SIR5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIR5_HUMAN
• UniProt AC: Q9NXA8
• Protein Name: NAD-dependent protein deacylase sirtuin-5, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03160}
• Gene Name: SIRT5 {ECO:0000255|HAMAP-Rule:MF_03160}
• Organism: Homo sapiens (Human).
• Sequence Length: 310
• Subcellular Localization: Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus.; Isoform 1: Cyt
• Protein Description: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. [PubMed: 21908771]
• Protein Sequence: MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	TFRGAGGYWRKWQAQ CCCCCCCCCCCCCHH	10.92	-
87	Phosphorylation	WQAQDLATPLAFAHN CCHHHCCCHHHHHCC	26.57	-
160	Phosphorylation	NLLEIHGSLFKTRCT CHHHHCHHHCCCCCC	19.23	28857561
167	Phosphorylation	SLFKTRCTSCGVVAE HHCCCCCCCCCCEEE	24.62	29759185
168	Phosphorylation	LFKTRCTSCGVVAEN HCCCCCCCCCCEEEC	16.70	21060948
203	Ubiquitination	DASIPVEKLPRCEEA CCCCCHHHCCCCHHC	65.12	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIR5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIR5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIR5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TF65_HUMAN	RELA	physical	19135889
SIR3_HUMAN	SIRT3	physical	17715127
A4_HUMAN	APP	physical	21832049
GLSK_HUMAN	GLS	physical	25700560

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB04786: Suramin