BIRC3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BIRC3_MOUSE
• UniProt AC: O08863
• Protein Name: Baculoviral IAP repeat-containing protein 3
• Gene Name: Birc3
• Organism: Mus musculus (Mouse).
• Sequence Length: 600
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8..
• Protein Sequence: MVQDSAFLAKLMKSADTFELKYDFSCELYRLSTYSAFPRGVPVSERSLARAGFYYTGANDKVKCFCCGLMLDNWKQGDSPMEKHRKLYPSCNFVQTLNPANSLEASPRPSLPSTAMSTMPLSFASSENTGYFSGSYSSFPSDPVNFRANQDCPALSTSPYHFAMNTEKARLLTYETWPLSFLSPAKLAKAGFYYIGPGDRVACFACDGKLSNWERKDDAMSEHQRHFPSCPFLKDLGQSASRYTVSNLSMQTHAARIRTFSNWPSSALVHSQELASAGFYYTGHSDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEYLLRIKGQEFVSQVQAGYPHLLEQLLSTSDSPEDENADAAIVHFGPGESSEDVVMMSTPVVKAALEMGFSRSLVRQTVQWQILATGENYRTVSDLVIGLLDAEDEMREEQMEQAAEEEESDDLALIRKNKMVLFQHLTCVTPMLYCLLSARAITEQECNAVKQKPHTLQASTLIDTVLAKGNTAATSFRNSLREIDPALYRDIFVQQDIRSLPTDDIAALPMEEQLRKLQEERMCKVCMDREVSIVFIPCGHLVVCKDCAPSLRKCPICRGTIKGTVRTFLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Acetylation	QDSAFLAKLMKSADT CHHHHHHHHHHHCCC	51.79	7969697
138	Phosphorylation	YFSGSYSSFPSDPVN CCCCCCCCCCCCCCC	32.70	-
168	Ubiquitination	HFAMNTEKARLLTYE CCCCCCCCCEEEEEE	36.45	-
183	Phosphorylation	TWPLSFLSPAKLAKA CCCHHHCCHHHHHHC	22.32	18779572
189	Ubiquitination	LSPAKLAKAGFYYIG CCHHHHHHCCEEEEC	60.52	-
243	Phosphorylation	LGQSASRYTVSNLSM HCCCCCHHHHCCHHH	14.70	22817900
244	Phosphorylation	GQSASRYTVSNLSMQ CCCCCHHHHCCHHHH	19.15	22817900
246	Phosphorylation	SASRYTVSNLSMQTH CCCHHHHCCHHHHHC	25.01	21183079
249	Phosphorylation	RYTVSNLSMQTHAAR HHHHCCHHHHHCHHH	17.07	21183079
388	Phosphorylation	AALEMGFSRSLVRQT HHHHCCCCHHHHHHH	18.41	25159016
390	Phosphorylation	LEMGFSRSLVRQTVQ HHCCCCHHHHHHHHH	29.98	25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Traf6	P70196	PMID:19898473

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BIRC3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BIRC3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYD88_MOUSE	Myd88	physical	19898473
TLR4_MOUSE	Tlr4	physical	19898473
TRAF3_MOUSE	Traf3	physical	18635759
CASP9_MOUSE	Casp9	physical	12815069
CASP3_MOUSE	Casp3	physical	12815069

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.