UFM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UFM1_HUMAN
• UniProt AC: P61960
• Protein Name: Ubiquitin-fold modifier 1
• Gene Name: UFM1
• Organism: Homo sapiens (Human).
• Sequence Length: 85
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. [PubMed: 15071506]
• Protein Sequence: MSKVSFKITLTSDPRLPYKVLSVPESTPFTAVLKFAAEEFKVPAATSAIITNDGIGINPAQTAGNVFLKHGSELRIIPRDRVGSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSKVSFKIT ------CCCEEEEEE	41.59	29116813
7 (in isoform 2)	Phosphorylation	-	27.55	20068231
8 (in isoform 2)	Phosphorylation	-	3.43	20068231
9 (in isoform 2)	Phosphorylation	-	25.27	20068231
9	Phosphorylation	SKVSFKITLTSDPRL CCEEEEEEECCCCCC	25.27	29116813
11	Phosphorylation	VSFKITLTSDPRLPY EEEEEEECCCCCCCC	23.57	29116813
12	Phosphorylation	SFKITLTSDPRLPYK EEEEEECCCCCCCCE	49.05	27251275
15	Methylation	ITLTSDPRLPYKVLS EEECCCCCCCCEEEE	53.97	54560461
18	Phosphorylation	TSDPRLPYKVLSVPE CCCCCCCCEEEECCC	20.51	20090780
19	Ubiquitination	SDPRLPYKVLSVPES CCCCCCCEEEECCCC	34.46	21890473
19	Acetylation	SDPRLPYKVLSVPES CCCCCCCEEEECCCC	34.46	25953088
22	Phosphorylation	RLPYKVLSVPESTPF CCCCEEEECCCCCCH	38.32	24719451
26	Phosphorylation	KVLSVPESTPFTAVL EEEECCCCCCHHHHH	35.00	28348404
27	Phosphorylation	VLSVPESTPFTAVLK EEECCCCCCHHHHHH	22.28	27251275
34	Ubiquitination	TPFTAVLKFAAEEFK CCHHHHHHHHHHHHC	26.76	33845483
69	Acetylation	TAGNVFLKHGSELRI CCCCEEECCCCEEEE	34.16	21466224
72	Phosphorylation	NVFLKHGSELRIIPR CEEECCCCEEEEEEC	32.93	-
75	Methylation	LKHGSELRIIPRDRV ECCCCEEEEEECCCC	22.27	115919505

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UFM1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UFM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UFM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GDIR2_HUMAN	ARHGDIB	physical	21900206
GDIR1_HUMAN	ARHGDIA	physical	21900206
ANCHR_HUMAN	ZFYVE19	physical	22939629
USP9X_HUMAN	USP9X	physical	22939629
VDAC1_HUMAN	VDAC1	physical	22939629
ZPR1_HUMAN	ZPR1	physical	22939629
YAP1_HUMAN	YAP1	physical	22939629
KBP_HUMAN	KIAA1279	physical	22863883
LPP_HUMAN	LPP	physical	22863883
NPL4_HUMAN	NPLOC4	physical	22863883
PANK4_HUMAN	PANK4	physical	22863883
RAGP1_HUMAN	RANGAP1	physical	22863883
CRIP1_HUMAN	CRIP1	physical	26344197
CSRP1_HUMAN	CSRP1	physical	26344197
MSI2H_HUMAN	MSI2	physical	26344197
PUR6_HUMAN	PAICS	physical	26344197
IPYR2_HUMAN	PPA2	physical	26344197
SERC_HUMAN	PSAT1	physical	26344197
RIFK_HUMAN	RFK	physical	26344197
TRAP1_HUMAN	TRAP1	physical	26344197
S10A6_HUMAN	S100A6	physical	28514442
PREP_HUMAN	PITRM1	physical	27173435
CB071_HUMAN	C2orf71	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.