dbPTM

SEPT4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SEPT4_HUMAN
UniProt AC	O43236
Protein Name	Septin-4
Gene Name	4-Sep
Organism	Homo sapiens (Human).
Sequence Length	478
Subcellular Localization	Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum . In platelets, found in areas surrounding alpha-granules. Found in the sperm annulus (PubMed:25588830). Isoform ARTS: Mitochondrion. Nucleus. While predominantly localized
Protein Description	Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. [PubMed: 25588830 May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.]
Protein Sequence	MDRSLGWQGNSVPEDRTEAGIKRFLEDTTDDGELSKFVKDFSGNASCHPPEAKTWASRPQVPEPRPQAPDLYDDDLEFRPPSRPQSSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDHKKRKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQKQMKENY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MDRSLGWQGNS ----CCCCCCCCCCC	27.28	28857561
4	Phosphorylation	----MDRSLGWQGNS ----CCCCCCCCCCC	27.28	19413330
5 (in isoform 3)	Phosphorylation	-	9.35	28450419
6 (in isoform 3)	Phosphorylation	-	18.86	28450419
9 (in isoform 3)	Phosphorylation	-	23.13	28450419
11	Phosphorylation	SLGWQGNSVPEDRTE CCCCCCCCCCCCCCH	45.96	29083192
19	Phosphorylation	VPEDRTEAGIKRFLE CCCCCCHHHHHHHHH	25.13	27732954
22	Phosphorylation	DRTEAGIKRFLEDTT CCCHHHHHHHHHCCC	35.86	27732954
23	Phosphorylation	RTEAGIKRFLEDTTD CCHHHHHHHHHCCCC	39.19	27732954
25	Phosphorylation	EAGIKRFLEDTTDDG HHHHHHHHHCCCCCC	7.27	27732954
26	Phosphorylation	AGIKRFLEDTTDDGE HHHHHHHHCCCCCCH	51.07	27732954
33	Phosphorylation	EDTTDDGELSKFVKD HCCCCCCHHHHHHHH	57.79	27732954
37	Phosphorylation	DDGELSKFVKDFSGN CCCHHHHHHHHCCCC	8.09	27732954
38	Phosphorylation	DGELSKFVKDFSGNA CCHHHHHHHHCCCCC	7.17	27732954
49	Phosphorylation	SGNASCHPPEAKTWA CCCCCCCCCCCCCHH	32.52	28674151
51	Ubiquitination	NASCHPPEAKTWASR CCCCCCCCCCCHHCC	68.22	30230243
70	Phosphorylation	EPRPQAPDLYDDDLE CCCCCCCCCCCCCCC	61.96	25693802
72	Phosphorylation	RPQAPDLYDDDLEFR CCCCCCCCCCCCCCC	25.38	25693802
75	Phosphorylation	APDLYDDDLEFRPPS CCCCCCCCCCCCCCC	45.24	25693802
80	Phosphorylation	DDDLEFRPPSRPQSS CCCCCCCCCCCCCCC	36.22	25693802
94	Phosphorylation	SDNQQYFCAPAPLSP CCCCCEEEECCCCCC	3.64	-
99	Ubiquitination	YFCAPAPLSPSARPR EEEECCCCCCCCCCC	14.80	30230243
100	Phosphorylation	FCAPAPLSPSARPRS EEECCCCCCCCCCCC	18.75	29083192
101	Phosphorylation	CAPAPLSPSARPRSP EECCCCCCCCCCCCC	39.43	29083192
106	Phosphorylation	LSPSARPRSPWGKLD CCCCCCCCCCCCCCC	50.20	29083192
107	Phosphorylation	SPSARPRSPWGKLDP CCCCCCCCCCCCCCC	27.90	29449344
109	Phosphorylation	SARPRSPWGKLDPYD CCCCCCCCCCCCCCC	20.14	29083192
111	Phosphorylation	RPRSPWGKLDPYDSS CCCCCCCCCCCCCCC	45.94	29083192
114	Phosphorylation	SPWGKLDPYDSSEDD CCCCCCCCCCCCCCC	45.31	29083192
115	Phosphorylation	PWGKLDPYDSSEDDK CCCCCCCCCCCCCCC	28.29	28857561
117	Phosphorylation	GKLDPYDSSEDDKEY CCCCCCCCCCCCCHH	29.77	25693802
117	Phosphorylation	GKLDPYDSSEDDKEY CCCCCCCCCCCCCHH	29.77	29083192
118	Phosphorylation	KLDPYDSSEDDKEYV CCCCCCCCCCCCHHE	41.99	25693802
118	Phosphorylation	KLDPYDSSEDDKEYV CCCCCCCCCCCCHHE	41.99	29083192
122	Phosphorylation	YDSSEDDKEYVGFAT CCCCCCCCHHEEEEE	64.37	27251275
124	Phosphorylation	SSEDDKEYVGFATLP CCCCCCHHEEEEECC	16.18	27732954
129	Phosphorylation	KEYVGFATLPNQVHR CHHEEEEECCCHHHH	40.25	23312004
132	Phosphorylation	VGFATLPNQVHRKSV EEEEECCCHHHHHHH	60.67	27251275
141	Ubiquitination	VHRKSVKKGFDFTLM HHHHHHHCCCCEEEE	63.76	-
170	Phosphorylation	SLFLTDLYRDRKLLG HHHHHHHHHCHHHHC	17.18	25693802
179	Ubiquitination	DRKLLGAEERIMQTV CHHHHCCHHHHHHHH	46.11	30230243
189	Phosphorylation	IMQTVEITKHAVDIE HHHHHHHHEECCCHH	11.85	23663014
190	Ubiquitination	MQTVEITKHAVDIEE HHHHHHHEECCCHHH	34.92	30230243
191	Ubiquitination	QTVEITKHAVDIEEK HHHHHHEECCCHHHC	23.49	30230243
195	Phosphorylation	ITKHAVDIEEKGVRL HHEECCCHHHCCEEE	6.23	24719451
195	Phosphorylation	ITKHAVDIEEKGVRL HHEECCCHHHCCEEE	6.23	28674151
196	Phosphorylation	TKHAVDIEEKGVRLR HEECCCHHHCCEEEE	49.55	29396449
198	Ubiquitination	HAVDIEEKGVRLRLT ECCCHHHCCEEEEEE	50.33	30230243
204	Phosphorylation	EKGVRLRLTIVDTPG HCCEEEEEEEECCCC	4.54	30622161
213	Ubiquitination	IVDTPGFGDAVNNTE EECCCCCCCCCCCCC	28.08	30230243
218	Phosphorylation	GFGDAVNNTECWKPV CCCCCCCCCCCHHHH	30.56	24719451
221	Phosphorylation	DAVNNTECWKPVAEY CCCCCCCCHHHHHHH	5.50	25693802
223	Phosphorylation	VNNTECWKPVAEYID CCCCCCHHHHHHHHH	41.07	25693802
229	Phosphorylation	WKPVAEYIDQQFEQY HHHHHHHHHHHHHHH	2.65	25693802
230	Phosphorylation	KPVAEYIDQQFEQYF HHHHHHHHHHHHHHH	35.01	25693802
233	Phosphorylation	AEYIDQQFEQYFRDE HHHHHHHHHHHHHCC	5.40	25693802
236	Phosphorylation	IDQQFEQYFRDESGL HHHHHHHHHHCCCCC	8.06	25693802
238	Phosphorylation	QQFEQYFRDESGLNR HHHHHHHHCCCCCCC	41.68	25693802
253	Phosphorylation	KNIQDNRVHCCLYFI CCCCCCCEEEEEEEE	5.20	25693802
258	Phosphorylation	NRVHCCLYFISPFGH CCEEEEEEEECCCCC	5.74	24719451
264	Phosphorylation	LYFISPFGHGLRPLD EEEECCCCCCCCCCC	19.82	22210691
271	Phosphorylation	GHGLRPLDVEFMKAL CCCCCCCCHHHHHHH	40.35	24719451
299	Phosphorylation	DTLTPPEVDHKKRKI CCCCCCCCCHHHHHH	13.25	23090842
300	Phosphorylation	TLTPPEVDHKKRKIR CCCCCCCCHHHHHHH	46.34	23090842
302	Phosphorylation	TPPEVDHKKRKIREE CCCCCCHHHHHHHHH	50.22	23090842
304	Ubiquitination	PEVDHKKRKIREEIE CCCCHHHHHHHHHHH	44.42	30230243
305	Phosphorylation	EVDHKKRKIREEIEH CCCHHHHHHHHHHHH	55.80	23090842
308	Phosphorylation	HKKRKIREEIEHFGI HHHHHHHHHHHHHCC	67.79	23090842
318	Phosphorylation	EHFGIKIYQFPDCDS HHHCCEEEECCCCCC	10.09	26033855
319	Phosphorylation	HFGIKIYQFPDCDSD HHCCEEEECCCCCCC	47.04	25693802
322	Ubiquitination	IKIYQFPDCDSDEDE CEEEECCCCCCCCCC	50.58	30230243
323	Phosphorylation	KIYQFPDCDSDEDED EEEECCCCCCCCCCC	5.70	25693802
325	Phosphorylation	YQFPDCDSDEDEDFK EECCCCCCCCCCCCH	49.59	22617229
325	Ubiquitination	YQFPDCDSDEDEDFK EECCCCCCCCCCCCH	49.59	32015554
329	Phosphorylation	DCDSDEDEDFKLQDQ CCCCCCCCCCHHHHH	64.40	25693802
340	Phosphorylation	LQDQALKESIPFAVI HHHHHHHHCCCEEEE	55.54	27251275
349	Phosphorylation	IPFAVIGSNTVVEAR CCEEEECCCCEEEEC	20.43	30622161
351	Phosphorylation	FAVIGSNTVVEARGR EEEECCCCEEEECCE	27.85	30622161
352	Ubiquitination	AVIGSNTVVEARGRR EEECCCCEEEECCEE	4.24	30230243
362	Phosphorylation	ARGRRVRGRLYPWGI ECCEEECCCEECCEE	22.53	25693802
363	Phosphorylation	RGRRVRGRLYPWGIV CCEEECCCEECCEEE	22.08	25693802
367	Phosphorylation	VRGRLYPWGIVEVEN ECCCEECCEEEEECC	8.79	25693802
370	Ubiquitination	RLYPWGIVEVENPGH CEECCEEEEECCCCC	6.25	30230243
372	Phosphorylation	YPWGIVEVENPGHCD ECCEEEEECCCCCCC	6.28	25693802
373	Ubiquitination	PWGIVEVENPGHCDF CCEEEEECCCCCCCH	44.17	32015554
393	Phosphorylation	MLVRTHMQDLKDVTR HHHHHHHHHHHHCCH	45.33	30622161
397	Phosphorylation	THMQDLKDVTRETHY HHHHHHHHCCHHHHH	55.08	30622161
401	Phosphorylation	DLKDVTRETHYENYR HHHHCCHHHHHHHHH	30.48	30622161
429	Phosphorylation	ERNRNKLTRESGTDF HHHHCCCCCCCCCCC	33.72	28857561
432	Phosphorylation	RNKLTRESGTDFPIP HCCCCCCCCCCCCCC	43.64	28857561
432	Ubiquitination	RNKLTRESGTDFPIP HCCCCCCCCCCCCCC	43.64	30230243
434	Phosphorylation	KLTRESGTDFPIPAV CCCCCCCCCCCCCCC	43.69	28857561
443	Ubiquitination	FPIPAVPPGTDPETE CCCCCCCCCCCHHHH	52.28	30230243
444	Ubiquitination	PIPAVPPGTDPETEK CCCCCCCCCCHHHHH	36.36	30230243
445	Phosphorylation	IPAVPPGTDPETEKL CCCCCCCCCHHHHHH	54.90	23312004
449	Phosphorylation	PPGTDPETEKLIREK CCCCCHHHHHHHHHH	43.75	23312004
450	Ubiquitination	PGTDPETEKLIREKD CCCCHHHHHHHHHHH	44.17	30230243
451	Ubiquitination	GTDPETEKLIREKDE CCCHHHHHHHHHHHH	57.54	30230243
452	Phosphorylation	TDPETEKLIREKDEE CCHHHHHHHHHHHHH	3.48	30622161
453	Ubiquitination	DPETEKLIREKDEEL CHHHHHHHHHHHHHH	8.72	32015554
454	Phosphorylation	PETEKLIREKDEELR HHHHHHHHHHHHHHH	56.18	30622161
456	Ubiquitination	TEKLIREKDEELRRM HHHHHHHHHHHHHHH	61.67	-
461	Ubiquitination	REKDEELRRMQEMLH HHHHHHHHHHHHHHH	34.99	30230243
462	Ubiquitination	EKDEELRRMQEMLHK HHHHHHHHHHHHHHH	43.70	30230243
466	Ubiquitination	ELRRMQEMLHKIQKQ HHHHHHHHHHHHHHH	2.40	30230243
469	Ubiquitination	RMQEMLHKIQKQMKE HHHHHHHHHHHHHHH	42.76	30230243
481	Phosphorylation	MKENY---------- HHHHC----------		30622161
483	Phosphorylation	ENY------------ HHC------------		30622161
484	Ubiquitination	NY------------- HC-------------		30230243
486	Phosphorylation	--------------- ---------------		30622161
493	Phosphorylation	---------------------- ----------------------		30622161
498	Phosphorylation	--------------------------- ---------------------------		30622161
503	Phosphorylation	-------------------------------- --------------------------------		30622161
716	Ubiquitination	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		30230243
969	Ubiquitination	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		30230243
987	Ubiquitination	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		30230243

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	XIAP	P98170	PMID:22185822
-	K	Ubiquitination	E3 ubiquitin ligase	PRKN	O60260	PMID:22792159

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SEPT4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SEPT4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYUA_HUMAN	SNCA	physical	12695511
XIAP_HUMAN	XIAP	physical	21185211
SIAH1_HUMAN	SIAH1	physical	21185211
AREL1_HUMAN	AREL1	physical	23479728
XIAP_HUMAN	XIAP	physical	15029247
SEP11_HUMAN	SEPT11	physical	26344197
XIAP_HUMAN	XIAP	physical	28224479
UBC_HUMAN	UBC	physical	28224479

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SEPT4_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325, AND MASSSPECTROMETRY.	18318008 [Abstract]