HDGR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HDGR3_HUMAN
• UniProt AC: Q9Y3E1
• Protein Name: Hepatoma-derived growth factor-related protein 3
• Gene Name: HDGFL3 {ECO:0000312|HGNC:HGNC:24937}
• Organism: Homo sapiens (Human).
• Sequence Length: 203
• Subcellular Localization: Nucleus .
• Protein Description: Enhances DNA synthesis and may play a role in cell proliferation..
• Protein Sequence: MARPRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPKDLFPYKEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQAIQQQSSSETEGEGGNTADASSEEEGDRVEEDGKGKRKNEKAGSKRKKSYTSKKSSKQSRKSPGDEDDKDCKEEENKSSSEGGDAGNDTRNTTSDLQKTSEGT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Ubiquitination	RPRPREYKAGDLVFA CCCCCCCCCCCEEEE	40.93	-
20	Ubiquitination	DLVFAKMKGYPHWPA CEEEEECCCCCCCCC	55.36	-
22	Phosphorylation	VFAKMKGYPHWPARI EEEECCCCCCCCCCH	6.09	22461510
66	Ubiquitination	PKDLFPYKEYKDKFG HHHCCCHHHHHHHHC	55.60	21890473
97	Phosphorylation	NNPGVKFTGYQAIQQ CCCCCCEEEEEHHHH	29.30	23927012
99	Phosphorylation	PGVKFTGYQAIQQQS CCCCEEEEEHHHHCC	7.54	23927012
106	Phosphorylation	YQAIQQQSSSETEGE EEHHHHCCCCCCCCC	31.34	28450419
107	Phosphorylation	QAIQQQSSSETEGEG EHHHHCCCCCCCCCC	28.05	28450419
108	Phosphorylation	AIQQQSSSETEGEGG HHHHCCCCCCCCCCC	54.51	23927012
110	Phosphorylation	QQQSSSETEGEGGNT HHCCCCCCCCCCCCC	51.76	23927012
117	Phosphorylation	TEGEGGNTADASSEE CCCCCCCCCCCCCHH	29.23	23927012
121	Phosphorylation	GGNTADASSEEEGDR CCCCCCCCCHHHCCC	38.54	26503892
122	Phosphorylation	GNTADASSEEEGDRV CCCCCCCCHHHCCCC	51.23	26503892
149	O-linked_Glycosylation	AGSKRKKSYTSKKSS CCCCCCCCHHCCCCC	36.36	30379171
150	Phosphorylation	GSKRKKSYTSKKSSK CCCCCCCHHCCCCCC	24.74	-
159	Phosphorylation	SKKSSKQSRKSPGDE CCCCCCCCCCCCCCC	45.47	26074081
162	Phosphorylation	SSKQSRKSPGDEDDK CCCCCCCCCCCCCCH	32.76	28348404
178	Phosphorylation	CKEEENKSSSEGGDA HHHHHHHCCCCCCCC	51.16	29255136
179	Phosphorylation	KEEENKSSSEGGDAG HHHHHHCCCCCCCCC	33.74	25849741
180	Phosphorylation	EEENKSSSEGGDAGN HHHHHCCCCCCCCCC	47.56	29255136
189	Phosphorylation	GGDAGNDTRNTTSDL CCCCCCCCCCCHHHH	29.80	23090842
192	Phosphorylation	AGNDTRNTTSDLQKT CCCCCCCCHHHHHHH	25.12	29396449
193	Phosphorylation	GNDTRNTTSDLQKTS CCCCCCCHHHHHHHC	24.64	29396449
194	Phosphorylation	NDTRNTTSDLQKTSE CCCCCCHHHHHHHCC	33.99	29396449
199	Phosphorylation	TTSDLQKTSEGT--- CHHHHHHHCCCC---	21.03	28450419
200	Phosphorylation	TSDLQKTSEGT---- HHHHHHHCCCC----	40.85	28450419
203	Phosphorylation	LQKTSEGT------- HHHHCCCC-------	31.24	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HDGR3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HDGR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HDGR3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HDGR3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.