S10A6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S10A6_HUMAN
• UniProt AC: P06703
• Protein Name: Protein S100-A6
• Gene Name: S100A6
• Organism: Homo sapiens (Human).
• Sequence Length: 90
• Subcellular Localization: Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
• Protein Description: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative..
• Protein Sequence: MACPLDQAIGLLVAIFHKYSGREGDKHTLSKKELKELIQKELTIGSKLQDAEIARLMEDLDRNKDQEVNFQEYVTFLGALALIYNEALKG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Ubiquitination	LLVAIFHKYSGREGD HHHHHHHHHCCCCCC	30.29	33845483
19	Phosphorylation	LVAIFHKYSGREGDK HHHHHHHHCCCCCCC	14.05	-
20	Phosphorylation	VAIFHKYSGREGDKH HHHHHHHCCCCCCCC	35.86	-
26	Acetylation	YSGREGDKHTLSKKE HCCCCCCCCCCCHHH	49.71	25825284
26	Ubiquitination	YSGREGDKHTLSKKE HCCCCCCCCCCCHHH	49.71	27667366
31	Ubiquitination	GDKHTLSKKELKELI CCCCCCCHHHHHHHH	54.07	21906983
32	Ubiquitination	DKHTLSKKELKELIQ CCCCCCHHHHHHHHH	65.97	22817900
35	Acetylation	TLSKKELKELIQKEL CCCHHHHHHHHHHHC	52.12	23954790
35	Ubiquitination	TLSKKELKELIQKEL CCCHHHHHHHHHHHC	52.12	21906983
40	Acetylation	ELKELIQKELTIGSK HHHHHHHHHCCCCHH	47.93	19608861
40	Ubiquitination	ELKELIQKELTIGSK HHHHHHHHHCCCCHH	47.93	27667366
40	Malonylation	ELKELIQKELTIGSK HHHHHHHHHCCCCHH	47.93	26320211
43	Phosphorylation	ELIQKELTIGSKLQD HHHHHHCCCCHHHCH	25.12	23927012
46	Phosphorylation	QKELTIGSKLQDAEI HHHCCCCHHHCHHHH	26.75	28355574
47	Ubiquitination	KELTIGSKLQDAEIA HHCCCCHHHCHHHHH	44.98	23000965
47	Succinylation	KELTIGSKLQDAEIA HHCCCCHHHCHHHHH	44.98	-
47	Acetylation	KELTIGSKLQDAEIA HHCCCCHHHCHHHHH	44.98	23954790
47	Malonylation	KELTIGSKLQDAEIA HHCCCCHHHCHHHHH	44.98	26320211
47	Succinylation	KELTIGSKLQDAEIA HHCCCCHHHCHHHHH	44.98	-
57	Sulfoxidation	DAEIARLMEDLDRNK HHHHHHHHHHHHCCC	2.91	30846556
89	Ubiquitination	LIYNEALKG------ HHHHHHHCC------	70.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S10A6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S10A6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S10A6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SGT1_HUMAN	SUGT1	physical	12746458
S10A6_HUMAN	S100A6	physical	11937060
CYBP_HUMAN	CACYBP	physical	18803400
SC24A_HUMAN	SEC24A	physical	22939629
TM1L2_HUMAN	TOM1L2	physical	22939629
SC23A_HUMAN	SEC23A	physical	22939629
CHIP_HUMAN	STUB1	physical	23344957
P53_HUMAN	TP53	physical	23796514

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-40, AND MASS SPECTROMETRY.
PubMed: 19608861