CASP9_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CASP9_MOUSE
• UniProt AC: Q8C3Q9
• Protein Name: Caspase-9
• Gene Name: Casp9
• Organism: Mus musculus (Mouse).
• Sequence Length: 454
• Protein Description: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) (By similarity)..
• Protein Sequence: MDEADRQLLRRCRVRLVSELQVAELWDALLSRELFTRDMIEDIQQAGSGSRRDQARQLVTDLETRGRQALPLFISCLEDTGQGTLASLLQSGRQAAKQDPEAVKPLDHLVPVVLGPMGLTAKEQRVVKLDPSQPAVGNLTPVVLGPEELWPARLKPEVLRPETPRPVDIGSGGAHDVCVPGKIRGHADMAYTLDSDPCGHCLIINNVNFCPSSGLGTRTGSNLDRDKLEHRFRWLRFMVEVKNDLTAKKMVTALMEMAHRNHRALDCFVVVILSHGCQASHLQFPGAVYGTDGCSVSIEKIVNIFNGSGCPSLGGKPKLFFIQACGGEQKDHGFEVACTSSQGRTLDSDSEPDAVPYQEGPRPLDQLDAVSSLPTPSDILVSYSTFPGFVSWRDKKSGSWYIETLDGILEQWARSEDLQSLLLRVANAVSAKGTYKQIPGCFNFLRKKLFFKTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
132	Phosphorylation	RVVKLDPSQPAVGNL EEEECCCCCCCCCCC		22324799
140	Phosphorylation	QPAVGNLTPVVLGPE CCCCCCCCCEECCHH		24719451
163	Phosphorylation	PEVLRPETPRPVDIG HHHCCCCCCCCCCCC		25367039
171	Phosphorylation	PRPVDIGSGGAHDVC CCCCCCCCCCCCCEE		25367039
191	Phosphorylation	RGHADMAYTLDSDPC CCCCCEEEECCCCCC		15657060
339	Phosphorylation	HGFEVACTSSQGRTL CCEEEEEECCCCCCC		30635358
340	Phosphorylation	GFEVACTSSQGRTLD CEEEEEECCCCCCCC		30635358
341	Phosphorylation	FEVACTSSQGRTLDS EEEEEECCCCCCCCC		30635358
345	Phosphorylation	CTSSQGRTLDSDSEP EECCCCCCCCCCCCC		17203969
348	Phosphorylation	SQGRTLDSDSEPDAV CCCCCCCCCCCCCCC		17203969
350	Phosphorylation	GRTLDSDSEPDAVPY CCCCCCCCCCCCCCC		17203969

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
163	T	Phosphorylation	Kinase	DYRK1A	Q13627	PSP
163	T	Phosphorylation	Kinase	DYRK1A	Q61214	PSP
163	T	Phosphorylation	Kinase	MAPK1	P63085	Uniprot
191	Y	Phosphorylation	Kinase	ABL1	P00520	Uniprot
348	S	Phosphorylation	Kinase	CSNK2A1	Q60737	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
163	T	Phosphorylation	Phosphorylated at Thr-163 by MAPK1/ERK2.	15657060
163	T	Phosphorylation	Phosphorylation at Thr-163 is sufficient to block caspase-9 processing and subsequent caspase-3 activation (By similarity).	15657060

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CASP9_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERA_MOUSE	Vcp	physical	14561754
PDCD6_MOUSE	Pdcd6	physical	14561754
JUN_MOUSE	Jun	physical	23678002

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.