RPOM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPOM_HUMAN
• UniProt AC: O00411
• Protein Name: DNA-directed RNA polymerase, mitochondrial
• Gene Name: POLRMT
• Organism: Homo sapiens (Human).
• Sequence Length: 1230
• Subcellular Localization: Mitochondrion .
• Protein Description: DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates..
• Protein Sequence: MSALCWGRGAAGLKRALRPCGRPGLPGKEGTAGGVCGPRRSSSASPQEQDQDRRKDWGHVELLEVLQARVRQLQAESVSEVVVNRVDVARLPECGSGDGSLQPPRKVQMGAKDATPVPCGRWAKILEKDKRTQQMRMQRLKAKLQMPFQSGEFKALTRRLQVEPRLLSKQMAGCLEDCTRQAPESPWEEQLARLLQEAPGKLSLDVEQAPSGQHSQAQLSGQQQRLLAFFKCCLLTDQLPLAHHLLVVHHGQRQKRKLLTLDMYNAVMLGWARQGAFKELVYVLFMVKDAGLTPDLLSYAAALQCMGRQDQDAGTIERCLEQMSQEGLKLQALFTAVLLSEEDRATVLKAVHKVKPTFSLPPQLPPPVNTSKLLRDVYAKDGRVSYPKLHLPLKTLQCLFEKQLHMELASRVCVVSVEKPTLPSKEVKHARKTLKTLRDQWEKALCRALRETKNRLEREVYEGRFSLYPFLCLLDEREVVRMLLQVLQALPAQGESFTTLARELSARTFSRHVVQRQRVSGQVQALQNHYRKYLCLLASDAEVPEPCLPRQYWEELGAPEALREQPWPLPVQMELGKLLAEMLVQATQMPCSLDKPHRSSRLVPVLYHVYSFRNVQQIGILKPHPAYVQLLEKAAEPTLTFEAVDVPMLCPPLPWTSPHSGAFLLSPTKLMRTVEGATQHQELLETCPPTALHGALDALTQLGNCAWRVNGRVLDLVLQLFQAKGCPQLGVPAPPSEAPQPPEAHLPHSAAPARKAELRRELAHCQKVAREMHSLRAEALYRLSLAQHLRDRVFWLPHNMDFRGRTYPCPPHFNHLGSDVARALLEFAQGRPLGPHGLDWLKIHLVNLTGLKKREPLRKRLAFAEEVMDDILDSADQPLTGRKWWMGAEEPWQTLACCMEVANAVRASDPAAYVSHLPVHQDGSCNGLQHYAALGRDSVGAASVNLEPSDVPQDVYSGVAAQVEVFRRQDAQRGMRVAQVLEGFITRKVVKQTVMTVVYGVTRYGGRLQIEKRLRELSDFPQEFVWEASHYLVRQVFKSLQEMFSGTRAIQHWLTESARLISHMGSVVEWVTPLGVPVIQPYRLDSKVKQIGGGIQSITYTHNGDISRKPNTRKQKNGFPPNFIHSLDSSHMMLTALHCYRKGLTFVSVHDCYWTHAADVSVMNQVCREQFVRLHSEPILQDLSRFLVKRFCSEPQKILEASQLKETLQAVPKPGAFDLEQVKRSTYFFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Methylation	MSALCWGRGAAGLKR CCCCCCCCCHHHHHH	13.69	115488221
28	Methylation	GRPGLPGKEGTAGGV CCCCCCCCCCCCCCC	51.54	23644510
77	Phosphorylation	VRQLQAESVSEVVVN HHHHHHCCCCEEEEC	33.68	19691289
79	Phosphorylation	QLQAESVSEVVVNRV HHHHCCCCEEEECCC	33.67	20860994
115	Phosphorylation	QMGAKDATPVPCGRW CCCCCCCCCCCCHHH	34.65	19007248
146	Sulfoxidation	RLKAKLQMPFQSGEF HHHHHHCCCCCCCHH	5.35	21406390
150	Phosphorylation	KLQMPFQSGEFKALT HHCCCCCCCHHHHHH	40.44	20860994
154	Ubiquitination	PFQSGEFKALTRRLQ CCCCCHHHHHHHHHC	37.88	-
201	Ubiquitination	LLQEAPGKLSLDVEQ HHHHCCCCCEEEHHC	33.57	-
211	Phosphorylation	LDVEQAPSGQHSQAQ EEHHCCCCCCCCCHH	54.85	20860994
215	Phosphorylation	QAPSGQHSQAQLSGQ CCCCCCCCCHHHCHH	21.23	20860994
220	Phosphorylation	QHSQAQLSGQQQRLL CCCCHHHCHHHHHHH	23.60	20860994
299	Phosphorylation	LTPDLLSYAAALQCM CCHHHHHHHHHHHHC	10.55	-
315	Phosphorylation	RQDQDAGTIERCLEQ CCCCCHHHHHHHHHH	22.76	-
370	Phosphorylation	QLPPPVNTSKLLRDV CCCCCCCHHHHHHHH	27.72	22468782
371	Phosphorylation	LPPPVNTSKLLRDVY CCCCCCHHHHHHHHH	18.99	29759185
385	Phosphorylation	YAKDGRVSYPKLHLP HCCCCCCCCCCCCCC	34.06	24719451
386	Phosphorylation	AKDGRVSYPKLHLPL CCCCCCCCCCCCCCH	11.09	-
394	Ubiquitination	PKLHLPLKTLQCLFE CCCCCCHHHHHHHHH	45.29	-
394	Acetylation	PKLHLPLKTLQCLFE CCCCCCHHHHHHHHH	45.29	26051181
402	Acetylation	TLQCLFEKQLHMELA HHHHHHHHHHHHHHH	51.31	25825284
410	Phosphorylation	QLHMELASRVCVVSV HHHHHHHHCEEEEEE	37.56	22210691
419	Acetylation	VCVVSVEKPTLPSKE EEEEEECCCCCCHHH	40.94	26822725
424	Phosphorylation	VEKPTLPSKEVKHAR ECCCCCCHHHHHHHH	44.56	24719451
425	Acetylation	EKPTLPSKEVKHARK CCCCCCHHHHHHHHH	65.67	26051181
436	Phosphorylation	HARKTLKTLRDQWEK HHHHHHHHHHHHHHH	30.09	-
443	Acetylation	TLRDQWEKALCRALR HHHHHHHHHHHHHHH	43.64	26051181
532	Ubiquitination	ALQNHYRKYLCLLAS HHHHHHHHHHHHHHC	35.09	-
595	Acetylation	QMPCSLDKPHRSSRL CCCCCCCCCCHHCCH	48.28	25953088
622	Acetylation	VQQIGILKPHPAYVQ CEEEEECCCCHHHHH	39.08	23236377
666	Phosphorylation	HSGAFLLSPTKLMRT CCCCEECCHHHHHHH	32.44	24719451
993	Phosphorylation	TRKVVKQTVMTVVYG HHHHHHHHHHHHHHH	13.41	-
999	Phosphorylation	QTVMTVVYGVTRYGG HHHHHHHHHHHHCCC	11.09	-
1004	Phosphorylation	VVYGVTRYGGRLQIE HHHHHHHCCCHHHHH	17.99	-
1101	Phosphorylation	GIQSITYTHNGDISR CEEEEEEECCCCCCC	10.54	28464451
1197	Ubiquitination	RFCSEPQKILEASQL HHCCCHHHHHHHHHH	61.03	21890473
1197	Acetylation	RFCSEPQKILEASQL HHCCCHHHHHHHHHH	61.03	26051181
1205	Ubiquitination	ILEASQLKETLQAVP HHHHHHHHHHHHCCC	40.80	-
1205	Acetylation	ILEASQLKETLQAVP HHHHHHHHHHHHCCC	40.80	26051181
1212	Ubiquitination	KETLQAVPKPGAFDL HHHHHCCCCCCCCCH	39.89	21890473
1213	Ubiquitination	ETLQAVPKPGAFDLE HHHHCCCCCCCCCHH	49.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPOM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPOM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPOM_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RPOM_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-115, AND MASSSPECTROMETRY.
PubMed: 19007248