dbPTM

RM12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RM12_HUMAN
UniProt AC	P52815
Protein Name	39S ribosomal protein L12, mitochondrial
Gene Name	MRPL12
Organism	Homo sapiens (Human).
Sequence Length	198
Subcellular Localization	Mitochondrion .
Protein Description	Associates with mitochondrial RNA polymerase to activate transcription..
Protein Sequence	MLPAAARPLWGPCLGLRAAAFRLARRQVPCVCAVRHMRSSGHQRCEALAGAPLDNAPKEYPPKIQQLVQDIASLTLLEISDLNELLKKTLKIQDVGLVPMGGVMSGAVPAAAAQEAVEEDIPIAKERTHFTVRLTEAKPVDKVKLIKEIKNYIQGINLVQAKKLVESLPQEIKANVAKAEAEKIKAALEAVGGTVVLE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Glutathionylation	RSSGHQRCEALAGAP HCCCCCHHHHHCCCC	2.63	22555962
138	Succinylation	TVRLTEAKPVDKVKL EEEECCCCCCCHHHH	39.06	27452117
138	Acetylation	TVRLTEAKPVDKVKL EEEECCCCCCCHHHH	39.06	23749302
138	2-Hydroxyisobutyrylation	TVRLTEAKPVDKVKL EEEECCCCCCCHHHH	39.06	-
142	Acetylation	TEAKPVDKVKLIKEI CCCCCCCHHHHHHHH	41.31	23749302
144	Ubiquitination	AKPVDKVKLIKEIKN CCCCCHHHHHHHHHH	50.68	23000965
147	Ubiquitination	VDKVKLIKEIKNYIQ CCHHHHHHHHHHHHC	64.92	23000965
150	Malonylation	VKLIKEIKNYIQGIN HHHHHHHHHHHCCCC	44.80	26320211
150	Ubiquitination	VKLIKEIKNYIQGIN HHHHHHHHHHHCCCC	44.80	23000965
150	Acetylation	VKLIKEIKNYIQGIN HHHHHHHHHHHCCCC	44.80	26051181
150	2-Hydroxyisobutyrylation	VKLIKEIKNYIQGIN HHHHHHHHHHHCCCC	44.80	-
150	Succinylation	VKLIKEIKNYIQGIN HHHHHHHHHHHCCCC	44.80	27452117
150	Succinylation	VKLIKEIKNYIQGIN HHHHHHHHHHHCCCC	44.80	-
152	Phosphorylation	LIKEIKNYIQGINLV HHHHHHHHHCCCCHH	6.93	28152594
162	Acetylation	GINLVQAKKLVESLP CCCHHHHHHHHHCCC	29.55	25953088
162	Malonylation	GINLVQAKKLVESLP CCCHHHHHHHHHCCC	29.55	26320211
162	Succinylation	GINLVQAKKLVESLP CCCHHHHHHHHHCCC	29.55	23954790
162	Succinylation	GINLVQAKKLVESLP CCCHHHHHHHHHCCC	29.55	-
163	Acetylation	INLVQAKKLVESLPQ CCHHHHHHHHHCCCH	61.86	26051181
163	Malonylation	INLVQAKKLVESLPQ CCHHHHHHHHHCCCH	61.86	26320211
163	Succinylation	INLVQAKKLVESLPQ CCHHHHHHHHHCCCH	61.86	27452117
173	2-Hydroxyisobutyrylation	ESLPQEIKANVAKAE HCCCHHHHHHHHHHH	32.91	-
173	Acetylation	ESLPQEIKANVAKAE HCCCHHHHHHHHHHH	32.91	27452117
178	Succinylation	EIKANVAKAEAEKIK HHHHHHHHHHHHHHH	42.34	-
178	Succinylation	EIKANVAKAEAEKIK HHHHHHHHHHHHHHH	42.34	-
178	Acetylation	EIKANVAKAEAEKIK HHHHHHHHHHHHHHH	42.34	25953088
183	Acetylation	VAKAEAEKIKAALEA HHHHHHHHHHHHHHH	57.46	25953088
194	Phosphorylation	ALEAVGGTVVLE--- HHHHCCCEEEEC---	11.08	20860994
409	Ubiquitination	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RM12_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RM12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RM12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RM12_HUMAN	MRPL12	physical	16169070
RM15_HUMAN	MRPL15	physical	22939629
RT26_HUMAN	MRPS26	physical	22939629
RM41_HUMAN	MRPL41	physical	22939629
RM23_HUMAN	MRPL23	physical	22939629
RM52_HUMAN	MRPL52	physical	22939629
RM42_HUMAN	MRPL42	physical	22939629
RM37_HUMAN	MRPL37	physical	22939629
RT28_HUMAN	MRPS28	physical	22939629
RT09_HUMAN	MRPS9	physical	22939629
UFM1_HUMAN	UFM1	physical	22939629
RNT2_HUMAN	RNASET2	physical	22939629
TMEM9_HUMAN	TMEM9	physical	22939629
SUCB2_HUMAN	SUCLG2	physical	22939629
SUCB1_HUMAN	SUCLA2	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
XRCC1_HUMAN	XRCC1	physical	22939629
RARG_HUMAN	RARG	physical	21988832
OLIG1_HUMAN	OLIG1	physical	21988832
CP131_HUMAN	CEP131	physical	28514442
SEP10_HUMAN	SEPT10	physical	28514442
FOXP2_HUMAN	FOXP2	physical	28514442
SEPT3_HUMAN	SEPT3	physical	28514442
D39U1_HUMAN	SDR39U1	physical	28514442
FOXP4_HUMAN	FOXP4	physical	28514442
MFR1L_HUMAN	MTFR1L	physical	28514442
GTPB8_HUMAN	GTPBP8	physical	28514442
CENPJ_HUMAN	CENPJ	physical	28514442
MTEF2_HUMAN	MTERF2	physical	28514442
RM10_HUMAN	MRPL10	physical	28514442
SEPT5_HUMAN	SEPT5	physical	28514442
TFB1M_HUMAN	TFB1M	physical	28514442
ACSF2_HUMAN	ACSF2	physical	28514442
SH3K1_HUMAN	SH3KBP1	physical	28514442
CA122_HUMAN	C1orf122	physical	28514442
MTG2_HUMAN	MTG2	physical	28514442
IF2M_HUMAN	MTIF2	physical	28514442
SEPT2_HUMAN	SEPT2	physical	28514442
SEPT8_HUMAN	SEPT8	physical	28514442
RT30_HUMAN	MRPS30	physical	28514442
TRUA_HUMAN	PUS1	physical	28514442
RPOM_HUMAN	POLRMT	physical	28514442
RUSD4_HUMAN	RPUSD4	physical	28514442
SYHM_HUMAN	HARS2	physical	28514442
TRM2_HUMAN	TRMT2B	physical	28514442
THOC7_HUMAN	THOC7	physical	28514442
RM47_HUMAN	MRPL47	physical	28514442
GTPB6_HUMAN	GTPBP6	physical	28514442
RM52_HUMAN	MRPL52	physical	28514442
MTG1_HUMAN	MTG1	physical	28514442
SEPT6_HUMAN	SEPT6	physical	28514442
TBRG4_HUMAN	TBRG4	physical	28514442
SEPT9_HUMAN	SEPT9	physical	28514442
OXND1_HUMAN	OXNAD1	physical	28514442
SEP11_HUMAN	SEPT11	physical	28514442
MCUB_HUMAN	CCDC109B	physical	28514442
MTEF4_HUMAN	MTERF4	physical	28514442
DIC_HUMAN	SLC25A10	physical	28514442
G45IP_HUMAN	GADD45GIP1	physical	28514442
RRF2M_HUMAN	GFM2	physical	28514442
FAKD2_HUMAN	FASTKD2	physical	28514442
RM33_HUMAN	MRPL33	physical	28514442
EFTS_HUMAN	TSFM	physical	28514442
PTPM1_HUMAN	PTPMT1	physical	28514442
MRM1_HUMAN	MRM1	physical	28514442
RM53_HUMAN	MRPL53	physical	28514442
SEPT7_HUMAN	SEPT7	physical	28514442
THOC5_HUMAN	THOC5	physical	28514442
NPS3A_HUMAN	NIPSNAP3A	physical	28514442
RM13_HUMAN	MRPL13	physical	28514442
GGYF2_HUMAN	GIGYF2	physical	28514442
THOC1_HUMAN	THOC1	physical	28514442
RM30_HUMAN	MRPL30	physical	28514442
EZRI_HUMAN	EZR	physical	28514442
RM32_HUMAN	MRPL32	physical	28514442
RM51_HUMAN	MRPL51	physical	28514442
RM38_HUMAN	MRPL38	physical	28514442
CD2AP_HUMAN	CD2AP	physical	28514442
RM17_HUMAN	MRPL17	physical	28514442
SYYM_HUMAN	YARS2	physical	28514442
RM03_HUMAN	MRPL3	physical	28514442
RM19_HUMAN	MRPL19	physical	28514442
RM49_HUMAN	MRPL49	physical	28514442
RFIP5_HUMAN	RAB11FIP5	physical	28514442
RM44_HUMAN	MRPL44	physical	28514442
RADI_HUMAN	RDX	physical	28514442
RM16_HUMAN	MRPL16	physical	28514442
RM48_HUMAN	MRPL48	physical	28514442
GATB_HUMAN	GATB	physical	28514442
MASU1_HUMAN	MALSU1	physical	28514442
RM41_HUMAN	MRPL41	physical	28514442
RM28_HUMAN	MRPL28	physical	28514442
RM20_HUMAN	MRPL20	physical	28514442
COR1A_HUMAN	CORO1A	physical	28514442
MRM2_HUMAN	FTSJ2	physical	28514442
MOES_HUMAN	MSN	physical	28514442
RT63_HUMAN	MRPL57	physical	28514442
RM39_HUMAN	MRPL39	physical	28514442
SYDM_HUMAN	DARS2	physical	28514442
CLPP_HUMAN	CLPP	physical	28514442
ICT1_HUMAN	ICT1	physical	28514442
RM15_HUMAN	MRPL15	physical	28514442
RM27_HUMAN	MRPL27	physical	28514442
RM04_HUMAN	MRPL4	physical	28514442
RM22_HUMAN	MRPL22	physical	28514442
RM40_HUMAN	MRPL40	physical	28514442
RM55_HUMAN	MRPL55	physical	28514442
PNPT1_HUMAN	PNPT1	physical	28514442
NDK6_HUMAN	NME6	physical	28514442
MRRP3_HUMAN	KIAA0391	physical	28514442
EFGM_HUMAN	GFM1	physical	28514442
BCKD_HUMAN	BCKDK	physical	28514442
THOC2_HUMAN	THOC2	physical	28514442
TRAP1_HUMAN	TRAP1	physical	27173435
SND1_HUMAN	SND1	physical	27173435
ANXA5_HUMAN	ANXA5	physical	27173435
IF2P_HUMAN	EIF5B	physical	27173435
G6PI_HUMAN	GPI	physical	27173435
IDHP_HUMAN	IDH2	physical	27173435
PDIA3_HUMAN	PDIA3	physical	27173435
UBE2N_HUMAN	UBE2N	physical	27173435

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RM12_HUMAN

Related Literatures of Post-Translational Modification