RM22_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RM22_HUMAN
• UniProt AC: Q9NWU5
• Protein Name: 39S ribosomal protein L22, mitochondrial
• Gene Name: MRPL22
• Organism: Homo sapiens (Human).
• Sequence Length: 206
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MAAAVLGQLGALWIHNLRSRGKLALGVLPQSYIHTSASLDISRKWEKKNKIVYPPQLPGEPRRPAEIYHCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEFRSNLYIAESTSGRGQCLKRIRYHGRGRFGIMEKVYCHYFVKLVEGPPPPPEPPKTAVAHAKEYIQQLRSRTIVHTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6 (in isoform 2)	Phosphorylation	-	2.87	29507054
25 (in isoform 2)	Ubiquitination	-	7.65	21890473
25	Ubiquitination	RSRGKLALGVLPQSY HHCCCEEEEECCHHH	7.65	29967540
68	Phosphorylation	PRRPAEIYHCRRQIK CCCCHHHHHHHHHHH	6.08	28152594
80	2-Hydroxyisobutyrylation	QIKYSKDKMWYLAKL HHHCCHHHHHHHHHH	34.76	-
86	Ubiquitination	DKMWYLAKLIRGMSI HHHHHHHHHHHCCCH	41.68	-
92	Phosphorylation	AKLIRGMSIDQALAQ HHHHHCCCHHHHHHH	26.32	28348404
104	Ubiquitination	LAQLEFNDKKGAKII HHHCCCCCHHHHHHH	60.40	29967540
105	Ubiquitination	AQLEFNDKKGAKIIK HHCCCCCHHHHHHHH	54.96	21906983
105 (in isoform 1)	Ubiquitination	-	54.96	21890473
111 (in isoform 2)	Ubiquitination	-	2.83	21890473
111	Ubiquitination	DKKGAKIIKEVLLEA CHHHHHHHHHHHHHH	2.83	21890473
111	Ubiquitination	DKKGAKIIKEVLLEA CHHHHHHHHHHHHHH	2.83	21890473
112	Ubiquitination	KKGAKIIKEVLLEAQ HHHHHHHHHHHHHHH	45.29	-
121	Sulfoxidation	VLLEAQDMAVRDHNV HHHHHHHHHHHCCCC	2.17	21406390
132	Phosphorylation	DHNVEFRSNLYIAES CCCCEEECCEEEEEC	36.19	21406692
135	Phosphorylation	VEFRSNLYIAESTSG CEEECCEEEEECCCC	11.44	21406692
139	Phosphorylation	SNLYIAESTSGRGQC CCEEEEECCCCCCCH	20.89	21406692
140	Phosphorylation	NLYIAESTSGRGQCL CEEEEECCCCCCCHH	27.06	21406692
141	Phosphorylation	LYIAESTSGRGQCLK EEEEECCCCCCCHHH	35.45	21406692
143	Methylation	IAESTSGRGQCLKRI EEECCCCCCCHHHHE	31.60	115483723
165	Phosphorylation	FGIMEKVYCHYFVKL CCHHCHHHEEEEEEE	5.65	28152594
184	Ubiquitination	PPPPEPPKTAVAHAK CCCCCCCCCHHHHHH	60.89	29967540
191	Malonylation	KTAVAHAKEYIQQLR CCHHHHHHHHHHHHH	40.98	26320211
191	Ubiquitination	KTAVAHAKEYIQQLR CCHHHHHHHHHHHHH	40.98	23000965
191 (in isoform 1)	Ubiquitination	-	40.98	21890473
193	Phosphorylation	AVAHAKEYIQQLRSR HHHHHHHHHHHHHHC	11.88	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RM22_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RM22_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RM22_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RS18_HUMAN	RPS18	physical	22939629
RM10_HUMAN	MRPL10	physical	26344197
RM17_HUMAN	MRPL17	physical	26344197
RM02_HUMAN	MRPL2	physical	26344197
RM24_HUMAN	MRPL24	physical	26344197
RM37_HUMAN	MRPL37	physical	26344197
RL12_HUMAN	RPL12	physical	26344197
EFTU_HUMAN	TUFM	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.