MYD88_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYD88_MOUSE
• UniProt AC: P22366
• Protein Name: Myeloid differentiation primary response protein MyD88
• Gene Name: Myd88 {ECO:0000312|MGI:MGI:108005}
• Organism: Mus musculus (Mouse).
• Sequence Length: 296
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. [PubMed: 9697844 Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response]
• Protein Sequence: MSAGDPRVGSGSLDSFMFSIPLVALNVGVRRRLSLFLNPRTPVAADWTLLAEEMGFEYLEIRELETRPDPTRSLLDAWQGRSGASVGRLLELLALLDREDILKELKSRIEEDCQKYLGKQQNQESEKPLQVARVESSVPQTKELGGITTLDDPLGQTPELFDAFICYCPNDIEFVQEMIRQLEQTDYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFALSLSPGVQQKRLIPIKYKAMKKDFPSILRFITICDYTNPCTKSWFWTRLAKALSLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	AGDPRVGSGSLDSFM CCCCCCCCCCCCHHH	23.50	24719451
34	Phosphorylation	VGVRRRLSLFLNPRT CCCHHHHHHHCCCCC	18.44	28833060
67	Dimethylation	EIRELETRPDPTRSL EEEECCCCCCCCHHH	25.01	-
67	Methylation	EIRELETRPDPTRSL EEEECCCCCCCCHHH	25.01	18965881
82	Phosphorylation	LDAWQGRSGASVGRL HHHHCCCCCCHHHHH	45.60	29514104
185	Phosphorylation	MIRQLEQTDYRLKLC HHHHHHHCCCEEEEE	26.14	24719451
187	Phosphorylation	RQLEQTDYRLKLCVS HHHHHCCCEEEEECC	22.64	24719451
242	Phosphorylation	FQTKFALSLSPGVQQ HHCEEEEECCCCCCC	24.30	23140645
244	Phosphorylation	TKFALSLSPGVQQKR CEEEEECCCCCCCCC	19.07	23140645
257	Phosphorylation	KRLIPIKYKAMKKDF CCEECCCHHHHHCCC	12.52	22817900
280	Glutathionylation	ICDYTNPCTKSWFWT HCCCCCCCCHHHHHH	8.97	24333276

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYD88_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYD88_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYD88_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CITE2_MOUSE	Cited2	genetic	21098220
PRP31_MOUSE	Prpf31	physical	15952741
TBB4B_MOUSE	Tubb4b	physical	15952741
TBB5_MOUSE	Tubb5	physical	15952741
TBA1C_MOUSE	Tuba1c	physical	15952741
ARL1_MOUSE	Arl1	physical	15952741
LRRF2_MOUSE	Lrrfip2	physical	15952741
FLII_MOUSE	Flii	physical	15952741
LRRF1_MOUSE	Lrrfip1	physical	15952741
IRAK1_MOUSE	Irak1	physical	15952741
GRP78_MOUSE	Hspa5	physical	15952741
HSP7C_MOUSE	Hspa8	physical	15952741
STK38_MOUSE	Stk38	physical	15952741
ANM5_MOUSE	Prmt5	physical	15952741
TMOD3_MOUSE	Tmod3	physical	15952741
IRAK4_MOUSE	Irak4	physical	19378012
TIRAP_MOUSE	Tirap	physical	19378012
TRAF3_MOUSE	Traf3	physical	19898473
TRAF6_MOUSE	Traf6	physical	19898473
BIRC3_MOUSE	Birc3	physical	19898473
CBLB_MOUSE	Cblb	physical	17618294
IRAK1_MOUSE	Irak1	physical	21743479
BECN1_MOUSE	Becn1	physical	18772134

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.