WDFY1_HUMAN - dbPTM
WDFY1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WDFY1_HUMAN
UniProt AC Q8IWB7
Protein Name WD repeat and FYVE domain-containing protein 1
Gene Name WDFY1
Organism Homo sapiens (Human).
Sequence Length 410
Subcellular Localization Early endosome .
Protein Description Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines. [PubMed: 25736436]
Protein Sequence MAAEIHSRPQSSRPVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGHDKCVSWMCTRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWNMDVSREEAPQWLESDSCQKCEQPFFWNIKQMWDTKTLGLRQHHCRKCGQAVCGKCSSKRSSYPVMGFEFQVRVCDSCYDSIKDEDRTSLATFHEGKHNISHMSMDIARGLMVTCGTDRIVKIWDMTPVVGCSLATGFSPH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MAAEIHSRPQSSRP
-CCCCCCCCCCCCCC		51.8528348404
11PhosphorylationEIHSRPQSSRPVLLS
CCCCCCCCCCCEEHH		30.8822210691
12PhosphorylationIHSRPQSSRPVLLSK
CCCCCCCCCCEEHHH		35.0422210691
18PhosphorylationSSRPVLLSKIEGHQD
CCCCEEHHHCCCCCC		27.6822210691
35UbiquitinationTAALLIPKEDGVITA
EEEEEEECCCCEEEC		62.54-
41PhosphorylationPKEDGVITASEDRTI
ECCCCEEECCCCCEE		23.02-
46MethylationVITASEDRTIRVWLK
EEECCCCCEEEEEEE		28.18115919901
56PhosphorylationRVWLKRDSGQYWPSI
EEEEECCCCCCCCCE		31.6523401153
59PhosphorylationLKRDSGQYWPSIYHT
EECCCCCCCCCEEEE		23.8623401153
62PhosphorylationDSGQYWPSIYHTMAS
CCCCCCCCEEEECCC		22.9523401153
64PhosphorylationGQYWPSIYHTMASPC
CCCCCCEEEECCCCC		8.7923401153
66PhosphorylationYWPSIYHTMASPCSA
CCCCEEEECCCCCCH		9.4723401153
69PhosphorylationSIYHTMASPCSAMAY
CEEEECCCCCCHHCE		18.6723401153
72PhosphorylationHTMASPCSAMAYHHD
EECCCCCCHHCEECC		25.1823401153
76PhosphorylationSPCSAMAYHHDSRRI
CCCCHHCEECCCCEE		6.1324043423
80PhosphorylationAMAYHHDSRRIFVGQ
HHCEECCCCEEEEEC		21.0724043423
247PhosphorylationGHHDKVQSLCYLQLT
CCHHHHHHHHHHHHH		24.3228509920
306PhosphorylationKQMWDTKTLGLRQHH
HHHCCCCCCCCCHHH		28.3128857561
330PhosphorylationGKCSSKRSSYPVMGF
CCCCCCCCCCCCCCE		37.6522210691
331PhosphorylationKCSSKRSSYPVMGFE
CCCCCCCCCCCCCEE		37.1728555341
332PhosphorylationCSSKRSSYPVMGFEF
CCCCCCCCCCCCEEE		10.9028555341
346PhosphorylationFQVRVCDSCYDSIKD
EEEEECHHHHHHCCC		14.9522210691
348PhosphorylationVRVCDSCYDSIKDED
EEECHHHHHHCCCCC		19.3727642862
350PhosphorylationVCDSCYDSIKDEDRT
ECHHHHHHCCCCCCC		12.6928857561
352AcetylationDSCYDSIKDEDRTSL
HHHHHHCCCCCCCCH		60.0427452117
357PhosphorylationSIKDEDRTSLATFHE
HCCCCCCCCHHEEEC		40.1828555341
361PhosphorylationEDRTSLATFHEGKHN
CCCCCHHEEECCCCC		30.7128857561
370PhosphorylationHEGKHNISHMSMDIA
ECCCCCCCEECHHHH		20.6029759185
402PhosphorylationMTPVVGCSLATGFSP
CCCCCCCEECCCCCC		18.3429396449
405PhosphorylationVVGCSLATGFSPH--
CCCCEECCCCCCC--		44.0125106551
408PhosphorylationCSLATGFSPH-----
CEECCCCCCC-----		24.3325159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WDFY1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WDFY1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WDFY1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ALDOC_HUMANALDOCphysical
26344197
COX5B_HUMANCOX5Bphysical
26344197
EHD1_HUMANEHD1physical
26344197
FAH2A_HUMANFAHD2Aphysical
26344197
GDIA_HUMANGDI1physical
26344197
SNX1_HUMANSNX1physical
26344197
SNX2_HUMANSNX2physical
26344197
TPD54_HUMANTPD52L2physical
26344197
VAMP3_HUMANVAMP3physical
28514442
KCD21_HUMANKCTD21physical
28514442
SIR5_HUMANSIRT5physical
28514442
CCNB2_HUMANCCNB2physical
28514442
VAMP2_HUMANVAMP2physical
28514442
HMMR_HUMANHMMRphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WDFY1_HUMAN

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Related Literatures of Post-Translational Modification

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