TIRAP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIRAP_MOUSE
• UniProt AC: Q99JY1
• Protein Name: Toll/interleukin-1 receptor domain-containing adapter protein
• Gene Name: Tirap
• Organism: Mus musculus (Mouse).
• Sequence Length: 241
• Subcellular Localization: Cytoplasm. Cell membrane. Membrane. Colocalizes with DAB2IP at the plasma membrane..
• Protein Description: Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response (By similarity). Positively regulates the production of TNF-alpha and interleukin-6 (By similarity)..
• Protein Sequence: MASSSSVPASSTPSKKPRDKIADWFRQALLKKPKKMPISQESHLYDGSQTATQDGLSPSSCSSPPSHSSPESRSSPSSCSSGMSPTSPPTHVDSSSSSSGRWSKDYDVCVCHSEEDLEAAQELVSYLEGSQASLRCFLQLRDAAPGGAIVSELCQALSRSHCRALLITPGFLRDPWCKYQMLQALTEAPASEGCTIPLLSGLSRAAYPPELRFMYYVDGRGKDGGFYQVKEAVIHYLETLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASSSSVPAS -----CCCCCCCCCC	29.47	30635358
4	Phosphorylation	----MASSSSVPASS ----CCCCCCCCCCC	19.66	30635358
5	Phosphorylation	---MASSSSVPASST ---CCCCCCCCCCCC	32.62	30635358
6	Phosphorylation	--MASSSSVPASSTP --CCCCCCCCCCCCC	33.78	30635358
10	Phosphorylation	SSSSVPASSTPSKKP CCCCCCCCCCCCCCC	28.77	30635358
11	Phosphorylation	SSSVPASSTPSKKPR CCCCCCCCCCCCCCH	46.58	30635358
12	Phosphorylation	SSVPASSTPSKKPRD CCCCCCCCCCCCCHH	29.14	30635358
14	Phosphorylation	VPASSTPSKKPRDKI CCCCCCCCCCCHHHH	54.09	30635358
74	Phosphorylation	HSSPESRSSPSSCSS CCCCCCCCCCCCCCC	56.74	29472430
75	Phosphorylation	SSPESRSSPSSCSSG CCCCCCCCCCCCCCC	27.91	29472430
77	Phosphorylation	PESRSSPSSCSSGMS CCCCCCCCCCCCCCC	46.02	29472430
78	Phosphorylation	ESRSSPSSCSSGMSP CCCCCCCCCCCCCCC	22.77	29472430
86	Phosphorylation	CSSGMSPTSPPTHVD CCCCCCCCCCCCCCC	46.70	-
90	Phosphorylation	MSPTSPPTHVDSSSS CCCCCCCCCCCCCCC	37.60	-
99	Phosphorylation	VDSSSSSSGRWSKDY CCCCCCCCCCCCCCE	34.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIRAP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIRAP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIRAP_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYD88_MOUSE	Myd88	physical	19378012
TNFL9_MOUSE	Tnfsf9	physical	24084649

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.