| UniProt ID | AREL1_HUMAN | |
|---|---|---|
| UniProt AC | O15033 | |
| Protein Name | Apoptosis-resistant E3 ubiquitin protein ligase 1 | |
| Gene Name | AREL1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 823 | |
| Subcellular Localization | Cytoplasm, cytosol . | |
| Protein Description | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation.. | |
| Protein Sequence | MFYVIGGITVSVVAFFFTIKFLFELAARVVSFLQNEDRERRGDRTIYDYVRGNYLDPRSCKVSWDWKDPYEVGHSMAFRVHLFYKNGQPFPAHRPVGLRVHISHVELAVEIPVTQEVLQEPNSNVVKVAFTVRKAGRYEITVKLGGLNVAYSPYYKIFQPGMVVPSKTKIVCHFSTLVLTCGQPHTLQIVPRDEYDNPTNNSMSLRDEHNYTLSIHELGPQEEESTGVSFEKSVTSNRQTFQVFLRLTLHSRGCFHACISYQNQPINNGEFDIIVLSEDEKNIVERNVSTSGVSIYFEAYLYNATNCSSTPWHLPPMHMTSSQRRPSTAVDEEDEDSPSECHTPEKVKKPKKVYCYVSPKQFSVKEFYLKIIPWRLYTFRVCPGTKFSYLGPDPVHKLLTLVVDDGIQPPVELSCKERNILAATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSEMELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGML | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | FYVIGGITVSVVAFF EEEECCEEHHHHHHH | 23401153 | ||
| 11 | Phosphorylation | VIGGITVSVVAFFFT EECCEEHHHHHHHHH | 23401153 | ||
| 18 | Phosphorylation | SVVAFFFTIKFLFEL HHHHHHHHHHHHHHH | 23401153 | ||
| 45 | Phosphorylation | RERRGDRTIYDYVRG HHHCCCCCHHHHHCC | 28796482 | ||
| 47 | Phosphorylation | RRGDRTIYDYVRGNY HCCCCCHHHHHCCCC | 28796482 | ||
| 49 | Phosphorylation | GDRTIYDYVRGNYLD CCCCHHHHHCCCCCC | 28796482 | ||
| 59 | Phosphorylation | GNYLDPRSCKVSWDW CCCCCCCCCCCEECC | - | ||
| 75 | Phosphorylation | DPYEVGHSMAFRVHL CCCCCCCCEEEEEEE | 30631047 | ||
| 84 | Phosphorylation | AFRVHLFYKNGQPFP EEEEEEEEECCCCCC | - | ||
| 327 | Phosphorylation | TSSQRRPSTAVDEED CCCCCCCCCCCCCCC | 23401153 | ||
| 328 | Phosphorylation | SSQRRPSTAVDEEDE CCCCCCCCCCCCCCC | 28348404 | ||
| 337 | Phosphorylation | VDEEDEDSPSECHTP CCCCCCCCCCCCCCH | 23401153 | ||
| 339 | Phosphorylation | EEDEDSPSECHTPEK CCCCCCCCCCCCHHH | 30108239 | ||
| 343 | Phosphorylation | DSPSECHTPEKVKKP CCCCCCCCHHHCCCC | 21712546 | ||
| 352 | Ubiquitination | EKVKKPKKVYCYVSP HHCCCCCEEEEEECC | 29967540 | ||
| 354 | Phosphorylation | VKKPKKVYCYVSPKQ CCCCCEEEEEECCCC | 22617229 | ||
| 356 | Phosphorylation | KPKKVYCYVSPKQFS CCCEEEEEECCCCCC | 22617229 | ||
| 358 | Phosphorylation | KKVYCYVSPKQFSVK CEEEEEECCCCCCHH | 22617229 | ||
| 368 | Phosphorylation | QFSVKEFYLKIIPWR CCCHHEEEEEECCCC | 21815630 | ||
| 431 | Ubiquitination | TFIRSLHKNIGGSET HHHHHHHHHCCCCHH | 29967540 | ||
| 436 | Phosphorylation | LHKNIGGSETFQDKV HHHHCCCCHHHHHHH | - | ||
| 442 | Ubiquitination | GSETFQDKVNFFQRE CCHHHHHHHHHHHHH | 29967540 | ||
| 477 | Ubiquitination | ALLESSLKATRNFSI HHHHHHHHHHCCCCH | 29967540 | ||
| 564 | Phosphorylation | RLVGKCLYESSLGGA HHHHHHHHHCCCCHH | - | ||
| 566 | Phosphorylation | VGKCLYESSLGGAYK HHHHHHHCCCCHHHH | - | ||
| 567 | Phosphorylation | GKCLYESSLGGAYKQ HHHHHHCCCCHHHHH | - | ||
| 572 | Phosphorylation | ESSLGGAYKQLVRAR HCCCCHHHHHHHHHH | - | ||
| 600 | Phosphorylation | MHYKYFETDDPEFYK HHHEEECCCCHHHHH | 29759185 | ||
| 609 | Ubiquitination | DPEFYKSKVCFILNN CHHHHHHCEEEEECC | 30230243 | ||
| 783 (in isoform 2) | Phosphorylation | - | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 783 | T | Phosphorylation | Kinase | GSK3B | P49841 | PSP |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AREL1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AREL1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| AREL1_HUMAN | AREL1 | physical | 23479728 | |
| UB2D1_HUMAN | UBE2D1 | physical | 23479728 | |
| HTRA2_MOUSE | Htra2 | physical | 23479728 | |
| DBLOH_HUMAN | DIABLO | physical | 23479728 | |
| HTRA2_HUMAN | HTRA2 | physical | 23479728 | |
| SEPT4_HUMAN | SEPT4 | physical | 23479728 | |
| UBC_HUMAN | UBC | physical | 25752577 | |
| UB2L3_HUMAN | UBE2L3 | physical | 25752577 | |
| UBC_HUMAN | UBC | physical | 25723849 | |
| UB2D1_HUMAN | UBE2D1 | physical | 25723849 | |
| UB2D2_HUMAN | UBE2D2 | physical | 25723849 | |
| UB2D3_HUMAN | UBE2D3 | physical | 25723849 | |
| UB2L3_HUMAN | UBE2L3 | physical | 25723849 | |
| AREL1_HUMAN | AREL1 | physical | 26949039 | |
| UB2D1_HUMAN | UBE2D1 | physical | 26949039 | |
| PIAS4_HUMAN | PIAS4 | physical | 27162139 | |
| GSK3B_HUMAN | GSK3B | physical | 27162139 | |
| UB2D1_HUMAN | UBE2D1 | physical | 27162139 | |
| UB2L3_HUMAN | UBE2L3 | physical | 27162139 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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