TAGL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAGL3_HUMAN
• UniProt AC: Q9UI15
• Protein Name: Transgelin-3
• Gene Name: TAGLN3
• Organism: Homo sapiens (Human).
• Sequence Length: 199
• Protein Sequence: MANRGPSYGLSREVQEKIEQKYDADLENKLVDWIILQCAEDIEHPPPGRAHFQKWLMDGTVLCKLINSLYPPGQEPIPKISESKMAFKQMEQISQFLKAAETYGVRTTDIFQTVDLWEGKDMAAVQRTLMALGSVAVTKDDGCYRGEPSWFHRKAQQNRRGFSEEQLRQGQNVIGLQMGSNKGASQAGMTGYGMPRQIM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MANRGPSYGLSREV -CCCCCCCCCCCHHH	34.36	29341593
8	Phosphorylation	MANRGPSYGLSREVQ CCCCCCCCCCCHHHH	25.81	29341593
11	Phosphorylation	RGPSYGLSREVQEKI CCCCCCCCHHHHHHH	23.25	29341593
128	Phosphorylation	DMAAVQRTLMALGSV CHHHHHHHHHHHCCE	12.09	24719451
134	Phosphorylation	RTLMALGSVAVTKDD HHHHHHCCEEEECCC	14.04	-
163	Phosphorylation	QQNRRGFSEEQLRQG HHHCCCCCHHHHHCC	42.94	29691806
180	Phosphorylation	VIGLQMGSNKGASQA EEEEECCCCCCCCCC	29.99	22912867
185	Phosphorylation	MGSNKGASQAGMTGY CCCCCCCCCCCCCCC	29.27	25159151
190	Phosphorylation	GASQAGMTGYGMPRQ CCCCCCCCCCCCCCC	26.74	21945579
192	Phosphorylation	SQAGMTGYGMPRQIM CCCCCCCCCCCCCCC	10.90	21945579
196	Methylation	MTGYGMPRQIM---- CCCCCCCCCCC----	29.75	24411459

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAGL3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAGL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAGL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLIC1_HUMAN	CLIC1	physical	26344197
CLIC4_HUMAN	CLIC4	physical	26344197
DUT_HUMAN	DUT	physical	26344197
ENOA_HUMAN	ENO1	physical	26344197
ENOG_HUMAN	ENO2	physical	26344197
ENOB_HUMAN	ENO3	physical	26344197
FABP5_HUMAN	FABP5	physical	26344197
FABP7_HUMAN	FABP7	physical	26344197
FKB1A_HUMAN	FKBP1A	physical	26344197
FKB1B_HUMAN	FKBP1B	physical	26344197
CH10_HUMAN	HSPE1	physical	26344197
NTF2_HUMAN	NUTF2	physical	26344197
PGK2_HUMAN	PGK2	physical	26344197
PIN1_HUMAN	PIN1	physical	26344197
SNX12_HUMAN	SNX12	physical	26344197
STIP1_HUMAN	STIP1	physical	26344197
TAGL2_HUMAN	TAGLN2	physical	26344197
TKT_HUMAN	TKT	physical	26344197
UBXN1_HUMAN	UBXN1	physical	26344197
UFM1_HUMAN	UFM1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-192, AND MASSSPECTROMETRY.
PubMed: 18083107