PRP31_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRP31_MOUSE
• UniProt AC: Q8CCF0
• Protein Name: U4/U6 small nuclear ribonucleoprotein Prp31
• Gene Name: Prpf31
• Organism: Mus musculus (Mouse).
• Sequence Length: 499
• Subcellular Localization: Nucleus . Nucleus speckle . Nucleus, Cajal body . Predominantly found in speckles and in Cajal bodies.
• Protein Description: Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome..
• Protein Sequence: MSLADELLADLEEAAEEEEGGSYGEEEEEPAIEDVQEETQLDLSGDSVKSIAKLWDSKMFAEIMMKIEEYISKQANVSEVMGPVEAAPEYRVIVDANNLTVEIENELNIIHKFIRDKYSKRFPELESLVPNALDYIRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLSDEELERLEEACDMALELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVAGGLTNLSKMPACNIMLLGAQRKTLSGFSSTSVLPHTGYIYHSDIVQSLPPDLRRKAARLVAAKCTLAARVDSFHESTEGKVGYELKDEIERKFDKWQEPPPVKQVKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKQANRMSFGEIEEDAYQEDLGFSLGHLGKSGSGRVRQTQVNEATKARISKTLQRTLQKQSVVYGGKSTIRDRSSGTASSVAFTPLQGLEIVNPQAAEKKVAEANQKYFSSMAEFLKVKGEKSGTMST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	AEEEEGGSYGEEEEE HHHHCCCCCCCCCCC	40.60	25338131
50	Phosphorylation	LSGDSVKSIAKLWDS CCCHHHHHHHHHHCH	26.14	29895711
205	Phosphorylation	NASKHRIYEYVESRM CCCHHHHHHHHHHHH	10.93	25367039
207	Phosphorylation	SKHRIYEYVESRMSF CHHHHHHHHHHHHCH	7.79	25367039
213	Phosphorylation	EYVESRMSFIAPNLS HHHHHHHCHHCCCEE	16.64	-
307	Phosphorylation	TLAARVDSFHESTEG HHHHCCCCCHHCCCC	26.16	22817900
341	Acetylation	PPPVKQVKPLPAPLD CCCCCCCCCCCCCCC	38.04	23236377
379	Phosphorylation	RKQANRMSFGEIEED HHHHHHCCCHHCCCH	27.19	29514104
395	Phosphorylation	YQEDLGFSLGHLGKS HHHHHCCCHHHCCCC	31.48	-
402	Phosphorylation	SLGHLGKSGSGRVRQ CHHHCCCCCCCCCCH	36.07	23375375
432	Phosphorylation	QRTLQKQSVVYGGKS HHHHHHCCEEECCCC	22.15	20139300
435	Phosphorylation	LQKQSVVYGGKSTIR HHHCCEEECCCCEEE	20.29	28066266
438	Acetylation	QSVVYGGKSTIRDRS CCEEECCCCEEECCC	39.81	23806337
439	Phosphorylation	SVVYGGKSTIRDRSS CEEECCCCEEECCCC	32.13	26824392
440	Phosphorylation	VVYGGKSTIRDRSSG EEECCCCEEECCCCC	24.42	23684622
445	Phosphorylation	KSTIRDRSSGTASSV CCEEECCCCCCCCEE	37.09	27087446
446	Phosphorylation	STIRDRSSGTASSVA CEEECCCCCCCCEEE	40.85	27087446
448	Phosphorylation	IRDRSSGTASSVAFT EECCCCCCCCEEEEE	25.89	21082442
450	Phosphorylation	DRSSGTASSVAFTPL CCCCCCCCEEEEEEC	25.78	27087446
451	Phosphorylation	RSSGTASSVAFTPLQ CCCCCCCEEEEEECC	18.27	27087446
455	Phosphorylation	TASSVAFTPLQGLEI CCCEEEEEECCCCEE	17.22	27087446
478	Acetylation	KVAEANQKYFSSMAE HHHHHHHHHHHHHHH	48.33	22826441
479	Phosphorylation	VAEANQKYFSSMAEF HHHHHHHHHHHHHHH	10.03	29550500
481	Phosphorylation	EANQKYFSSMAEFLK HHHHHHHHHHHHHHH	19.00	29550500
482	Phosphorylation	ANQKYFSSMAEFLKV HHHHHHHHHHHHHHH	16.47	29550500
494	Phosphorylation	LKVKGEKSGTMST-- HHHHCCCCCCCCC--	34.88	27087446
498	Phosphorylation	GEKSGTMST------ CCCCCCCCC------	30.70	27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRP31_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRP31_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRP31_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PRP31_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.