NR0B2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NR0B2_MOUSE
• UniProt AC: Q62227
• Protein Name: Nuclear receptor subfamily 0 group B member 2
• Gene Name: Nr0b2
• Organism: Mus musculus (Mouse).
• Sequence Length: 260
• Subcellular Localization: Cytoplasm. Nucleus. Colocalizes with NEUROD1 in the nucleus..
• Protein Description: Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1..
• Protein Sequence: MSSGQSGVCPCQGSAGRPTILYALLSPSPRTRPVAPASHSHCLCQQQRPVRLCAPHRTCREALDVLAKTVAFLRNLPSFCHLPHEDQRRLLECCWGPLFLLGLAQDAVTFEVAEAPVPSILKKILLEEASSGTQGAQPSDRPQPSLAAVQWLQRCLESFWSLELGPKEYAYLKGTILFNPDVPGLRASCHIAHLQQEAHWALCEVLEPWYPASQGRLARILLMASTLKNIPGTLLVDLFFRPIMGDVDITELLEDMLLLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	TILYALLSPSPRTRP EEEEECCCCCCCCCC	24.96	22817900
57	Symmetric dimethylarginine	VRLCAPHRTCREALD CEECCCCHHHHHHHH	34.17	-
57	Methylation	VRLCAPHRTCREALD CEECCCCHHHHHHHH	34.17	21262773
58	Phosphorylation	RLCAPHRTCREALDV EECCCCHHHHHHHHH	16.93	-
122	Ubiquitination	APVPSILKKILLEEA CCCCHHHHHHHHHHH	35.78	-
123	Ubiquitination	PVPSILKKILLEEAS CCCHHHHHHHHHHHC	34.83	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
26	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
26	S	Phosphorylation	Kinase	MAPK3	P27361	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NR0B2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NR0B2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RARA_HUMAN	RARA	physical	8650544
RXRG_HUMAN	RXRG	physical	8650544
THA_HUMAN	THRA	physical	8650544
NR5A2_MOUSE	Nr5a2	physical	20211142
HNF4G_MOUSE	Hnf4g	physical	20211142
SIR1_MOUSE	Sirt1	physical	20375098
ANM5_MOUSE	Prmt5	physical	21262773
TF65_MOUSE	Rela	physical	21725320
TRAF6_MOUSE	Traf6	physical	21725320
TRAF6_MOUSE	Traf6	physical	14500659
SHPS1_MOUSE	Sirpa	physical	15699129
IRAK1_MOUSE	Irak1	physical	19104650
ARNT_HUMAN	ARNT	physical	11368516

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.