FAH2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FAH2A_HUMAN
• UniProt AC: Q96GK7
• Protein Name: Fumarylacetoacetate hydrolase domain-containing protein 2A
• Gene Name: FAHD2A
• Organism: Homo sapiens (Human).
• Sequence Length: 314
• Protein Description: May have hydrolase activity..
• Protein Sequence: MLVSGRRRLLTVLLQAQKWPFQPSRDMRLVQFRAPHLVGPHLGLETGNGGGVINLNAFDPTLPKTMTQFLEQGEATLSVARRALAAQLPVLPRSEVTFLAPVTRPDKVVCVGMNYVDHCKEQNVPVPKEPIIFSKFASSIVGPYDEVVLPPQSQEVDWEVELAVVIGKKGKHIKATDAMAHVAGFTVAHDVSARDWQMRRNGKQWLLGKTFDTFCPLGPALVTKDSVADPHNLKICCRVNGEVVQSGNTNQMVFKTEDLIAWVSQFVTFYPGDVILTGTPPGVGVFRKPPVFLKKGDEVQCEIEELGVIINKVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
94	Phosphorylation	QLPVLPRSEVTFLAP CCCCCCCCCEEEEEE	34.18	22210691
120	Ubiquitination	MNYVDHCKEQNVPVP CCCCHHHHHCCCCCC	59.94	-
120	2-Hydroxyisobutyrylation	MNYVDHCKEQNVPVP CCCCHHHHHCCCCCC	59.94	-
128	Ubiquitination	EQNVPVPKEPIIFSK HCCCCCCCCCCEEEC	76.10	-
134	Phosphorylation	PKEPIIFSKFASSIV CCCCCEEECCCHHCC	19.22	24719451
174	Malonylation	GKKGKHIKATDAMAH CCCCCCCEEHHHHHH	44.98	26320211
192	Phosphorylation	FTVAHDVSARDWQMR CEEEEECCHHHHHHH	24.52	22210691
203	Acetylation	WQMRRNGKQWLLGKT HHHHHCCEEEEECCE	41.68	19608861
203	Ubiquitination	WQMRRNGKQWLLGKT HHHHHCCEEEEECCE	41.68	19608861
203	Malonylation	WQMRRNGKQWLLGKT HHHHHCCEEEEECCE	41.68	26320211
209	Ubiquitination	GKQWLLGKTFDTFCP CEEEEECCEECCCCC	46.09	-
213	Phosphorylation	LLGKTFDTFCPLGPA EECCEECCCCCCCCE	23.97	20068231
223	Phosphorylation	PLGPALVTKDSVADP CCCCEEECCCCCCCC	29.95	20068231
224	Ubiquitination	LGPALVTKDSVADPH CCCEEECCCCCCCCC	40.29	-
234	Malonylation	VADPHNLKICCRVNG CCCCCCCEEEEEECC	38.73	26320211
234	Ubiquitination	VADPHNLKICCRVNG CCCCCCCEEEEEECC	38.73	19608861
234	Acetylation	VADPHNLKICCRVNG CCCCCCCEEEEEECC	38.73	22642383
288	Ubiquitination	PGVGVFRKPPVFLKK CCCCCCCCCCEECCC	42.06	-
295	Ubiquitination	KPPVFLKKGDEVQCE CCCEECCCCCEEEEE	73.98	-
312	Ubiquitination	ELGVIINKVV----- ECEEEEEECC-----	33.69	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FAH2A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FAH2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FAH2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FAH2B_HUMAN	FAHD2B	physical	26186194
ODB2_HUMAN	DBT	physical	26186194
BOLA3_HUMAN	BOLA3	physical	26186194
FAH2B_HUMAN	FAHD2B	physical	28514442
BOLA3_HUMAN	BOLA3	physical	28514442
ODB2_HUMAN	DBT	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.