation	RTYQNLVKYYRHLAP CHHHHHHHHHHHHCH	39.47	26051181
65	Ubiquitination	RTYQNLVKYYRHLAP CHHHHHHHHHHHHCH	39.47	23000965
93	Phosphorylation	LEQEIPQSVPGVQTL HHCCCCCCCCCHHHH	25.56	24732914
99	Phosphorylation	QSVPGVQTLLGAGRQ CCCCCHHHHHCCHHH	22.88	24732914
107	Phosphorylation	LLGAGRQSLLRTNKS HHCCHHHHHHHCCCC	28.19	24732914
116	Acetylation	LRTNKSCKHVVWKGS HHCCCCCCCEEECHH	46.67	26051181
116	Ubiquitination	LRTNKSCKHVVWKGS HHCCCCCCCEEECHH	46.67	29967540
123	Phosphorylation	KHVVWKGSALAALHC CCEEECHHHHHHHHC	19.18	24732914
136	Phosphorylation	HCGRPPESPVNYGSP HCCCCCCCCCCCCCC	39.66	25159151
140	Phosphorylation	PPESPVNYGSPPSIA CCCCCCCCCCCCCHH	21.15	24732914
142	Phosphorylation	ESPVNYGSPPSIADT CCCCCCCCCCCHHHH	24.23	25159151
145	Phosphorylation	VNYGSPPSIADTLFS CCCCCCCCHHHHHHH	33.52	24732914
149	Phosphorylation	SPPSIADTLFSRKLN CCCCHHHHHHHHHCC	22.23	24732914
152	Phosphorylation	SIADTLFSRKLNGKY CHHHHHHHHHCCCCC	31.45	24732914
174	Ubiquitination	TAVYQHMKMHKRILG HHHHHHHHHHHHHHH	35.41	21890473
174	Ubiquitination	TAVYQHMKMHKRILG HHHHHHHHHHHHHHH	35.41	21890473
185	Phosphorylation	RILGHLSSVYCVTFD HHHHHHCCEEEEEEC	24.38	27732954
187	Phosphorylation	LGHLSSVYCVTFDRT HHHHCCEEEEEECCC	5.33	27732954
190	Phosphorylation	LSSVYCVTFDRTGRR HCCEEEEEECCCCCE	19.09	27732954
212	Ubiquitination	CLVKIWATDDGRLLA EEEEEEECCCCCEEH	21.45	23000965
218	Ubiquitination	ATDDGRLLATLRGHA ECCCCCEEHHHHHHH	3.09	23000965
223	Ubiquitination	RLLATLRGHAAEISD CEEHHHHHHHHHHHH	20.21	22817900
228	Ubiquitination	LRGHAAEISDMAVNY HHHHHHHHHHHCCCC	3.47	21890473
235	Phosphorylation	ISDMAVNYENTMIAA HHHHCCCCCCCEEEC	12.17	22210691
238	Phosphorylation	MAVNYENTMIAAGSC HCCCCCCCEEECCCC	9.67	22210691
283	Acetylation	SPLCSGSKRYLSSTG CCCCCCCCEEHHHCC	48.89	26051181
367	Ubiquitination	ELEFHTDKVDSIQFS EEEEECCCCCEEEEE	49.44	29967540
370	Phosphorylation	FHTDKVDSIQFSNTS EECCCCCEEEEECCC	22.68	22210691
374	Phosphorylation	KVDSIQFSNTSNRFV CCCEEEEECCCCCCC	23.87	20068231
376	Phosphorylation	DSIQFSNTSNRFVSG CEEEEECCCCCCCCC	26.61	20068231
377	Phosphorylation	SIQFSNTSNRFVSGS EEEEECCCCCCCCCC	30.20	22210691
382	Phosphorylation	NTSNRFVSGSRDGTA CCCCCCCCCCCCCCC	28.48	22210691
395	Ubiquitination	TARIWQFKRREWKSI CCHHHEEHHHHHHHH	35.13	22817900
400	Ubiquitination	QFKRREWKSILLDMA EEHHHHHHHHHHHHH	23.90	21890473
400	Ubiquitination	QFKRREWKSILLDMA EEHHHHHHHHHHHHH	23.90	21890473
421	Sumoylation	NLQGIEDKITKMKVT CCCCHHHHHHCCEEE	39.21	28112733
421	Ubiquitination	NLQGIEDKITKMKVT CCCCHHHHHHCCEEE	39.21	29967540
423	Phosphorylation	QGIEDKITKMKVTMV CCHHHHHHCCEEEEE	30.72	25159151
438	Phosphorylation	AWDRHDNTVITAVNN EEECCCCEEEEEEEC	21.24	-
441	Phosphorylation	RHDNTVITAVNNMTL CCCCEEEEEEECCEE	21.88	-
447	Phosphorylation	ITAVNNMTLKVWNSY EEEEECCEEEEHHHH	26.08	-
450	Ubiquitination	VNNMTLKVWNSYTGQ EECCEEEEHHHHHHH	7.04	21890473
455	Ubiquitination	LKVWNSYTGQLIHVL EEEHHHHHHHHHHHC	20.48	23000965
477	Ubiquitination	FVLEPHPFDPRVLFS EEECCCCCCCCEEEE	21.48	21890473
505	Phosphorylation	RGVKIRSYFNMIEGQ CCCEEHHHEECCCCC	6.79	22817900
507	Ubiquitination	VKIRSYFNMIEGQGH CEEHHHEECCCCCCC	23.45	23000965
595	Ubiquitination	PFLVDVDGNPHPSRY CEEECCCCCCCCHHH	49.79	21890473
601	Ubiquitination	DGNPHPSRYQRLVPG CCCCCCHHHHHCCCC	35.73	23000965
633	Phosphorylation	SGLNQVLSQQANQEI HHHHHHHHHHHHCCC	22.76	22817900
641	Phosphorylation	QQANQEISPLDSMIQ HHHHCCCCHHHHHHH	20.75	20068231
645	Phosphorylation	QEISPLDSMIQRLQQ CCCCHHHHHHHHHHH	26.01	20068231
659	Phosphorylation	QEQDLRRSGEAVISN HHHHHHHHCCEEECC	34.25	20068231
671	Phosphorylation	ISNTSRLSRGSISST ECCCCCCCCCCCCCC	33.22	21955146
672	Methylation	SNTSRLSRGSISSTS CCCCCCCCCCCCCCC	47.68	115487475
674	Phosphorylation	TSRLSRGSISSTSEV CCCCCCCCCCCCCCC	20.42	25159151
676	Phosphorylation	RLSRGSISSTSEVHS CCCCCCCCCCCCCCC	29.30	30266825
677	Phosphorylation	LSRGSISSTSEVHSP CCCCCCCCCCCCCCC	33.99	30266825
678	Phosphorylation	SRGSISSTSEVHSPP CCCCCCCCCCCCCCC	23.32	30266825
679	Phosphorylation	RGSISSTSEVHSPPN CCCCCCCCCCCCCCC	39.30	30266825
683	Phosphorylation	SSTSEVHSPPNVGLR CCCCCCCCCCCCCCC	47.42	30266825
692	Phosphorylation	PNVGLRRSGQIEGVR CCCCCCCCCCCCHHH	28.72	25159151
703	Phosphorylation	EGVRQMHSNAPRSEI CHHHHHHCCCCHHHC	29.37	-
734	Phosphorylation	ELSAGVASRQEEWRT HHCCCHHHCHHHHHH	31.90	24275569
749	Acetylation	AKGEEEIKTYRSEEK HCCHHHHHHHCCHHH	42.66	26051181
761	Phosphorylation	EEKRKHLTVPKENKI HHHHHCCCCCCCCCC	34.19	24719451
764	Ubiquitination	RKHLTVPKENKIPTV HHCCCCCCCCCCCCC	70.37	29967540
766	Ubiquitination	HLTVPKENKIPTVSK CCCCCCCCCCCCCCC	54.40	23000965
767	Ubiquitination	LTVPKENKIPTVSKN CCCCCCCCCCCCCCC	51.67	23000965
770	Phosphorylation	PKENKIPTVSKNHAH CCCCCCCCCCCCCCC	40.67	20068231
772	O-linked_Glycosylation	ENKIPTVSKNHAHEH CCCCCCCCCCCCCHH	30.16	30379171
772	Ubiquitination	ENKIPTVSKNHAHEH CCCCCCCCCCCCCHH	30.16	23000965
773	Ubiquitination	NKIPTVSKNHAHEHF CCCCCCCCCCCCHHH	48.71	-
773	Ubiquitination	NKIPTVSKNHAHEHF CCCCCCCCCCCCHHH	48.71	23000965
787	Ubiquitination	FLDLGESKKQQTNQH HHCCCHHHCHHCCCC	50.75	32015554
796	Phosphorylation	QQTNQHNYRTRSALE HHCCCCCHHHHHHHH	15.96	30622161
798	Phosphorylation	TNQHNYRTRSALEET CCCCCHHHHHHHHCC	20.72	30622161
816	Phosphorylation	SEEIENGSSSSDEGE HHHCCCCCCCCCCCC	38.33	25849741
817	Phosphorylation	EEIENGSSSSDEGEV HHCCCCCCCCCCCCE	34.95	25849741
818	Phosphorylation	EIENGSSSSDEGEVV HCCCCCCCCCCCCEE	43.43	25849741
819	Phosphorylation	IENGSSSSDEGEVVA CCCCCCCCCCCCEEE	41.45	25849741
832	Phosphorylation	VAVSGGTSEEEERAW EEEECCCCHHHHHHC	46.41	19007248
833	Ubiquitination	AVSGGTSEEEERAWH EEECCCCHHHHHHCC	70.08	21890473
838	Ubiquitination	TSEEEERAWHSDGSS CCHHHHHHCCCCCCC	16.18	21890473
841	Phosphorylation	EEERAWHSDGSSSDY HHHHHCCCCCCCCCC	32.72	30576142
846	Phosphorylation	WHSDGSSSDYSSDYS CCCCCCCCCCCCCCC	42.12	30576142
860	Ubiquitination	SDWTADAGINLQPPK CCCCCCCCCCCCCCC	15.18	21890473
871	2-Hydroxyisobutyrylation	QPPKKVPKNKTKKAE CCCCCCCCCCCCCCC	74.25	-
879	Phosphorylation	NKTKKAESSSDEEEE CCCCCCCCCCHHHHH	39.75	26055452
880	Phosphorylation	KTKKAESSSDEEEES CCCCCCCCCHHHHHH	33.06	26055452
881	Phosphorylation	TKKAESSSDEEEESE CCCCCCCCHHHHHHH	59.32	28176443
887	Phosphorylation	SSDEEEESEKQKQKQ CCHHHHHHHHHHHHH	54.06	28176443
890	Ubiquitination	EEEESEKQKQKQIKK HHHHHHHHHHHHHHH	49.73	23000965
911	Phosphorylation	EEKDGPISPKKKKPK CCCCCCCCCCCCCHH	33.53	29255136
973	Ubiquitination	YFRQGHEAYVEMARK EEECCHHHHHHHHHH	14.16	21890473
978	Ubiquitination	HEAYVEMARKNKIYS HHHHHHHHHHCCCEE	13.04	21890473
982	Ubiquitination	VEMARKNKIYSINPK HHHHHHCCCEEECCC	46.16	29967540
984	Phosphorylation	MARKNKIYSINPKKQ HHHHCCCEEECCCCC	12.71	24719451
985	Phosphorylation	ARKNKIYSINPKKQP HHHCCCEEECCCCCC	21.25	24719451
987	Ubiquitination	KNKIYSINPKKQPWH HCCCEEECCCCCCCC	36.08	21890473
989	Ubiquitination	KIYSINPKKQPWHKM CCEEECCCCCCCCCC	60.60	29967540
990	Ubiquitination	IYSINPKKQPWHKME CEEECCCCCCCCCCC	63.95	29967540
995	Ubiquitination	PKKQPWHKMELREQE CCCCCCCCCCHHHHH	30.15	23000965
998	Ubiquitination	QPWHKMELREQELMK CCCCCCCHHHHHHHH	6.99	23000965
1004	Ubiquitination	ELREQELMKIVGIKY CHHHHHHHHHHCCCC	2.47	21890473
1005	Ubiquitination	LREQELMKIVGIKYE HHHHHHHHHHCCCCC	47.03	21890473
1005	Ubiquitination	LREQELMKIVGIKYE HHHHHHHHHHCCCCC	47.03	23000965
1009	Ubiquitination	ELMKIVGIKYEVGLP HHHHHHCCCCCCCHH	2.73	23000965
1010	Acetylation	LMKIVGIKYEVGLPT HHHHHCCCCCCCHHH	29.45	26051181
1010	Ubiquitination	LMKIVGIKYEVGLPT HHHHHCCCCCCCHHH	29.45	23000965
1011	Phosphorylation	MKIVGIKYEVGLPTL HHHHCCCCCCCHHHH	17.58	-
1031	Ubiquitination	AFLDPDTGKLTGGSF EEECCCCCCCCCCEE	30.29	21890473
1032	Ubiquitination	FLDPDTGKLTGGSFT EECCCCCCCCCCEEE	44.99	21890473
1032	Ubiquitination	FLDPDTGKLTGGSFT EECCCCCCCCCCEEE	44.99	23000965
1037	Phosphorylation	TGKLTGGSFTMKYHD CCCCCCCEEEEEECC	20.91	19845377
1041	Ubiquitination	TGGSFTMKYHDMPDV CCCEEEEEECCCCCH	36.05	23000965
1047	Ubiquitination	MKYHDMPDVIDFLVL EEECCCCCHHHHHHH	43.28	23000965
1061	Ubiquitination	LRQQFDDAKYRRWNI HHHHCCCHHHHCCCC	16.78	23000965
1062	Ubiquitination	RQQFDDAKYRRWNIG HHHCCCHHHHCCCCH	46.41	-
1062	Ubiquitination	RQQFDDAKYRRWNIG HHHCCCHHHHCCCCH	46.41	23000965
1146	Phosphorylation	LTDGECRSLIYKPLD CCCCCHHHEEEECCC	30.67	28122231
1149	Ubiquitination	GECRSLIYKPLDGEW CCHHHEEEECCCCCC	16.31	21890473
1150	Ubiquitination	ECRSLIYKPLDGEWG CHHHEEEECCCCCCC	31.91	21890473
1150	Ubiquitination	ECRSLIYKPLDGEWG CHHHEEEECCCCCCC	31.91	22817900
1181	Ubiquitination	QLMTLDIASAFVAPV HHHHHCHHHHCCCCC	8.41	21890473
1221	Ubiquitination	ENRFYRRVSSLMWEV HHHHHHHHHHHHHHE	3.18	21890473
1222	Phosphorylation	NRFYRRVSSLMWEVR HHHHHHHHHHHHHEE	18.88	28348404
1223	Phosphorylation	RFYRRVSSLMWEVRY HHHHHHHHHHHHEEE	21.27	22617229
1243	Phosphorylation	RTFNEPGSPIVKSAK CCCCCCCCCHHHHHH	23.36	28985074
1264	Phosphorylation	LHFIKDQTCYNIIPL HHHHCCCCHHHHHHH	27.39	20068231
1266	Phosphorylation	FIKDQTCYNIIPLYN HHCCCCHHHHHHHHH	16.88	20068231
1272	Phosphorylation	CYNIIPLYNSMKKKV HHHHHHHHHHHHHHH	10.39	20068231
1274	Phosphorylation	NIIPLYNSMKKKVLS HHHHHHHHHHHHHCC	20.58	21815630
1281	Phosphorylation	SMKKKVLSDSEDEEK HHHHHHCCCCCCHHH	41.92	29255136
1283	Phosphorylation	KKKVLSDSEDEEKDA HHHHCCCCCCHHHCC	43.50	29255136
1295	Phosphorylation	KDADVPGTSTRKRKD HCCCCCCCCHHCCCC	22.36	25159151
1296	Phosphorylation	DADVPGTSTRKRKDH CCCCCCCCHHCCCCC	31.93	25159151
1297	Phosphorylation	ADVPGTSTRKRKDHQ CCCCCCCHHCCCCCC	39.79	23927012
1315	Phosphorylation	RLRNRAQSYDIQAWK HHHHHHHHHCHHHHH	24.64	25159151
1316	Phosphorylation	LRNRAQSYDIQAWKK HHHHHHHHCHHHHHH	12.65	28176443
1322	Acetylation	SYDIQAWKKQCEELL HHCHHHHHHHHHHHH	35.66	26051181
1356	Ubiquitination	EYPDYRDIIDTPMDF CCCCHHHHCCCCCCH	1.96	21890473
1359	Phosphorylation	DYRDIIDTPMDFATV CHHHHCCCCCCHHHH	15.31	21815630
1361	Ubiquitination	RDIIDTPMDFATVRE HHHCCCCCCHHHHHH	7.80	23000965
1369	Phosphorylation	DFATVRETLEAGNYE CHHHHHHHHHCCCCC	21.23	20068231
1370	Ubiquitination	FATVRETLEAGNYES HHHHHHHHHCCCCCC	3.48	21890473
1375	Phosphorylation	ETLEAGNYESPMELC HHHHCCCCCCHHHHH	19.50	29396449
1377	Phosphorylation	LEAGNYESPMELCKD HHCCCCCCHHHHHHH	21.13	21815630
1378	Ubiquitination	EAGNYESPMELCKDV HCCCCCCHHHHHHHH	14.34	23000965
1381	Ubiquitination	NYESPMELCKDVRLI CCCCHHHHHHHHEEH	3.42	23000965
1383	Ubiquitination	ESPMELCKDVRLIFS CCHHHHHHHHEEHCC	72.40	-
1390	Phosphorylation	KDVRLIFSNSKAYTP HHHEEHCCCCCCCCC	32.95	18669648
1392	Phosphorylation	VRLIFSNSKAYTPSK HEEHCCCCCCCCCCC	19.91	18669648
1392	Ubiquitination	VRLIFSNSKAYTPSK HEEHCCCCCCCCCCC	19.91	21890473
1393	Ubiquitination	RLIFSNSKAYTPSKR EEHCCCCCCCCCCCC	50.06	21890473
1393	Ubiquitination	RLIFSNSKAYTPSKR EEHCCCCCCCCCCCC	50.06	21890473
1395	Phosphorylation	IFSNSKAYTPSKRSR HCCCCCCCCCCCCHH	23.95	20860994
1396	Phosphorylation	FSNSKAYTPSKRSRI CCCCCCCCCCCCHHH	26.41	20860994
1398	Phosphorylation	NSKAYTPSKRSRIYS CCCCCCCCCCHHHHE	32.66	20860994
1399	Acetylation	SKAYTPSKRSRIYSM CCCCCCCCCHHHHEE	56.44	23749302
1404	Phosphorylation	PSKRSRIYSMSLRLS CCCCHHHHEEHHHHH	9.37	22817900
1405	Phosphorylation	SKRSRIYSMSLRLSA CCCHHHHEEHHHHHH	10.26	16565220
1407	Phosphorylation	RSRIYSMSLRLSAFF CHHHHEEHHHHHHHH	12.37	19691289
1424	Ubiquitination	HISSVLSDYKSALRF HHHHHHHHHHHHHHH	51.20	23000965
1425	Phosphorylation	ISSVLSDYKSALRFH HHHHHHHHHHHHHHH	11.94	22817900
1430	Ubiquitination	SDYKSALRFHKRNTI HHHHHHHHHHHHCHH	31.19	23000965
1438	O-linked_Glycosylation	FHKRNTITKRRKKRN HHHHCHHHHHHHHHC	19.23	30379171
1443	Acetylation	TITKRRKKRNRSSSV HHHHHHHHHCCCCCC	53.76	7378649
1447	Phosphorylation	RRKKRNRSSSVSSSA HHHHHCCCCCCCCCC	30.43	20873877
1448	Phosphorylation	RKKRNRSSSVSSSAA HHHHCCCCCCCCCCC	31.36	20873877
1449	Phosphorylation	KKRNRSSSVSSSAAS HHHCCCCCCCCCCCC	27.54	20873877
1451	Phosphorylation	RNRSSSVSSSAASSP HCCCCCCCCCCCCCH	22.11	30576142
1452	Phosphorylation	NRSSSVSSSAASSPE CCCCCCCCCCCCCHH	23.11	25627689
1453	Phosphorylation	RSSSVSSSAASSPER CCCCCCCCCCCCHHH	21.98	26074081
1456	Phosphorylation	SVSSSAASSPERKKR CCCCCCCCCHHHHHH	46.25	25849741
1457	Phosphorylation	VSSSAASSPERKKRI CCCCCCCCHHHHHHH	26.50	25159151
1461	Acetylation	AASSPERKKRILKPQ CCCCHHHHHHHCCHH	44.75	7378659
1466	Ubiquitination	ERKKRILKPQLKSES HHHHHHCCHHHCCCC	28.48	29967540
1470	Sumoylation	RILKPQLKSESSTSA HHCCHHHCCCCCCCC	47.10	25114211
1470	Ubiquitination	RILKPQLKSESSTSA HHCCHHHCCCCCCCC	47.10	29967540
1471	Phosphorylation	ILKPQLKSESSTSAF HCCHHHCCCCCCCCC	51.83	19691289
1473	Phosphorylation	KPQLKSESSTSAFST CHHHCCCCCCCCCCC	46.11	16565220
1474	Phosphorylation	PQLKSESSTSAFSTP HHHCCCCCCCCCCCC	23.48	30266825
1475	Phosphorylation	QLKSESSTSAFSTPT HHCCCCCCCCCCCCC	33.10	30266825
1476	Phosphorylation	LKSESSTSAFSTPTR HCCCCCCCCCCCCCC	29.30	30266825
1479	Phosphorylation	ESSTSAFSTPTRSIP CCCCCCCCCCCCCCC	32.94	30266825
1480	Phosphorylation	SSTSAFSTPTRSIPP CCCCCCCCCCCCCCC	23.40	30266825
1482	Phosphorylation	TSAFSTPTRSIPPRH CCCCCCCCCCCCCCC	36.82	30266825
1484	Phosphorylation	AFSTPTRSIPPRHNA CCCCCCCCCCCCCCC	41.76	24719451
1497	Acetylation	NAAQINGKTESSSVV CCCCCCCCCCCCCCE	44.63	19608861
1497	Ubiquitination	NAAQINGKTESSSVV CCCCCCCCCCCCCCE	44.63	32015554
1498	Phosphorylation	AAQINGKTESSSVVR CCCCCCCCCCCCCEE	42.36	21712546
1500	Phosphorylation	QINGKTESSSVVRTR CCCCCCCCCCCEECC	32.90	24732914
1501	Phosphorylation	INGKTESSSVVRTRS CCCCCCCCCCEECCC	22.41	24732914
1502	Phosphorylation	NGKTESSSVVRTRSN CCCCCCCCCEECCCC	33.63	24732914
1506	Phosphorylation	ESSSVVRTRSNRVVV CCCCCEECCCCCEEE	27.17	28450419
1508	Phosphorylation	SSVVRTRSNRVVVDP CCCEECCCCCEEECC	28.51	30576142
1518	Phosphorylation	VVVDPVVTEQPSTSS EEECCEECCCCCCCC	29.18	24732914
1522	Phosphorylation	PVVTEQPSTSSAAKT CEECCCCCCCCCHHH	40.39	25159151
1523	Phosphorylation	VVTEQPSTSSAAKTF EECCCCCCCCCHHHH	33.12	25159151
1524	Phosphorylation	VTEQPSTSSAAKTFI ECCCCCCCCCHHHHH	23.47	25159151
1525	Phosphorylation	TEQPSTSSAAKTFIT CCCCCCCCCHHHHHH	32.13	25159151
1527	Ubiquitination	QPSTSSAAKTFITKA CCCCCCCHHHHHHHH	17.23	21890473
1528	Ubiquitination	PSTSSAAKTFITKAN CCCCCCHHHHHHHHC	43.62	21890473
1528	Acetylation	PSTSSAAKTFITKAN CCCCCCHHHHHHHHC	43.62	23749302
1528	Ubiquitination	PSTSSAAKTFITKAN CCCCCCHHHHHHHHC	43.62	23000965
1532	Ubiquitination	SAAKTFITKANASAI CCHHHHHHHHCCCCC	21.66	23000965
1533	Acetylation	AAKTFITKANASAIP CHHHHHHHHCCCCCC	34.52	19608861
1533	Ubiquitination	AAKTFITKANASAIP CHHHHHHHHCCCCCC	34.52	23000965
1541	Ubiquitination	ANASAIPGKTILENS HCCCCCCCCCHHHCC	33.36	21890473
1542	Ubiquitination	NASAIPGKTILENSV CCCCCCCCCHHHCCH	27.34	21890473
1542	Acetylation	NASAIPGKTILENSV CCCCCCCCCHHHCCH	27.34	23749302
1542	Ubiquitination	NASAIPGKTILENSV CCCCCCCCCHHHCCH	27.34	23000965
1548	Phosphorylation	GKTILENSVKHSKAL CCCHHHCCHHHCHHH	24.14	25159151
1549	Ubiquitination	KTILENSVKHSKALN CCHHHCCHHHCHHHH	11.03	23000965
1550	Ubiquitination	TILENSVKHSKALNT CHHHCCHHHCHHHHC	41.82	23000965
1552	Ubiquitination	LENSVKHSKALNTLS HHCCHHHCHHHHCCC	17.57	23000965
1553	Ubiquitination	ENSVKHSKALNTLSS HCCHHHCHHHHCCCC	57.52	-
1553	Acetylation	ENSVKHSKALNTLSS HCCHHHCHHHHCCCC	57.52	23749302
1553	Ubiquitination	ENSVKHSKALNTLSS HCCHHHCHHHHCCCC	57.52	23000965
1557	Phosphorylation	KHSKALNTLSSPGQS HHCHHHHCCCCCCCC	28.94	27134283
1559	Phosphorylation	SKALNTLSSPGQSSF CHHHHCCCCCCCCCC	32.23	25159151
1560	Phosphorylation	KALNTLSSPGQSSFS HHHHCCCCCCCCCCC	35.84	25159151
1564	Phosphorylation	TLSSPGQSSFSHGTR CCCCCCCCCCCCCCC	38.99	25159151
1564	Ubiquitination	TLSSPGQSSFSHGTR CCCCCCCCCCCCCCC	38.99	21890473
1565	Phosphorylation	LSSPGQSSFSHGTRN CCCCCCCCCCCCCCC	23.92	25159151
1567	Phosphorylation	SPGQSSFSHGTRNNS CCCCCCCCCCCCCCH	23.97	21712546
1570	Phosphorylation	QSSFSHGTRNNSAKE CCCCCCCCCCCHHHH	25.46	26055452
1574	Phosphorylation	SHGTRNNSAKENMEK CCCCCCCHHHHHHHC	44.24	26074081
1591	Phosphorylation	PVKRKMKSSVLPKAS CCCHHHHHCCCCCCC	23.37	20068231
1592	Phosphorylation	VKRKMKSSVLPKAST CCHHHHHCCCCCCCC	23.35	20068231
1595	Ubiquitination	KMKSSVLPKASTLSK HHHHCCCCCCCCCCC	28.19	23000965
1596	Ubiquitination	MKSSVLPKASTLSKS HHHCCCCCCCCCCCC	51.30	23000965
1598	Phosphorylation	SSVLPKASTLSKSSA HCCCCCCCCCCCCCC	35.69	20068231
1599	Phosphorylation	SVLPKASTLSKSSAV CCCCCCCCCCCCCCE	39.65	20068231
1601	Phosphorylation	LPKASTLSKSSAVIE CCCCCCCCCCCCEEE	30.49	20068231
1601	Ubiquitination	LPKASTLSKSSAVIE CCCCCCCCCCCCEEE	30.49	23000965
1602	Ubiquitination	PKASTLSKSSAVIEQ CCCCCCCCCCCEEEC	52.09	-
1602	Acetylation	PKASTLSKSSAVIEQ CCCCCCCCCCCEEEC	52.09	25953088
1602	Ubiquitination	PKASTLSKSSAVIEQ CCCCCCCCCCCEEEC	52.09	23000965
1613	Acetylation	VIEQGDCKNNALVPG EEECCCCCCCCCCCC	58.96	26051181
1613	Ubiquitination	VIEQGDCKNNALVPG EEECCCCCCCCCCCC	58.96	32015554
1633	Acetylation	GHGGQPSKLVKRGPG CCCCCCCCCCCCCCC	65.07	25953088
1644	Sumoylation	RGPGRKPKVEVNTNS CCCCCCCCEEECCCC	54.80	28112733
1644	Ubiquitination	RGPGRKPKVEVNTNS CCCCCCCCEEECCCC	54.80	29967540
1649	Phosphorylation	KPKVEVNTNSGEIIH CCCEEECCCCCCEEE	35.62	24732914
1651	Phosphorylation	KVEVNTNSGEIIHKK CEEECCCCCCEEECC	35.45	25159151
1657	Acetylation	NSGEIIHKKRGRKPK CCCCEEECCCCCCCC	33.48	25953088
1670	Sumoylation	PKKLQYAKPEDLEQN CCCCCCCCHHHHHHC	43.96	28112733
1702	Ubiquitination	LSETNNVKEDLLQKK HHCCCCHHHHHHHHH	47.86	32015554
1724	Acetylation	KRKMKTQKLDADLLV CHHCCCCCCCHHHHH	54.27	26051181
1724	Ubiquitination	KRKMKTQKLDADLLV CHHCCCCCCCHHHHH	54.27	33845483
1734	Phosphorylation	ADLLVPASVKVLRRS HHHHHHHHHHHHHHC	19.19	30266825
1735	Ubiquitination	DLLVPASVKVLRRSN HHHHHHHHHHHHHCC	5.59	21890473
1736	Ubiquitination	LLVPASVKVLRRSNR HHHHHHHHHHHHCCC	32.81	-
1736	Acetylation	LLVPASVKVLRRSNR HHHHHHHHHHHHCCC	32.81	25953088
1736	Ubiquitination	LLVPASVKVLRRSNR HHHHHHHHHHHHCCC	32.81	23000965
1745	Ubiquitination	LRRSNRKKIDDPIDE HHHCCCCCCCCCCCH	48.40	29967540
1760	Ubiquitination	EEEFEELKGSEPHMR HHHHHHHCCCCCCCC	64.77	29967540
1762	Phosphorylation	EFEELKGSEPHMRTR HHHHHCCCCCCCCCC	46.50	25159151
1775	Phosphorylation	TRNQGRRTAFYNEDD CCCCCCCCCCCCCCC	21.54	23927012
1778	Phosphorylation	QGRRTAFYNEDDSEE CCCCCCCCCCCCCHH	18.38	23927012
1783	Phosphorylation	AFYNEDDSEEEQRQL CCCCCCCCHHHHHHH	60.26	22167270
1795	Phosphorylation	RQLLFEDTSLTFGTS HHHHHCCCCCCCCCC	20.59	20068231
1796	Phosphorylation	QLLFEDTSLTFGTSS HHHHCCCCCCCCCCC	37.42	20068231
1798	Phosphorylation	LFEDTSLTFGTSSRG HHCCCCCCCCCCCHH	21.56	27251275
1804	Methylation	LTFGTSSRGRVRKLT CCCCCCCHHHHHHHH	36.38	80702805
1815	Ubiquitination	RKLTEKAKANLIGW- HHHHHHHHHHHCCC-	49.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PHIP_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PHIP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PHIP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL4B_HUMAN	CUL4B	physical	16949367
CUL4A_HUMAN	CUL4A	physical	16949367
DDB1_HUMAN	DDB1	physical	16949367
DDB1_HUMAN	DDB1	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PHIP_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1497 AND LYS-1533, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1281; SER-1283;SER-1315; SER-1734 AND SER-1783, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1281; SER-1283; SER-1315AND SER-1783, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136; TYR-140; SER-911;SER-1281; SER-1283; SER-1405; SER-1479; THR-1480; SER-1734; SER-1762AND SER-1783, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-683, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-692; SER-832; SER-911;SER-1296; SER-1315; SER-1474; THR-1480; SER-1524; SER-1525; SER-1548;SER-1651 AND SER-1783, AND MASS SPECTROMETRY.	19007248 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1281; SER-1315;SER-1405; SER-1473 AND SER-1783, AND MASS SPECTROMETRY.	16565220 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-911; SER-1281; SER-1283;SER-1315; SER-1591 AND SER-1592, AND MASS SPECTROMETRY.	17081983 [Abstract]