HTRA2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HTRA2_MOUSE
• UniProt AC: Q9JIY5
• Protein Name: Serine protease HTRA2, mitochondrial
• Gene Name: Htra2
• Organism: Mus musculus (Mouse).
• Sequence Length: 458
• Subcellular Localization: Mitochondrion intermembrane space. Mitochondrion membrane ; Single-pass membrane protein . Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria
• Protein Description: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis (By similarity)..
• Protein Sequence: MAALKAGRGANWSLRAWRALGGIFWRKPPLLAPDLRALLTSGTPDSQIWMTYGTPSLPAQVPEGFLASRADLTSRTPDLWARLNVGTSGSSDQEARRSPGSRRREWLAVAVGAGGAVVLLLWGWGRGLSTVLAAVPAPPPTSPRSQYNFIADVVEKTAPAVVYIEILDRHPFSGREVPISNGSGFVVASDGLIVTNAHVVADRRRVRVRLPSGDTYEAMVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQNNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSWFGTSGSQRRYIGVMMLTLTPSILIELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEKLAQNAEDVYEAVRTQSQLAVRIRRGSETLTLYVTPEVTE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
98	Phosphorylation	SDQEARRSPGSRRRE CHHHHHCCCCCHHHH	28.23	25338131
129	Phosphorylation	WGWGRGLSTVLAAVP ECCCCCHHHHHHCCC	21.20	-
130	Phosphorylation	GWGRGLSTVLAAVPA CCCCCHHHHHHCCCC	25.28	-
141	Phosphorylation	AVPAPPPTSPRSQYN CCCCCCCCCCHHHCC	58.08	-
142	Phosphorylation	VPAPPPTSPRSQYNF CCCCCCCCCHHHCCC	24.88	-
212	Phosphorylation	RVRVRLPSGDTYEAM CEEEECCCCCCEEEE	54.62	26745281
215	Phosphorylation	VRLPSGDTYEAMVTA EECCCCCCEEEEEEE	27.13	26745281
216	Phosphorylation	RLPSGDTYEAMVTAV ECCCCCCEEEEEEEE	13.36	23984901
221	Phosphorylation	DTYEAMVTAVDPVAD CCEEEEEEEEECCCC	14.10	23984901
237	Ubiquitination	ATLRIQTKEPLPTLP EEEEECCCCCCCCCC	40.74	27667366
348	Malonylation	FLHRGEKKNSWFGTS HHHCCCCCCCCCCCC	52.49	26320211
350	Phosphorylation	HRGEKKNSWFGTSGS HCCCCCCCCCCCCCC	32.44	23684622
354	Phosphorylation	KKNSWFGTSGSQRRY CCCCCCCCCCCCCEE	22.05	30635358
355	Phosphorylation	KNSWFGTSGSQRRYI CCCCCCCCCCCCEEE	36.51	30635358
357	Phosphorylation	SWFGTSGSQRRYIGV CCCCCCCCCCEEEEE	21.93	30635358
400	Phosphorylation	IHKVILGSPAHRAGL EEEHHHCCHHHHCCC	18.57	21701498
435	Phosphorylation	YEAVRTQSQLAVRIR HHHHHHHHHHHHEEE	26.92	-
445	Phosphorylation	AVRIRRGSETLTLYV HHEEECCCCEEEEEE	26.12	30635358
447	Phosphorylation	RIRRGSETLTLYVTP EEECCCCEEEEEECC	27.09	30635358
449	Phosphorylation	RRGSETLTLYVTPEV ECCCCEEEEEECCCC	24.38	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HTRA2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HTRA2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HTRA2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BIRC3_MOUSE	Birc3	physical	12815069
CASB_MOUSE	Csn2	physical	12815069
BIRC2_MOUSE	Birc2	physical	12815069
XIAP_MOUSE	Xiap	physical	12815069
DIAP1_MOUSE	Diap1	physical	12815069
BIRC7_MOUSE	Birc7	physical	12815069

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.