PREP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PREP_HUMAN
• UniProt AC: Q5JRX3
• Protein Name: Presequence protease, mitochondrial {ECO:0000305|PubMed:16849325}
• Gene Name: PITRM1 {ECO:0000312|HGNC:HGNC:17663}
• Organism: Homo sapiens (Human).
• Sequence Length: 1037
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. [PubMed: 10360838]
• Protein Sequence: MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	ACERALQYKLGDKIH HHHHHHHHHCCCCCC	14.72	-
41	Acetylation	CERALQYKLGDKIHG HHHHHHHHCCCCCCC	32.79	25953088
45	Acetylation	LQYKLGDKIHGFTVN HHHHCCCCCCCEECC	34.50	25038526
50	Phosphorylation	GDKIHGFTVNQVTSV CCCCCCEECCCCCCC	24.12	29888752
55	Phosphorylation	GFTVNQVTSVPELFL CEECCCCCCCCHHHE	17.78	29888752
56	Phosphorylation	FTVNQVTSVPELFLT EECCCCCCCCHHHEE	36.50	29888752
63	Phosphorylation	SVPELFLTAVKLTHD CCCHHHEEEEEECCC	23.28	29888752
82	Ubiquitination	RYLHLAREDTNNLFS CEEEEEEECCCCCEE	64.68	23503661
85	Ubiquitination	HLAREDTNNLFSVQF EEEEECCCCCEEEEE	56.37	23503661
93	Ubiquitination	NLFSVQFRTTPMDST CCEEEEEECCCCCCC	22.16	24816145
100	Ubiquitination	RTTPMDSTGVPHILE ECCCCCCCCCCCEEE	37.62	21890473
117	Ubiquitination	VLCGSQKYPCRDPFF CCCCCCCCCCCCHHH	10.42	24816145
125	Acetylation	PCRDPFFKMLNRSLS CCCCHHHHHHHHHHH	42.74	25953088
125	Ubiquitination	PCRDPFFKMLNRSLS CCCCHHHHHHHHHHH	42.74	24816145
175	Ubiquitination	FFPCLRELDFWQEGW CCHHHHHCCHHHHCC	5.49	27667366
194	Phosphorylation	ENPSDPQTPLVFKGV CCCCCCCCCEEEEEE	24.79	-
199	Ubiquitination	PQTPLVFKGVVFNEM CCCCEEEEEEECCCC	43.23	27667366
207	Ubiquitination	GVVFNEMKGAFTDNE EEECCCCCCCCCCCH	40.69	-
207	Ubiquitination	GVVFNEMKGAFTDNE EEECCCCCCCCCCCH	40.69	21906983
207 (in isoform 1)	Ubiquitination	-	40.69	21890473
207 (in isoform 2)	Ubiquitination	-	40.69	21890473
255	Ubiquitination	EQLKQFHATHYHPSN HHHHHHCCCCCCCCC	9.43	23503661
258	Phosphorylation	KQFHATHYHPSNARF HHHCCCCCCCCCCEE	15.86	-
258	Ubiquitination	KQFHATHYHPSNARF HHHCCCCCCCCCCEE	15.86	23503661
273	Ubiquitination	FTYGNFPLEQHLKQI EEECCCCHHHHHHHH	9.65	21890473
273	Ubiquitination	FTYGNFPLEQHLKQI EEECCCCHHHHHHHH	9.65	21890473
279	Ubiquitination	PLEQHLKQIHEEALS CHHHHHHHHHHHHHH	48.94	23503661
282	Ubiquitination	QHLKQIHEEALSKFQ HHHHHHHHHHHHHHC	46.74	23503661
287	Ubiquitination	IHEEALSKFQKIEPS HHHHHHHHHCCCCCC	53.30	23503661
290	Ubiquitination	EALSKFQKIEPSTVV HHHHHHCCCCCCCEE	52.77	-
290	Ubiquitination	EALSKFQKIEPSTVV HHHHHHCCCCCCCEE	52.77	23503661
290 (in isoform 2)	Ubiquitination	-	52.77	-
297	Ubiquitination	KIEPSTVVPAQTPWD CCCCCCEECCCCCCC	3.09	21890473
305	Ubiquitination	PAQTPWDKPREFQIT CCCCCCCCCCEEEEE	41.95	21890473
305	Ubiquitination	PAQTPWDKPREFQIT CCCCCCCCCCEEEEE	41.95	21890473
305 (in isoform 1)	Ubiquitination	-	41.95	21890473
305 (in isoform 2)	Ubiquitination	-	41.95	21890473
388	Phosphorylation	NGYTREAYFSVGLQG CCCCCEEEEEECCCC	7.51	18083107
418	2-Hydroxyisobutyrylation	TIDEVVEKGFEDDRI HHHHHHHCCCCHHHH	58.24	-
424	Methylation	EKGFEDDRIEALLHK HCCCCHHHHHHHHHH	40.75	115487619
441	Ubiquitination	IQMKHQSTSFGLMLT HHCCCCCCCHHHHHH	22.85	29967540
451	Ubiquitination	GLMLTSYIASCWNHD HHHHHHHHHHHCCCC	1.97	29967540
473	Acetylation	KLGNQLAKFRQCLQE HHHHHHHHHHHHHHH	50.07	25953088
473	Ubiquitination	KLGNQLAKFRQCLQE HHHHHHHHHHHHHHH	50.07	29967540
481	Ubiquitination	FRQCLQENPKFLQEK HHHHHHHCHHHHHHH	31.91	29967540
483	Acetylation	QCLQENPKFLQEKVK HHHHHCHHHHHHHHH	71.00	25953088
483	Ubiquitination	QCLQENPKFLQEKVK HHHHHCHHHHHHHHH	71.00	29967540
488	Ubiquitination	NPKFLQEKVKQYFKN CHHHHHHHHHHHHHC	41.60	-
488	Ubiquitination	NPKFLQEKVKQYFKN CHHHHHHHHHHHHHC	41.60	24816145
493	Ubiquitination	QEKVKQYFKNNQHKL HHHHHHHHHCCCCEE	6.73	23503661
508	Ubiquitination	TLSMRPDDKYHEKQA EEEECCCCHHHHHHH	56.97	29967540
509	Acetylation	LSMRPDDKYHEKQAQ EEECCCCHHHHHHHH	56.75	25038526
513	2-Hydroxyisobutyrylation	PDDKYHEKQAQVEAT CCCHHHHHHHHHHHH	37.31	-
513	Ubiquitination	PDDKYHEKQAQVEAT CCCHHHHHHHHHHHH	37.31	29967540
523	Ubiquitination	QVEATKLKQKVEALS HHHHHHHHHHHHHCC	50.02	24816145
530	Phosphorylation	KQKVEALSPGDRQQI HHHHHHCCCCCHHHH	33.61	25849741
534	Methylation	EALSPGDRQQIYEKG HHCCCCCHHHHHHHH	35.90	115487631
540	Ubiquitination	DRQQIYEKGLELRSQ CHHHHHHHHHHHHCC	52.39	-
540	Ubiquitination	DRQQIYEKGLELRSQ CHHHHHHHHHHHHCC	52.39	29967540
550	Malonylation	ELRSQQSKPQDASCL HHHCCCCCCCCCCCC	42.22	26320211
554	Ubiquitination	QQSKPQDASCLPALK CCCCCCCCCCCCCEE	9.26	24816145
559	Ubiquitination	QDASCLPALKVSDIE CCCCCCCCEEHHHCC	13.68	23503661
589	Ubiquitination	DIPVQYCAQPTNGMV CCCCEEEECCCCCEE	17.29	24816145
613	Ubiquitination	TLPEELRPYVPLFCS CCCHHHHHHHHHHHH	47.28	21890473
652	Ubiquitination	GMSASPHVLPDDSHM CCCCCCCCCCCCCCC	10.61	29967540
661	Ubiquitination	PDDSHMDTYEQGVLF CCCCCCCHHHHHHHH	22.76	24816145
666	Ubiquitination	MDTYEQGVLFSSLCL CCHHHHHHHHHHHHH	4.95	23503661
672	Ubiquitination	GVLFSSLCLDRNLPD HHHHHHHHHCCCCHH	3.92	23503661
675	Ubiquitination	FSSLCLDRNLPDMMQ HHHHHHCCCCHHHHH	33.37	23503661
679	Ubiquitination	CLDRNLPDMMQLWSE HHCCCCHHHHHHHHH	48.64	21890473
685	Ubiquitination	PDMMQLWSEIFNNPC HHHHHHHHHHHCCCC	29.43	24816145
690	Ubiquitination	LWSEIFNNPCFEEEE HHHHHHCCCCCCCHH	24.78	23503661
693	Ubiquitination	EIFNNPCFEEEEHFK HHHCCCCCCCHHHHH	16.27	24816145
696	Ubiquitination	NNPCFEEEEHFKVLV CCCCCCCHHHHHHHH	49.96	24816145
698	Ubiquitination	PCFEEEEHFKVLVKM CCCCCHHHHHHHHHH	30.98	23503661
717	Phosphorylation	LANGIPDSGHLYASI HHCCCCCCCCCCEEE	23.82	-
720	Ubiquitination	GIPDSGHLYASIRAG CCCCCCCCCEEEECC	4.33	24816145
721	Phosphorylation	IPDSGHLYASIRAGR CCCCCCCCEEEECCC	7.82	-
723	Phosphorylation	DSGHLYASIRAGRTL CCCCCCEEEECCCCC	10.07	-
728	Ubiquitination	YASIRAGRTLTPAGD CEEEECCCCCCCCCC	26.10	24816145
731	Phosphorylation	IRAGRTLTPAGDLQE EECCCCCCCCCCHHH	15.52	-
738	Ubiquitination	TPAGDLQETFSGMDQ CCCCCHHHHHCCHHH	60.15	23503661
741	Ubiquitination	GDLQETFSGMDQVRL CCHHHHHCCHHHHHH	40.40	23503661
750	Ubiquitination	MDQVRLMKRIAEMTD HHHHHHHHHHHHHCC	45.29	29967540
751	Ubiquitination	DQVRLMKRIAEMTDI HHHHHHHHHHHHCCC	21.27	24816145
755	Sulfoxidation	LMKRIAEMTDIKPIL HHHHHHHHCCCHHHH	2.78	21406390
756	Phosphorylation	MKRIAEMTDIKPILR HHHHHHHCCCHHHHH	26.52	27135362
756	Ubiquitination	MKRIAEMTDIKPILR HHHHHHHCCCHHHHH	26.52	23503661
759	Acetylation	IAEMTDIKPILRKLP HHHHCCCHHHHHHCH	28.90	23954790
759	Malonylation	IAEMTDIKPILRKLP HHHHCCCHHHHHHCH	28.90	26320211
759	Ubiquitination	IAEMTDIKPILRKLP HHHHCCCHHHHHHCH	28.90	24816145
760	Acetylation	AEMTDIKPILRKLPR HHHCCCHHHHHHCHH	31.05	-
760	Ubiquitination	AEMTDIKPILRKLPR HHHCCCHHHHHHCHH	31.05	-
760	Ubiquitination	AEMTDIKPILRKLPR HHHCCCHHHHHHCHH	31.05	24816145
760 (in isoform 2)	Ubiquitination	-	31.05	-
764	Ubiquitination	DIKPILRKLPRIKKH CCHHHHHHCHHHHHH	60.44	23503661
765	Ubiquitination	IKPILRKLPRIKKHL CHHHHHHCHHHHHHH	2.52	23503661
770	Acetylation	RKLPRIKKHLLNGDN HHCHHHHHHHCCCCC	36.79	25825284
770	Malonylation	RKLPRIKKHLLNGDN HHCHHHHHHHCCCCC	36.79	26320211
770	Succinylation	RKLPRIKKHLLNGDN HHCHHHHHHHCCCCC	36.79	-
770	Succinylation	RKLPRIKKHLLNGDN HHCHHHHHHHCCCCC	36.79	27452117
786	Ubiquitination	RCSVNATPQQMPQTE CEECCCCCCCCCCHH	21.72	21890473
786	Ubiquitination	RCSVNATPQQMPQTE CEECCCCCCCCCCHH	21.72	21890473
794	Ubiquitination	QQMPQTEKAVEDFLR CCCCCHHHHHHHHHH	62.21	24816145
795	Ubiquitination	QMPQTEKAVEDFLRS CCCCHHHHHHHHHHH	12.05	24816145
810	Ubiquitination	IGRSKKERRPVRPHT HCCCCCCCCCCCCCC	58.02	21890473
818	Ubiquitination	RPVRPHTVEKPVPSS CCCCCCCCCCCCCCC	8.94	21890473
845	Ubiquitination	VIRKLVMEPTFKPWQ HHHHHHHCCCCCCCE	33.44	23503661
848	Ubiquitination	KLVMEPTFKPWQMKT HHHHCCCCCCCEEEE	15.20	23503661
849	Acetylation	LVMEPTFKPWQMKTH HHHCCCCCCCEEEEC	48.07	25038526
849	Succinylation	LVMEPTFKPWQMKTH HHHCCCCCCCEEEEC	48.07	-
849	Succinylation	LVMEPTFKPWQMKTH HHHCCCCCCCEEEEC	48.07	-
858	Ubiquitination	WQMKTHFLMPFPVNY CEEEECEEECCCCCH	3.10	23503661
869	Ubiquitination	PVNYVGECIRTVPYT CCCHHHEEEEECCCC	1.78	23503661
872	Ubiquitination	YVGECIRTVPYTDPD HHHEEEEECCCCCCC	13.11	23503661
876	Ubiquitination	CIRTVPYTDPDHASL EEEECCCCCCCHHHH	34.68	21890473
877	Ubiquitination	IRTVPYTDPDHASLK EEECCCCCCCHHHHH	40.56	23503661
880	Ubiquitination	VPYTDPDHASLKILA CCCCCCCHHHHHHHH	23.70	23503661
882	Ubiquitination	YTDPDHASLKILARL CCCCCHHHHHHHHHH	27.12	23503661
884	Acetylation	DPDHASLKILARLMT CCCHHHHHHHHHHHH	32.93	25953088
884	Malonylation	DPDHASLKILARLMT CCCHHHHHHHHHHHH	32.93	26320211
884	Ubiquitination	DPDHASLKILARLMT CCCHHHHHHHHHHHH	32.93	21890473
885	Ubiquitination	PDHASLKILARLMTA CCHHHHHHHHHHHHH	4.39	21890473
885	Ubiquitination	PDHASLKILARLMTA CCHHHHHHHHHHHHH	4.39	21890473
885 (in isoform 2)	Ubiquitination	-	4.39	21890473
890	Ubiquitination	LKILARLMTAKFLHT HHHHHHHHHHHHHCH	2.60	23503661
891	Phosphorylation	KILARLMTAKFLHTE HHHHHHHHHHHHCHH	31.15	24719451
902	Acetylation	LHTEIREKGGAYGGG HCHHHHHHCCCCCCC	53.44	25038526
911	Acetylation	GAYGGGAKLSHNGIF CCCCCCCCCCCCCEE	54.52	25038526
922	Phosphorylation	NGIFTLYSYRDPNTI CCEEEEEEECCCCHH	19.46	24719451
923 (in isoform 2)	Phosphorylation	-	12.89	24719451
935	Ubiquitination	TIETLQSFGKAVDWA HHHHHHHHHHHHHHH	8.20	23503661
937	Acetylation	ETLQSFGKAVDWAKS HHHHHHHHHHHHHHC	43.13	25038526
938	Ubiquitination	TLQSFGKAVDWAKSG HHHHHHHHHHHHHCC	12.60	23503661
943	2-Hydroxyisobutyrylation	GKAVDWAKSGKFTQQ HHHHHHHHCCCCCHH	56.33	-
943	Ubiquitination	GKAVDWAKSGKFTQQ HHHHHHHHCCCCCHH	56.33	23503661
944	Ubiquitination	KAVDWAKSGKFTQQD HHHHHHHCCCCCHHH	39.20	23503661
946	Acetylation	VDWAKSGKFTQQDID HHHHHCCCCCHHHHH	52.94	25825284
946	Succinylation	VDWAKSGKFTQQDID HHHHHCCCCCHHHHH	52.94	-
946	Succinylation	VDWAKSGKFTQQDID HHHHHCCCCCHHHHH	52.94	-
946	Ubiquitination	VDWAKSGKFTQQDID HHHHHCCCCCHHHHH	52.94	21906983
946 (in isoform 1)	Ubiquitination	-	52.94	21890473
947	Ubiquitination	DWAKSGKFTQQDIDE HHHHCCCCCHHHHHH	9.46	23503661
947 (in isoform 2)	Ubiquitination	-	9.46	21890473
948	Ubiquitination	WAKSGKFTQQDIDEA HHHCCCCCHHHHHHH	28.89	23503661
956	Ubiquitination	QQDIDEAKLSVFSTV HHHHHHHHHEEEEEE	38.97	21906983
956 (in isoform 1)	Ubiquitination	-	38.97	21890473
957	Ubiquitination	QDIDEAKLSVFSTVD HHHHHHHHEEEEEEC	7.32	23503661
957 (in isoform 2)	Ubiquitination	-	7.32	21890473
958	Phosphorylation	DIDEAKLSVFSTVDA HHHHHHHEEEEEECC	22.02	21406692
961	Phosphorylation	EAKLSVFSTVDAPVA HHHHEEEEEECCCCC	25.93	21406692
962	Phosphorylation	AKLSVFSTVDAPVAP HHHEEEEEECCCCCC	15.79	21406692
970	Phosphorylation	VDAPVAPSDKGMDHF ECCCCCCCCCCCCHH	42.06	21406692
1000	2-Hydroxyisobutyrylation	LFAVSHDKLLAVSDR HHHCCHHHHEEECEE	39.72	-
1000	Acetylation	LFAVSHDKLLAVSDR HHHCCHHHHEEECEE	39.72	25038526
1000	Malonylation	LFAVSHDKLLAVSDR HHHCCHHHHEEECEE	39.72	26320211
1007	Methylation	KLLAVSDRYLGTGKS HHEEECEECCCCCCC	22.52	115487625
1011	Phosphorylation	VSDRYLGTGKSTHGL ECEECCCCCCCCCCE	38.55	24719451
1012 (in isoform 2)	Phosphorylation	-	21.81	24719451
1013	Malonylation	DRYLGTGKSTHGLAI EECCCCCCCCCCEEE	52.60	26320211
1014	Phosphorylation	RYLGTGKSTHGLAIL ECCCCCCCCCCEEEC	27.29	28348404
1015	Phosphorylation	YLGTGKSTHGLAILG CCCCCCCCCCEEECC	24.37	28348404
1027	Acetylation	ILGPENPKIAKDPSW ECCCCCCCCCCCCCC	67.87	25953088
1027	Malonylation	ILGPENPKIAKDPSW ECCCCCCCCCCCCCC	67.87	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PREP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PREP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PREP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RIF1_HUMAN	RIF1	physical	22939629
RM12_HUMAN	MRPL12	physical	22939629
VAPB_HUMAN	VAPB	physical	22939629
SUCB2_HUMAN	SUCLG2	physical	22939629
CB071_HUMAN	C2orf71	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.