ANM5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANM5_MOUSE
• UniProt AC: Q8CIG8
• Protein Name: Protein arginine N-methyltransferase 5
• Gene Name: Prmt5
• Organism: Mus musculus (Mouse).
• Sequence Length: 637
• Subcellular Localization: Cytoplasm . Nucleus . Golgi apparatus .
• Protein Description: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. [PubMed: 15485929]
• Protein Sequence: MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIHPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDVIANAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKVQQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKETNVQVLMVLGAGRGPLVNASLRAAKQAERRIRLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPKPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYRDITLSIRPETHSPGMFSWFPIFFPIKQPITVHEGQNICVRFWRCSNSKKVWYEWAVTAPVCSSIHNPTGRSYTIGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAMAVGGA ------CCCCCCCCC	13.12	-
12	Phosphorylation	AVGGAGGSRVSSGRD CCCCCCCCCCCCCCC	28.70	24759943
67	Phosphorylation	KNRPGPQTRSDLLLS CCCCCCCCHHHHHHC	34.96	30635358
69	Phosphorylation	RPGPQTRSDLLLSGR CCCCCCHHHHHHCCC	35.68	30635358
95	Ubiquitination	PWIHPDSKVEKIRRN CCCCCCHHHHHHHHC	62.89	22790023
227	Ubiquitination	RWLGEPIKAAILPTS HHCCCCCEEEEECCC	42.34	22790023
240	Ubiquitination	TSIFLTNKKGFPVLS CCEEEECCCCCCCHH	49.38	22790023
241	Ubiquitination	SIFLTNKKGFPVLSK CEEEECCCCCCCHHH	68.78	-
304	Phosphorylation	YELFAKGYEDYLQSP HHHHHCCHHHHHCCC	12.62	23984901
307	Phosphorylation	FAKGYEDYLQSPLQP HHCCHHHHHCCCCHH	8.49	23984901
310	Phosphorylation	GYEDYLQSPLQPLMD CHHHHHCCCCHHHHH	25.61	23984901
321	Phosphorylation	PLMDNLESQTYEVFE HHHHCHHHCCEEHHH	30.87	23984901
323	Phosphorylation	MDNLESQTYEVFEKD HHCHHHCCEEHHHCC	30.81	23984901
324	Phosphorylation	DNLESQTYEVFEKDP HCHHHCCEEHHHCCC	11.49	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANM5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANM5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANM5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SF3B4_MOUSE	Sf3b4	physical	17218272
RU1C_MOUSE	Snrpc	physical	17218272
TCRG1_MOUSE	Tcerg1	physical	17218272
RSMB_MOUSE	Snrpb	physical	17218272
PABP1_MOUSE	Pabpc1	physical	17218272
HNRPD_MOUSE	Hnrnpd	physical	17218272
PAIRB_MOUSE	Serbp1	physical	17218272
CHTOP_MOUSE	Chtop	physical	19858291
SMCA4_MOUSE	Smarca4	physical	17043109
MYOD1_MOUSE	Myod1	physical	17043109
NR0B2_MOUSE	Nr0b2	physical	21262773
ICLN_HUMAN	CLNS1A	physical	26496610
RSMB_HUMAN	SNRPB	physical	26496610
FARP1_HUMAN	FARP1	physical	26496610
COPRS_HUMAN	COPRS	physical	26496610
WIZ_HUMAN	WIZ	physical	26496610
MEP50_HUMAN	WDR77	physical	26496610
RIOK1_HUMAN	RIOK1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.