FLII_MOUSE - dbPTM
FLII_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FLII_MOUSE
UniProt AC Q9JJ28
Protein Name Protein flightless-1 homolog
Gene Name Flii
Organism Mus musculus (Mouse).
Sequence Length 1271
Subcellular Localization Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, focal adhesion. Colocalizes to actin-rich structures in blastocysts and, together with HRAS, RHOA and CDC42, in migrating fibroblasts
Protein Description May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling (By similarity). Essential for early embryonic development. May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation..
Protein Sequence MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNHLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNGIDSIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMMALQTLHLRNTQRTQSNLPTSLEGLSNLSDVDLSCNDLTRVPECLYTLPSLRRLNLSSNQIAELSLCIDQWVHLETLNLSRNQLTSLPSAICKLTKLKKLYLNSNKLDFDGLPSGIGKLTSLEEFMAANNNLELIPESLCRCPKLKKLVLNKNRLVTLPEAIHFLTEIQVLDVRENPSLVMPPKPADRTAEWYNIDFSLQNQLRLAGASPATVAAAAAVGSGSKDPLARKMRLRRRKDSAQDVQAKQVLKGMSDVAQEKNKNQEESIDARAPGGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGSSLDPRFVFLLDQGLDIYVWRGAQATLSNTTKARLFAEKINKNERKGKAEITLLVQGQEPPGFWDVLGGEPSEIKNHVPDDFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKKRPKVELMPGMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHTVVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQGQGLSGKVKRDTEKTDQMKADLTALFLPRQPPMPLAEAEQLMEEWNEDLDGMEGFVLEGRKFTRLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKTEDKEGKASAEAREGEEAAAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKFIIHRGKRKVTQGTLQPTLYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDASYSKQVINEGEEPENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHTRSKEHERPRRLRLVRKGNEQRAFTRCFHAWSTFRQAPA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEATGVLP
-------CCCCCCCC		36.30-
21AcetylationDLSGNDFKGGYFPEN
ECCCCCCCCCCCCHH		55.0523236377
21UbiquitinationDLSGNDFKGGYFPEN
ECCCCCCCCCCCCHH		55.0522790023
24PhosphorylationGNDFKGGYFPENVKA
CCCCCCCCCCHHHHH		25.3225159016
33PhosphorylationPENVKAMTSLRWLKL
CHHHHHHHHHCEEEC		29.4825159016
34PhosphorylationENVKAMTSLRWLKLN
HHHHHHHHHCEEECC		11.6725159016
241S-palmitoylationDLTRVPECLYTLPSL
CCCCCCHHHHCCHHH		2.6328526873
406PhosphorylationQLRLAGASPATVAAA
HHHHCCCCHHHHHHH		17.7226824392
409PhosphorylationLAGASPATVAAAAAV
HCCCCHHHHHHHHHH		17.6729472430
436PhosphorylationRLRRRKDSAQDVQAK
HHHHCCCCHHHHHHH		30.7525521595
458AcetylationDVAQEKNKNQEESID
HHHHHHHCCHHHCHH		71.6923806337
560GlutathionylationATLDKKACSAIHAVN
CCCCHHHHHHHHHHH		3.7624333276
665PhosphorylationVWRGAQATLSNTTKA
EEECCHHCCCCHHHH		20.7418779572
669PhosphorylationAQATLSNTTKARLFA
CHHCCCCHHHHHHHH		26.7118779572
730UbiquitinationPPQPKLYKVGLGLGY
CCCCCEEEECCCCCE		40.0222790023
737PhosphorylationKVGLGLGYLELPQIN
EECCCCCEEECCCCC		11.3122817900
808GlutathionylationLKLGQELCGMLHRPR
HHHHHHHHHHHCCCC		2.7224333276
831UbiquitinationEGTEAQVFKAKFKNW
CCCCHHHHHHHCCCC		4.1827667366
832UbiquitinationGTEAQVFKAKFKNWD
CCCHHHHHHHCCCCC		52.3822790023
836UbiquitinationQVFKAKFKNWDDVLT
HHHHHHCCCCCCCEE		57.3222790023
860PhosphorylationVLQGQGLSGKVKRDT
HHCCCCCCCCCCCCC		43.3129176673
862UbiquitinationQGQGLSGKVKRDTEK
CCCCCCCCCCCCCCC		41.0022790023
946PhosphorylationRYWVPVEYEEEEKTE
ECEEECCCCHHHCCC		28.9526026062
1031UbiquitinationTQQQENPKFLSHFKR
CCCCCCCHHHHHHHH		71.2022790023
1037UbiquitinationPKFLSHFKRKFIIHR
CHHHHHHHHHEEEEC		49.6122790023
1177PhosphorylationRCSNEKGYFAVTEKC
EECCCCCEEEEEECH		10.22-
1226GlutathionylationIKLSLKACQVYIQHT
EEHHHHHHHHHHHHC		2.4124333276
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
436SPhosphorylationKinaseSGK3Q9ERE3
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FLII_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FLII_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of FLII_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FLII_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-436, AND MASSSPECTROMETRY.

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