SIR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIR3_HUMAN
• UniProt AC: Q9NTG7
• Protein Name: NAD-dependent protein deacetylase sirtuin-3, mitochondrial
• Gene Name: SIRT3
• Organism: Homo sapiens (Human).
• Sequence Length: 399
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: NAD-dependent protein deacetylase. [PubMed: 12186850]
• Protein Sequence: MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Methylation	DDVSAGLRGSHGARG CCCCCCCCCCCCCCC	43.58	24411429
57	Methylation	LRGSHGARGEPLDPA CCCCCCCCCCCCCCC	55.38	24411435
101	Phosphorylation	SIKGGRRSISFSVGA CCCCCCCEEEEEEEC	22.63	20068231
103	Phosphorylation	KGGRRSISFSVGASS CCCCCEEEEEEECCE	16.83	20068231
105	Phosphorylation	GRRSISFSVGASSVV CCCEEEEEEECCEEE	16.92	20068231
109	Phosphorylation	ISFSVGASSVVGSGG EEEEEECCEEECCCC	20.10	29449344
110	Phosphorylation	SFSVGASSVVGSGGS EEEEECCEEECCCCC	21.93	19690332
114	Phosphorylation	GASSVVGSGGSSDKG ECCEEECCCCCCCCC	28.50	20068231
117	Phosphorylation	SVVGSGGSSDKGKLS EEECCCCCCCCCCCC	38.60	20068231
118	Phosphorylation	VVGSGGSSDKGKLSL EECCCCCCCCCCCCH	46.76	20068231
122	Acetylation	GGSSDKGKLSLQDVA CCCCCCCCCCHHHHH	40.41	23236377
122	Succinylation	GGSSDKGKLSLQDVA CCCCCCCCCCHHHHH	40.41	-
122	Succinylation	GGSSDKGKLSLQDVA CCCCCCCCCCHHHHH	40.41	-
150	Phosphorylation	MVGAGISTPSGIPDF EECCCCCCCCCCCCC	21.39	-
159	Phosphorylation	SGIPDFRSPGSGLYS CCCCCCCCCCCCHHH	33.34	-
219	2-Hydroxyisobutyrylation	FLRLLHDKGLLLRLY HHHHHHHCCHHHHHH	40.48	-
226	Phosphorylation	KGLLLRLYTQNIDGL CCHHHHHHCCCCCCH	10.39	26329039
227	Phosphorylation	GLLLRLYTQNIDGLE CHHHHHHCCCCCCHH	21.52	26329039
276	Methylation	RADVMADRVPRCPVC CHHHHCCCCCCCCCC	30.70	115916993
284	Phosphorylation	VPRCPVCTGVVKPDI CCCCCCCCCCCCCCE	32.99	-
336	Phosphorylation	SLTEAVRSSVPRLLI HHHHHHHHCCCCHHC	29.14	26329039
337	Phosphorylation	LTEAVRSSVPRLLIN HHHHHHHCCCCHHCC	26.10	26329039
356	Methylation	GPLAWHPRSRDVAQL CCCCCCCCCCCHHHH	31.28	115916997
391	Phosphorylation	RDLVQRETGKLDGPD HHHHHHHHCCCCCCC	41.63	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
150	T	Phosphorylation	Kinase	CDK1	P06493	PSP
159	S	Phosphorylation	Kinase	CDK1	P06493	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	SKP2	Q13309	PMID:24658274

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FOXO3_HUMAN	FOXO3	physical	18781224
XRCC6_HUMAN	XRCC6	physical	18710944
TAT_HV1H2	tat	physical	15719057
ATPA_HUMAN	ATP5A1	physical	19343720
HSP74_HUMAN	HSPA4	physical	19343720
ATPB_HUMAN	ATP5B	physical	19343720
CH60_HUMAN	HSPD1	physical	19343720
CND1_HUMAN	NCAPD2	physical	19343720
GRN_HUMAN	GRN	physical	19343720
GRP78_HUMAN	HSPA5	physical	19343720
HS71L_HUMAN	HSPA1L	physical	19343720
ENPL_HUMAN	HSP90B1	physical	19343720
CMYA5_HUMAN	CMYA5	physical	19343720
PGAP1_HUMAN	PGAP1	physical	19343720
RIF1_HUMAN	RIF1	physical	19343720
GRP75_HUMAN	HSPA9	physical	19343720
MTMR5_HUMAN	SBF1	physical	19343720
HERC2_HUMAN	HERC2	physical	19343720
TTF2_HUMAN	TTF2	physical	19343720
SNTB1_HUMAN	SNTB1	physical	19343720
QCR6_HUMAN	UQCRH	physical	19343720
UGDH_HUMAN	UGDH	physical	19343720
CH60_HUMAN	HSPD1	physical	21840382
SKP2_HUMAN	SKP2	physical	23045395
SKP2_HUMAN	SKP2	physical	22770219
DMC1_HUMAN	DMC1	physical	26186194
MDM2_HUMAN	MDM2	physical	28196907
ODPA_HUMAN	PDHA1	physical	24486017
PDP1_HUMAN	PDP1	physical	24486017
SDHA_HUMAN	SDHA	physical	28514442
CH60_HUMAN	HSPD1	physical	28514442
DMC1_HUMAN	DMC1	physical	28514442
TMM25_HUMAN	TMEM25	physical	28514442
ALDH2_HUMAN	ALDH2	physical	28248093

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.