dbPTM

HSP74_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HSP74_HUMAN
UniProt AC	P34932
Protein Name	Heat shock 70 kDa protein 4
Gene Name	HSPA4
Organism	Homo sapiens (Human).
Sequence Length	840
Subcellular Localization	Cytoplasm .
Protein Description
Protein Sequence	MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISFGPKNRSIGAAAKSQVISNAKNTVQGFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAESVLKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGTMNRGKFLEMCNDLLARVEPPLRSVLEQTKLKKEDIYAVEIVGGATRIPAVKEKISKFFGKELSTTLNADEAVTRGCALQCAILSPAFKVREFSITDVVPYPISLRWNSPAEEGSSDCEVFSKNHAAPFSKVLTFYRKEPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSASLVEVHKSEENEEPMETDQNAKEEEKMQVDQEEPHVEEQQQQTPAENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVDLPIENQLLWQIDREMLNLYIENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSEDDRNSFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKNLGQPIKIRFQESEERPKLFEELGKQIQQYMKIISSFKNKEDQYDHLDAADMTKVEKSTNEAMEWMNNKLNLQNKQSLTMDPVVKSKEIEAKIKELTSTCSPIISKPKPKVEPPKEEQKNAEQNGPVDGQGDNPGPQAAEQGTDTAVPSDSDKKLPEMDID

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSVVGIDLG ------CCEEEEECC	26.05	24043423
12	Phosphorylation	GIDLGFQSCYVAVAR EEECCCCCEEEEHHH	12.73	24719451
14	Phosphorylation	DLGFQSCYVAVARAG ECCCCCEEEEHHHHC	9.18	24043423
30	Phosphorylation	IETIANEYSDRCTPA HHHHHHHCCCCCCHH	18.71	28152594
31	Phosphorylation	ETIANEYSDRCTPAC HHHHHHCCCCCCHHH	16.64	28152594
33	Methylation	IANEYSDRCTPACIS HHHHCCCCCCHHHHC	21.92	115479747
34	S-nitrosocysteine	ANEYSDRCTPACISF HHHCCCCCCHHHHCC	6.84	-
34	S-nitrosylation	ANEYSDRCTPACISF HHHCCCCCCHHHHCC	6.84	19483679
38	S-nitrosocysteine	SDRCTPACISFGPKN CCCCCHHHHCCCCCC	2.56	-
38	S-nitrosylation	SDRCTPACISFGPKN CCCCCHHHHCCCCCC	2.56	19483679
44	Acetylation	ACISFGPKNRSIGAA HHHCCCCCCCCCCHH	66.43	26051181
44	Ubiquitination	ACISFGPKNRSIGAA HHHCCCCCCCCCCHH	66.43	24816145
47	Phosphorylation	SFGPKNRSIGAAAKS CCCCCCCCCCHHHHH	34.46	21406692
53	Acetylation	RSIGAAAKSQVISNA CCCCHHHHHHHHHCC	36.37	25953088
53	Malonylation	RSIGAAAKSQVISNA CCCCHHHHHHHHHCC	36.37	26320211
53	Ubiquitination	RSIGAAAKSQVISNA CCCCHHHHHHHHHCC	36.37	21906983
54	Phosphorylation	SIGAAAKSQVISNAK CCCHHHHHHHHHCCC	25.59	28985074
58	Phosphorylation	AAKSQVISNAKNTVQ HHHHHHHHCCCHHHH	31.70	21406692
61	Acetylation	SQVISNAKNTVQGFK HHHHHCCCHHHHHHH	58.35	25953088
61	Malonylation	SQVISNAKNTVQGFK HHHHHCCCHHHHHHH	58.35	26320211
61	Ubiquitination	SQVISNAKNTVQGFK HHHHHCCCHHHHHHH	58.35	29967540
68	Acetylation	KNTVQGFKRFHGRAF CHHHHHHHHHCCCCC	62.06	25953088
68	Succinylation	KNTVQGFKRFHGRAF CHHHHHHHHHCCCCC	62.06	23954790
68	Ubiquitination	KNTVQGFKRFHGRAF CHHHHHHHHHCCCCC	62.06	27667366
76	Phosphorylation	RFHGRAFSDPFVEAE HHCCCCCCCCCHHHH	43.31	19664994
84	Ubiquitination	DPFVEAEKSNLAYDI CCCHHHHHCCCCEEE	52.25	29967540
85	Phosphorylation	PFVEAEKSNLAYDIV CCHHHHHCCCCEEEE	28.69	27050516
89	Phosphorylation	AEKSNLAYDIVQLPT HHHCCCCEEEEECCC	14.90	22817900
96	Phosphorylation	YDIVQLPTGLTGIKV EEEEECCCCCCCCEE	54.11	-
99	Phosphorylation	VQLPTGLTGIKVTYM EECCCCCCCCEEEEE	37.90	-
102	Ubiquitination	PTGLTGIKVTYMEEE CCCCCCCEEEEEHHH	29.84	-
106	Sulfoxidation	TGIKVTYMEEERNFT CCCEEEEEHHHCCCC	3.69	21406390
113	Phosphorylation	MEEERNFTTEQVTAM EHHHCCCCHHHHHHH	32.73	19664995
114	Phosphorylation	EEERNFTTEQVTAML HHHCCCCHHHHHHHH	21.93	19664995
118	Phosphorylation	NFTTEQVTAMLLSKL CCCHHHHHHHHHHHH	13.17	19664995
120	Sulfoxidation	TTEQVTAMLLSKLKE CHHHHHHHHHHHHHH	2.56	21406390
123	Phosphorylation	QVTAMLLSKLKETAE HHHHHHHHHHHHHHH	31.79	21712546
124	Ubiquitination	VTAMLLSKLKETAES HHHHHHHHHHHHHHH	64.64	21906983
126	Acetylation	AMLLSKLKETAESVL HHHHHHHHHHHHHHH	57.67	26051181
126	Ubiquitination	AMLLSKLKETAESVL HHHHHHHHHHHHHHH	57.67	21906983
134	Ubiquitination	ETAESVLKKPVVDCV HHHHHHHCCCCCEEE	53.53	33845483
135	Acetylation	TAESVLKKPVVDCVV HHHHHHCCCCCEEEE	38.59	26051181
135	Ubiquitination	TAESVLKKPVVDCVV HHHHHHCCCCCEEEE	38.59	-
148	Phosphorylation	VVSVPCFYTDAERRS EEECCCCCCCHHHCC	15.49	28152594
149	Phosphorylation	VSVPCFYTDAERRSV EECCCCCCCHHHCCC	14.42	28152594
155	Phosphorylation	YTDAERRSVMDATQI CCCHHHCCCCHHHHH	28.19	21712546
157	Sulfoxidation	DAERRSVMDATQIAG CHHHCCCCHHHHHHC	2.82	30846556
167	Glutathionylation	TQIAGLNCLRLMNET HHHHCHHHHHHCCHH	2.55	22555962
184	Phosphorylation	VALAYGIYKQDLPAL HHHHHCHHHCCCHHH	9.76	-
185	Ubiquitination	ALAYGIYKQDLPALE HHHHCHHHCCCHHHH	35.10	-
194	Acetylation	DLPALEEKPRNVVFV CCHHHHCCCCCEEEE	39.64	23749302
194	Ubiquitination	DLPALEEKPRNVVFV CCHHHHCCCCCEEEE	39.64	21906983
219	Ubiquitination	VCAFNRGKLKVLATA EEEECCCCEEEEEEE	41.73	22817900
221	Ubiquitination	AFNRGKLKVLATAFD EECCCCEEEEEEEEC	38.39	21906983
229	Phosphorylation	VLATAFDTTLGGRKF EEEEEECCCCCCCCH	19.91	23186163
230	Phosphorylation	LATAFDTTLGGRKFD EEEEECCCCCCCCHH	25.83	21601212
235	Acetylation	DTTLGGRKFDEVLVN CCCCCCCCHHHHHHH	61.51	26051181
235	Ubiquitination	DTTLGGRKFDEVLVN CCCCCCCCHHHHHHH	61.51	23000965
245	S-nitrosocysteine	EVLVNHFCEEFGKKY HHHHHHHHHHHCHHH	3.68	-
245	S-nitrosylation	EVLVNHFCEEFGKKY HHHHHHHHHHHCHHH	3.68	20140087
250	Acetylation	HFCEEFGKKYKLDIK HHHHHHCHHHCCCHH	59.24	25953088
250	Ubiquitination	HFCEEFGKKYKLDIK HHHHHHCHHHCCCHH	59.24	32015554
257	Acetylation	KKYKLDIKSKIRALL HHHCCCHHHHHHHHH	45.42	25953088
257	Ubiquitination	KKYKLDIKSKIRALL HHHCCCHHHHHHHHH	45.42	27667366
265	Methylation	SKIRALLRLSQECEK HHHHHHHHHHHHHHH	32.89	115479755
272	Acetylation	RLSQECEKLKKLMSA HHHHHHHHHHHHHHC	76.81	23749302
272	Ubiquitination	RLSQECEKLKKLMSA HHHHHHHHHHHHHHC	76.81	33845483
278	Phosphorylation	EKLKKLMSANASDLP HHHHHHHHCCHHHCC	28.89	28176443
282	Phosphorylation	KLMSANASDLPLSIE HHHHCCHHHCCCEEE	39.21	28176443
287	Phosphorylation	NASDLPLSIECFMND CHHHCCCEEEEHHCC	17.88	28176443
290	Glutathionylation	DLPLSIECFMNDVDV HCCCEEEEHHCCCCC	3.60	22555962
298	Phosphorylation	FMNDVDVSGTMNRGK HHCCCCCCCCCCHHH	24.88	28176443
300	Phosphorylation	NDVDVSGTMNRGKFL CCCCCCCCCCHHHHH	12.08	28176443
305	Acetylation	SGTMNRGKFLEMCND CCCCCHHHHHHHHHH	43.47	25953088
305	Ubiquitination	SGTMNRGKFLEMCND CCCCCHHHHHHHHHH	43.47	22053931
309	Sulfoxidation	NRGKFLEMCNDLLAR CHHHHHHHHHHHHHH	2.55	21406390
310	Glutathionylation	RGKFLEMCNDLLARV HHHHHHHHHHHHHHC	2.33	22555962
329	Acetylation	RSVLEQTKLKKEDIY HHHHHHHCCCHHCEE	58.99	23749302
329	Malonylation	RSVLEQTKLKKEDIY HHHHHHHCCCHHCEE	58.99	26320211
329	Ubiquitination	RSVLEQTKLKKEDIY HHHHHHHCCCHHCEE	58.99	32015554
331	Acetylation	VLEQTKLKKEDIYAV HHHHHCCCHHCEEEE	56.52	25953088
331	Ubiquitination	VLEQTKLKKEDIYAV HHHHHCCCHHCEEEE	56.52	29967540
332	Ubiquitination	LEQTKLKKEDIYAVE HHHHCCCHHCEEEEE	71.68	29967540
336	Nitration	KLKKEDIYAVEIVGG CCCHHCEEEEEEECC	19.54	-
336	Phosphorylation	KLKKEDIYAVEIVGG CCCHHCEEEEEEECC	19.54	27273156
345	Phosphorylation	VEIVGGATRIPAVKE EEEECCCCCCHHHHH	32.19	28152594
351	Ubiquitination	ATRIPAVKEKISKFF CCCCHHHHHHHHHHH	56.23	33845483
353	Ubiquitination	RIPAVKEKISKFFGK CCHHHHHHHHHHHCC	46.71	-
356	Acetylation	AVKEKISKFFGKELS HHHHHHHHHHCCHHH	48.46	23749302
356	Ubiquitination	AVKEKISKFFGKELS HHHHHHHHHHCCHHH	48.46	22817900
360	Ubiquitination	KISKFFGKELSTTLN HHHHHHCCHHHHCCC	50.77	21906983
363	Phosphorylation	KFFGKELSTTLNADE HHHCCHHHHCCCHHH	22.04	26437602
364	Phosphorylation	FFGKELSTTLNADEA HHCCHHHHCCCHHHH	48.18	21406692
365	Phosphorylation	FGKELSTTLNADEAV HCCHHHHCCCHHHHH	18.03	20068231
373	Phosphorylation	LNADEAVTRGCALQC CCHHHHHHHHHHHHH	28.52	21406692
376	Glutathionylation	DEAVTRGCALQCAIL HHHHHHHHHHHHHHH	2.85	22555962
376	S-palmitoylation	DEAVTRGCALQCAIL HHHHHHHHHHHHHHH	2.85	29575903
380	S-palmitoylation	TRGCALQCAILSPAF HHHHHHHHHHHCCCE	2.37	29575903
384	Phosphorylation	ALQCAILSPAFKVRE HHHHHHHCCCEEEEE	14.20	25159151
388	Methylation	AILSPAFKVREFSIT HHHCCCEEEEEEECC	42.35	7869861
388	Ubiquitination	AILSPAFKVREFSIT HHHCCCEEEEEEECC	42.35	32142685
393	Phosphorylation	AFKVREFSITDVVPY CEEEEEEECCEEEEC	21.59	27050516
395	Phosphorylation	KVREFSITDVVPYPI EEEEEECCEEEECCC	22.88	20068231
400	Phosphorylation	SITDVVPYPISLRWN ECCEEEECCCEEECC	11.11	20068231
403	Phosphorylation	DVVPYPISLRWNSPA EEEECCCEEECCCCC	13.84	20068231
408	Phosphorylation	PISLRWNSPAEEGSS CCEEECCCCCCCCCC	20.66	30576142
414	Phosphorylation	NSPAEEGSSDCEVFS CCCCCCCCCCCEECC	26.70	23927012
415	Phosphorylation	SPAEEGSSDCEVFSK CCCCCCCCCCEECCC	58.08	23927012
417	S-nitrosocysteine	AEEGSSDCEVFSKNH CCCCCCCCEECCCCC	5.33	-
417	Glutathionylation	AEEGSSDCEVFSKNH CCCCCCCCEECCCCC	5.33	22555962
417	S-nitrosylation	AEEGSSDCEVFSKNH CCCCCCCCEECCCCC	5.33	19483679
417	S-palmitoylation	AEEGSSDCEVFSKNH CCCCCCCCEECCCCC	5.33	26865113
421	Phosphorylation	SSDCEVFSKNHAAPF CCCCEECCCCCCCCH	37.41	23927012
422	Acetylation	SDCEVFSKNHAAPFS CCCEECCCCCCCCHH	41.09	23749302
422	Ubiquitination	SDCEVFSKNHAAPFS CCCEECCCCCCCCHH	41.09	21963094
429	Phosphorylation	KNHAAPFSKVLTFYR CCCCCCHHHHEEEEE	22.31	20363803
430	Acetylation	NHAAPFSKVLTFYRK CCCCCHHHHEEEEEC	41.46	19608861
430	Malonylation	NHAAPFSKVLTFYRK CCCCCHHHHEEEEEC	41.46	26320211
430	Ubiquitination	NHAAPFSKVLTFYRK CCCCCHHHHEEEEEC	41.46	23000965
433	Phosphorylation	APFSKVLTFYRKEPF CCHHHHEEEEECCCE	22.93	23312004
435	Phosphorylation	FSKVLTFYRKEPFTL HHHHEEEEECCCEEE	18.62	25839225
437	Ubiquitination	KVLTFYRKEPFTLEA HHEEEEECCCEEEEE	59.36	22817900
466	Ubiquitination	IAQFSVQKVTPQSDG HEEEEEEEEECCCCC	46.01	29967540
468	Phosphorylation	QFSVQKVTPQSDGSS EEEEEEEECCCCCCC	23.73	21406692
471	Phosphorylation	VQKVTPQSDGSSSKV EEEEECCCCCCCCCE	45.18	20068231
474	Phosphorylation	VTPQSDGSSSKVKVK EECCCCCCCCCEEEE	36.11	20068231
475	Phosphorylation	TPQSDGSSSKVKVKV ECCCCCCCCCEEEEE	39.44	30576142
476	Phosphorylation	PQSDGSSSKVKVKVR CCCCCCCCCEEEEEE	43.07	20068231
477	Acetylation	QSDGSSSKVKVKVRV CCCCCCCCEEEEEEE	48.28	25953088
477	Ubiquitination	QSDGSSSKVKVKVRV CCCCCCCCEEEEEEE	48.28	33845483
479	Ubiquitination	DGSSSKVKVKVRVNV CCCCCCEEEEEEEEE	39.82	-
491	Phosphorylation	VNVHGIFSVSSASLV EEEEEEEEEECCEEE	21.11	29255136
493	Phosphorylation	VHGIFSVSSASLVEV EEEEEEEECCEEEEE	20.98	29255136
494	Phosphorylation	HGIFSVSSASLVEVH EEEEEEECCEEEEEC	21.52	29255136
503	Phosphorylation	SLVEVHKSEENEEPM EEEEECCCCCCCCCC	34.95	21601212
512	Phosphorylation	ENEEPMETDQNAKEE CCCCCCCCCCCHHHH	36.31	21601212
517	Ubiquitination	METDQNAKEEEKMQV CCCCCCHHHHHHCCC	73.53	21906983
521	Ubiquitination	QNAKEEEKMQVDQEE CCHHHHHHCCCCCCC	37.60	22817900
538	Phosphorylation	VEEQQQQTPAENKAE HHHHHHCCCCCHHHH	21.81	25159151
543	Ubiquitination	QQTPAENKAESEEME HCCCCCHHHHHHHHH	45.06	21906983
546	Phosphorylation	PAENKAESEEMETSQ CCCHHHHHHHHHHHC	43.65	19664994
549	Sulfoxidation	NKAESEEMETSQAGS HHHHHHHHHHHCCCC	6.29	30846556
551	Phosphorylation	AESEEMETSQAGSKD HHHHHHHHHCCCCCC	25.48	30576142
552	Phosphorylation	ESEEMETSQAGSKDK HHHHHHHHCCCCCCC	12.53	17525332
556	Phosphorylation	METSQAGSKDKKMDQ HHHHCCCCCCCCCCC	40.47	30576142
557	Trimethylation	ETSQAGSKDKKMDQP HHHCCCCCCCCCCCC	73.06	-
557	Acetylation	ETSQAGSKDKKMDQP HHHCCCCCCCCCCCC	73.06	23236377
557	Methylation	ETSQAGSKDKKMDQP HHHCCCCCCCCCCCC	73.06	23644510
557	Ubiquitination	ETSQAGSKDKKMDQP HHHCCCCCCCCCCCC	73.06	21906983
559	Trimethylation	SQAGSKDKKMDQPPQ HCCCCCCCCCCCCCC	54.45	-
559	Acetylation	SQAGSKDKKMDQPPQ HCCCCCCCCCCCCCC	54.45	26051181
559	Methylation	SQAGSKDKKMDQPPQ HCCCCCCCCCCCCCC	54.45	23644510
559	Ubiquitination	SQAGSKDKKMDQPPQ HCCCCCCCCCCCCCC	54.45	22817900
560	Ubiquitination	QAGSKDKKMDQPPQA CCCCCCCCCCCCCCH	58.82	22817900
561	Sulfoxidation	AGSKDKKMDQPPQAK CCCCCCCCCCCCCHH	7.73	30846556
568	Ubiquitination	MDQPPQAKKAKVKTS CCCCCCHHCCCCCEE	48.28	21906983
569	Ubiquitination	DQPPQAKKAKVKTST CCCCCHHCCCCCEEC	57.36	22817900
571	Ubiquitination	PPQAKKAKVKTSTVD CCCHHCCCCCEECCC	53.82	22817900
573	Ubiquitination	QAKKAKVKTSTVDLP CHHCCCCCEECCCCC	35.73	21906983
574	Phosphorylation	AKKAKVKTSTVDLPI HHCCCCCEECCCCCH	32.39	21712546
575	Phosphorylation	KKAKVKTSTVDLPIE HCCCCCEECCCCCHH	22.25	25693802
576	Phosphorylation	KAKVKTSTVDLPIEN CCCCCEECCCCCHHH	24.22	18669648
593	Sulfoxidation	LWQIDREMLNLYIEN HHHCCHHHHHHHHHC	2.91	30846556
603	Acetylation	LYIENEGKMIMQDKL HHHHCCCEEHHHHHH	21.05	129921
603	Ubiquitination	LYIENEGKMIMQDKL HHHHCCCEEHHHHHH	21.05	29901268
604	Sulfoxidation	YIENEGKMIMQDKLE HHHCCCEEHHHHHHH	4.54	30846556
606	Sulfoxidation	ENEGKMIMQDKLEKE HCCCEEHHHHHHHHH	3.64	30846556
609	Ubiquitination	GKMIMQDKLEKERND CEEHHHHHHHHHHHH	41.47	21890473
612	Ubiquitination	IMQDKLEKERNDAKN HHHHHHHHHHHHHHH	72.85	22817900
618	Ubiquitination	EKERNDAKNAVEEYV HHHHHHHHHHHHHHH	48.59	32015554
624	Phosphorylation	AKNAVEEYVYEMRDK HHHHHHHHHHHHHHH	8.53	29978859
626	Phosphorylation	NAVEEYVYEMRDKLS HHHHHHHHHHHHHCC	11.78	28450419
628	Sulfoxidation	VEEYVYEMRDKLSGE HHHHHHHHHHHCCCC	3.53	28465586
631	Acetylation	YVYEMRDKLSGEYEK HHHHHHHHCCCCHHH	33.90	23749302
631	Ubiquitination	YVYEMRDKLSGEYEK HHHHHHHHCCCCHHH	33.90	33845483
633	Phosphorylation	YEMRDKLSGEYEKFV HHHHHHCCCCHHHCC	35.01	28796482
636	Phosphorylation	RDKLSGEYEKFVSED HHHCCCCHHHCCCCC	28.13	28796482
638	Ubiquitination	KLSGEYEKFVSEDDR HCCCCHHHCCCCCCC	50.60	23000965
641	Phosphorylation	GEYEKFVSEDDRNSF CCHHHCCCCCCCCCE	38.14	28176443
645	Methylation	KFVSEDDRNSFTLKL HCCCCCCCCCEEEEE	53.68	115479763
647	Phosphorylation	VSEDDRNSFTLKLED CCCCCCCCEEEEEEE	22.09	23401153
649	Phosphorylation	EDDRNSFTLKLEDTE CCCCCCEEEEEEECC	23.86	30266825
660	Phosphorylation	EDTENWLYEDGEDQP EECCCCCCCCCCCCC	12.00	18083107
668	Ubiquitination	EDGEDQPKQVYVDKL CCCCCCCCEEEHHHH	46.92	23000965
671	Phosphorylation	EDQPKQVYVDKLAEL CCCCCEEEHHHHHHH	10.63	28152594
674	Acetylation	PKQVYVDKLAELKNL CCEEEHHHHHHHHHC	39.28	23749302
674	Ubiquitination	PKQVYVDKLAELKNL CCEEEHHHHHHHHHC	39.28	23000965
679	Acetylation	VDKLAELKNLGQPIK HHHHHHHHHCCCCEE	41.45	19608861
679	Malonylation	VDKLAELKNLGQPIK HHHHHHHHHCCCCEE	41.45	26320211
679	Ubiquitination	VDKLAELKNLGQPIK HHHHHHHHHCCCCEE	41.45	23000965
686	Acetylation	KNLGQPIKIRFQESE HHCCCCEEEEECCCC	34.22	25953088
686	Malonylation	KNLGQPIKIRFQESE HHCCCCEEEEECCCC	34.22	26320211
686	Ubiquitination	KNLGQPIKIRFQESE HHCCCCEEEEECCCC	34.22	23000965
692	Phosphorylation	IKIRFQESEERPKLF EEEEECCCCHHHHHH	33.69	28985074
697	Acetylation	QESEERPKLFEELGK CCCCHHHHHHHHHHH	72.53	25953088
697	Ubiquitination	QESEERPKLFEELGK CCCCHHHHHHHHHHH	72.53	22817900
704	Ubiquitination	KLFEELGKQIQQYMK HHHHHHHHHHHHHHH	57.78	23000965
711	Acetylation	KQIQQYMKIISSFKN HHHHHHHHHHHHCCC	31.77	25953088
711	Ubiquitination	KQIQQYMKIISSFKN HHHHHHHHHHHHCCC	31.77	22817900
717	Ubiquitination	MKIISSFKNKEDQYD HHHHHHCCCCHHHCC	69.89	32015554
719	Acetylation	IISSFKNKEDQYDHL HHHHCCCCHHHCCCC	64.36	26051181
719	Ubiquitination	IISSFKNKEDQYDHL HHHHCCCCHHHCCCC	64.36	22817900
723	Phosphorylation	FKNKEDQYDHLDAAD CCCCHHHCCCCCHHH	20.04	25884760
733	Acetylation	LDAADMTKVEKSTNE CCHHHHHHHHHHHHH	41.58	23236377
733	Ubiquitination	LDAADMTKVEKSTNE CCHHHHHHHHHHHHH	41.58	33845483
736	Acetylation	ADMTKVEKSTNEAME HHHHHHHHHHHHHHH	66.62	25953088
736	Ubiquitination	ADMTKVEKSTNEAME HHHHHHHHHHHHHHH	66.62	22817900
742	Sulfoxidation	EKSTNEAMEWMNNKL HHHHHHHHHHHHHHH	3.18	30846556
745	Sulfoxidation	TNEAMEWMNNKLNLQ HHHHHHHHHHHHCCC	2.23	30846556
748	Acetylation	AMEWMNNKLNLQNKQ HHHHHHHHHCCCCCC	33.47	25953088
748	Ubiquitination	AMEWMNNKLNLQNKQ HHHHHHHHHCCCCCC	33.47	23000965
754	Malonylation	NKLNLQNKQSLTMDP HHHCCCCCCCCCCCC	28.44	26320211
754	Ubiquitination	NKLNLQNKQSLTMDP HHHCCCCCCCCCCCC	28.44	23000965
756	Phosphorylation	LNLQNKQSLTMDPVV HCCCCCCCCCCCCCC	27.67	23186163
758	Phosphorylation	LQNKQSLTMDPVVKS CCCCCCCCCCCCCCH	25.44	23186163
759	Sulfoxidation	QNKQSLTMDPVVKSK CCCCCCCCCCCCCHH	7.13	21406390
764	Acetylation	LTMDPVVKSKEIEAK CCCCCCCCHHHHHHH	56.92	25953088
766	Acetylation	MDPVVKSKEIEAKIK CCCCCCHHHHHHHHH	57.92	26210075
771	Ubiquitination	KSKEIEAKIKELTST CHHHHHHHHHHHHHC	41.33	23000965
773	Methylation	KEIEAKIKELTSTCS HHHHHHHHHHHHCCC	46.06	24129315
773	Ubiquitination	KEIEAKIKELTSTCS HHHHHHHHHHHHCCC	46.06	23000965
776	Phosphorylation	EAKIKELTSTCSPII HHHHHHHHHCCCCCC	24.07	20068231
777	Phosphorylation	AKIKELTSTCSPIIS HHHHHHHHCCCCCCC	39.79	28102081
778	Phosphorylation	KIKELTSTCSPIISK HHHHHHHCCCCCCCC	16.27	29978859
780	Phosphorylation	KELTSTCSPIISKPK HHHHHCCCCCCCCCC	21.15	25159151
784	Phosphorylation	STCSPIISKPKPKVE HCCCCCCCCCCCCCC	43.56	23898821
785	Acetylation	TCSPIISKPKPKVEP CCCCCCCCCCCCCCC	46.80	25953088
785	Ubiquitination	TCSPIISKPKPKVEP CCCCCCCCCCCCCCC	46.80	21906983
787	Ubiquitination	SPIISKPKPKVEPPK CCCCCCCCCCCCCCH	62.30	29967540
789	Ubiquitination	IISKPKPKVEPPKEE CCCCCCCCCCCCHHH	66.41	22817900
794	Ubiquitination	KPKVEPPKEEQKNAE CCCCCCCHHHHCCHH	81.98	21906983
798	Ubiquitination	EPPKEEQKNAEQNGP CCCHHHHCCHHHCCC	62.50	22817900
822	Phosphorylation	PQAAEQGTDTAVPSD HHHHHHCCCCCCCCC	29.85	25850435
824	Phosphorylation	AAEQGTDTAVPSDSD HHHHCCCCCCCCCCC	29.41	25850435
828	Phosphorylation	GTDTAVPSDSDKKLP CCCCCCCCCCCCCCC	43.05	25159151
830	Phosphorylation	DTAVPSDSDKKLPEM CCCCCCCCCCCCCCC	56.52	25850435
832	Acetylation	AVPSDSDKKLPEMDI CCCCCCCCCCCCCCC	61.23	26051181
832	Ubiquitination	AVPSDSDKKLPEMDI CCCCCCCCCCCCCCC	61.23	27667366
833	Ubiquitination	VPSDSDKKLPEMDID CCCCCCCCCCCCCCC	74.41	-
837	Sulfoxidation	SDKKLPEMDID---- CCCCCCCCCCC----	5.30	21406390

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	TRAF6	Q9Y4K3	PMID:14702098
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:19648119

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HSP74_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HSP74_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TTC1_HUMAN	TTC1	physical	14503850
HPBP1_HUMAN	HSPBP1	physical	14503850
DNJB1_HUMAN	DNAJB1	physical	14503850
HDAC1_HUMAN	HDAC1	physical	11777905
HDAC2_HUMAN	HDAC2	physical	11777905
CDC73_HUMAN	CDC73	physical	16169070
NQO1_HUMAN	NQO1	physical	11821413
SGTA_HUMAN	SGTA	physical	12482202
APAF_HUMAN	APAF1	physical	10934467
K1C18_HUMAN	KRT18	physical	7529764
PRKN_HUMAN	PARK2	physical	18248624
LIMK1_HUMAN	LIMK1	physical	17512523
KPCB_HUMAN	PRKCB	physical	16954220
TERA_HUMAN	VCP	physical	16621797
PARK7_HUMAN	PARK7	physical	15525661
SODC_HUMAN	SOD1	physical	15198682
HIF1A_HUMAN	HIF1A	physical	16507982
CUL5_HUMAN	CUL5	physical	19933325
FANCC_HUMAN	FANCC	physical	11500375
COMD1_HUMAN	COMMD1	physical	19802386
CHIP_HUMAN	STUB1	physical	17317785
A4_HUMAN	APP	physical	17317785
CHIP_HUMAN	STUB1	physical	21454478
ERG_HUMAN	ERG	physical	21183741
ABC3G_HUMAN	APOBEC3G	physical	21228271
VIF_HV1B1	vif	physical	21228271
VIF_HV1BR	vif	physical	21228271
VIF_HV1H2	vif	physical	21228271
NEP_HUMAN	MME	physical	17342744
UBE3A_HUMAN	UBE3A	physical	19233847
M3K5_HUMAN	MAP3K5	physical	20349136
CHIP_HUMAN	STUB1	physical	20349136
TRIA1_HUMAN	TRIAP1	physical	15735003
BAG5_HUMAN	BAG5	physical	15603737
PRKN_HUMAN	PARK2	physical	15603737
APAF_HUMAN	APAF1	physical	22143029
TF65_HUMAN	RELA	physical	9250404
REL_HUMAN	REL	physical	9250404
NFKB1_HUMAN	NFKB1	physical	9250404
TLR4_HUMAN	TLR4	physical	22461698
HSF1_HUMAN	HSF1	physical	14532117
CHIP_HUMAN	STUB1	physical	14532117
BAG3_HUMAN	BAG3	physical	19229298
BAG1_HUMAN	BAG1	physical	19229298
B2L11_HUMAN	BCL2L11	physical	19622774
KCNH2_HUMAN	KCNH2	physical	12775586
CRYAB_HUMAN	CRYAB	physical	12812987
CHIP_HUMAN	STUB1	physical	21775628
HOP_HUMAN	HOPX	physical	22824801
CHIP_HUMAN	STUB1	physical	22824801
APRIO_HUMAN	PRNP	physical	20964628
PRIO_HUMAN	PRNP	physical	20964628
FAF1_HUMAN	FAF1	physical	15596450
DDIT4_HUMAN	DDIT4	physical	16713569
CHIP_HUMAN	STUB1	physical	20661446
FKBP5_HUMAN	FKBP5	physical	20661446
DNJC7_HUMAN	DNAJC7	physical	20661446
HSP7C_HUMAN	HSPA8	physical	18408180
HS90A_HUMAN	HSP90AA1	physical	18408180
NUB1_HUMAN	NUB1	physical	18408180
PHLA1_HUMAN	PHLDA1	physical	17024176
SYUA_HUMAN	SNCA	physical	17010992
SYUA_HUMAN	SNCA	physical	21985244
TCPA_HUMAN	TCP1	physical	14532270
HSP7C_HUMAN	HSPA8	physical	22939629
RSSA_HUMAN	RPSA	physical	22939629
TOX4_HUMAN	TOX4	physical	22939629
NAL12_HUMAN	NLRP12	physical	17947705
TAU_HUMAN	MAPT	physical	23271055
CHIP_HUMAN	STUB1	physical	23271055
OLA1_HUMAN	OLA1	physical	23412384
CHIP_HUMAN	STUB1	physical	23412384
CHIP_HUMAN	STUB1	physical	23410750
PLK1_HUMAN	PLK1	physical	21887822
GRAB_HUMAN	GZMB	physical	12874291
MTOR_HUMAN	MTOR	physical	18505677
RICTR_HUMAN	RICTOR	physical	18505677
RAF1_HUMAN	RAF1	physical	16093354
MGRN1_HUMAN	MGRN1	physical	23756845
BAG3_HUMAN	BAG3	physical	23824909
STIP1_HUMAN	STIP1	physical	11877417
CAND1_HUMAN	CAND1	physical	22863883
HS105_HUMAN	HSPH1	physical	22863883
PLAK_HUMAN	JUP	physical	22863883
SYK_HUMAN	KARS	physical	22863883
PPM1G_HUMAN	PPM1G	physical	22863883
RNBP6_HUMAN	RANBP6	physical	22863883
RO60_HUMAN	TROVE2	physical	22863883
NDRG1_HUMAN	NDRG1	physical	19622774
PA2G4_HUMAN	PA2G4	physical	24651434
TRIM5_MACMU	TRIM5	physical	20053985
HIF1A_HUMAN	HIF1A	physical	23722539
P53_HUMAN	TP53	physical	25144556
TRAF6_HUMAN	TRAF6	physical	16697380
S12A3_MOUSE	Slc12a3	physical	22027832
APBP2_HUMAN	APPBP2	physical	25416956
ATRAP_HUMAN	AGTRAP	physical	25416956
MIM1_YEAST	MIM1	physical	23959800
P53_HUMAN	TP53	physical	23109422
VEGFA_HUMAN	VEGFA	physical	23109422
PGH2_HUMAN	PTGS2	physical	23109422
TCPB_HUMAN	CCT2	physical	26344197
DNJA1_HUMAN	DNAJA1	physical	26344197
DNJA2_HUMAN	DNAJA2	physical	26344197
DNJA4_HUMAN	DNAJA4	physical	26344197
DNJB1_HUMAN	DNAJB1	physical	26344197
DNJB4_HUMAN	DNAJB4	physical	26344197
DNJB5_HUMAN	DNAJB5	physical	26344197
DJC10_HUMAN	DNAJC10	physical	26344197
DNJC3_HUMAN	DNAJC3	physical	26344197
TAGL2_HUMAN	TAGLN2	physical	26344197
TAGL3_HUMAN	TAGLN3	physical	26344197
TBB5_HUMAN	TUBB	physical	26344197
SNUT2_HUMAN	USP39	physical	26344197
GCR_HUMAN	NR3C1	physical	16131566
TADBP_HUMAN	TARDBP	physical	26936937
DDIAS_HUMAN	DDIAS	physical	28079882
DNJB2_HUMAN	DNAJB2	physical	28504929
DNJB8_HUMAN	DNAJB8	physical	28504929
RIR2_HUMAN	RRM2	physical	25452130

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HSP74_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-430 AND LYS-679, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76 AND TYR-336, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-415, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76 AND THR-538, AND MASSSPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-89 AND TYR-336, AND MASSSPECTROMETRY.	15592455 [Abstract]