MTEF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTEF2_HUMAN
• UniProt AC: Q49AM1
• Protein Name: Transcription termination factor 2, mitochondrial
• Gene Name: MTERF2
• Organism: Homo sapiens (Human).
• Sequence Length: 385
• Subcellular Localization: Mitochondrion . Mitochondrion matrix, mitochondrion nucleoid .
• Protein Description: Binds mitochondrial DNA and plays a role in the regulation of transcription of mitochondrial mRNA and rRNA species..
• Protein Sequence: MLWKLLLRSQSCRLCSFRKMRSPPKYRPFLACFTYTTDKQSSKENTRTVEKLYKCSVDIRKIRRLKGWVLLEDETYVEEIANILQELGADETAVASILERCPEAIVCSPTAVNTQRKLWQLVCKNEEELIKLIEQFPESFFTIKDQENQKLNVQFFQELGLKNVVISRLLTAAPNVFHNPVEKNKQMVRILQESYLDVGGSEANMKVWLLKLLSQNPFILLNSPTAIKETLEFLQEQGFTSFEILQLLSKLKGFLFQLCPRSIQNSISFSKNAFKCTDHDLKQLVLKCPALLYYSVPVLEERMQGLLREGISIAQIRETPMVLELTPQIVQYRIRKLNSSGYRIKDGHLANLNGSKKEFEANFGKIQAKKVRPLFNPVAPLNVEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	LWKLLLRSQSCRLCS HHHHHHHCCCHHCCC		26074081
11	Phosphorylation	KLLLRSQSCRLCSFR HHHHHCCCHHCCCHH		26074081
16	Phosphorylation	SQSCRLCSFRKMRSP CCCHHCCCHHCCCCC		24719451
26	Phosphorylation	KMRSPPKYRPFLACF CCCCCCCCCCEEEEE		27134283
36	Phosphorylation	FLACFTYTTDKQSSK EEEEEEEECCCCCCC		27134283
41	Phosphorylation	TYTTDKQSSKENTRT EEECCCCCCCCCCCH		29691806
42	Phosphorylation	YTTDKQSSKENTRTV EECCCCCCCCCCCHH		29691806
46	Phosphorylation	KQSSKENTRTVEKLY CCCCCCCCCHHHHHH		29691806
61	Ubiquitination	KCSVDIRKIRRLKGW HCCCCHHHHHHCCCE		-
201	Phosphorylation	SYLDVGGSEANMKVW HHHCCCCCHHHHHHH		24505115
249	Phosphorylation	FEILQLLSKLKGFLF HHHHHHHHHHCCHHH		24719451
268	Phosphorylation	RSIQNSISFSKNAFK HHHHHHHCCCCCCCC		24719451
339	Phosphorylation	YRIRKLNSSGYRIKD HHHHHHHCCCCEECC		24505115
340	Phosphorylation	RIRKLNSSGYRIKDG HHHHHHCCCCEECCC		30631047

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTEF2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTEF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTEF2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDGR3_HUMAN	HDGFRP3	physical	26186194
HDGR3_HUMAN	HDGFRP3	physical	28514442
DCX_HUMAN	DCX	physical	28514442
PPM1A_HUMAN	PPM1A	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.