SEPT3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEPT3_HUMAN
• UniProt AC: Q9UH03
• Protein Name: Neuronal-specific septin-3
• Gene Name: 3-Sep
• Organism: Homo sapiens (Human).
• Sequence Length: 358
• Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, synapse.
• Protein Description: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)..
• Protein Sequence: MSKGLPETRTDAAMSELVPEPRPKPAVPMKPMSINSNLLGYIGIDTIIEQMRKKTMKTGFDFNIMVVGQSGLGKSTLVNTLFKSQVSRKASSWNREEKIPKTVEIKAIGHVIEEGGVKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNIIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFDEDLEDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKTPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKRLNDNGGLPPGEGLLGTVLPPVPATPCPTAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSKGLPETR ------CCCCCCCCH	35.12	29978859
8	Phosphorylation	MSKGLPETRTDAAMS CCCCCCCCHHHHHHH	36.61	29978859
10	Phosphorylation	KGLPETRTDAAMSEL CCCCCCHHHHHHHHC	37.09	29978859
15	Phosphorylation	TRTDAAMSELVPEPR CHHHHHHHHCCCCCC	24.05	24248375
30	Methylation	PKPAVPMKPMSINSN CCCCCCCCCCCCCCC	31.34	23644510
41	Phosphorylation	INSNLLGYIGIDTII CCCCHHHHHCHHHHH	8.92	24248375
70	Phosphorylation	NIMVVGQSGLGKSTL EEEEECCCCCCHHHH	30.01	-
84	Phosphorylation	LVNTLFKSQVSRKAS HHHHHHHHHHHHHCC	28.60	-
87	Phosphorylation	TLFKSQVSRKASSWN HHHHHHHHHHCCCCC	22.04	-
91	Phosphorylation	SQVSRKASSWNREEK HHHHHHCCCCCCCCC	38.63	15107017
92	Phosphorylation	QVSRKASSWNREEKI HHHHHCCCCCCCCCC	32.98	-
118	Ubiquitination	VIEEGGVKMKLTVID EHHHCCEEEEEEEEE	33.32	30230243
155	Ubiquitination	EQYEKFLKEEVNIAR HHHHHHHHHHHHHHH	55.77	32142685
221	Ubiquitination	LEEKSEFKQRVRKEL HHHHHHHHHHHHHHH	32.89	23000965
226	Ubiquitination	EFKQRVRKELEVNGI HHHHHHHHHHHHCCE	64.89	23000965
226	Acetylation	EFKQRVRKELEVNGI HHHHHHHHHHHHCCE	64.89	11688629
226 (in isoform 1)	Ubiquitination	-	64.89	21890473
226 (in isoform 2)	Ubiquitination	-	64.89	21890473
616	Ubiquitination	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		30230243
653	Ubiquitination	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		32142685
719	Ubiquitination	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		23000965
724	Ubiquitination	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEPT3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
91	S	Phosphorylation	Phosphorylated by PKG on Ser-91 (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEPT3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SEPT3_HUMAN	SEPT3	physical	25416956
SEPT4_HUMAN	SEPT4	physical	26186194
SEPT2_HUMAN	SEPT2	physical	26186194
SEPT7_HUMAN	SEPT7	physical	26186194
SEP14_HUMAN	SEPT14	physical	26186194
SEPT5_HUMAN	SEPT5	physical	26186194
SEPT6_HUMAN	SEPT6	physical	26186194
SEPT8_HUMAN	SEPT8	physical	26186194
SEP11_HUMAN	SEPT11	physical	26186194
SEP10_HUMAN	SEPT10	physical	26186194
DHB8_HUMAN	HSD17B8	physical	26186194
SEPT9_HUMAN	SEPT9	physical	26186194
BTBD9_HUMAN	BTBD9	physical	26186194
CBR4_HUMAN	CBR4	physical	26186194
PCMD2_HUMAN	PCMTD2	physical	26186194
SEPT7_HUMAN	SEPT7	physical	28514442
SEP10_HUMAN	SEPT10	physical	28514442
SEPT6_HUMAN	SEPT6	physical	28514442
SEPT8_HUMAN	SEPT8	physical	28514442
SEPT5_HUMAN	SEPT5	physical	28514442
SEP14_HUMAN	SEPT14	physical	28514442
SEPT4_HUMAN	SEPT4	physical	28514442
SEP11_HUMAN	SEPT11	physical	28514442
DHB8_HUMAN	HSD17B8	physical	28514442
SEPT9_HUMAN	SEPT9	physical	28514442
BTBD9_HUMAN	BTBD9	physical	28514442
PCMD1_HUMAN	PCMTD1	physical	28514442
PCMD2_HUMAN	PCMTD2	physical	28514442
WDTC1_HUMAN	WDTC1	physical	28514442
CBR4_HUMAN	CBR4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.